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Monica Dwi Hartanti, Monica Dwi
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Dengue virus transovarial transmission by Aedes aegypti Hartanti, Monica Dwi; Suryani, Suryani; Tirtadjaja, Ingrid A.
Universa Medicina Vol 29, No 2 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.65-70

Abstract

Dengue is a disease that is caused by dengue virus and transmitted to humans through the bite of infected Aedes mosquitoes, especially Aedes aegypti. The disease is hyper-endemic in Southeast Asia, where a more severe form, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), is a major public health concern. The purpose of the present study was to find evidence of dengue virus transovarial transmision in local vectors in Jakarta. Fifteen Aedes larvae were collected in 2009 from two areas in Tebet subdistrict in South Jakarta, namely one area with the highest and one with the lowest DHF prevalence. All mosquitoes were reared inside two cages in the laboratory, eight mosquitoes in one cage and seven mosquitoes in another cage and given only sucrose solution as their food. The results showed that 20% of the mosquitoes were positive for dengue virus. Dengue virus detection with an immunohistochemical method demonstrated the occurrence of transovarial transmission in local DHF vectors in Tebet subdistrict. Transovarial dengue infection in Ae.aegypti larvae appeared to maintain or enhance epidemics. Further research is needed to investigate the relation of dengue virus transovarial transmission with DHF endemicity in Jakarta.
Real time polymerase chain reaction for detecting SARS-COV-2 in Indonesia: are the results reliable? Hartanti, Monica Dwi
Universa Medicina Vol 39, No 2 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.972 KB) | DOI: 10.18051/UnivMed.2020.v39.71-73

Abstract

Since it was first reported in Wuhan, China in December 2019, coronavirus disease 2019 (COVID-19) has been considered as a pandemic. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the Coronavirus family. In Indonesia, this disease first detected in the middle of March 2020 and it was spreading all over Indonesia. The Indonesian Government has implemented several strategies in order to detain the spreading of COVID-19, including improving diagnostic management. Until now, the most reliable method of detecting COVID-19 is real time-PCR.
Relationship of Stressors and Psychosocial Support with Occurrence of Post-Traumatic Stress Disorder in Patients with Covid-19 Ellyamurti, Devanti Octavia; Hartanti, Monica Dwi
International Journal of Multidisciplinary: Applied Business and Education Research Vol. 4 No. 5 (2023): International Journal of Multidisciplinary: Applied Business and Education Rese
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ijmaber.04.05.08

Abstract

Post Traumatic Stress Disorder (PTSD) is common in COVID-19 survivors and can be caused by a variety of stressors, including the duration of infection, severity, and location of isolation when infected with COVID-19. Furthermore, public anxiety caused by the rapid increase in the number of cases and deaths caused by COVID-19 plays a role in the occurrence of PTSD. To reduce the risk of mental disorders, psychosocial support is required. The purpose of this study was to describe the incidence of PTSD in COVID-19 survivors, to describe aspects of psychosocial support for COVID-19 survivors, and to assess the relationship between stressor factors and psychosocial support and the occurrence of PTSD in COVID-19 survivors. This research used an analytical observational research design with a cross sectional approach, involving 149 respondents aged 17-65 years, 52 men and 97 women from the COVID-19 survivor community known as COVID Survivor Indonesia (CSI) in DKI Jakarta. The Medical Outcomes Study–Social Support Survey (MOS-SSS) and The Impact Of Event Scale-Revised (IES-R) questionnaires were distributed via Google Form to collect data. Data was processed and analyzed using the Statistical Package for Social Sciences (SPSS) for Windows version 26.0, and results were analyzed using descriptive univariate and bivariate using Chi Square. There is a significant relationship between stressor factors and the occurrence of PTSD, specifically the duration of infection with COVID-19 (P = 0,026), severity when infected with COVID-19 (P = 0,027), and place of isolation when infected with COVID-19 (P = 0,023). Furthermore, there was a significant relationship between psychosocial support and the occurrence of PTSD (p = 0,001). Management of COVID-19 patients is required to detect stressor factors and provide psychosocial support so that COVID-19 survivors can return physical and psychological health.
PENGGUNAAN SKOR KANDIDA UNTUK PEMBERIAN ANTIJAMUR RASIONAL PASA PASIEN ICU DENGAN RISIKO CANDIDIASIS INVASIF Bella, Isa; Hartanti, Monica Dwi; Prasetyaningsih, Noviani; Amalia, Husnun
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 8, Nomor 1, Januari 2023
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v8i1.15107

