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All Journal Medical Journal of Indonesia Indonesian Journal of Urology Narra J Brawijaya Journal of Urology
Nurhadi, Pradana
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Coenzyme Q10 as adjuvant therapy could reduce oxidative stress and enhance sperm quality in cryptorchidism animal models Nurhadi, Pradana; Daryanto, Besut; Dhani, Fauzan K.; Purnomo, Athaya F.; Kusworini, Kusworini; Alfandy, Tommy N.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.2474

Abstract

The role of coenzyme Q10 (CoQ10) as an antioxidant in the context of cryptorchidism is increasingly recognized due to its potential protective effects against oxidative stress, a key contributor to testicular dysfunction in this condition. The aim of this study was to evaluate the antioxidant activity of CoQ10 and its impact on sperm parameters as an adjuvant therapy in a cryptorchidism mouse model. A total of 36 male Sprague Dawley mice were divided into six groups: control (negative control), cryptorchidism (positive control), orchidopexy only, and orchidopexy treated with CoQ10 at 5, 10 and 20 mg/kg body weight (BW). After seven days of induction into the cryptorchidism model, the mice underwent orchidopexy, and CoQ10 was administered orally from day 1 to day 7 post-orchidopexy. At the end of the treatment period, all mice were euthanized, and the left testes were collected for immunohistochemical analysis of malondialdehyde (MDA) and superoxide dismutase (SOD), as well as histological examination and sperm parameter assessment. Testicular tissue damage was assessed using the Cosentino grade, while spermatogenesis was evaluated using the Johnsen scoring system. Additionally, sperm parameters were analyzed from the left testis. MDA expression in the cryptorchidism group was significantly lower than in all CoQ10-treated groups (p<0.001). In contrast, SOD expression was significantly higher in the cryptorchidism group compared to the 10 mg/kg BW and 20 mg/kg BW CoQ10 groups (both had p<0.001). Cosentino grade and Johnsen score showed no significant differences between the control group and the group treated with 20 mg/kg BW CoQ10 (p=0.891 and p=0.123, respectively). Furthermore, the 20 mg/kg BW CoQ10 group had significantly greater sperm concentration and motility compared to the cryptorchidism group (p<0.001 for both). These findings demonstrated that CoQ10 had significant antioxidant activity as an adjuvant therapy in a cryptorchidism mouse model. CoQ10 supplementation could reduce oxidative stress markers, enhance antioxidant enzyme expression, and improve sperm parameters, supporting its potential to mitigate testicular damage associated with cryptorchidism.
THE RELATIONSHIP OF NEUTROPHIL-TO-LYMPHOCYTE RATIO (NLR) WITH LOCALIZED AND NON-LOCALIZED TESTICULAR GERM CELL TUMORS Seputra, Kurnia Penta; Nurhadi, Pradana; Husein, Rahmat
Indonesian Journal of Urology Vol 32 No 3 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i3.1019

Abstract

Objective: This study aim to reveal the relationship preoperative neutrophil-to-lymphocyte ratio (NLR) with testicular germ cell tumors (GCT). Material & Methods: A total of twenty-six patients diagnosed with TGCT from 2017 to 2022 in Saiful Anwar Hospital, Malang were included in this retrospective study. Patients were grouped as localized and non-localized. Hematological and biochemical blood measured the days before radical orchiectomy. Results: Eleven patients (42.3%) had seminomas and fifteen patients (57.7%) had non-seminomatous testicular cancer. Six patients (23.1%) had localized and twenty patients (76.9%) had non-localized testicular cancer. There was a statistically significant difference between mean NLR of the localized patients and non-localized patients (localized NLR: 1.7±0.84, non-localized: 3.65±0.97, p=0.000). The optimal cut-off value for localized and non-localized TGCT was 3.05 with sensitivity 83.33% and specificity 75%. That was statistically significant between cut-off value NLR with localized and non-localized TGCT (correlation coefficient 0.505, p=0.008). Conclusion: NLR appears to be a useful marker for TGCT. It is successful in predicting localized and non-localized disease in early preoperative period. Keywords: Neutrophil-to-lymphocyte ratio, testicular cancer, testicular germ cell tumors.
AN ANALYSIS OF FACTORS ASSOCIATED WITH DELAYED DIAGNOSIS AND TREATMENT OF UNDESCENDED TESTIS Rachmat Setiawan, Ilham; Nurhadi, Pradana; Daryanto, Besut
Indonesian Journal of Urology Vol 32 No 3 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i3.1080

