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KOMBINASI PEMERIKSAAN FINE NEEDLE APIRATION BIOPSY DAN BASIL TAHAN ASAM SEBAGAI ALTERNATIF TES PCR DALAM DIAGNOSIS LIMFADENITIS TUBERKULOSIS Chendrasari, Julian; Lestari, Indah Widya
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 9, Nomor 2, Juli 2024
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v9i2.18198

Tuberkulosis adalah penyakit infeksi bakteri kronik granulomatosa yang disebabkan oleh Mycobacterium tuberculosis. Tuberkulosis selain di paru dapat juga mengenai organ di luar paru dan yang tersering adalah limfadenitis tuberkulosis pada kelenjar getah bening leher. Tuberkulosis menjadi penyebab tersering radang granulomatosa di negara tropis. Ciri utama tuberkulosis secara histologik adalah adanya nekrosis kaseosa yang berhubungan dengan sel datia granulomatosa. Sedangkan secara sitologik, apusan aspirat dari limfadenitis tuberkulosis dapat menunjukkan salah satu dari tiga pola utama: granuloma epitelioid tanpa nekrosis, granuloma epitelioid dengan nekrosis, dan nekrosis tanpa granuloma epitelioid. Pulasan Ziehl Neelsen digunakan untuk mengidentifikasi adanya basil tahan asam. Pulasan tahan asam ini relatif rendah sensitivitasnya dan sering memberikan hasil negatif karena diperlukan jumlah basil minimal untuk memberikan hasil yang positif. Polymerase chain reaction merupakan teknik lain untuk mendeteksi Mycobacterium tuberculosis. Pemeriksaan ini memiliki sensitivitas hingga 70% dibandingkan dengan kultur pada sampel yang bukan berasal dari saluran respirasi. Saat ini, polymerase chain reaction merupakan baku emas untuk diagnosis tetapi biayanya cukup mahal untuk pemeriksaan diagnosis rutin. Fine needle aspiration biopsy merupakan metode alternatif untuk diagnosis yang cepat dan mudah, serta dapat memberikan kesimpulan yang akurat pada pasien dengan limfadenopati karena tuberkulosis. Walaupun, sensitivitas fine needle aspiration biopsy bervariasi dari 10% hingga 80%, tetapi sering digunakan untuk diagnostik awal. Fine needle aspiration biopsy dengan pulasan basil tahan asam sebaiknya menjadi pemeriksaan lini pertama pada kasus limfadenopati yang dicurigai tuberkulosis.

Pencegahan Kanker Payudara Melalui Penyuluhan di Masyarakat Nagrak Digambiro, Reza Aditya; Chendrasari, Julian; Ilona, Florinda; Lestari, Indah Widya; Setyaningrum, Dyah Ayu Woro; Fadillah, Ibnu Haris
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 11 (2025): Januari
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i11.1922

Kanker payudara tetap menjadi masalah kesehatan masyarakat yang signifikan di Indonesia, terutama di daerah berkembang seperti Nagrak. Tantangan dalam deteksi dini akibat kurangnya kesadaran, fasilitas kesehatan yang terbatas, dan stigma budaya memperburuk prevalensi dan mortalitas akibat kanker payudara. Program pengabdian masyarakat yang dilakukan oleh Fakultas Kedokteran Universitas Trisakti bertujuan untuk meningkatkan kesadaran masyarakat dan memberdayakan perempuan di Nagrak untuk melakukan pemeriksaan payudara sendiri (SADARI) sebagai langkah pencegahan. Program ini melibatkan survei awal untuk menilai pengetahuan masyarakat, diikuti dengan seminar edukasi dan sesi simulasi SADARI yang dipandu oleh tenaga medis dan mahasiswa. Evaluasi pasca-kegiatan menunjukkan peningkatan signifikan dalam pengetahuan dan keterampilan peserta, yang menegaskan efektivitas program ini. Rekomendasi utama meliputi pelaksanaan edukasi rutin, penguatan kerjasama dengan fasilitas kesehatan lokal, dan pemanfaatan media digital untuk memperluas dampak edukasi. Inisiatif ini menegaskan pentingnya pendekatan berbasis komunitas dalam menurunkan prevalensi kanker payudara melalui deteksi dini dan perubahan gaya hidup.