Abstract

Pasien yang dirawat di ICU memiliki risiko tinggi terserang kandidiasis invasive. Hal ini dikarenakan kondisi klinis dan tatalaksana pada pasien ICU yang menjadi faktor risiko terjadinya infeksi invasif oleh candida. Hal yang dapat menyebabkan adalah penggunaan antibiotik spektrum luas dalam jangka waktu lama, penyakit penyerta yang mengakibatkan kondisi imunokompromais, riwayat operasi abdomen, pemakaian obat-obat imunosupresan, pemberian nutrisi total parenteral, dan pemakaian alat-alat invasif antara lain central venous catheter (CVC) dan ventilator. Pemberian anti jamur empirik pada pasien sakit kritis dengan kolonisasi Candida sp. atau pasien dengan faktor risiko lainnya merupakan intervensi dini yang diperlukan. Pemberian antijamur sedini mungkin pada pasien sakit kritis terduga kandidiasis invasif di ICU dapat menurunkan angka kematian. Pada keadaan normal Candida dapat berkolonisasi di saluran cerna, saluran napas bagian atas, vagina dan kulit. Sehingga isolat Candida sp. yang didapat dari biakan sampel sputum, broncho-alveolar lavage (BAL), brush protected specimen (BPS), dan sekret endotrakeal, belum dapat disimpulkan sebagai etiologi penyebab infeksi, masih terdapat kemungkinan merupakan komensal. Klinisi membutuhkan tersedianya pedoman pemberian antijamur empirik untuk pasien ICU guna mencapai hasil klinis yang diharapkan dan menghindari penggunaan antijamur yang berlebihan. Skor kandida dari Leon menawarkan penggunaan yang mudah untuk membantu klinisi menggolongkan pasien sakit kritis ICU yang perlu mendapat terapi empirik anti jamur dan pasien yang kecil sekali kemungkinan menderita kandidiasis invasif. Peningkatan spesifisitas pemberian antijamur empirik untuk pasien yang memiliki risiko menderita kandidiasis invasif dapat mengurangi biaya pengobatan yang tidak diperlukan dan mengurangi laju timbulnya resistensi terhadap obat antijamur.
RADIKAL BEBAS SEBAGAI FAKTOR RISIKO PENYAKIT KATARAK TERKAIT UMUR Prasetyaningsih, Noviani; Hartanti, Monica Dwi; Bella, Isa
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 8, Nomor 1, Januari 2023
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v8i1.15160

Abstract

Oksigen merupakan komponen penting dalam kehidupan manusia. Sebagian besar oksigen akan digunakan sebagai energi, sedangkan sebagian kecil menjadi sisa metabolisme oksigen yang berdampak kurang baik bagi kesehatan tubuh manusia. Sisa metabolisme tersebut disebut radikal bebas atau Reactive Oxygen Species (ROS). Radikal bebas dapat dihasilkan oleh faktor endogen seperti produk metabolik didalam mitokondria, inflamasi atau infeksi, dan faktor eksogen seperti radiasi sinar UV, polusi, alkohol atau asap rokok. Radikal bebas mempunyai elektron yang tidak berpasangan, sangat tidak stabil, sangat reaktif, dan bila menumpuk didalam sel akan mengakibatkan kerusakan sel. Mekanisme pertahanan tubuh untuk melawan radikal bebas dilakukan oleh antioksidan. Salah satu enzim antioksidan adalah Superoksida Dismutase (SOD). Kadar radikal bebas biasanya dilakukan dengan mengukur aktivitas antioksidan. Banyak penyakit yang disebabkan oleh radikal bebas, salah satu penyakit yang disebabkan oleh radikal bebas adalah katarak terkait umur. Penyakit katarak terkait umur merupakan penyakit degenerative yang menyerang usia diatas 50 tahun, ditandai dengan kekeruhan lensa yang makin parah sesuai bertambahnya umur. Katarak merupakan penyebab kebutaan terbanyak diseluruh dunia. Radikal bebas sebagai penyebab katarak terkait umur telah banyak diteliti, tetapi hal tersebut masih belum terbukti. Sulitnya mengukur kadar antioksidan di dalam lensa secara in vivo dan tidak memungkinkan didapatkan lensa normal sebagai kelompok kontrol merupakan penyebabnya. Beberapa peneliti mengukur aktivitas SOD di aqueous humor dan didalam darah untuk mengetahui hubungan antara radikal bebas dengan katarak terkait umur.
Edukasi Kesehatan untuk Meningkatkan Kualitas Hidup Pada Kelompok Lanjut Usia Meiyanti; Yohana; Margo, Eveline; Kartadinata, Erlani; Sisca; Hartanti, Monica Dwi
Jurnal Pengabdian Nasional (JPN) Indonesia Vol. 5 No. 2 (2024): Mei
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM) STMIK Indonesia Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jpni.v5i2.765

