Garuda - Garba Rujukan Digital

Effects of Euthanasia on Animal Research Maharani, Ni Putu Radela; Fadlyah, Nur Ashfiya; Setyaningrum, Dyah Ayu Woro; Hairunisa, Nany
Veterinary Biomedical and Clinical Journal Vol. 6 No. 1 (2024)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2024.006.01.6

The use of experimental animals is widely conducted in the medical field, both for research on the processes of disease occurrence (pathogenesis), the causes of disease (etiology), and research on therapy. Therefore, it is important to understand how euthanasia in experimental animals affects the integrity of the sample and its influence on research results. This article was compiled from several literature sources searched from Google Schoolar and PubMed published within the last 10 years, with keywords such as "code of ethics in experimental animals", "methods of euthanasia in experimental animals", "overdose anesthesia methods in animal euthanasia", "barbiturate injection methods in rats", "inhalation methods in animal euthanasia", "biochemical effects of euthanasia", and "histological effects of euthanasia". This paper discusses euthanasia methods, namely overdose anesthesia, inhalation, and injection. This paper aims to discuss how the method of euthanasia and the choice of drugs can impact the biochemical and histological changes in animals after the euthanasia process. Choosing the right euthanasia method is essential, as the species of animals involved and the research goals are considered. Using methods that align with the biological characteristics and behavior of the animals can help ensure the success of the research while also considering ethical aspects and animal welfare.

Edukasi Mengenai Hipertensi Pada Kader Kelurahan Kali Anyar Kecamatan Tambora Jakarta Barat Setyaningrum, Dyah Ayu Woro; Florinda Ilona; Julian Chendrasari; Rima Anindita; Nany Hairunisa; Eric Fahed Faza
JUARA: Jurnal Wahana Abdimas Sejahtera Volume 5, Nomor 1, Januari 2024
Publisher : Jurusan Teknik Lingkungan Fakultas Arsitektur Lanskap dan Teknologi Lingkungan, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/juara.v5i1.17412

Hypertension which is commonly referred to as a silent killer because it can cause death but is often asymptomatic is still a global problem. The incidence rate is high, but the patient's awareness is low so the disease gets worse with severe and even fatal complications such as heart disease and stroke. The high prevalence of hypertension mainly occurs in low- and middle-income countries which may be related to the level of education and knowledge about this disease. Purpose: This PkM aims to determine the extent of knowledge about hypertension, and provide knowledge/education about this disease. The method used is distributing questionnaires to assess the level of knowledge about hypertension, as well as providing counseling and health checks to increase knowledge about this disease. The results of this PkM activity show that the knowledge of Kali Anyar village cadres about hypertension is quite good, and the incidence of hypertension is 34.5% close to the national prevalence of 34.1%. Education about hypertension is expected to have a good effect on reducing the prevalence of hypertension and its complications because the better the level of knowledge about hypertension, the lower the incidence of hypertension.

Pencegahan Kanker Payudara Melalui Penyuluhan di Masyarakat Nagrak Digambiro, Reza Aditya; Chendrasari, Julian; Ilona, Florinda; Lestari, Indah Widya; Setyaningrum, Dyah Ayu Woro; Fadillah, Ibnu Haris
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 11 (2025): Januari
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i11.1922

Kanker payudara tetap menjadi masalah kesehatan masyarakat yang signifikan di Indonesia, terutama di daerah berkembang seperti Nagrak. Tantangan dalam deteksi dini akibat kurangnya kesadaran, fasilitas kesehatan yang terbatas, dan stigma budaya memperburuk prevalensi dan mortalitas akibat kanker payudara. Program pengabdian masyarakat yang dilakukan oleh Fakultas Kedokteran Universitas Trisakti bertujuan untuk meningkatkan kesadaran masyarakat dan memberdayakan perempuan di Nagrak untuk melakukan pemeriksaan payudara sendiri (SADARI) sebagai langkah pencegahan. Program ini melibatkan survei awal untuk menilai pengetahuan masyarakat, diikuti dengan seminar edukasi dan sesi simulasi SADARI yang dipandu oleh tenaga medis dan mahasiswa. Evaluasi pasca-kegiatan menunjukkan peningkatan signifikan dalam pengetahuan dan keterampilan peserta, yang menegaskan efektivitas program ini. Rekomendasi utama meliputi pelaksanaan edukasi rutin, penguatan kerjasama dengan fasilitas kesehatan lokal, dan pemanfaatan media digital untuk memperluas dampak edukasi. Inisiatif ini menegaskan pentingnya pendekatan berbasis komunitas dalam menurunkan prevalensi kanker payudara melalui deteksi dini dan perubahan gaya hidup.

