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All Journal JURNAL MANAJEMEN PENDIDIKAN ISLAM AL-IDARAH JURNAL FARMASIMED (JFM) Jurnal Ilmiah Edunomika (JIE) Indonesian Journal of Pharmaceutical and Clinical Research Mejuajua SABAJAYA Jurnal Pengabdian Kepada Masyarakat GEMBIRA (Pengabdian Kepada Masyarakat) Jurnal Indah Sains dan Klinis
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Journal : Indonesian Journal of Pharmaceutical and Clinical Research

 1 
Test of Burn Wounds Healing Effects of Collagen From Snakehead Fish (Channa striata) Bone in The Preparation of Cream on Male White Rats (Rattus norvegicus) Hasri, Najwa Miladi; Zebua, Nilsya; Sudewi
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 1 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i1.3977

Abstract

Abstract. The use of snakehead fish (Channa striata) collagen in cream is an alternative toreduce fish wastes. It has been proved that snakehead fish (Channa striata) contain collagen.This research aims to study the burn wound healing effectivity of bone’s collagen fromsnakehead fish (Channa striata) that is formulated into a cream. This study used theexperimental method with the bone of snakehead fish (Channa striata) as a sample. This studyconsisted of 4 (four) such as isolation of collagen from snakehead fish's (Channa striata) bone,characterization of collagen by analyzing moisture, ash, protein, fat and functional groupanalysis with FTIR, formulation, and evaluations of cream such as organoleptic test,homogeneity test, pH measurement, stability test, and irritation test, and burn wound healingtest in male white rats (Rattus norvegicus) and the result is analyzed using SPSS 22.0 Free trialand One Way ANOVA and Post-Hoc Tukey HSD. The results showed that fish collagen couldbe isolated from snakehead fish (Channa striata) and the yield obtained is 33.3%. The results ofcollagen characterization and evaluation test met the collagen standard requirements. Results ofthe burn wound healing test on male white rats (Rattus norvegicus) showed that K1 burn woundrecovered on day 21, K2 on day 12, K3 on day 15, K4 on day 18, and K5 on day 18.Measurement of burn wound diameter on day 21 showed K1 = 1.20 cm, K2 = 0.15 cm, K3 =0.10 cm, K4 = 0.45 cm, K5 = 0.40 cm. The results of the statistical analysis of burn wounddiameter showed a significant difference p = 0,000 (p <0.05) between each group. K3 showedthe reduction in the burn wound diameter is faster and the smallest, it can be concluded that theoptimal dose of snakehead fish bone’s collagen cream is a concentration of 3%.
Dry Suspension Formulation of Ethanol Extract from Wuluh Starfruit (Averrhoa bilimbi L.) with Arenga Gum as Suspending Agent Zebua, Nilsya Febrika; Syafitri, Yuni; Sudewi; Novriansyah, Reza
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 1 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i1.6910

Abstract

Wuluh starfruit (Averrhoa bilimbi L.) has a sour taste and high water content which makes the fruit easily damaged and has a short shelf life. It is necessary to process wuluh starfruit in order to obtain a product that has a longer shelf life and tastes better without reducing its benefits. The purpose of this study was to determine the wuluh starfruit in the form of ethanol extract can be formulated into a dry suspension dosage form with arenga gum as a suspension which at a certain concentration can be an optimal suspending agent. Based on the results showed that the ethanol extract of wuluh starfruit (Averrhoa bilimbi L.) could be formulated into a dry suspension. The preparation with 0.5% arenga gum as a suspending agent is the best preparation which has a moisture content of 0.46%, stationary angle of 26.48º, flow time of 4.77 seconds, compressibility index of 18%, particle size distribution 152.133μm, viscosity 106.00 cP, pH 4.16 and sedimentation volume 0.55. Data were analyzed using SPSS 26.0 using one-way analysis of variance (ANOVA) test and post hoc Multiple Comprasions Tukey HSD test.
Co-Authors Andreas Andoyo Fauzi Hardini Ariningrum Hasanah , Fenny Hasri, Najwa Miladi Lubis, Salmah Handayani Miftah Riska Maulana Cahyani Muflihah Fujiko Muhtar, Entang Adhy Nilsya Febrika Zebua, Nilsya Febrika Novita Andriayani Novita Andriyani Novriansyah, Reza Nur Lela Nurlela NURUL KARIMAH Peronika Tampubolon Rahma Yulia Rara Maselina Jupon Riau, Dwi Putranto Rinawati Siti Arum Widiyanti Sumardi Supran Hidayat Suryanto Syafitri, Yuni Tambunan, Ika Julianti Tri Susilowati Tri Susilowati Trisnawati Wiwik Handayani WULANDARI Yessi Febriani Yoli Anathasia Yufida Laia