Abstract

The increase in the elderly population raises concerns regarding the potential lack of understanding of chronic illnesses in this age group and their impact on quality of life. The main objective of this initiative is to provide education on a better understanding of the health issues faced by the elderly and how to manage them effectively. The study was conducted in November 2023 with 25 participants involved: 1) Preparing educational materials, 2) Providing education to elderly caregivers, and 3) Evaluating the impact of these activities through pre-and post-tests. As a result of the study, an increase in knowledge about various health problems and strategies to improve the quality of life of the elderly was observed after receiving education. As part of this activity, health status examinations were conducted, and the quality of life of elderly individuals was assessed using questionnaires. It was found that 52% of the participants reported suffering from hypertension, heart disease, or metabolic endocrine diseases. It is worth noting that the physical domain had the lowest quality-of-life score compared to other domains. In conclusion, it could be argued that community health education activities may play a crucial role in enhancing the quality of life of the elderly by equipping them with the necessary knowledge and skills to manage their health challenges
mRNA Relative Expression Catalase in Hypertension Yohana, Yohana; Faradilla, Meutia Atika; Meiyanti, Meiyanti; Hartanti, Monica Dwi; Margo, Eveline; Anastasya, Karina Shasri
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12825

Abstract

Hypertension is number one worldwide disease which lead to death. Initially hypertension is caused by changes in the walls of blood vessels. These vascular changes are due to the accumulation of ROS (Reactive Oxygen Species). ROS is the result of the balance between antioxidants and oxidants, but uncontrolled conditions will cause vascular damage. One of ROS product from metabolism which could played role in downregulation antioxidant gene expression is hydrogen peroxide. Hydrogen peroxide could be neutralized by catalase enzyme. Studies about catalase expression in hypertension subject is still limited. This research aims to determine mRNA relative expression catalase in hypertension. In this case control study, thrity subject hypertension and normotension subject were recruited within the age of 50-60 years. Hypertension subject was chosen according to JNC 8. Two millilitres vein blood was isolated into RNA. mRNA expression was detected by qRT PCR with 2 steps. Relative expression was determined using livak method. The data was analyzed using Mann Withney test with GraphPad software. Research results show that (1) catalase mRNA relative expression was 0,6 fold in hypertension; (2) catalase relative expression was not significantly lower in hypertension; (3) other antioxidants might have other mechanism to detoxify ROS and prevent hypertension.
Alpha-Actinin-3 (ACTN3) R577X Polymorphism on Brain-derived Neurotrophic Factor (BDNF) Levels of Pre- and Post-Eccentric Exercised Male Subjects Khadijah, Audira Syafana; Aryati, Aurel; Arpy, Aurel Diffa; Susetyo, Angela Excellcia Larasaty; Hartanti, Monica Dwi
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3465

Abstract

BACKGROUND: Eccentric exercise, characterized by muscle lengthening underload, elicits physiological responses, including alterations in brain-derived neurotrophic factor (BDNF) levels, crucial for neuroplasticity and exercise adaptations. The Alpha-Actinin-3 (ACTN3) gene encodes α-actinin-3, a protein in fast-twitch muscle fibers associated with explosive performance. The R577X polymorphism in ACTN3 is associated with athletic performance, particularly in power-based activities. However, its influence on the BDNF response to eccentric exercise remains unclear. This study investigated whether the ACTN3 R577X polymorphism modulates BDNF levels post-exercise.METHODS: Male subjects aged 18-30 years old, who were not involved in structured physical activity, and abstaining from alcohol and protein supplements within specified periods, were involved in this study. Subjects’ genotypes were identified using polymerase chain reaction (PCR) and classified into different ACTN3 genotypes (RR, RX, XX). All subjects underwent an eccentric exercise protocol. BDNF levels were measured pre-exercise, post-exercise, and 72 hours post-exercise using sandwich Enzyme-Linked Immunosorbent Assay (ELISA).RESULTS: Most of subjects had RX genotype (52.2%), followed by XX (39.1%) and RR genotypes (8.7%), respectively. BDNF levels decreased significantly across all time points. The RR genotype showed a decrease from approximately 270 pg/mL to 230 pg/mL, while RX and XX genotypes showed similar patterns of reduction. No significant differences in BDNF levels were observed between genotypes at any time point.CONCLUSION: Eccentric exercise leads to a consistent decrease in BDNF levels, with no significant modulation by ACTN3 genotype. These findings suggest a uniform response to exercise-induced stress across genotypes.KEYWORDS: ACTN3, BDNF, eccentric exercises, genotype, adaptation
Improving Early Childhood Tooth Brushing Habits: A Case Study at TK Kristen Anugerah Jakarta Sisca, Sisca; Kurniawan, Yani; Hartanti, Monica Dwi; Orliando Roeslan, Muhamad
Room of Civil Society Development Vol. 4 No. 2 (2025): Room of Civil Society Development
Publisher : Lembaga Riset dan Inovasi Masyarakat Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59110/rcsd.558