The Impact of High Dose Ozone Therapy on Hematological and Biochemical Profiles : An Observational Study Digambiro, Reza Aditya; Parwanto, Edy; Lestari, Indah Widya; Chendrasari, Julian; Setyaningrum, Dyah Ayu Woro; Ilona, Florinda
The Avicenna Medical Journal Vol 5, No 1 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i1.34859

Background: Ozone therapy, namely High Dose Ozone Therapy (HDO), has become a versatile medical treatment in several clinical settings. Although it is becoming more well acknowledged, there is still a lack of extensive evidence about the impact of this on hematological and biochemical indicators. This study seeks to address this void by examining the consequences of this phenomenon in a clinical environment.Method: An observational study was done, which followed a structured approach, comprising a total of 100 patients who were selected from the SMC Clinic. Hematological and biochemical indices were evaluated before and after ozone therapy sessions to analyze blood parameters. Two blood samples were obtained at two specific time points: prior to the commencement of the ozone therapy (T0) and after the therapy was finished (T1).Results: Substantial alterations were noted in both hematological and biochemical parameters after the therapy. The hematological changes observed in this study showed a substantial rise in the red blood cell count (p=0.009), hemoglobin levels (p=0.004), and hematocrit (p=0.039), along with a decrease in erythrocyte sedimentation rate (ESR) (p=0.020). Notable biochemical changes were observed, including significant modifications in total plasma protein (TPP) (p=0.008) and lactate levels (p=0.001). Furthermore, there was a noteworthy decrease (p<0.05) in the levels of malondialdehyde (MDA), which is a marker for oxidative stress.Conclusion: HDO exerts a regulatory influence on crucial hematological, biochemical, and oxidative stress factors. These findings indicate that HDO may have therapeutic benefits for treating chronic disorders and cancer. It can improve blood parameters and reduce oxidative stress. The decrease in markers of oxidative stress, such as MDA, suggests a potential reduction in the likelihood of problems associated with oxidative damage in chronic diseases. Nevertheless, additional research is required to validate these findings, investigate their wider therapeutic implications, and comprehend the long-term consequences and safety of HDO therapy.

PELATIHAN PEMBUATAN SABUN NATURAL KAYA ANTIOKSIDAN SEBAGAI ALTERNATIF PERSONAL CARE PRODUCT YANG MENGGANGGU KESEHATAN REPRODUKSI Anggraini, Kirana; Setyaningrum, Dyah Ayu Woro; Wiranti, Hervi; malik, kirana
Jurnal AKAL: Abdimas dan Kearifan Lokal Vol. 6 No. 1 (2025): Jurnal AKAL : Abdimas dan Kearifan Lokal
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/akal.v6i1.20906

Personal Care Product (PCP) adalah produk perawatan diri tanpa resep yang digunakan untuk kebersihan, perawatan, dan kecantikan. PCP mengandung kontaminan yang memiliki dampak buruk terhadap kesehatan reproduksi. Peningkatan penggunaan PCP saat ini meningkatkan kerentanan terhadap paparan beberapa PCP sekaligus, sehingga berpotensi terpapar campuran senyawa yang lebih banyak setiap harinya. Perempuan merupakan pengguna terbesar PCP, dimulai sejak usia remaja, usia reproduktif (hamil, melahirkan, menyusui) sampai usia menopause, sehingga memiliki kerentanan yang tinggi terhadap dampak negatif PCP baik untuk kesehatan pribadi maupun generasi berikutnya. Oleh karena itu, perlu dilakukan edukasi dampak PCP pada kesehatan reproduksi dan pelatihan pembuatan produk yang bebas bahan kimia dan alami, sebagai alternatif yang lebih aman dibandingkan PCP berbasis bahan kimia. Kegiatan ini dilakukan di kantor OK OCE Jakarta dihadiri 25 sosiopreneur perempuan usia reproduktif yang tidak memiliki keterampilan membuat sabun natural. Penilaian keterampilan peserta dalam membuat sabun natural dilakukan dengan melakukan observasi sesuai rubrik penilaian. Hasil yang didapatkan yaitu sebagian besar peserta mampu mempersiapkan seluruh alat dan bahan (74%), mampu menggunakan aplikasi soapcal (70%), mampu mengerjakan dengan benar dan berurutan (85%), mampu mengerjakan dengan cepat (83%), mampu mempresentasikan kandungan dan manfaat (90%), tekstur sabun yang dihasilkan baik (85%). Kesimpulannya setelah mengikuti pelatihan seluruh peserta mampu membuat sabun natural dengan hasil sangat baik.

