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All Journal Jurnal Riset Kimia Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional The Indonesian Journal of Public Health Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia
Endriastuti, Nialiana Endah
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Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Perbedaan Heparin dengan Fondafarinux terhadap Efektivitas dan Kejadian Yang Tidak Diinginkan pada Pasien Infark Miokard Akut Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Endriastuti, Nialiana Endah; Astuti, Dwi Aprilia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1680

Abstract

Acute Myocardial Infarction (AMI) is a cardiovascular condition that involves necrosis of the heart muscle because of a decrease in blood supply to the heart caused by an obstruction of the coronary arteries. The prevalence of cardiac disease is 1.5% including AMI, and ranked 4th above all provinces in Indonesia. Anticoagulants are administered for the management of AMI treatment. Anticoagulants are treatments utilized to prevent thrombosis and reduce ischemic injury, preventing hemorrhage from developing in the heart's arteries and veins. Unfractionated heparin (UFH) and fondaparinux are both anticoagulants, that are utilized frequently in the treatment of AMI-EST patients. In decreasing the production of thrombin and preventing coagulation, unfractionated heparin, and fondaparinux can avoid death and recurrent myocardial infarction. The research was conducted as an observational study with retrospective data collection from medical records of inpatients diagnosed with acute transmural myocardial infarction of the anterior wall at Prof. Dr. Margono Soekarjo Purwokerto from January 2019 to December 2021. The chi-square test was used to examine the association between the type of anticoagulant therapy (unfractionated heparin or fondaparinux) and the incidence of recurrent myocardial infarction. The statistical analysis showed a significant association between the type of anticoagulant therapy and the incidence of recurrent myocardial infarction (p < 0.05). A higher proportion of patients treated with fondaparinux did not experience recurrent myocardial infarction compared to those treated with unfractionated heparin, suggesting that fondaparinux may be more effective in preventing recurrence.
KNOWLEDGE, ATTITUDE, AND PRACTICE TOWARD PREVENTION AND MANAGEMENT OF MEDICATION ERRORS AMONG PATIENTS: A CROSS-SECTIONAL STUDY Ilma, Dewi Latifatul; Nugraheni, Bayu; Sholihat, Nia Kurnia; Endriastuti, Nialiana Endah
The Indonesian Journal of Public Health Vol. 21 No. 1 (2026): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v21i1.2026.3-17

Abstract

Introduction: Medication errors are events that can compromise patients’ safety. A total of 19,639 cases were reported in community pharmacies in Toronto between 2018-2021, with pharmacists and patients identifying 7,053 (35.9%) and 6,533 cases (33.3%), respectively. Several studies have shown that improving patient engagement is a key strategy to reduce the frequency and impact of the errors. Aims: This study aims to assess the knowledge, attitude, and practice (KAP) regarding the prevention and management of medication errors among patients. Methods: A cross-sectional study was conducted using self-administered questionnaires distributed to patients at pharmacies in Banyumas Regency, Central Java, Indonesia. Data were then analyzed quantitatively using descriptive and inferential statistics. The Mann-Whitney U test, Kruskal-Wallis test, and Spearman's rank correlation were applied to identify variables that significantly affected knowledge, attitude, and practice. Results: The results showed that among 385 respondents, the average total knowledge score was 86.18%, which was considered a high level of knowledge. More than 90% of respondents agreed or strongly agreed with statements related to the prevention and management of medication errors, while 37.69% actively engaged in such practice. The results also showed that age, gender, occupation, and education were found to influence patients' attitude and practice. In addition, patients with a positive attitude were more likely to engage in practice that prevents and manages medication errors. Conclusions: The knowledge, attitude, and practice survey confirmed that patients’ attitudes significantly affect their practices in preventing and managing medication errors, indicating the need to strengthen patient practices to reduce medication errors and improve patient safety.
Detection of Clove Essential Oil Purity Using a Combination of Chemometric Models with UV-Vis Spectrophotometry Wijaya, Triyadi Hendra; Rehana, Rehana; Endriastuti, Nialiana Endah; Suryoputri, Masita Wulandari; Defa, Ines Naila
Jurnal Riset Kimia Vol. 17 No. 1 (2026): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v17i1.846