Abstract

Maintaining oral hygiene from an early age is essential to prevent dental caries and gum diseases. However, many preschool children lack the knowledge and proper technique to brush their teeth effectively. This study aimed to evaluate the effectiveness of a structured tooth brushing training program at TK Kristen Anugerah Jakarta. Utilizing a participatory descriptive method, the program integrated interactive discussions, audiovisual demonstrations, and supervised practice sessions. A total of [jumlah peserta, jika tersedia] children participated in pre- and post-training assessments to measure improvements in their brushing habits. The findings showed significant gains: understanding the importance of brushing increased from 40% to 85%, brushing frequency improved from 20% to 65%, and correct brushing technique rose from 30% to 75%. These results suggest that school-based interactive training can positively influence children’s dental hygiene behavior. This study recommends incorporating such programs into early childhood education curricula and emphasizes the importance of parental involvement for sustaining long-term oral health practices.
APOA2–265 T>C Polymorphism as A Genetic Marker Associated with Lipid Profiles and Cardiovascular Risk in A Healthy Indonesian Population Hartanti, Monica Dwi; Hizbulloh, Ilham; Satibi, Janice Puteri; Virgo, Ricardo Lie; Anastasya, Karina Shasri; Adli, Mizanul; Amarendra, Gerie; Junnata, Agung
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3472

Abstract

BACKGROUND: Apolipoprotein A (APOA)2–265 T>C polymorphism significantly affects lipid metabolism and body composition, as well as plays a key role in cardiovascular diseases (CVD) and metabolic syndrome. In this study, association between the APOA2 polymorphism, lipid profiles, body composition, and cardiovascular disease (CVD) risk in a healthy Indonesian population was investigated. Although similar studies have been conducted in other populations, this study addresses the urgent need to understand genetic factors influencing lipid profiles in Southeast and East Asia, where hypercholesterolemia rate keep rising, particularly in Indonesia.METHODS: A cross-sectional study involving 84 healthy participants was performed. Genotyping for the APOA2–265 T>C polymorphism was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Plasma levels of APOA2 and APOB100 were measured with enzyme-linked immunosorbent assay (ELISA), and APOB100/APOA2 ratio was calculated to assess CVD risk. Lipid profiles were evaluated with enzymatic methods, and body fat percentage was measured using calipers.RESULTS: CT/CC genotypes showed significantly lower plasma APOA2 levels compared to the TT genotype (p=0.0215). APOB100/APOA2 ratio was significantly higher in CT/CC genotypes (p=0.0020) and remained significant after Bonferroni correction. No significant differences were found in lipid profiles and body fat percentages between genotypes after correction, although trends suggested higher cholesterol and low-density lipoprotein (LDL) levels in TT genotypes and higher median body fat percentages in CC/CT genotypes.CONCLUSION: APOA2–265 T>C polymorphism is linked to changes in lipid profiles and body composition, potentially raising CVD risk in CT/CC genotypes. However, limited sample size and modest effect sizes suggest that the practical use of APOA2 genotyping for risk assessment might require further investigation.KEYWORDS: APOA2 polymorphism, APOB100, hypercholesterolemia, cardiovascular disease, lipid profile, body fat percentage
Co-Authors Adli, Mizanul Anastasya, Karina Shasri Arpy, Aurel Diffa Aryati, Aurel Bella, Isa Chendrasari, Julian Devita, Arleen Effendi, Ida Ellyamurti, Devanti Octavia Erlani Kartadinata, Erlani Eveline Margo, Eveline Faradilla, Meutia Atika Gerie Amarendra Hartini Hizbulloh, Ilham Husnun Amalia, Husnun Ilona, Florinda Ingrid A. Tirtadjaja, Ingrid A. Junnata, Agung Khadijah, Audira Syafana Khariri Khariri Lestari, Indah Widya Meiyanti Meiyanti Meiyanti, Meiyanti ML Edy Parwanto Orliando Roeslan, Muhamad Prasetyaningsih, Noviani Reni Zuraida Rina Fitriana, Rina Robertus, Thomas Satibi, Janice Puteri Setyaningrum, Dyah Ayu Woro sisca Sisca Sisca, Sisca Suryani Suryani Susetyo, Angela Excellcia Larasaty THABIT, JIHAN SAMIRA Virgo, Ricardo Lie Wegig Murwonugroho Yani Kurniawan, Yani Yohana Yohana Yohana