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Saputra, Gilang
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Ointment Formulation from Collagen Extract of Tilapia Fish Skin (Oreochromis niloticus) for Healing Burns in Mus musculus Nugroho, Romy Triadi; Saputra, Gilang; Aini, Annisa Nurul; Dewi, Aisha Andini Indira; Tarigan, Indra Lasmana
Pharmaceutical Journal of Indonesia Vol. 8 No. 1 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.008.01.2

Abstract

Introduction: Burns are injuries that caused by contact with a heat source. The natural alternative burn treatment can use hydrolyzed collagen derived from aquatic ecosystems, one of them is fish.Objectives: The aim of this research was to find the optimum formulation of tilapia fish collagen extract ointment.Methods: Fish skin that has been separated was prepared using the solution of NaOH 0,1 N and Butyl Alcohol 10%.Then the fish skin was extracted using a 0.5 M acetic acid solution and precipitated with a 0.9 M NaCl solution. Then, dialysis was performed using a plastic membrane (14 KDa) in a 0.1 M acetic acid solution and distilled water to obtain a wet collagen extract which was then in the FreezeDryer to reduce the water content.Results: The collagen extract obtained was used for ointment formulations with different concentrations of collagen extract, that is 5%, 10%, and 15% and 2 additional miana plant extracts were used with collagen extract 5+5% and 10+10%. The results of the formulation were tested on burns with a diameter of 0.715 cm in mice.Conclusion: From the results of the effectiveness test, the formulation with 15% collagen extract showed effective results. Indicated by the rate of wound healing in mice observations
Co-Authors ., Yudhi Abda Abda Agustin, Enur Haeni aini, annisa nurul Algonim, Fadhel Aminulloh, Muhammad Ani Listriyana Ari Nurhaqi Choiriya, Wulan Afni Choyriya, Wulan Afny Dewi, Aisha Andini Indira Emeliya, Alfiyah Fahrezi, Rachman Hera, Hera Ikhsan, Teguh Pribadi Indra Dwisaputra Indra Lasmana Tarigan Maulana, Farrel Rizqullah Ilham Muhyi, Abdul Nugroho, Romy Triadi Nurhayati, Rina Ocsirendi Oktaviani, Feny Prasetyo, Muhammad Rasyid Ramadhan, Cahya Surya Sanusi Sanusi Silviyanti, Nurul Amalia Suryani, Danu Yona Eka Pratiwi