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All Journal Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmu Kefarmasian Indonesia
Endriastuti, Nialiana Endah
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Perbedaan Heparin dengan Fondafarinux terhadap Efektivitas dan Kejadian Yang Tidak Diinginkan pada Pasien Infark Miokard Akut Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Endriastuti, Nialiana Endah; Astuti, Dwi Aprilia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1680

Abstract

Acute Myocardial Infarction (AMI) is a cardiovascular condition that involves necrosis of the heart muscle because of a decrease in blood supply to the heart caused by an obstruction of the coronary arteries. The prevalence of cardiac disease is 1.5% including AMI, and ranked 4th above all provinces in Indonesia. Anticoagulants are administered for the management of AMI treatment. Anticoagulants are treatments utilized to prevent thrombosis and reduce ischemic injury, preventing hemorrhage from developing in the heart's arteries and veins. Unfractionated heparin (UFH) and fondaparinux are both anticoagulants, that are utilized frequently in the treatment of AMI-EST patients. In decreasing the production of thrombin and preventing coagulation, unfractionated heparin, and fondaparinux can avoid death and recurrent myocardial infarction. The research was conducted as an observational study with retrospective data collection from medical records of inpatients diagnosed with acute transmural myocardial infarction of the anterior wall at Prof. Dr. Margono Soekarjo Purwokerto from January 2019 to December 2021. The chi-square test was used to examine the association between the type of anticoagulant therapy (unfractionated heparin or fondaparinux) and the incidence of recurrent myocardial infarction. The statistical analysis showed a significant association between the type of anticoagulant therapy and the incidence of recurrent myocardial infarction (p < 0.05). A higher proportion of patients treated with fondaparinux did not experience recurrent myocardial infarction compared to those treated with unfractionated heparin, suggesting that fondaparinux may be more effective in preventing recurrence.
Co-Authors Astuti, Dwi Aprilia Azzahra, Alfita Devitasari, Arinda Dewi Latifatul Ilma Fitriani, Novita Inawanda Hanif Nasiatul Baroroh Heny Ekowati Laksmi Maharani Mumpun, Jitayu Sekarininta Nadzif, Faradina Qorina Purgiantari, Purgiantari Putri, Atika Suryoputri, Masita Wulandari Triyadi Hendra Wijaya Tunggul Adi Purwonugroho Waluyo, Syaikah Syahidah