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All Journal Pharmaciana: Jurnal Kefarmasian Pharmacology and Clinical Pharmacy Research Jurnal Ilmiah Farmako Bahari Indonesian Journal of Community Empowerment
ASMAN SADINO, ASMAN
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences Other

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Antioxidant Activity of Ethanol Extract of Polygonum pulchrum Blume Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.767 KB) | DOI: 10.15416/pcpr.v1i2.15201

Abstract

The use of antioxidants from natural resources has attracted increasing interest. One of theplant that was empirically used as an antioxidant dietary supplement was Polygonum pulchrumBlume (P. pulchrum Blume). This study aimed to investigate antioxidant activityof roots, stems, leaves and flowers ethanol extract of P. pulchrum Blume. The extract wasobtained by maceration method using ethanol solvent. Antioxidant activity was determinedwith 1,1-diphenyl-picrylhydrazyl (DPPH) method. We found that ethanol extracts of P. pulchrumBlume roots and stems had strong antioxidant activity with IC50 values of 25.2 mg/land 43.26 mg/l, respectively. Ethanol extract of flowers had the weakest antioxidant activitywith IC50 value of 202.96 mg/l. Vitamin C had very strong antioxidant activity with IC50value of 3.97 mg/l. In conclusion, our study revealed that ethanol extract of Polygonumpulchrum Blume roots and stems had strong antioxidant activity. Therefore, P. pulchrumBlume might be potential as an excellent source for natural antioxidant agents for medicalapplication.Keywords: Polygonum pulchrum Blume, DPPH, antioxidant, maceration, ethanol
Antibacterial Activity of Polygonum pulchrum Blume Ethanol Extract on Staphylococcus aureus and Escherichia coli Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 3, No 2 (2018)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.919 KB)

Abstract

The emergence of resistant bacteria strain has become a global health concern. It encourages the exploration of potential antibacterial agents, particularly from natural sources. The aim of this study was to investigate the antibacterial activity of ethanol extract of root, stems, leaves, and flowers of Polygonum pulchrum Blume against Staphylococcus aureus and Escherichia coli, through disc diffusion method using cup-plate method. Inhibition zone against S. aureus from roots, stems, leaves, and flowers ethanol extract were 3.5 mm, 2.5 mm, 2.25 mm, and 2.62 mm, respectively, while the inhibition zone against E. coli were 2.25 mm, 2.12 mm, 1.62 mm, and 1.75 mm, respectively. In conclusion, ethanol extract of root, stem, leaves, and flower of P. pulchrum Bl possessed weak antibacterial activity against S. aureus and E. coli.Keywords: P. pulchrum Bl, antibacterial, E. coli, S. aureus, cup-plate technique
Acute Toxicity of Ethanol Extract of Polygonum pulchrum Blume using Brine Shrimp Lethality Test Method Sadino, Asman; Sahidin, Idin; Wahyuni, Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.058 KB) | DOI: 10.15416/pcpr.v2i2.15210

Abstract

The potential toxicity effect presents in the medicinal plants is important to be identified forthe safety assurance. Accute toxicity study is an initial step in the drug safety assurance test.Thus, the aim of this study is to identify the potential acute toxicity of roots, stems, leaves,and flowers ethanol extracts of bamboo bamboo plants (Polygonum pulchrum Blume). Thisstudy used brine shrimp lethality test (BSLT) method. The total number of larvae used ineach concentrations in three times replications was 330 larvae. Each group was given consecutivelyroots, stems, leaves and flowers ethanol extracts of P. pulchrum Blume plants withvariation concentrations 12.5 μg/ml, 25 μg/ml, 50 μg/ml, 100 μg/ml, 125 μg/ml, 250 μg/ml, 500 μg/ml, 1000 μg/ml, 2000 μg/ml, and 4000 μg/ml. The number of dead larvae after24 hours treatment were calculated to obtain the mortality percentages and to determine theLC50 value, which were determined by probit analysis using MiniTab application version17.1.0. Ethanol extract of P. pulchrum roots and stems resulted LC50 values of 933.08 μg/mland 919.58 μg/ml, respectively. While the LC50 values of leaves and flowers extracts were2207.06 μg/ml and 1081.90 μg/ml, respectively. In conclusion, P. pulchrum Blume roots andstems were classified as toxic according to BLST method, while leaves and flowers were not.Keywords: acute toxicity, brine shrimp lethality test, Polygonum pulchrum Blume
HYPNOTIC-SEDATIVE ACTIVITY TEST OF 70% ETHANOL EXTRACT OF LETTUCE (Lactuca sativa L.) IN MALE WHITE MICE SWISS WEBSTER STRAIN Sadino, Asman; Renggana, Hesti; Suwendar, Suwendar; Apriani, Riza; Nurhandayani, Yuni
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3090

