Garuda - Garba Rujukan Digital

Potensi interaksi obat nutrasetikal pada epilepsi anak Endriastuti, Nialiana Endah; Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Purwonugroho, Tunggul Adi
Acta Pharmaciae Indonesia Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.4352

Background: The trend of using nutraceuticals in Indonesia increases every year. This study aims to describe nutraceuticals consumed in pediatrics with epilepsy as additional antiepileptic therapy and analyze their potential drug interactions. Methods: This research was a cross-sectional study with total sampling method which was carried out in the period of June to July 2020. Inclusion criteria were children with epilepsy aged 0-17 years who were members of the Indonesian Epilepsy Community, had a doctor's diagnosis of epilepsy, received oral antiepileptic medication, and took nutraceutical products/food supplements. Data were analyzed descriptively based on data obtained through electronic data filling sheets and interviews. Results: There were 106 participants from the Indonesian Epilepsy Community in total, with 14 children (13.2 %) using nutraceutical supplements. They were male (n=8; 57.1%), 2-12 years old (n=10; 71.4%), and good nutritional status (n=10; 71.4%). Most nutraceuticals consumed were dietary supplements containing vitamins (n=10; 71.4%). Of the eight potential drug interactions identified, 25% (n=2) were significant interactions, and 75% (n=6) were minor interactions. The potential for major interactions occurred in administering nutraceutical products containing vitamin D with the antiepileptic drug phenytoin and phenobarbital. Conclusion: In this study, nutraceuticals and antiepileptic drugs had a little clinically meaningful interaction effect.

Perbandingan Efektivitas Sacubitril/Valsartan dengan Enalapril pada Pasien Gagal Jantung: Literature Review Mumpun, Jitayu Sekarininta; Maharani, Laksmi; Endriastuti, Nialiana Endah
Acta Pharmaciae Indonesia Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.4408

ARNI (Angiotensin Receptor-Neprilysin Inhibitor) is a new therapy for heart failure patients that have been approved since 2016, which is a combination of sacubitril (Neprilisin Inhibitor) and valsartan (ARB). The aim of this study was to review the comparison of the effectiveness sacubitril/valsartan and enalapril in heart failure patients through a literature review method. Database used were Cochrane and PubMed. Keywords search based on PICO (heart failure, sacubitril/valsartan or LCZ696, enalapril, and efficacy or effectiveness). The inclusion criteria were articles in English, available in full text and free access, published in 2010-2020, and RCT. The exclusion criteria were review articles. The searching was conducted from 10 July to 23 July 2020 and 20 December 2020. From this searching, researcher obtained 160 articles, after the process of selection and eligibility, 16 articles were included in the inclusion criteria as primary articles, and 2 articles were included as secondary articles. Studies showed that sacubitril/valsartan reduces the incidence of readmission and has a better QoL score than enalapril, and also decreases the risk of death. According to primary research of PARADIGM-HF and 15 advanced analysis article, it’s known that the usage of sacubitril/valsartan is more beneficial than enalapril in heart failure patients.

Pengaruh Tingkat Pengetahuan Terhadap Kepatuhan Pasien Minum Obat Anti Tuberkulosis (OAT) di Puskesmas Kota Pekalongan Purgiantari, Purgiantari; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah
Acta Pharmaciae Indonesia Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5661

Background: Adherence is one of the most critical factors in the success of pulmonary tuberculosis therapy. Non-compliance of patients taking anti-tuberculosis drug results in a high rate of treatment failure, increasing the risk of disease severity and death. Objective: This study aims to investigate the impact of knowledge level on patient compliance in taking anti-tubercular medication. Methods: This observational, cross-sectional study employed a total sampling method. The levels of knowledge and compliance were assessed using a validated questionnaire administered to patients with pulmonary tuberculosis at the Pekalongan City health center (Puskesmas). Results: Among the 52 participants, 44.23% (n=23) demonstrated a high level of knowledge, and 86.5% (n=45) exhibited good compliance. Spearman correlation test analysis revealed a significant influence of knowledge level on patient compliance in taking antituberculosis drugs (p=0.001, r=0.341), indicating that higher knowledge levels correspond to better patient compliance. Conclusion: The study suggests that patient compliance with antitubercular medication improves as knowledge level increases.

The effectiveness of N-acetylcysteine in alleviating clinical Symptoms of COVID-19 hospitalized patients at Santa Elisabeth Purwokerto General Hospital, Indonesia Ekowati, Heny; Nadzif, Faradina Qorina; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah; Baroroh, Hanif Nasiatul
Acta Pharmaciae Indonesia Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.7548

Background: COVID-19 has been associated with increased innate immune system activation, leading to increased mucus production, inflammation, and tissue damage. N-Acetylcystysteine (NAC), an antioxidant and mucolytic, has demonstrated potential as a COVID-19 therapy. Objective: The purpose of this study was to evaluate the effectiveness of NAC on the clinical symptoms of hospitalized COVID-19 patients at Santa Elisabeth Purwokerto General Hospital in Indonesia. Methods: An observational analytical study design was employed, with data collected from the medical records of hospitalized COVID-19 patients at Santa Elisabeth Purwokerto General Hospital over the period of July 2020 to July 2021. The study included 209 patients who met the eligibility criteria. Results: The results indicated that the use of NAC affected the clinical symptoms of cough, oxygen saturation (SPO2), and respiratory rate in patients with mild and moderate degrees of COVID-19 patients (p<0.05). However, it was found not to affect patients with severe degrees of the disease (p>0.05). Conclusion: This study suggests that NAC may be a useful treatment option for patients with mild and moderate COVID-19. Further research is needed to confirm these findings and determine their effectiveness in severe cases.

