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All Journal Pharmaceutical Sciences and Research (PSR) Jurnal Penyakit Dalam Indonesia
C. Martin Rumende, C. Martin
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Medicine & Pharmacology

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Factors Related to Diagnosis of Community-Acquired Pneumonia in the Elderly Sari, Elza Febria; Rumende, C. Martin; Harimurti, Kuntjoro
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 4
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Introduction. Diagnosing community-acquired pneumonia (CAP) in the elderly remains a clinical challenge for various reasons. The clinical manifestation in the elderly is not frank and atypical manifestations, e.g. falls, decrease of functional status and food intake or urinary incontinence, may be present. These reasons may be associated with under or over diagnosis, which consequently contribute to the higher observed mortality rate in the elderly population with CAP. Study about factors related to diagnosis of CAP in the elderly was ra rely performed. Methods. From January to October 2010, 158 elderly patients suspected of having pneumonia at RSCM were registered. Relationship between clinical, laboratory and radiologic factors which consist of classic manifestations (cough, productive cough, dyspnea, fever, rales, leucocytosis, infiltrates) and atypical manifestations (decrease of intake and functional status, falls, urinary incontinence) with diagnosis community acquired pneumonia were analyzed. Receiver operating characteristics analysis of C-reactive protein was performed to find its association with diagnosis of pneumonia. Results. Of 158 subject, 106 were confirmed of having pneumonia. Final model of multiple logistics regression analysis revealed three factors: cough (p Conclusions. Factors related with diagnosis of community-acquired penumoni in the elderly are cough, rhales and infiltrates. All four atypical manifestations are proven unrelated with diagnosis of pneumonia. C-reactive protein does not predict diagnosis of CAP in the eldery.
Hipoalbuminemia pada Pasien Usia Lanjut dengan Pneumonia Komunitas: Prevalensi dan Pengaruhnya Terhadap Kesintasan Kurniawan, Wawan; Rumende, C. Martin; Harimurti, Kuntjoro
Jurnal Penyakit Dalam Indonesia Vol. 1, No. 2
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Pendahuluan. Hipoalbuminemia merupakan salah satu penanda risiko mortalitas, tetapi belum banyak yang mempertimbangkan faktor waktu (seberapa cepat terjadinya mortalitas). Penelitian ini mengevaluasi pengaruh hipoalbuminemia terhadap kecepatan terjadinya mortalitas pada pasien usia lanjut dengan pneumonia komunitas. Penelitian ini bertujuan untuk mengetahui prevalensi hipoalbuminemia dan pengaruhnya terhadap kesintasan pasien usia lanjut yang dirawat dengan pneumonia komunitas. Metode. Penelitian dengan disain kohort retrospektif dilakukan terhadap 142 pasien usia lanjut dengan pneumonia komunitas yang dirawat di RSCM pada kurun waktu Januari-Oktober 2010. Data klinis dan laboratoris diambil dalam 24 jam pertama kedatangan (data sekunder) dan kemudian diikuti dalam 30 hari untuk melihat status mortalitasnya. Perbedaan kesintasan hipoalbuminemia ditampilkan dalam kurva Kaplan Meier dan perbedaan kesintasan diantara dua atau lebih kelompok akan diuji dengan Log-rank test, dengan batas kemaknaan Hasil. Prevalensi hipoalbuminemia pada pasien usila dengan pneumonia komunitas sebesar 71,1% (IK95% 0,64-0,78). Rerata kesintasan pada kelompok dengan kadar albumin normal adalah 27 hari (IK95% 24,35-30,98), sedangkan pada kelompok albumin 2,5-3,4 g/dL rerata kesintasannya adalah 22 hari (IK95% 19,66-25,13) dan pada kelompok albumin kurang dari 2,5 g/dL rerata kesintasannya adalah 19 hari (IK95% 13,07-26,23). Crude hazard ratio (HR) pasien dengan kadar albumin antara 2,5-3,4 g/dL adalah 4,49 (IK95% 1,05-19,20) dan pada pasien dengan kadar albumin kurang dari 2,5 g/dL adalah 7,26 (IK95% 1,46-36,09) bila dibandingkan dengan pasien dengan kadar albumin normal (≥3,5 g/dL). Setelah penambahan variabel perancu, didapatkan fully adjusted hazard ratio sebesar 3,81 (IK95% 0,86-16,95) untuk kelompok albumin antara 2,5-3,4 g/dL dan 11,09 (IK95% 1,79-68,65) untuk kelompok albumin kurang dari 2,5 g/dL. Simpulan. Prevalensi hipoalbuminemia pada usia lanjut dengan pneumonia komunitas adalah 71,1%. Terdapat perbedaan kesintasan 30 hari pasien pneumonia usia lanjut yang mengalami hipoalbuminemia dibanding dengan yang normoalbuminemia (≥3,5 g/dL). Kesintasan pada pasien dengan keadaan hipoalbuminemia yang berat lebih buruk dibandingkan pada keadaan hipoalbuminemia ringan.
