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All Journal Jurnal Penelitian Farmasi dan Herbal JAFP (Jurnal Akademi Farmasi Prayoga) Buletin Kedokteran dan Kesehatan Prima TRANSPUBLIKA INTERNATIONAL RESEARCH IN EXACT SCIENCES (TIRES) Journal of Community Health Provision Journal of Pharmaceutical and Sciences. Jurnal Novem Medika Farmasi
Sembiring, Novitaria Br
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary

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POTENSI ANTIBAKTERI PAREM KARO UNTUK MENANGANI INFEKSI Staphylococcocus aureus PADA PENDERITA DIABETIC FOOT Br Tarigan, Jenny Alfa Dilla; Sembiring, Novitaria Br; Bangar S, Roy Idrianto
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2411

Abstract

One of the cronic and serious complications of diabetes mellitus is diabetic foot. Staphyloccocus aureus bacteria is the most common bacteria found in this type of wound. The purpose of this study is to determine the antibacterial activity of parem Karo, which is one of the traditional medicines of the ethnic culture of the Karo tribe which is rich in spices. Testing the antibacterial activity of Karo hot parem against staphylococcus aureus bacteria using disc diffusion method with 255, 50% and 75% concentration of Karo hot parem extract, positive control Ciprofloxacin Disks (5µg) and negative control DMSO 10%. This disc diffusion method was carried out to determine the diameter of the inhibition formed by Karo hot parem extract in inhibiting the growth of Staphyloccocus aureus bacteria. The results showed inhibitory activity at higher concentrations with the largest average inhibition diameter at 75% concentration against Staphyloccocus aureus bacteria (8.23 ± 0.72 mm) followed by 50% concentration with an average inhibition zone at all. The conclusion obtained from this study is that there is antibacterial activity of Karo hot parem extract at a concentration of 75% and 50% against the growth of Staphyloccocus aureus bacteria.
Efek Nefroprotektif Ekstrak Bunga Telang (Clitoria ternatea L.) Pada Tikus Model Nefrotoksisitas: Analisis Biokimia, Histopatologi, Antioksidan, dan Sitokin Lubis, Asyrun Alkhairi; Sembiring, Novitaria Br; Razoki, Razoki; Siregar, Citra Alvia Nazmi; Kaban, Ade Yasmin; Pandiangan, Qori Tari Jelitta; Sitanggang, Kristia Andini
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1444

Abstract

Background: Butterfly pea flower (Clitoria ternatea L.) is rich in antioxidants and bioactive compounds that may protect the kidney from nephrotoxic injury. Objective: This study aimed to evaluate the nephroprotective effect of ethanolic extract of butterfly pea flower in gentamicin-induced rats. Methods: This in vivo experimental study used 30 male Wistar rats divided into five groups: normal control, negative control, and three treatment groups receiving butterfly pea flower extract at doses of 100, 200, and 400 mg/kgBW. The extract was administered orally, while gentamicin 100 mg/kgBW was given intraperitoneally. Parameters observed included BUN, urea, IL-6, TNF-α, renal morphology, kidney weight, and histopathology. Results: Gentamicin increased BUN, urea, IL-6, and TNF-α levels and caused histopathological damage and morphological changes in the kidney. Administration of butterfly pea flower extract reduced inflammatory response, improved histopathology, and restored renal morphology and kidney weight toward normal. The best histopathological improvement was observed at 200 mg/kgBW, whereas the strongest anti-inflammatory effect was found at 400 mg/kgBW. Conclusion: Ethanolic extract of butterfly pea flower has potential as a nephroprotective agent against gentamicin-induced nephrotoxicity.  
Co-Authors ANDARI, Putri Anselia , Bella Asyrun Alkhairi Lubis Bangar S, Roy Idrianto Bangar S., Roy Idrianto Br Ginting, Astriani Natalia Br Tarigan, Jenny Alfa Dilla Ginting, Astriani Natalia Br Kaban, Ade Yasmin Lubis, Khairunnisya Muhammad Yunus Pandiangan, Qori Tari Jelitta Putri, Tamy Yolanda Razoki, Razoki Siregar, Citra Alvia Nazmi Sitanggang, Kristia Andini Situmorang, Carmenita M. Cindy Tiara Surbekti , Destiana Tata Tania, Kelly Tarigan, Diwa Imanuel Tarigan, Jenny Alfa Dilla Br Vera Estefania Kaban