Abstract

Clove Essential Oil (CEO) has extensive benefits for health, cosmetics, and food. Low extraction yield (<1%) causes relatively high production costs. This becomes an opportunity for deliberate adulteration to gain greater business profits. This study developed a combination of UV-Vis spectrophotometry with chemometrics to separate pure CEO and adulterated CEO. The adulterants used included Corn Oil (CO) and Olive Oil (OO) at several adulteration levels to see their spectrum and absorption profiles using UV-Vis spectrophotometry. The data were analyzed using PCA and HCA chemometric techniques through R Studio 4.3.3 software. The results of UV-Vis spectrophotometry measurements on CEO adulteration showed similarities in the spectrum profiles of pure CEO and adulterated CEO. Data analysis with PCA can separate pure CEO from adultered CEO with a percentage of cumulative variance of the resulting spectrum of 98.2%. The more similar the composition of a particular oil in a sample, the closer the position of the sample to the oil on the score plot of PCA. HCA analysis can cluster pure CEO separately from adultered CEO. Cluster I in the dendogram consists of samples with large CO concentrations, while samples with large CEO and OO concentrations will be included in Cluster II. The combination of UV-Vis spectrophotometry and chemometrics can be used as a method to separate pure CEO from adultered CEO.
Hubungan Kadar Obat Gentamisin Dalam Darah Terhadap Outcome Clinic Pada Pasien Anak Yang Menderita Pneumonia Di RSUD Ajibarang Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Endriastuti, Nialiana Endah
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 3 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i3.61849

Abstract

Gentamisin merupakan obat dengan indeks terapi sempit yang perlu dilakukan pemantauan kadar obat dalam darah karena dapat berpengaruh pada luaran klinis pasien. Penelitian ini bertujuan untuk mengetahui hubungan kadar gentamisin dengan outcome clinic pada pasien anak yang menderita pneumonia. Perhitungan kadar gentamisin dalam darah dapat dilakukan secara farmakokinetika berdasarkan dosis dan frekuensi pemberian obat menggunakan rumus matematika. Penelitian ini merupakan penelitian dengan desain observasional dan retrospektif. Pengumpulan data dilakukan selama 3 bulan di Instalasi Rekam Medik RSUD Ajibarang. Pengambilan data secara total sampling yang memenuhi kriteria inklusi dan eksklusi. Analisis data statistik menggunakan uji chi square untuk mengetahui hubungan kadar gentamisin dengan outcome clinic responden. Hasil penelitian ini menunjukkan terdapat 52 responden (96,3%) memiliki kadar Cssave sesuai kisaran terapi (0,5-10mg/L) dan 2 responden (3,7%) memiliki kadar Cssave tidak sesuai kisaran terapi. Dari 52 responden yang memiliki kadar Cssave sesuai kisaran terapi (0,5-10mg/L) terdapat 21 responden memberikan outcome clinic membaik dan 31 responden memberikan outcome clinic belum membaik, sedangkan 2 responden yang memiliki kadar Cssave tidak sesuai kisaran terapi terdapat 1 responden memberikan outcome clinic membaik dan 1 responden memberikan outcome clinic belum membaik. Kesimpulan: berdasarkan perhitungan estimasi kadar obat gentamisin, tidak terdapat hubungan yang signifikan antara kadar Cssave gentamisin dengan outcome clinic pasien anak penderita pneumonia di RSUD Ajibarang (p>0.05).
Co-Authors Astuti, Dwi Aprilia Azzahra, Alfita Defa, Ines Naila Devitasari, Arinda Dewi Latifatul Ilma Fitriani, Novita Inawanda Hanif Nasiatul Baroroh Heny Ekowati Laksmi Maharani Mumpun, Jitayu Sekarininta Nadzif, Faradina Qorina Nia Kurnia Sholihat, Nia Kurnia Nugraheni, Bayu Purgiantari, Purgiantari Putri, Atika Rehana, Rehana Suryoputri, Masita Wulandari Triyadi Hendra Wijaya Tunggul Adi Purwonugroho Waluyo, Syaikah Syahidah