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Wicaksana, Bramantya
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Medicine & Pharmacology

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Coronavirus Disease 2019: Review of Current Literatures Susilo, Adityo; Rumende, C. Martin; Pitoyo, Ceva W; Santoso, Widayat Djoko; Yulianti, Mira; Herikurniawan, Herikurniawan; Sinto, Robert; Singh, Gurmeet; Nainggolan, Leonard; Nelwan, Erni J; Chen, Lie Khie; Widhani, Alvina; Wijaya, Edwin; Wicaksana, Bramantya; Maksum, Maradewi; Annisa, Firda; Jasirwan, Chyntia OM; Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 1
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Profil Anafilaksis di RSU Hasanah Graha Afiah, Depok pada Januari 2023 – April 2024 Koesnoe, Sukamto; Wulandari, Risky; Wicaksana, Bramantya
Jurnal Penyakit Dalam Indonesia
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Introduction. Anaphylaxis is a severe hypersensitivity reaction that occurs rapidly and can be life-threatening. This reaction disrupts the respiratory, cardiovascular, digestive, and/or integumentary systems. The global prevalence of anaphylaxis is 1-2%, with a mortality rate of 0.3%. However, data on anaphylaxis in Indonesia is very limited. The aim of this study was to obtain anaphylaxis profile at Hasanah Graha Afiah Hospital, Depok. Methods. This study used a cross-sectional descriptive study from January 2023 to April 2024 at Hasanah Graha Afiah Hospital, Depok, Jawa Barat. Inclusion criteria include patients aged ≥17 years, diagnosed with anaphylaxis in medical records in inpatient and/or emergency units. Data was collected from electronic medical records. Demographic variables include gender, age, marital status, occupation, education, comorbidities, causes of anaphylaxis, diagnostic criteria, severity, initial therapy, and mortality. Results.This study found an anaphylaxis incidence rate of 0.8%, with the highest occurrence in the 26-35 age group (28%). Most anaphylaxis cases were in females (59%). The most common triggers were NSAIDs (34.4%), followed by antibiotics (28.1%), paracetamol (9.4%), anti-bleeding agents (9.4%), and anti-tuberculosis drugs (6.2%). Interestingly, we found food, blood products, and cold as other causes. Anaphylactic shock occurred in 19% of cases. The most used therapies were methylprednisolone (43%), diphenhydramine (28%), epinephrine (17%), and dexamethasone (12%). There were no anaphylaxis-related mortalities. Conclusions. The incidence of anaphylaxis at RSU Hasanah Graha Afiah, Depok, was 0.8%. Most cases occurred in females aged 26–35 years, with medications being the primary trigger. Vigilance in selecting disease treatment, early recognition of anaphylaxis, and prompt and appropriate management are essential instruments in the successful handling of anaphylaxis.
Advanced HIV Disease: Wajah HIV yang Hampir Terlupakan Yunihastuti, Evy; Wicaksana, Bramantya
Jurnal Penyakit Dalam Indonesia
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Campak dan Vaksinasi Campak pada Orang Dewasa Sinto, Robert; Koesnoe, Sukamto; Nelwan, Erni Juwita; Widhani, Alvina; Shakinah, Sharifah; Pasaribu, Adeline; Duindrahajeng, Bernadine Gracia; Suwarto, Suhendro; Nainggolan, Leonard; Chen, Lie Khie; Susilo, Adityo; Maria, Suzy; Hasibuan, Anshari Saifuddin; Wicaksana, Bramantya
Jurnal Penyakit Dalam Indonesia
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Measles is a highly contagious viral infection that remains a significant global health problem despite the availability of an effective vaccine. Measles re-emergence is driven by gaps in immunization coverage, waning post-vaccination immunity, and increased population mobility. In adults, measles infection is associated with greater disease severity compared to children. This literature review was conducted by reviewing recent scientific publications addressing the epidemiology, pathogenesis, clinical manifestations, diagnosis, management, complications, and prevention of measles, with a focus on the adult population.  Measles is caused by an RNA virus of the Paramyxoviridae family and is transmitted through respiratory droplets and aerosols. Typical clinical features include fever, cough, coryza, conjunctivitis, and a maculopapular rash with a centrifugal and cephalocaudal distribution. Diagnosis is based on clinical findings and confirmed by laboratory tests such as RT-PCR and measles-specific IgM serology. Measles infection causes significant immunosuppression, including immune amnesia, which increases susceptibility to secondary infections. Management is primarily supportive and vitamin A supplementation has been shown to reduce mortality in certain populations. In adults, complications tend to be more severe, particularly pneumonia as the leading cause of morbidity and mortality, as well as neurological complications such as encephalitis and subacute sclerosing panencephalitis (SSPE). Measles vaccination with the MMR vaccine remains the main prevention strategy. However, its implementation faces challenges, including gaps in immunization coverage, vaccine hesitancy, and limited adult immunization record system. Measles in adults remains a significant health concern with a high risk of severe complication. Strengthening immunization program, improving public education, and developing integrated surveillance system are essential to reduce disease incidence and burden.
Co-Authors Adityo Susilo, Adityo Alvina Widhani, Alvina Annisa, Firda C. Martin Rumende, C. Martin Ceva W. Pitoyo Duindrahajeng, Bernadine Gracia Edwin Wijaya, Edwin Erni J Nelwan, Erni J Erni Juwita Nelwan, Erni Juwita Evy Yunihastuti Gurmeet Singh Hasibuan, Anshari Saifuddin Herikurniawan, Herikurniawan Jasirwan, Chyntia OM Khie Chen Leonard Nainggolan Maksum, Maradewi Mira Yulianti, Mira Pasaribu, Adeline Robert Sinto Shakinah, Sharifah Suhendro Suwarto, Suhendro Sukamto Koesnoe Suzy Maria Widayat Djoko Santoso, Widayat Djoko Wulandari, Risky