THE USE OF TELEMEDICINE IN PRIMARY HEALTHCARE SERVICES IN JAKARTA Digambiro, Reza Aditya; Ilona, Florinda; Setyaningrum, Dyah Ayu Woro; Chendrasari, Julian; Lestari, Indah Widya
HEARTY Vol 13 No 3 (2025): JUNI
Publisher : Fakultas Ilmu Kesehatan, Universitas Ibn Khaldun, Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/hearty.v13i3.18339

Background: The advancement of digital technology has transformed the healthcare sector, and telemedicine has become an important innovation in providing remote clinical services. Methods: The research method used is a mixed-method approach, combining quantitative and qualitative approaches. Data collection was conducted through questionnaires distributed to 400 telemedicine users. The sample size was determined using the Slovin formula with a 5% margin of error. Results: 75% of respondents used telemedicine more than once in the past year, with 70% of respondents expressing high satisfaction with the services received. The main reasons for using telemedicine include convenience (65%) and time savings. However, several challenges were identified, such as technical issues (30%), lack of physical examinations, and concerns about service quality. Discussion: The main challenges identified include inadequate technological infrastructure, low digital literacy among certain groups, and unclear regulations. Development opportunities include the integration of telemedicine with electronic health records and increased public education. Conclusion: Telemedicine has great potential to improve the accessibility and efficiency of healthcare services in Jakarta. However, improvements in infrastructure, digital literacy, and supportive regulatory frameworks are needed to maximize the benefits of telemedicine within the healthcare system.

The Effect of Zinc Supplementation on Reducing Dengue-Related Morbidity in Pediatric Patients in Jakarta Digambiro, Reza Aditya; Setyaningrum, Dyah Ayu Woro; Dewi, Intan Keumala; Ananingsih, Pangisti Dwi
The Indonesian Journal of Infectious Diseases Vol. 11 No. 1 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i1.268

Background: Dengue hemorrhagic fever is an endemic disease that causes significant morbidity, particularly in Jakarta. Based on previous studies, zinc has immunomodulatory properties that can function to improve the immune response to infections, including dengue. This study aims to evaluate the effectiveness of zinc supplementation in reducing morbidity and improving clinical conditions in pediatric patients with dengue hemorrhagic fever. Methods: This study utilized a prospective cohort method with a sample of 200 pediatric patients suffering from dengue hemorrhagic fever. The sample was divided into two groups: the intervention group (given zinc supplementation) and the control group (standard care without zinc supplementation). Laboratory assessments included serum zinc levels, severity of clinical symptoms, and hematological examination results. Results: The analysis showed a significant increase in serum zinc levels in the group given zinc supplementation, with the mean increasing from 100.34 ± 27.69 µg/dL to 104.28 ± 28.65 µg/dL on day 14 (p < 0.05). The number of patients whose clinical symptoms gradually became milder increased from 40% to 55% in the intervention group, whereas in the control group, there was a decrease in the number of patients with gradually milder symptoms, from 40% to 36%. Conclusion: Zinc supplementation is quite effective in reducing morbidity and improving clinical conditions in pediatric patients with dengue hemorrhagic fever.

Overview of the Functions of Ginger Rhizome (Zingiber officinale Roscoe), Black Cumin (Nigella sativa), and Pasak Bumi (Eurycoma longifolia Jack) in Male Infertility Setyaningrum, Dyah Ayu Woro; Anggraini, Kirana
The Avicenna Medical Journal Vol 4, No 2 (2023): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v4i2.32322

