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Analisis Kualitatif Faktor-Faktor Pendukung Kepatuhan Pasien Infeksi Dalam Meminum Antibiotik Cefixime Setelah Masa Rawat Inap Di Rumah Sakit Prof. Dr. Margono Soekarjo Mahardika, Elisa; Maharani, Laksmi; Suryoputri, Masita Wulandari
Acta Pharmaciae Indonesia Vol 6 No 2 (2018): Acta Pharmaciae Indonesia Volume 6 No.2 Tahun 2018
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.909 KB)

Latar Belakang: Penggunaan antibiotik harus sesuai dengan regimen yang telah ditentukan dokter atau apoteker untuk mencegah resistensi. Pasien setelah masa rawat inap berpotensi pada masalah kepatuhan dalam penggunaan antibiotik. Penelitian ini bertujuan untuk mengeksplorasi faktor-faktor pendukung kepatuhan pasien infeksi dalam meminum antibiotik cefixime setelah masa rawat inap di Rumah Sakit Prof. Dr. Margono Soekarjo. Metode: Penelitian dilakukan menggunakan metode non-experimental berdasarkan pada pendekatan kualitatif fenomenologis dengan cara wawancara mendalam (indepth interview). Wawancara dilakukan di rumah informan pada hari ke-7 setelah keluar dari rumah sakit dan triangulasi waktu (wawancara kedua) dilakukan satu minggu setelah wawancara pertama. Hasil wawancara dianalisis secara deskriptif dengan proses berfikir induktif. Hasil dan Kesimpulan: Hasil penelitian menunjukkan bahwa faktor-faktor pendukung kepatuhan pasien infeksi dalam meminum antibiotik cefixime setelah masa rawat inap adalah keinginan untuk sembuh, informasi bahwa antibiotik harus dihabiskan, takut terjadi kekambuhan, diingatkan anggota keluarga, bentuk sediaan, kondisi kesehatan yang memburuk dan mengikuti saran dokter. Selain itu, didapatkan hasil bahwa pasien patuh meminum dan menghabiskan antibiotik sesuai aturan pakai, etiket membantu pasien dalam mengingat jam minum obat, pasien mendapatkan informasi antibiotik harus dihabiskan dari tenaga kesehatan dan pasien mendapatkan informasi manfaat obat dari internet.

Pengaruh Edukasi Dan Simulasi Dagusibu Obat Terhadap Peningkatan Keluarga Sadar Obat Di Desa Kedungbanteng Banyumas Suryoputri, Masita Wulandari; Sunarto, Ade Martinus
JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Vol 3 No 1 (2019): Vol 3 No 1 (2019): JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat)
Publisher : Dewan Pimpinan Daerah (DPD) Forum Dosen Indonesia JATIM

Education and simulation to dagusibu of drug is one of effort to prevent unwanted result of using drug, this includes increasing knowledge and awareness of the residents of kedungbanteng village related to the using and storing drugs. Education method that we used was active and participatory learning, this explains how to use and manage drug in proper ways (Dagusibu of drug), application through simulation or demonstration in how to manage properly, and also by evaluation through pretest and post-test. This activity is aimed for PKK candidate and residents Kedungbanteng, Kedungbanteng region, Banyumas regency. Based on the results of the pretest and posttest evaluation showed an increase in knowledge after being given education in the form of counseling, namely the number of respondents who received good grades (80-100) increased from 1 respondent (2.5%) to 12 respondents (30%). Monitoring results home visite also shows the existence of respondents who apply the method of using and managing drugs well and correctly, one of which is by storing drugs in a medicine box. Based on that shows education of Dagusibu and simulation of drug for drug management may increase people's knowledge in order to raise people's wealthness and family awareness of drug

Potensi interaksi obat nutrasetikal pada epilepsi anak Endriastuti, Nialiana Endah; Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Purwonugroho, Tunggul Adi
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.4352