The Impact of High Dose Ozone Therapy on Hematological and Biochemical Profiles : An Observational Study Digambiro, Reza Aditya; Parwanto, Edy; Lestari, Indah Widya; Chendrasari, Julian; Setyaningrum, Dyah Ayu Woro; Ilona, Florinda
The Avicenna Medical Journal Vol 5, No 1 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i1.34859

Background: Ozone therapy, namely High Dose Ozone Therapy (HDO), has become a versatile medical treatment in several clinical settings. Although it is becoming more well acknowledged, there is still a lack of extensive evidence about the impact of this on hematological and biochemical indicators. This study seeks to address this void by examining the consequences of this phenomenon in a clinical environment.Method: An observational study was done, which followed a structured approach, comprising a total of 100 patients who were selected from the SMC Clinic. Hematological and biochemical indices were evaluated before and after ozone therapy sessions to analyze blood parameters. Two blood samples were obtained at two specific time points: prior to the commencement of the ozone therapy (T0) and after the therapy was finished (T1).Results: Substantial alterations were noted in both hematological and biochemical parameters after the therapy. The hematological changes observed in this study showed a substantial rise in the red blood cell count (p=0.009), hemoglobin levels (p=0.004), and hematocrit (p=0.039), along with a decrease in erythrocyte sedimentation rate (ESR) (p=0.020). Notable biochemical changes were observed, including significant modifications in total plasma protein (TPP) (p=0.008) and lactate levels (p=0.001). Furthermore, there was a noteworthy decrease (p<0.05) in the levels of malondialdehyde (MDA), which is a marker for oxidative stress.Conclusion: HDO exerts a regulatory influence on crucial hematological, biochemical, and oxidative stress factors. These findings indicate that HDO may have therapeutic benefits for treating chronic disorders and cancer. It can improve blood parameters and reduce oxidative stress. The decrease in markers of oxidative stress, such as MDA, suggests a potential reduction in the likelihood of problems associated with oxidative damage in chronic diseases. Nevertheless, additional research is required to validate these findings, investigate their wider therapeutic implications, and comprehend the long-term consequences and safety of HDO therapy.

THE USE OF TELEMEDICINE IN PRIMARY HEALTHCARE SERVICES IN JAKARTA Digambiro, Reza Aditya; Ilona, Florinda; Setyaningrum, Dyah Ayu Woro; Chendrasari, Julian; Lestari, Indah Widya
HEARTY Vol 13 No 3 (2025): JUNI
Publisher : Fakultas Ilmu Kesehatan, Universitas Ibn Khaldun, Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/hearty.v13i3.18339

Background: The advancement of digital technology has transformed the healthcare sector, and telemedicine has become an important innovation in providing remote clinical services. Methods: The research method used is a mixed-method approach, combining quantitative and qualitative approaches. Data collection was conducted through questionnaires distributed to 400 telemedicine users. The sample size was determined using the Slovin formula with a 5% margin of error. Results: 75% of respondents used telemedicine more than once in the past year, with 70% of respondents expressing high satisfaction with the services received. The main reasons for using telemedicine include convenience (65%) and time savings. However, several challenges were identified, such as technical issues (30%), lack of physical examinations, and concerns about service quality. Discussion: The main challenges identified include inadequate technological infrastructure, low digital literacy among certain groups, and unclear regulations. Development opportunities include the integration of telemedicine with electronic health records and increased public education. Conclusion: Telemedicine has great potential to improve the accessibility and efficiency of healthcare services in Jakarta. However, improvements in infrastructure, digital literacy, and supportive regulatory frameworks are needed to maximize the benefits of telemedicine within the healthcare system.

PENYULUHAN KESEHATAN SEBAGAI UPAYA MENINGKATKAN KUALITAS HIDUP LANSIA DI POSYANDU BERINGIN III, BEKASI Digambiro, Reza Aditya; Ilona, Florinda; Chendrasari, Julian; Lestari, Indah Widya; Setianingrum, Dyah Ayu Woro
Jurnal Gembira: Pengabdian Kepada Masyarakat Vol 3 No 03 (2025): JUNI 2025
Publisher : Media Inovasi Pendidikan dan Publikasi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Lansia merupakan kelompok masyarakat yang memiliki risiko tinggi terhadap berbagai penyakit degeneratif, terutama akibat perubahan fisiologis seiring bertambahnya usia. Kondisi ini diperparah oleh rendahnya tingkat pendidikan, kurangnya akses terhadap informasi kesehatan, dan minimnya aktivitas fisik di kalangan lansia. Penyuluhan kesehatan berbasis komunitas menjadi salah satu upaya strategis untuk meningkatkan kualitas hidup lansia. Kegiatan ini dilaksanakan di Posyandu Beringin III, Jaticempaka, Bekasi, dengan metode seminar edukatif dan simulasi praktik langsung untuk meningkatkan pemahaman lansia tentang pola hidup sehat, deteksi dini penyakit degeneratif, serta pentingnya menjaga kesehatan mental dan sosial. Kegiatan ini melibatkan 30 peserta lansia dan dipandu oleh tim dari Fakultas Kedokteran Universitas Trisakti. Evaluasi kegiatan menunjukkan adanya peningkatan signifikan dalam pengetahuan dan kesadaran peserta terhadap pentingnya perilaku hidup sehat. Melalui program ini, diharapkan lansia dapat lebih mandiri dalam menjaga kesehatannya dan tetap produktif dalam kehidupan sehari-hari.