Abstract

Humans who use medicines for insomnia may experience a variety of adverse effects, including dependence. Traditional medicine frequently uses lettuce (Lactuca sativa L.) to treat various conditions, including sleep difficulties. Terpenoids, which are secondary metabolites found in lettuce plants, are to blame for this. This study aimed to see if an ethanolic extract of lettuce leaf had any sedative-hypnotic activity in Swiss Webster strain male white mice induced by phenobarbital at a dose of 90 mg/KgBB intraperitoneally. In this study, the post-test-only control strategy was employed. The animals were divided into six groups (n = 4): negative (aqua dest), positive (Na-CMC 0.5%), comparison (diazepam 1.3 mg/KgBB), and ethanolic extract of lettuce leaf at doses of 300 mg/KgBB, 400 mg/KgBB, and 500 mg/KgBB. The parameters observed in this study were a combination of parameters from previous studies, namely the number of falls, sleep onset, and sleep duration in mice. The data obtained were then processed statistically using the one-way ANOVA (analysis of variance) and post-hoc test follow-up analysis with the LSD (least significant difference) test. The results showed that the ethanolic extract of lettuce leaves at 300, 400, and 500 mg/KgBB had a sedative-hypnotic effect. Doses of 300 mg/KgBB only increased sleep duration. In contrast, 400 and 500 mg/KgBB increased the number of falls, rapid sleep onset, and increased sleep duration, significantly different from positive controls (p<0.05). The effective dose of ethanolic extract of lettuce leaf as a sedative-hypnotic was 400 mg/KgBB.
HYPNOTIC-SEDATIVE ACTIVITY TEST OF 70% ETHANOL EXTRACT OF LETTUCE (Lactuca sativa L.) IN MALE WHITE MICE SWISS WEBSTER STRAIN Sadino, Asman; Renggana, Hesti; Suwendar, Suwendar; Apriani, Riza; Nurhandayani, Yuni
Jurnal Ilmiah Farmako Bahari Vol 15 No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3090

Abstract

Humans who use medicines for insomnia may experience a variety of adverse effects, including dependence. Traditional medicine frequently uses lettuce (Lactuca sativa L.) to treat various conditions, including sleep difficulties. Terpenoids, which are secondary metabolites found in lettuce plants, are to blame for this. This study aimed to see if an ethanolic extract of lettuce leaf had any sedative-hypnotic activity in Swiss Webster strain male white mice induced by phenobarbital at a dose of 90 mg/KgBB intraperitoneally. In this study, the post-test-only control strategy was employed. The animals were divided into six groups (n = 4): negative (aqua dest), positive (Na-CMC 0.5%), comparison (diazepam 1.3 mg/KgBB), and ethanolic extract of lettuce leaf at doses of 300 mg/KgBB, 400 mg/KgBB, and 500 mg/KgBB. The parameters observed in this study were a combination of parameters from previous studies, namely the number of falls, sleep onset, and sleep duration in mice. The data obtained were then processed statistically using the one-way ANOVA (analysis of variance) and post-hoc test follow-up analysis with the LSD (least significant difference) test. The results showed that the ethanolic extract of lettuce leaves at 300, 400, and 500 mg/KgBB had a sedative-hypnotic effect. Doses of 300 mg/KgBB only increased sleep duration. In contrast, 400 and 500 mg/KgBB increased the number of falls, rapid sleep onset, and increased sleep duration, significantly different from positive controls (p<0.05). The effective dose of ethanolic extract of lettuce leaf as a sedative-hypnotic was 400 mg/KgBB.
The Relationship between Knowledge Level and Self-Medication Behavior for Scabies at SMK Plus Al-Istiqomah Sadino, Asman; Suwandi, Deden Winda; Susanti, Risa; Nuari, Doni Anshar; Renggana, Hesti; Rohimah, Vina Siti; Apriliani, Nisa Siti
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 02 (2024): Indonesian Journal of Community Empowerment (May)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i2.712