Background: More than 186 million individuals worldwide from Southeast Asian and African nations are affected by infertility, a common health issue, specifically among men. In Indonesia, the use of "jamu" or herbal preparations derived from a diverse variety of herbal sources remains a widely practiced therapeutic approach. Furthermore, the Research and Development Center of the Indonesian Ministry of Health conducted extensive investigations between 2012 and 2018, including 204 distinct plant species used as stimulants and fertility enhancers. Among the species extensively used by ethnic traditional healers are pasak bumi (Eurycoma longifolia Jack), Pimpinella alpina Kds or Pimpinella pruatjan Molk (purwoceng), ginger rhizome (Zingiber officinale Roscoe), and black cumin (Nigella sativa).Methods: This study was compiled as an overview of ten original articles from PubMed and Google Scholar using keywords related to the effects of ginger rhizome, black cumin, and pasak bumi on male infertility.Results: The three plants were useful for improving sperm parameters by antioxidant activity, and increasing the production of reproductive hormones.Conclusion:These plants had a potential role in treating and protecting male infertility by the antioxidant activities.

Overview of the Functions of Ginger Rhizome (Zingiber officinale Roscoe), Black Cumin (Nigella sativa), and Pasak Bumi (Eurycoma longifolia Jack) in Male Infertility Setyaningrum, Dyah Ayu Woro; Anggraini, Kirana
The Avicenna Medical Journal Vol. 4 No. 2 (2023): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v4i2.32322

Background: More than 186 million individuals worldwide from Southeast Asian and African nations are affected by infertility, a common health issue, specifically among men. In Indonesia, the use of "jamu" or herbal preparations derived from a diverse variety of herbal sources remains a widely practiced therapeutic approach. Furthermore, the Research and Development Center of the Indonesian Ministry of Health conducted extensive investigations between 2012 and 2018, including 204 distinct plant species used as stimulants and fertility enhancers. Among the species extensively used by ethnic traditional healers are pasak bumi (Eurycoma longifolia Jack), Pimpinella alpina Kds or Pimpinella pruatjan Molk (purwoceng), ginger rhizome (Zingiber officinale Roscoe), and black cumin (Nigella sativa).Methods: This study was compiled as an overview of ten original articles from PubMed and Google Scholar using keywords related to the effects of ginger rhizome, black cumin, and pasak bumi on male infertility.Results: The three plants were useful for improving sperm parameters by antioxidant activity, and increasing the production of reproductive hormones.Conclusion:These plants had a potential role in treating and protecting male infertility by the antioxidant activities.

The Impact of High Dose Ozone Therapy on Hematological and Biochemical Profiles : An Observational Study Digambiro, Reza Aditya; Parwanto, Edy; Lestari, Indah Widya; Chendrasari, Julian; Setyaningrum, Dyah Ayu Woro; Ilona, Florinda
The Avicenna Medical Journal Vol. 5 No. 1 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i1.34859

Background: Ozone therapy, namely High Dose Ozone Therapy (HDO), has become a versatile medical treatment in several clinical settings. Although it is becoming more well acknowledged, there is still a lack of extensive evidence about the impact of this on hematological and biochemical indicators. This study seeks to address this void by examining the consequences of this phenomenon in a clinical environment.Method: An observational study was done, which followed a structured approach, comprising a total of 100 patients who were selected from the SMC Clinic. Hematological and biochemical indices were evaluated before and after ozone therapy sessions to analyze blood parameters. Two blood samples were obtained at two specific time points: prior to the commencement of the ozone therapy (T0) and after the therapy was finished (T1).Results: Substantial alterations were noted in both hematological and biochemical parameters after the therapy. The hematological changes observed in this study showed a substantial rise in the red blood cell count (p=0.009), hemoglobin levels (p=0.004), and hematocrit (p=0.039), along with a decrease in erythrocyte sedimentation rate (ESR) (p=0.020). Notable biochemical changes were observed, including significant modifications in total plasma protein (TPP) (p=0.008) and lactate levels (p=0.001). Furthermore, there was a noteworthy decrease (p<0.05) in the levels of malondialdehyde (MDA), which is a marker for oxidative stress.Conclusion: HDO exerts a regulatory influence on crucial hematological, biochemical, and oxidative stress factors. These findings indicate that HDO may have therapeutic benefits for treating chronic disorders and cancer. It can improve blood parameters and reduce oxidative stress. The decrease in markers of oxidative stress, such as MDA, suggests a potential reduction in the likelihood of problems associated with oxidative damage in chronic diseases. Nevertheless, additional research is required to validate these findings, investigate their wider therapeutic implications, and comprehend the long-term consequences and safety of HDO therapy.

Title

Found 10 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 10 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 10 Documents
Search