Prevalence and characteristics of potential drug-drug interactions in hospitalized atrial fibrillation patients receiving anticoagulant therapy Putri, Atika; Ilma, Dewi Latifatul; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah
Acta Pharmaciae Indonesia Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.2.11882

Background: Anticoagulants are essential for stroke prophylaxis in atrial fibrillation but carry significant interaction potential with commonly used medications. Understanding the prevalence and patterns of these interactions is crucial for optimizing therapy. Objective: To assess the incidence and characteristics of potential drug-drug interactions (DDIs) in hospitalized atrial fibrillation patients receiving anticoagulant therapy. Methods: This retrospective, descriptive observational study analyzed medical records of 324 atrial fibrillation patients hospitalized between January 2019 and December 2021 at a regional hospital in Banyumas Regency. Potential DDIs were assessed using Lexicomp, Drugs.com, and Merck Manual databases, and categorized by severity, mechanism, and clinical manifestation. Results: Nearly all patients (98.90%) experienced at least one potential DDI. Of 1,249 identified DDI events, most were moderate in severity (83.27%) and primarily involved warfarin (69.73%). Pharmacodynamic mechanisms predominated (51.24%), and decreased anticoagulant efficacy was the most common potential clinical manifestation (64.21%). Warfarin accounted for most pharmacokinetic (10.49%) and pharmacodynamic (32.42%) interactions. Elderly patients (>65 years) constituted the largest population group (40.74%), and most patients (65.74%) had atrial fibrillation as a secondary diagnosis. Conclusion: The high prevalence of potential DDIs involving anticoagulants in hospitalized atrial fibrillation patients underscores the need for vigilant medication management, particularly for patients receiving warfarin and those with multiple comorbidities.

Hepatoprotective effects of celery in diethylene glycol induced toxicity in rats Ekowati, Heny; Waluyo, Syaikah Syahidah; Endriastuti, Nialiana Endah
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.172-180

Background Diethylene glycol (DEG) is a contaminant in pharmaceutical solvents and potentially induces hepatotoxicity. Celery is hepatoprotective due to its antioxidant properties. The objective of this study was to evaluate the hepatoprotective effects of celery on DEG-induced liver injury in rats. Methods An experimental laboratory study was conducted involving 25 male Wistar rats weighing 200 grams. They were randomized into five groups (5 rats in each group). Group A served as the control group, while Group B received oral administration of DEG at a dose of 3 g/kg BW twice daily for three days, following six days of food and water administration. The other three groups received DEG at 3 g/kg BW following six days of celery extract once daily administration of 100 mg/kg BW (C), 200 mg/kg BW (D), and 400 mg/kg BW (E). After 14 days, all rats were sacrificed. Observations were conducted macroscopically and microscopically using H&E staining. Liver damage was scored, Kruskal-Wallis followed by the Mann-Whitney was used to analyze the data. Results Macroscopic and microscopic examinations of the liver tissue in the celery groups revealed normal histological architecture with a significant reduction in liver damage. The ethanol extract of celery demonstrated hepatoprotective effects, as evidenced by a statistically significant reduction (p<0.05) in the activation of Kupffer cells, sinusoidal dilation, hepatocyte degeneration, and necrosis. Conclusion Celery has a protective effect against DEG-induced liver damage in rats based on the reduction in Kupffer cell activation, sinusoidal dilation, hepatocyte degeneration, and necrosis.

Nephroprotective and Hepatoprotective Effects of Turmeric in Diethylene Glycol Induced Toxicity in Rats Ekowati, Heny; Devitasari, Arinda; Fitriani, Novita Inawanda; Endriastuti, Nialiana Endah; Wijaya, Triyadi Hendra
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95225