Abstract

Scabies is a skin disease that is often ignored. Scabies is still common in Islamic boarding schools with a high prevalence rate. Self-medication is used to treat mild to moderate illnesses without consulting a doctor first. This community service aims to determine the relationship between the level of understanding of scabies' self-medication behavior at SMK Plus Al Istiqomah. The method used begins with the distribution of an initial questionnaire (pre-test), presentation of the material with the help of PowerPoint slides, a question and answer session between students (i) and the presenter, and distribution of the final questionnaire (post-test). The results of this community service activity showed an increase in knowledge of scabies from a percentage of 5% to 87.5%. This means that the education provided can be well received by students at SMK Plus Al-Istiqomah.
Nutritional Counseling for Pregnant and Breastfeeding Mothers as an Effort to Prevent Stunting in Sekarwangi Village, Malangbong District, Garut Regencyt Apriani, Riza; Senania, Astri; Kanto, Dhini Annisa Rahmasari; Sadino, Asman
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 02 (2024): Indonesian Journal of Community Empowerment (May)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i2.923

Abstract

Stunting menjadi salah satu masalah kesehatan yang menjadi perhatian pemerintah karena berdampak pada kualitas sumber daya manusia Indonesia. Hingga saat ini, kasus terjadinya stunting di Indonesia masih tergolong tinggi. Salah satu cara yang dianggap efektif untuk mempercepat capaian zero stunting adalah dengan meningkatkan kesadaran masyarakat tentang pencegahan stunting, khususnya pada ibu hamil dan menyusui. Tujuan dari kegiatan pengabdian ini adalah untuk mendukung program pemerintah untuk mencapai zero stunting melalui peningkatan pengetahuan ibu hamil dan menyusui mengenai gizi yang baik pada 1000 Hari Pertama Kehidupan. Metode yang digunakan adalah dengan pemberian penyuluhan dan penyebaran brosur. Peserta kegiatan ini yaitu ibu hamil, ibu menyusui dan ibu PKK di lingkungan Desa Sekarwangi, Kecamatan Malangbong, Kabupaten Garut. Total peserta kegiatan ini yaitu 50 orang. Kegiatan ini dilaksanakan pada hari Sabtu, 20 Agustus 2022. Hasil kegiatan ini didapatkan bahwa terdapat peningkatan skor pengetahuan setelah diberikan penyuluhan. Berdasarkan hal tersebut dapat disimpulkan bahwa penyuluhan tentang pencegahan stunting dapat meningkatkan pengetahuan ibu hamil dan menyusui di wilayah Desa Sekarwangi, Kecamatan Malangbong, Kabupaten Garut. Adanya peningkatan pengetahuan ini diharapkan dapat mendukung pencapaian zero stunting di daerah tersebut.
Introduction to the Pharmacist Profession and Education on Wise Choice of Snacks and the Dangers of Cigarettes and Drugs for Teenagers Renggana, Hesti; Susanti, Risa; Qowiyyah, Atun; Dewi, Asri; Winda, Deden; Anshar, Doni; Sadino, Asman
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 01 (2024): Indonesian Journal of Community Empowerment (February)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i1.925

