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All Journal Jurnal Anestesiologi Indonesia Majalah Kedokteran Bandung Jurnal Ilmu Kedokteran dan Kesehatan Science Midwifery Jurnal Anestesi Obstetri Indonesia JOURNAL LA MEDIHEALTICO Jurnal Neuroanestesi Indonesia Biomedika Frontiers on Healthcare Research
Hidayat, Nopian
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Prognostic Value of the Lactate/Albumin Ratio for Mortality in Sepsis-Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis Tanjung, Fariz Fadhly; Wijaya, Wan Novriza; Anggraeni, Novita; Hidayat, Nopian; Muharrami, Vera; Irawan, Dino
JAI (Jurnal Anestesiologi Indonesia) Vol 18, No 1 (2026): JAI (Jurnal Anestesiologi Indonesia)
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.76698

Abstract

Objectives: Early risk stratification in patients with sepsis-associated acute kidney injury (SA-AKI) remains challenging because conventional clinical markers have limited prognostic accuracy. The lactate/albumin ratio (LAR), reflecting metabolic stress and systemic inflammation, has emerged as a potential prognostic biomarker. This systematic review and meta-analysis aimed to evaluate the prognostic value of LAR for mortality prediction in adult patients with SA-AKI.Study design: A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Observational cohort studies reporting adjusted hazard ratios (HRs) for the association between LAR and mortality in adult patients with SA-AKI were included. Risk of bias was assessed using the Quality in Prognosis Studies (QUIPS) tool. Pooled effect estimates were calculated using a random-effects inverse-variance model.Data sources: The PubMed, Embase, and Web of Science were systematically searched from database inception to July 2025 without language restrictions. Reference lists of relevant articles were also screened to identify additional studies.Data synthesis: Eight studies were included in the systematic review, and six retrospective cohort studies involving more than 25,000 critically ill patients were eligible for meta-analysis. Elevated LAR measured during early ICU admission was independently associated with increased mortality. The pooled hazard ratio comparing the highest versus lowest LAR categories was 1.97 (95% CI: 1.42–2.73), indicating nearly a twofold higher risk of death. This association remained consistent across different populations and mortality endpoints, although substantial heterogeneity was observed (I² = 91%).Conclusions: LAR is a simple, accessible, and cost-effective biomarker for early mortality risk stratification in SA-AKI. Early measurement of LAR in ICU settings might improve the prognosis of mortality risk, thereby helping with timely decision-making.Registration: The protocol for this systematic review was prospectively registered in PROSPERO.
Short-term care strategy in a cesarean section patient with pulmonary hypertension, EF 25% and intraventricular thrombus: A case report Syafrita, Novella; Muharrami, Vera; Anggraeni, Novita; Hidayat, Nopian
Science Midwifery Vol 14 No 1 (2026): Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2294

Abstract

Cesarean section in patients with pulmonary hypertension and interventricular septal thrombus is a high-risk condition that requires an integrated care strategy and multidisciplinary preparation. The primary goals of care are to ensure hemodynamic stability, control pulmonary artery pressure, and prevent thromboembolic complications during and after surgery. Prior to the procedure, patients are prepared with careful anticoagulation therapy using heparin, strict fluid management, and oxygenation support. The choice of anesthetic is made considering its impact on pulmonary pressure and right heart function. Invasive monitoring, such as arterial lines and central venous pressure (CVP), is used intraoperatively for close monitoring. Collaboration between the obstetrics, anesthesia, cardiology, and intensive care teams is crucial to minimize maternal and fetal risks and ensure a safe cesarean section.
Co-Authors Ananda, Pratama Awanda Herman Bambang Suryono, Bambang Dewi Anggraini Dino Irawan Fajri, Doni Fauzia Andrini Gusti Yulindra, Utari Johannas Marthendro, Triade Masjkur, Diana Maya Savira Muharrami, Vera Novita Anggraeni Pardede, Annisaa Shafira Putra Setiawan Riki Sukiandra Syafrita, Novella Tanjung, Fariz Fadhly Ton, Yori Yarson Wijaya, Wan Novriza Yusmein Uyun