Article Per Year (5 Year)
p-Index From 2021 - 2026
1.564
P-Index
This Author published in this journals
All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Sari Pediatri Paediatrica Indonesiana Indonesian Journal for Health Sciences (IJHS) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Integration of Management Studies
Ahmedz Widiasta
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Umum Pusat Dr. Hasan Sadikin, Bandung
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Health Professions Medicine & Pharmacology Nursing Public Health

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
ALKYLATING AGENT TREATMENT IN CHILDREN WITH STEROID-RESISTANT NEPHROTIC SYNDROME IN WEST JAVA Widiasta, Ahmedz; Rachmadi, Dedi; Hilmanto, Dany
Indonesian Journal of Health Science Vol 9 No 1 (2025): March
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v9i1.8383

Abstract

Objective: to evaluate SRNS therapy in children. Steroid-resistant nephrotic syndrome (SRNS) is one of the most common causes of chronic kidney disease in children. Kidney Disease Initiative for Global Outcome (KDIGO) no longer recommends an alkylating agent (AA) as the treatment protocol for SRNS, still in some developing countries, such as Indonesia, there are some limitations in obtaining immunosuppressive agents other than AA. Method: Data were collected from the medical records of SRNS children with SRNS aged between 1 and 18 years from January 2016 to December 2021. The data included time to remission, adverse effects, and relapse-free period after receiving AA treatment based on the lesion type.  Results: Among the 369 patients enrolled from January 2016 to December 2018, 244 patients (66.12%) had remission with AA, and 125 patients experienced persistent proteinuria. Most of them had remission during the fifth to seventh cycles of intravenous AA (after 6 – 8 months). None of the patients experienced severe adverse effects of AA. Only a small proportion of patients had chronic kidney disease (CKD) stage II–V during follow-up. Conclusions: AA is still effective in treating SRNS in children, with only a few and less harmful adverse effects
Left Ventricular Function in Steroid-Resistant Nephrotic Syndrome At Dr. Hasan Sadikin Hospital Kusumaputri, Aghnia Ghassani; Rahayuningsih, Sri Endah; Rossanti, Rini; Apandi, Putria Rayani; Widiasta, Ahmedz
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4406

Abstract

Steroid-resistant nephrotic syndrome (SRNS) is a nephrotic syndrome (NS) which does not respond to high-dose corticosteroid therapy after 4 to 8 weeks. SRNS occurs in approximately 10–20% of childhood idiopathic nephrotic syndrome. SRNS patients are at risk of developing cardiovascular complications due to the long duration of the disease. This retrospective descriptive study investigated left ventricular function in pediatric patients with steroid-resistant nephrotic syndrome (SRNS) at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from 2018 to 2022. A total of 42 patients aged 1 month to 18 years who underwent transthoracic echocardiography (TTE) were included. Left ventricular function was assessed using ejection fraction (EF) and fractional shortening (FS). Most patients (61.9%) had normal EF and FS values, while 38.1% showed decreased systolic function. The mean EF and FS were 55.8% and 30.2%, respectively, with median values of 59.3% and 31.2%. An important finding in this study is that some children with SRNS exhibited decreased EF and FS values despite having no other identifiable risk factors for ventricular dysfunction, such as congenital heart disease (CHD), rheumatic heart disease (RHD), chronic kidney disease (CKD), or hypertension. This finding sugest that ventricular dysfunction may still occur independently in some cases of SRNS.
Co-Authors Angelreika Libowo Bagaskara, Danang Pangestu Gusti Dany Hilmanto Dedi Rachmadi Dedi Rachmadi Erni Nuraeni Faiisal Faisal Fairuz Sani Khairunnisa, Alya Roosrahima Kurnia Wahyudi, Kurnia Kusumaputri, Aghnia Ghassani Muhammad Ilman, Muhammad Novina Novina Putria Rayani Apandi, Putria Rayani Rahadi, Raden Aswin Rodman Tarigan Rossanti, Rini Sri Endah Rahayuningsih Stanza Uga Peryoga