Umbilical Cord MSC-Secretome Therapy Enhances Erectile Function in Elderly Men Digambiro, Reza Aditya; Fiji, Wijaya Taufik; Ilona, florinda; Chendrasari, Julian
UMI Medical Journal Vol 10 No 1 (2025): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v10i1.348

Background: Reduced erectile capacity often appears as part of physiological shifts during aging potentially implicating broader physiological or social realms. These declines originate from intricate underlying conditions: endothelial dysfunction, unstable hormonal patterns, compromised vascular structures, oxidative stress escalations, and inflammatory cascades. Recently, attention has drifted towards secretome derived from umbilical cord mesenchymal stem cells (UCMSC)—an eclectic blend of cytokines, extracellular vesicles, and growth factors—suggesting foundational regenerative qualities surpassing conventional symptomatic therapies, like phosphodiesterase-5 inhibitors (PDE-5i). Methods: In this study, ederly male participants (n=64, aged ≥60) diagnosed with erectile dysfunction (ED) received intracavernosal UCMSC-secretome injections every two weeks for three sessions. No control group was included; efficacy was tracked through pre- and post-intervention evaluations using the International Index of Erectile Function (IIEF-5). Results: A statistically notable improvement emerged—average IIEF-5 scores increasing by about 5.49 points (p<0.001; Cohen’s d=1.99). With the satisfaction averaging approximately 8.03/10. Conclusion: Extensive, randomized controlled trials could more conclusively elucidate the genuine potential of secretome interventions.

The Impact of High Dose Ozone Therapy on Hematological and Biochemical Profiles : An Observational Study Digambiro, Reza Aditya; Parwanto, Edy; Lestari, Indah Widya; Chendrasari, Julian; Setyaningrum, Dyah Ayu Woro; Ilona, Florinda
The Avicenna Medical Journal Vol. 5 No. 1 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i1.34859

Background: Ozone therapy, namely High Dose Ozone Therapy (HDO), has become a versatile medical treatment in several clinical settings. Although it is becoming more well acknowledged, there is still a lack of extensive evidence about the impact of this on hematological and biochemical indicators. This study seeks to address this void by examining the consequences of this phenomenon in a clinical environment.Method: An observational study was done, which followed a structured approach, comprising a total of 100 patients who were selected from the SMC Clinic. Hematological and biochemical indices were evaluated before and after ozone therapy sessions to analyze blood parameters. Two blood samples were obtained at two specific time points: prior to the commencement of the ozone therapy (T0) and after the therapy was finished (T1).Results: Substantial alterations were noted in both hematological and biochemical parameters after the therapy. The hematological changes observed in this study showed a substantial rise in the red blood cell count (p=0.009), hemoglobin levels (p=0.004), and hematocrit (p=0.039), along with a decrease in erythrocyte sedimentation rate (ESR) (p=0.020). Notable biochemical changes were observed, including significant modifications in total plasma protein (TPP) (p=0.008) and lactate levels (p=0.001). Furthermore, there was a noteworthy decrease (p<0.05) in the levels of malondialdehyde (MDA), which is a marker for oxidative stress.Conclusion: HDO exerts a regulatory influence on crucial hematological, biochemical, and oxidative stress factors. These findings indicate that HDO may have therapeutic benefits for treating chronic disorders and cancer. It can improve blood parameters and reduce oxidative stress. The decrease in markers of oxidative stress, such as MDA, suggests a potential reduction in the likelihood of problems associated with oxidative damage in chronic diseases. Nevertheless, additional research is required to validate these findings, investigate their wider therapeutic implications, and comprehend the long-term consequences and safety of HDO therapy.