In 2022, children in Indonesia experienced acute renal failure due to antipyretic syrup contaminated with diethylene glycol (DEG). DEG is a known contaminant in pharmaceutical solvents that can induce inflammation and act as a free radical, leading to kidney and liver damage. Turmeric (Curcuma Longa) has been reported to have nephroprotective and hepatoprotective effects due to anti-inflammatory and antioxidant properties. This study aims to evaluate the protective effects of turmeric ethanol extract on rat kidneys and liver subjected to DEG toxicity. Rats were divided into five groups (n=5 per group): Group I served as the normal control, while Group II received DEG orally at 3 g/kg BW twice daily for three days. Groups III, IV, and V were treated with DEG (3 g/kg BW) along with turmeric ethanol extract at a doses of 100, 200, and 400 mg/kg BW, respectively, administered orally twice daily for six days. After 14 days, all rats were sacrificed for macroscopic and microscopic evaluation using hematoxylin-eosin (H&E) staining. The results showed that rats treated with turmeric extract exhibited significantly significantly less kidney and liver damage (p<0.05). Kidney protection was evidenced by improvements in endothelial tissue, glomeruli, and tubules, while liver protection was indicated by reduced Kupffer cell activation, sinusoidal dilatation, hepatocyte degeneration, and necrosis. In conclusion, turmeric ethanol extract effectively protects against DEG-induced kidney and liver toxicity in rats.

Pemantauan Penggunaan Antikoagulan terhadap Perubahan Nilai aPTT pada Pasien Kardiovaskuler Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Endriastuti, Nialiana Endah
Indonesian Journal of Clinical Pharmacy Vol 14, No 2 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2025.v14i2.49454

Antikoagulan merupakan obat pengencer darah untuk mencegah pembentukan dan perkembangan trombus pada aliran darah. Warfarin dan heparin termasuk antikoagulan generasi lama. Rivaroxaban, edoksaban, dabigatran, dan apiksaban termasuk antikoagulan generasi baru. Obat ini memerlukan monitor yang ketat karena berindeks terapi sempit, dan memiliki potensi efek samping obat berupa perdarahan. Tujuan penelitian ini untuk mengetahui pengaruh penggunaan antikoagulan terhadap perubahan nilai aPTT dan mengetahui adanya kejadian adverse drug reaction (ADR) pada pasien kardiovaskuler di RSUD Prof. Dr. Margono Soekarjo Purwokerto. Metode penelitian ini dilakukan dengan rancangan deskriptif observational retrospektif, serta pengumpulan data didapat dari data rekam medis pasien rawat inap penyakit kardiovaskuler. Hasil penelitian ini menunjukkan bahwa responden paling banyak terdiagnosis miokard infark sebesar 39,9%, berusia 20–60 tahun (44%) dan paling banyak berjenis kelamin laki-laki (69,8%). Penggunaan antikoagulan yang digunakan pada responden penelitian ini, antara lain: heparin i.v. (64,70%), warfarin oral (14,11%), fondaparinux i.v. (18,86%), rivaroxaban oral (1,17%), dan enoxaparin oral (1,17%). Kejadian ADR yang timbul pada pasien yang menggunakan antikoagulan UFH mengalami hematuria (56,52%), epistaksis (13,04%), melena (13,04%), batuk berdarah (8,7%), hematemesis (4,35%), dan gusi berdarah (4,35%). Sedangkan pasien yang menggunakan antikoagulan fondaparinux mengalami hematuria (66,67%), epistaksis (11,11%), hematemesis (11,11%), dan gusi berdarah (11,11%). Hasil paired t-test menunjukkan terdapat pengaruh perubahan nilai aPTT setelah penggunaan antikoagulan heparin (p<0,05), dan kejadian ADR antikoagulan yang paling banyak timbul adalah hematuria. Penggunaan antikoagulan heparin dapat mengubah nilai aPTT sehingga perlu adanya monitoring tanda gejala perdarahan lebih lanjut.

Correlation Between Warfarin Levels in the Blood and the Value of Normal INR in Fibrillation Atrium Inpatients Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah; Ilma, Dewi Latifatul; Azzahra, Alfita
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.89898

Background: Warfarin is an anticoagulant inhibitor of vitamin K that is effective in preventing systemic embolization in atrial fibrillation patients. Warfarin has a narrow therapeutic index, so it requires monitoring of rates to prevent the occurrence of toxic effects and to ensure the passage of INR values.Objectives: The study aims to find out the correlation between warfarin levels and normal INR values.Methods: Observational research method with the collection of retrospective data on the medical records of patients treated with atrial fibrillation at Prof. Dr. Margono Soekarjo Hospital, Purwokerto, in January 2019–December 2021. Warfarin levels were calculated pharmacokinetically using the steady-state concentration (Css) and plasma concentration (Cp) formulas. Data analysis is carried out using the Spearman test to determine the correlation between warfarin levels and normal INR values.Results: The number of patients with normal INR values was less than the number of patients with abnormal INR values, namely 21 patients and 48 patients. The Spearman test results show a p-value of 0.31 (p>0.05), showing that the correlation between warfarin levels in the blood and the corresponding INR value is not significant (p> 0.05), and the R value in the Spearman test is 0.122, showing that the direction of the correlation is positive with very weak correlation strength.Conclusion: The correlation between warfarin levels in the blood and the appropriate INR value is not significant (p>0.05), where the R value in the Spearman test shows R=0.122, meaning the direction of the correlation is positive with a very weak correlation strength.

Title

Found 9 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 9 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 9 Documents
Search