Background: The trend of using nutraceuticals in Indonesia increases every year. This study aims to describe nutraceuticals consumed in pediatrics with epilepsy as additional antiepileptic therapy and analyze their potential drug interactions. Methods: This research was a cross-sectional study with total sampling method which was carried out in the period of June to July 2020. Inclusion criteria were children with epilepsy aged 0-17 years who were members of the Indonesian Epilepsy Community, had a doctor's diagnosis of epilepsy, received oral antiepileptic medication, and took nutraceutical products/food supplements. Data were analyzed descriptively based on data obtained through electronic data filling sheets and interviews. Results: There were 106 participants from the Indonesian Epilepsy Community in total, with 14 children (13.2 %) using nutraceutical supplements. They were male (n=8; 57.1%), 2-12 years old (n=10; 71.4%), and good nutritional status (n=10; 71.4%). Most nutraceuticals consumed were dietary supplements containing vitamins (n=10; 71.4%). Of the eight potential drug interactions identified, 25% (n=2) were significant interactions, and 75% (n=6) were minor interactions. The potential for major interactions occurred in administering nutraceutical products containing vitamin D with the antiepileptic drug phenytoin and phenobarbital. Conclusion: In this study, nutraceuticals and antiepileptic drugs had a little clinically meaningful interaction effect.

Pengaruh Tingkat Pengetahuan Terhadap Kepatuhan Pasien Minum Obat Anti Tuberkulosis (OAT) di Puskesmas Kota Pekalongan Purgiantari, Purgiantari; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5661

Background: Adherence is one of the most critical factors in the success of pulmonary tuberculosis therapy. Non-compliance of patients taking anti-tuberculosis drug results in a high rate of treatment failure, increasing the risk of disease severity and death. Objective: This study aims to investigate the impact of knowledge level on patient compliance in taking anti-tubercular medication. Methods: This observational, cross-sectional study employed a total sampling method. The levels of knowledge and compliance were assessed using a validated questionnaire administered to patients with pulmonary tuberculosis at the Pekalongan City health center (Puskesmas). Results: Among the 52 participants, 44.23% (n=23) demonstrated a high level of knowledge, and 86.5% (n=45) exhibited good compliance. Spearman correlation test analysis revealed a significant influence of knowledge level on patient compliance in taking antituberculosis drugs (p=0.001, r=0.341), indicating that higher knowledge levels correspond to better patient compliance. Conclusion: The study suggests that patient compliance with antitubercular medication improves as knowledge level increases.

Drug utilization of N-Acetylcysteine in COVID-19 inpatients at Santa Elisabeth Hospital, Purwokerto Ekowati, Heny; Nadzif, Faradina Qorina; Suryoputri, Masita Wulandari
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5776

Background: COVID-19 is associated to an oxidant-antioxidant imbalance, which leads to inflammation and tissue damage. N-Acetylcysteine (NAC), in addition to being a mucolytic, has been shown to be an effective antioxidant in the therapy of COVID-19. Objective: The purpose of this study is to evaluate at the NAC usage profile in COVID-19 inpatients at Santa Elisabeth Hospital in Purwokerto. Methods: A descriptive observational design was used to perform the study. Retrospective data were obtained from medical records from July 2020 to July 2021. All patients who met the inclusion criteria were sampled using the total sampling technique. Results: NAC was commonly administered to COVID-19 inpatients who have a mild illness of the disease. The most common symptoms were cough and fever. Patients with mild and moderate severity were given NAC orally (600 mg 3 times a day) and intravenously (5 gram/day), respectively. The duration of NAC administration was in the range of 8-14 days. Conclusion: NAC was one of the therapies used at Santa Elisabeth Hospital Purwokerto for COVID-19 inpatients.

The effectiveness of N-acetylcysteine in alleviating clinical Symptoms of COVID-19 hospitalized patients at Santa Elisabeth Purwokerto General Hospital, Indonesia Ekowati, Heny; Nadzif, Faradina Qorina; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah; Baroroh, Hanif Nasiatul
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.7548

Background: COVID-19 has been associated with increased innate immune system activation, leading to increased mucus production, inflammation, and tissue damage. N-Acetylcystysteine (NAC), an antioxidant and mucolytic, has demonstrated potential as a COVID-19 therapy. Objective: The purpose of this study was to evaluate the effectiveness of NAC on the clinical symptoms of hospitalized COVID-19 patients at Santa Elisabeth Purwokerto General Hospital in Indonesia. Methods: An observational analytical study design was employed, with data collected from the medical records of hospitalized COVID-19 patients at Santa Elisabeth Purwokerto General Hospital over the period of July 2020 to July 2021. The study included 209 patients who met the eligibility criteria. Results: The results indicated that the use of NAC affected the clinical symptoms of cough, oxygen saturation (SPO2), and respiratory rate in patients with mild and moderate degrees of COVID-19 patients (p<0.05). However, it was found not to affect patients with severe degrees of the disease (p>0.05). Conclusion: This study suggests that NAC may be a useful treatment option for patients with mild and moderate COVID-19. Further research is needed to confirm these findings and determine their effectiveness in severe cases.

