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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Diponegoro International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Sari Pediatri Paediatrica Indonesiana Indonesian Journal for Health Sciences (IJHS) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Integration of Management Studies
Ahmedz Widiasta
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Umum Pusat Dr. Hasan Sadikin, Bandung
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Health Professions Medicine & Pharmacology Nursing Public Health

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Dapatkah Progresivitas Penyakit Ginjal Kronik pada Anak Kita Hentikan?: Suatu Perspektif Proteomik pada Penyakit Glomerulus Widiasta, Ahmedz
Majalah Kedokteran Indonesia Vol 75 No 2 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.2-2025-1257

Abstract

Penyakit ginjal kronik (PGK) merupakan penyakit tidak menular dengan morbiditas, mortalitas dan penurunan kualitas hidup yang bermakna, ditandai dengan adanya kerusakan struktural dan gangguan fungsional ginjal.1,2 Meskipun begitu, data prevalensi PGK pada populasi anak di dunia diperkirakan mencapai 18 per 1 juta orang.3,4
ALKYLATING AGENT TREATMENT IN CHILDREN WITH STEROID-RESISTANT NEPHROTIC SYNDROME IN WEST JAVA Widiasta, Ahmedz; Rachmadi, Dedi; Hilmanto, Dany
Indonesian Journal of Health Science Vol 9 No 1 (2025): March
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v9i1.8383

Abstract

Objective: to evaluate SRNS therapy in children. Steroid-resistant nephrotic syndrome (SRNS) is one of the most common causes of chronic kidney disease in children. Kidney Disease Initiative for Global Outcome (KDIGO) no longer recommends an alkylating agent (AA) as the treatment protocol for SRNS, still in some developing countries, such as Indonesia, there are some limitations in obtaining immunosuppressive agents other than AA. Method: Data were collected from the medical records of SRNS children with SRNS aged between 1 and 18 years from January 2016 to December 2021. The data included time to remission, adverse effects, and relapse-free period after receiving AA treatment based on the lesion type.  Results: Among the 369 patients enrolled from January 2016 to December 2018, 244 patients (66.12%) had remission with AA, and 125 patients experienced persistent proteinuria. Most of them had remission during the fifth to seventh cycles of intravenous AA (after 6 – 8 months). None of the patients experienced severe adverse effects of AA. Only a small proportion of patients had chronic kidney disease (CKD) stage II–V during follow-up. Conclusions: AA is still effective in treating SRNS in children, with only a few and less harmful adverse effects
Co-Authors Angelreika Libowo Bagaskara, Danang Pangestu Gusti Dany Hilmanto Dedi Rachmadi Dedi Rachmadi Erni Nuraeni Faiisal Faisal Fairuz Sani Jambak, Muhammad Khalid Khairunnisa, Alya Roosrahima Kurnia Wahyudi, Kurnia Muhammad Ilman, Muhammad Nanan Sekarwana Novina Novina Rahadi, Raden Aswin Rodman Tarigan Stanza Uga Peryoga