Risk Factors of Antituberculosis Induced-Hepatotoxicity amongHIV/AIDS Patients Luthariana, Lies; Karjadi, Teguh H.; Hasan, Irsan; Rumende, C. Martin
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 1
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Introduction. Antituberculosis (ATT) induced hepatotoxicity is commonly found among HIV/AIDS patients. Several risk factor related to drug-induced hepatotoxicity such as alcoholism, hepatitis B or hepatitis C infection, abnormal baseline aminotransferase/bilirubin, poor nutritional status and concomitant hepatotoxic drugs consumption, are usually found in these patients. This study was conducted to evaluate risk factor of ATT-induced hepatotoxicity in HIV/AIDS patients. Methods. This is a case control retrospective study with matching of age, sex, antituberculosis regimen, and alcohol consumption. Risk factors evaluated are hepatitis C and hepatitis B coinfection, concomitant hepatotoxic drugs consumption, abnormal baseline aminotransferase and or bilirubin. Results. We collected data of 33 cases and 33 controls We found 82% subjects in case group and 76% subjects in control group have hepatitis C coinfection; 18% subjects in case group and 6% subjects in control group have hepatitis B coinfection. Fifty four point five percent (54.5%) subjects in case group and 42.4% subjects in control group consume other hepatotoxic drugs. Elevated baseline ALT level was found in 51.5% subjects in case group and 12% subject in control group. Bivariate analysis showed that the risk of hepatotoxicity was higher in patients with elevated baseline ALT level (OR=7.5; 95% CI 1,72- 32,80; p < 0,05). Conclusions. Elevated baseline ALT level will increase antituberculosis drug induce hepatotoxicity risk up to 7.5 times. There were no association between hepatitis C, hepatitis B, concomitant hepatotoxic drugs consumption and antituberculosis drug-induced hepatotoxicity in HIV/AIDS patients.
Coronavirus Disease 2019: Review of Current Literatures Susilo, Adityo; Rumende, C. Martin; Pitoyo, Ceva W; Santoso, Widayat Djoko; Yulianti, Mira; Herikurniawan, Herikurniawan; Sinto, Robert; Singh, Gurmeet; Nainggolan, Leonard; Nelwan, Erni J; Chen, Lie Khie; Widhani, Alvina; Wijaya, Edwin; Wicaksana, Bramantya; Maksum, Maradewi; Annisa, Firda; Jasirwan, Chyntia OM; Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 1
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Penilaian Domain Pengkajian Paripurna Pasien Geriatri (P3G) sebagai Faktor yang Berpengaruh terhadap Kejadian Pneumonia Nosokomial pada Pasien Usia Lanjut yang Dirawat di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo Victor, Hildebrand Hanoch; Wahyudi, Edy Rizal; Rumende, C. Martin; Soejono, C. H.; Rooshoeroe, A. G.; Shatri, Hamzah; Nainggolan, Leonard; Irawan, Cosphiadi
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Introduction. Nosocomial pneumonia is a lung infection that occurs after the patient is hospitalized for more than 48 hours, without any signs of pulmonary infection at the time of treatment. When compared with young individuals, elderly individuals are more likely to have community-sourced and nosocomial infections with worse outcomes. Comprehensive Geriatric Assessment (CGA) domains are expected to explain the factors that contribute to nosocomial pneumonia in elderly patients. This study aimed to determine the proportion of elderly treated at Dr. Cipto Mangunkusumo National Central General Hospital who experienced nosocomial pneumonia and whether the CGA domains influence the occurrence of nosocomial pneumonia. Methods. A retrospective cohort study was conducted by analyzing the medical records of patients aged 60 years or older who were hospitalized in the medical ward of Geriatric Internal Medicine at Dr. Cipto Mangunkusomo National Central General Hospital in January – September 2019. We also collected secondary data from the geriatric division’s research. The sample consisted of inpatients aged ≥60 years who