Prevalence and characteristics of potential drug-drug interactions in hospitalized atrial fibrillation patients receiving anticoagulant therapy Putri, Atika; Ilma, Dewi Latifatul; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah
Acta Pharmaciae Indonesia Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.2.11882

Background: Anticoagulants are essential for stroke prophylaxis in atrial fibrillation but carry significant interaction potential with commonly used medications. Understanding the prevalence and patterns of these interactions is crucial for optimizing therapy. Objective: To assess the incidence and characteristics of potential drug-drug interactions (DDIs) in hospitalized atrial fibrillation patients receiving anticoagulant therapy. Methods: This retrospective, descriptive observational study analyzed medical records of 324 atrial fibrillation patients hospitalized between January 2019 and December 2021 at a regional hospital in Banyumas Regency. Potential DDIs were assessed using Lexicomp, Drugs.com, and Merck Manual databases, and categorized by severity, mechanism, and clinical manifestation. Results: Nearly all patients (98.90%) experienced at least one potential DDI. Of 1,249 identified DDI events, most were moderate in severity (83.27%) and primarily involved warfarin (69.73%). Pharmacodynamic mechanisms predominated (51.24%), and decreased anticoagulant efficacy was the most common potential clinical manifestation (64.21%). Warfarin accounted for most pharmacokinetic (10.49%) and pharmacodynamic (32.42%) interactions. Elderly patients (>65 years) constituted the largest population group (40.74%), and most patients (65.74%) had atrial fibrillation as a secondary diagnosis. Conclusion: The high prevalence of potential DDIs involving anticoagulants in hospitalized atrial fibrillation patients underscores the need for vigilant medication management, particularly for patients receiving warfarin and those with multiple comorbidities.

Immunostimulatory Effects of Zingiber ottensii Rhizome Extract on Mouse Lymphocytes and Peritoneal Macrophages Baroroh, Hanif Nasiatul; Warsinah, Warsinah; Suryoputri, Masita Wulandari; Ekowati, Heny
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95105

Zingiber ottensii (bangle hantu) is a member of the Zingiberaceae family, known for its pharmacological effects. Several studies have demonstrated immunomodulatory potential of Zingiberaceae rhizomes, including Zingiber officinale, Zingiber zerumbet, and Zingiber cassumunar. This study aimed to evaluate the immunomodulatory effects of Z. ottensii extract on mouse peritoneal macrophages and lymphocytes. The extract was prepared using a maceration method with 96% ethanol (1:6) and the extract compound was observed by phytochemical screening with thin layer chromatography (TLC). Phagocytotic macrophage activity was quantified using a phagocytotic assay, which use mouse peritoneal macrophages. Lymphocyte proliferation was assessed with the MTT assay and absorbance measured at 595 nm. TLC results, showed that Z. ottensii extract tested positive for flavonoids and terpenoids. The Z. ottensii extract stimulated macrophage phagocytosis activity, significantly increasing the phagocytotic index at 25 and 50 µg/mL concentrations compared to the control. Additionally, significant lymphocyte proliferation was observed with the treatment of the extract. The Z. ottensii extract may be developed for adjuvant therapy to enhance the immune responses, offering a promising natural approach to immunomodulation.