Abstract

Pharmacists are competent health professionals in drug management. Many efforts have been made so that the role of pharmacists in carrying out pharmaceutical work is more felt in the community. Therefore, community service is carried out in the form of education on introducing the pharmacist profession, wisely choosing snacks, and about the dangers of cigarettes and drugs. It is expected that from this service, students who are part of the community can better understand the pharmacist profession and its role in adolescent health. Education was carried out on MIT and MTs Baitul Aziz Majalaya students. Before the education, a pretest was carried out and after the education, a posttest was carried out using a questionnaire related to the material. Data were processed and analyzed using descriptive statistics. The results of the education showed that the level of knowledge of MIT students increased, especially in the good category, from 8% to 76% for knowledge of the pharmacist profession, and from 80% to 95% for knowledge of wisely choosing snacks. In addition, the level of knowledge of MTs students regarding the dangers of cigarettes and drugs also increased, especially in the good category from 13% to 75% after education.
Analgesic and anti-inflammatory activities of the extract of Polypodium feei mett roots Suwandi, Deden Winda; Renggana, Hesti; Subarnas, Anas; Rostinawati, Tina; Muchtaridi, Muchtaridi; Sadino, Asman
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.25133

Abstract

The limited scientific evidence on the analgesic and anti-inflammatory effects of Polypodium feei roots, despite their traditional use in rheumatism treatment, highlights the need for pharmacological validation. The study investigates the analgesic and anti-inflammatory properties of Polypodium feei roots, a traditional medicine used to treat rheumatism, in mice and rats with carrageenan-induced paw edema, using acetylsalicylic acid and tramadol as analgesics and diclofenac sodium as an anti-inflammatory. The writhing test results demonstrate that the extract of P. feei roots (EPFR) at dosages of 50 and 100 mg/kgBW lowered the writhing responses of rat significantly (p <0.01). The dose of 100 mg/kgBW provided more protection than acetylsalicylic acid at a level of 65 mg/kgBW. In the hot plate method, the extract increased the latency period significantly (p <0.05) as compared with the control. In the anti-inflammatory examination, the EPFR decreased edema of rat paws induced by carrageenan. The significant effect of the EPFR was shown by the dose of 100 mg/kgBW (p <0.05), but its inhibition was lower than that of a standard agent, diclofenac sodium. This study concluded that the EPFR may have peripherally and centrally analgesic activity and anti-inflammatory activity. This evidence supports the folklore claim of the efficacy of EPFR as traditional medicine for rheumatism.
Improving Elderly Knowledge on Hypertension through Health Education in Parakan Village, Garut Sadino, Asman; Lubis, Novriyanti; Suryana, Shendi; Prasetiawati, Riska; Hermawan, Belya Anindia; Cahyati, Effan; Apriani, Riza; Karina, Karina; Rena, Rena
Indonesian Journal of Community Empowerment (IJCE) Vol 6 No 2 (2025): Indonesian Journal of Community Empowerment (May)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v6i2.1034

Abstract

Hypertension is a non-communicable disease often referred to as a "silent killer" because it may develop without noticeable symptoms and can lead to serious complications if left untreated. Elderly individuals are among the high-risk groups who require special attention in efforts to prevent and control hypertension. This community service activity aimed to improve the knowledge of elderly residents regarding hypertension through health education as a preventive measure against further complications. The program was conducted in Parakan Village, Garut Regency, involving 30 elderly participants. The method used was health education combined with pre-test and post-test assessments to evaluate knowledge improvement. The results showed a significant increase in understanding after the session, particularly regarding the symptoms and prevention of hypertension. Another notable finding was that most participants had only elementary-level education, which influenced their receptiveness to health information. In conclusion, health education proved effective in enhancing the elderly's knowledge of hypertension and its potential complications. Periodic follow-up education and collaboration with local health services are recommended to sustain the impact.
Co-Authors Anas Subarnas Apriani, Riza Apriliani, Nisa Siti Asri Dewi, Asri Astri Senania, Astri Atun Qowiyyah Cahyati, Effan Hermawan, Belya Anindia Kanto, Dhini Annisa Rahmasari Karina Karina Mochammad Imron Awalludin Muchtaridi Muchtaridi Novriyanti Lubis, Novriyanti Nuari, Doni Anshar Nurhandayani, Yuni Rena Rena Renggana, Hesti Riska Prasetiawati, Riska Rohimah, Vina Siti Sahidin, Idin Suryana, Shendi Susanti, Risa Suwandi, Deden Winda Suwendar Suwendar Tina Rostinawati