were hospitalized for more than 48 hours. Those who died within the first 48 hours of hospitalization and subjects with incomplete CGA domain data were excluded from the study. The criteria for nosocomial pneumonia used in this study followed the CDC’s pneumonia criteria for geriatric patients. Data processing was conducted using the application of Statistical Product and Service Solutions (SPSS) 16. Results. Of 228 subjects, the proportion of nosocomial pneumonia in elderly patients hospitalized was 31,14%. The mean age was 69 years with the subject’s age range between 60-89 years. Nutritional status (OR 2.226; CI95% 1.027-4.827) and functional status (OR 3.578; 95%CI 1.398-9.161) are factors that influence the incidence of nosocomial pneumonia in elderly patients who are hospitalized at Dr. Cipto Mangunkusumo National Central General Hospital. Conclusions. The proportion of elderly patients with nosocomial pneumonia was 31.14%. Nutritional status and functional status are factors that influence the incidence of nosocomial pneumonia in elderly patients who are hospitalized at Dr. Cipto Mangunkusumo National Central General Hospital. Keywords: Comprehensive geriatric assessment, elderly, nosocomial pneumonia
The Potential of Herbal Combinations as Adjunctive Therapy for Standard Care of COVID-19 Patients: A Lesson Learned from Indonesia Rozaliyani, Anna; Pratama, Satria; Setianingrum, Findra; Yunita, Fenny; Rumende, C. Martin
Pharmaceutical Sciences and Research Vol. 10, No. 3
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The pandemic of novel coronavirus disease (COVID-19) has become a global disaster that occurred between the end of 2019 and 2023. It caused immeasurable damage to almost all aspects of human life. The disease has opened a lot of new perspectives on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) origins and pathogenesis, the nature of the virus, the potential for new treatments, and new policies to overcome this pandemic. This review aims to know the potential of plants that are beneficial to combat the diseases, including immunomodulators in the management of COVID-19. Studies reporting COVID-19 with the keywords SARS-CoV-2, COVID-19, pathogenesis, clinical manifestations, medicinal plants, and their benefits were included. We also discussed the molecular pathways of the bioactive compound that may interact with the pathogenesis of COVID-19. Clinical management for COVID-19 is still being refined from time to time because many aspects are not yet fully understood and need further studies. Therefore, effective, non-invasive, and affordable treatment must be sought immediately to meet this very urgent need. The commotion situation of the COVID-19 pandemic has encouraged various efforts to develop new drugs, including alternative therapies from potential medicinal plants. The pharmacotherapeutic activity of Indonesia-based medicinal plants for COVID-19 has evolved, including Phyllanthus niruri, Andrographis paniculata, Anacardium occidentale, Zingiber officinale, and Glycyrrhiza glabra. The potential benefits of that combination of herbal medicinal plants also need to be explored for better contribution in managing COVID-19, particularly in Indonesia.
Co-Authors Adityo Susilo, Adityo Alvina Widhani, Alvina Anna Rozaliyani Annisa, Firda Ceva W. Pitoyo Cosphiadi Irawan Dharmeizar Dharmeizar E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edwin Wijaya, Edwin Edy Rizal Wahyudi Elza Febria Sari Endang Susalit Erni J Nelwan, Erni J Evy Yunihastuti Gurmeet Singh Herikurniawan, Herikurniawan Irsan Hasan Jasirwan, Chyntia OM Khie Chen Kuntjoro Harimurti Leonard Nainggolan Lies Luthariana Maksum, Maradewi Marihot Tambunan, Marihot Mira Yulianti, Mira Robert Sinto Rooshoeroe, A. G. Satria Pratama Setianingrum, Findra Soejono, C. H. Teguh H. Karjadi, Teguh H. Victor, Hildebrand Hanoch Wicaksana, Bramantya Widayat Djoko Santoso, Widayat Djoko Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yunita, Fenny