Analisis Pengaruh Faktor Sosiodemografi Pada Persepsi Masyarakat Terhadap Peran Apoteker di Apotek Kabupaten Pandeglang Noviyanto, Fajrin; Haiti, Fajar Alam; Stiani, Sofy Nurmay; Suryoputri, Masita Wulandari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 2 (2024): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i2.20744

Para peneliti mulai mempelajari bagaimana orang melihat apoteker secara umum, menurut mereka apa yang dilakukan apoteker, dan apa yang mereka antisipasi dari layanan farmasi dan untuk memberikan gambaran tentang aspek sosial ekonomi dan demografi yang mempengaruhi pandangan masyarakat terhadap Kabupaten Pandeglang. Ini adalah penelitian observasional yang menggunakan metodologi kuantitatif dengan fokus pada angka. Kabupaten Pandeglang akan memiliki jumlah penduduk sebanyak 1.272.687 jiwa pada tahun 2021, menurut metode random sampling dan stratified random sampling. Ada 110 total peserta dalam jajak pendapat. Berdasarkan hasil temuan, warga Kabupaten Pandeglang memiliki kesan yang baik (86,4 persen) terhadap kontribusi apoteker dalam penyelenggaraan pelayanan kefarmasian. Sebagian besar penduduk di Kabupaten Pandeglang (82,6%) memiliki kesan yang baik terhadap apoteker, bahkan sebagian besar (83,3%) memiliki harapan yang tinggi terhadap pelayanan kefarmasian yang akan mereka dapatkan dari apotek lokal. Pandangan masyarakat terhadap kontribusi apoteker terhadap pelayanan kefarmasian berkorelasi dengan karakteristik sosial ekonomi meliputi usia dan pendapatan (p(0,05)). Nilai P (lebih besar dari a(0,05) menunjukkan bahwa tidak terdapat hubungan yang signifikan secara statistik antara variabel sosiodemografi dengan pandangan masyarakat Kabupaten Pandeglang terhadap kontribusi apoteker terhadap pelayanan kefarmasian.

Pemantauan Penggunaan Antikoagulan terhadap Perubahan Nilai aPTT pada Pasien Kardiovaskuler Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Endriastuti, Nialiana Endah
Indonesian Journal of Clinical Pharmacy Vol 14, No 2 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2025.v14i2.49454

Antikoagulan merupakan obat pengencer darah untuk mencegah pembentukan dan perkembangan trombus pada aliran darah. Warfarin dan heparin termasuk antikoagulan generasi lama. Rivaroxaban, edoksaban, dabigatran, dan apiksaban termasuk antikoagulan generasi baru. Obat ini memerlukan monitor yang ketat karena berindeks terapi sempit, dan memiliki potensi efek samping obat berupa perdarahan. Tujuan penelitian ini untuk mengetahui pengaruh penggunaan antikoagulan terhadap perubahan nilai aPTT dan mengetahui adanya kejadian adverse drug reaction (ADR) pada pasien kardiovaskuler di RSUD Prof. Dr. Margono Soekarjo Purwokerto. Metode penelitian ini dilakukan dengan rancangan deskriptif observational retrospektif, serta pengumpulan data didapat dari data rekam medis pasien rawat inap penyakit kardiovaskuler. Hasil penelitian ini menunjukkan bahwa responden paling banyak terdiagnosis miokard infark sebesar 39,9%, berusia 20–60 tahun (44%) dan paling banyak berjenis kelamin laki-laki (69,8%). Penggunaan antikoagulan yang digunakan pada responden penelitian ini, antara lain: heparin i.v. (64,70%), warfarin oral (14,11%), fondaparinux i.v. (18,86%), rivaroxaban oral (1,17%), dan enoxaparin oral (1,17%). Kejadian ADR yang timbul pada pasien yang menggunakan antikoagulan UFH mengalami hematuria (56,52%), epistaksis (13,04%), melena (13,04%), batuk berdarah (8,7%), hematemesis (4,35%), dan gusi berdarah (4,35%). Sedangkan pasien yang menggunakan antikoagulan fondaparinux mengalami hematuria (66,67%), epistaksis (11,11%), hematemesis (11,11%), dan gusi berdarah (11,11%). Hasil paired t-test menunjukkan terdapat pengaruh perubahan nilai aPTT setelah penggunaan antikoagulan heparin (p<0,05), dan kejadian ADR antikoagulan yang paling banyak timbul adalah hematuria. Penggunaan antikoagulan heparin dapat mengubah nilai aPTT sehingga perlu adanya monitoring tanda gejala perdarahan lebih lanjut.

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