Hubungan Kadar Timbal (Pb) Darah Dengan Hipertensi Pada Pengemudi Ojek Chendrasari, Julian; Lestari, Indah Widya; Ilona, Florinda; Digambiro, Reza
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.17-23

Background Hypertension is a disease that is a major health problem in developed and developing countries and is the number one cause of death in the world every year. The causes of hypertension can be divided into genetic and environmental factors. One of the causes of hypertension from environmental causes is exposure to lead. This study aims to determine the relationship between blood lead levels and hypertension. Methods The design of this research is descriptive research with laboratory analysis using a cross-sectional approach. Sample selection using a purposive sampling method. The research sample was online motorcycle taxi drivers aged >35 years, with a minimum of 1 year as an online motorcycle taxi driver. Research samples were taken at the Faculty of Medicine, Trisakti University in September 2022. Laboratory examinations were carried out at the Prodia clinical laboratory, in Jakarta. Results Of the 133 samples examined, high lead levels were found in 20 respondents (15%) and low lead levels in 113 respondents (85%). High lead levels were found in 7 respondents who had hypertension and 13 respondents with normal blood pressure. The chi-square statistical test value shows a p-value = 0.260. Conclusions Blood lead levels do not have a significant relationship with blood pressure in motorbike taxi drivers.

Meckel's Diverticulum-Induced Intussusception Coinciding with Diabetes Mellitus in a Young Adult Male: A Rare Case Study Digambiro, Reza Aditya; Parwanto, Edy; Setianingrum, Dyah Ayu Woro; Ilona, Florinda; Lestari, Indah Widya; Chendrasari, Julian
Jurnal Kedokteran Meditek Vol 31 No 1 (2025): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i1.3084

Introduction: Intussusception in adults, especially when caused by Meckel's Diverticulum, is a rare occurrence, often presenting with nonspecific symptoms such as abdominal pain and nausea, making it challenging to diagnose. When concurrent with conditions like diabetes mellitus, the situation need particular care. Case Illustration: A 27-year-old male with a medical history of diabetes presented with severe right abdominal pain, nausea, and a reduced appetite. Initial symptomatic treatment did not alleviate the condition. Subsequent CT scans revealed an ileo-ileal intussusception triggered by Meckel's Diverticulum and partial high obstruction ileus, leading to surgical intervention. Discussion: Ileo-ileal resection (end to end anastomosis) and adhesiolysis surgery were successfully performed, followed by vigilant postoperative monitoring for complications, effective pain management, maintenance of drain patency, and careful glucose level monitoring. The patient's significant postoperative improvement underscores the importance of early diagnosis and timely surgical intervention in managing Meckel's Diverticulum-induced intussusception in adults. Conclusion: The clinical course also highlighted the importance of tailoring postoperative care considering the patient's comorbidities, in this case, diabetes mellitus. This case served as a reminder for clinicians to consider Meckel's Diverticulum as a potential cause of intussusception in adults presenting with abdominal pain.

D-dimer sebagai Biomarker Diagnostik Tuberkulosis Paru pada Efusi Pleura: Tinjauan Pustaka Digambiro, Reza Aditya; Ilona, Florinda; Chendrasari, Julian; Lestari, Indah Widya; Parwanto, Edy
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1242

Background: Tuberculosis (TB) remains a major health threat, especially in developing countries. Although the lungs are the most affected organ, systemic manifestations are quite significant. D-dimer, as one of the fibrin degradation products and also an indicator of coagulation activity, has been extensively researched for its predictive and diagnostic value in various diseases. This study aims to assess the effectiveness of D-dimer as a diagnostic biomarker for pulmonary tuberculosis (TB) in patients with pleural effusion compared to those with non-TB pleural effusion. Methods: The study was conducted as an observational case-control on 64 patients with pulmonary TB with pleural effusion were compared to 64 non-TB subjects with pleural effusion. Result: In the TB patient group, 62.5% of patients were smokers, 46.9% of patients had been exposed to TB. Patients were assessed based on the TB symptom scale and with radiological lung examinations, either x-rays or CT scans. D-dimer levels were correlated with the TB severity. D-dimer levels above the threshold value were significantly higher in patients with severe TB symptoms. Conclusion: A direct correlation was observed between the size of radiological lung lesions and D-dimer levels. The average D-dimer level in the control group was 220 ± 60 ng/mL, which increased to 450 ± 90 ng/mL in TB patients with severe lesions.

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