Abstract

Objective: This study aimed to analyze factors contributing to delayed diagnosis and treatment of UDT patients at Saiful Anwar General Hospital in Malang. Material & Methods: This retrospective study was conducted at Saiful Anwar General Hospital focusing on patients who underwent orchiopexy or orchiectomy for UDT between January 2019 to February 2024. Delays in treatment were defined as surgery performed after 18 months of age. Statistical analysis involved a comparative study between delayed and non-delayed cases, with a significance level of p<0.05. Results: This study evaluated 140 patients with UDT, aged 3.7 ± 3.87 years old, with 77.1% experiencing delayed referrals. The most common associated anomaly was hypospadias (29.3%). Factors contributing to delayed referral include undiagnosed UDT, inadequate follow-up, and advice to await spontaneous testicular descent, observed in 62% of delayed cases (p = 0.025). Parental unawareness of the risks associated with delayed surgery and misdiagnosis by healthcare providers were significant contributors, affecting 72% and 74% of delayed cases, respectively (p = 0.032 and p < 0.005). Referral sources differed significantly, with pediatricians accounting for 43% of non-delayed referrals, compared to only 8% for delayed cases. General practitioners were responsible for 70% of delayed referrals, and 22% were self-referred (p < 0.005). Conclusion: Most pediatric patients at Dr. Saiful Anwar General Hospital experienced delayed treatment of UDT, often due to referral delays and undiagnosed conditions. Training for primary health-care providers and routine testicular examinations are essential. Keywords: Delayed factors, diagnosis and treatment, undescended testis.
PREVALENCE AND SCREENING OF PHIMOSIS IN TODDLERS AT THE INTEGRATED SERVICE POST WITHIN THE WORKING AREA OF WAGIR COMMUNITY HEALTH CENTER, MALANG REGENCY Clark Rizqullah Suhermanto, Muhammad; Daryanto, Besut; Nurhadi, Pradana
Indonesian Journal of Urology Vol 32 No 3 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i3.1081

Abstract

Objective: This study aimed to determine the prevalence of phimosis in toddlers at the health posts within the working area of the Wagir Health Center, Malang Regency, assess parents' knowledge, and analyze the factors that influenced parents' knowledge about phimosis. Material & Methods: This study was descriptive and observational analytical and involved 248 male toddlers. Data were obtained through questionnaire responses and physical Examination which were then analyzed using the SPSS software by Pearson’s Chi-Square comparative test and Binary Logistic regression. Results: Phimosis cases were found in 71.77% of 248 toddlers, with 82.6% of them having parents with a lack of knowledge. There was a significant association (p-value <0.05) between family history factors and parents' income level with parents' knowledge of phimosis. However, there was no significant relationship (p-value > 0.05) between the factors of parents' education history and the access to healthcare facilities with parents' knowledge of phimosis. Conclusion: Parents' knowledge of phimosis is low or still lacking. Keywords: Phimosis, parents' knowledge, sociodemographic factors, health factors, prevalence.
HIGH FLOW PRIAPISM IN 7 YEARS-OLD BOY AFTER ACCIDENTALLY CONSUMING APHRODISIAC CHOCOLATE: A CASE REPORT Samudra, Fathan Satria; Seputra, Kurnia Penta; Daryanto, Besut; Nurhadi, Pradana
Indonesian Journal of Urology Vol 30 No 3 (2023)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v30i3.904

Abstract

ABSTRACT Objective: This case report aimed to present our experience of conservative treatments for High Flow Priapism in children. Case(s) Report: A 7 years old boy presented with persistent and painless erections without sexual stimulation for 24 hours, the erection was first noticed when he woke up in the morning after accidentally consuming aphrodisiac chocolate 2 days before admitted to the hospital. There was no previous history of priapism and trauma or other risk factors. Discussion: Laboratory studies were within normal limits. Physical examination revealed a fully erect, nontender penile with rigid corpora cavernosa, soft glans, and erection hardness scale (EHS) 3. A cavernosal blood gas analysis was collected with the following values PH 7.41, pO2 117,7 mmHg, and pCO2 24, 8 mmHg. With diagnosis of High Flow Priapism, he was observed and got conservative treatments; ice and site-specific compression and after that EHS become 1. On follow-up after 2 months reported that patient had normal erections with no further episodes of priapism. Conclusion: High flow priapism in old boy after accidentally consuming aphrodisiac chocolate can managed by conservative therapy with favourable outcome. Keywords: Aphrodisiac chocolate, penile erection, priapism.
CLINICAL PROFILE OF PATIENTS WITH UNDESCENDED TESTIS IN TERTIARY HOSPITAL Sulistyanti, Rachma Fitri; Daryanto, Besut; Nurhadi, Pradana
Indonesian Journal of Urology Vol 32 No 1 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i1.1020

Abstract

Objective: The objective of this study is to present the clinical profile of patients with UDT in tertiary hospital. Material & Methods: This study used a descriptive retrospective approached with approved ethical number 400/019/K.3/102.7/2024. Collecting identification was done by tracing UDT case-patient documents from January 2015 to December 2023. The characteristics observed were age, location of UDT, unpalpable or palpable, patient's address, and antenatal care examination. Results: From 107 UDT patients, 16 patients (24.31%) was diagnosed at the age 19 until 24 months old and decreased in puberty ages. 74 cases of UDT (69.16%) are unilateral UDT with almost the same distribution between left and right. In 75 cases of unpalpable UDT (70.09%), it was found that the testis were still viable in 57 cases during diagnostic laparoscopic. On average, there are 63 patients (58.87%) coming from the Malang area. The average number of patients receiving antenatal care from midwives is 61 cases (62.61%). Conclusion: In all, many cases of UDT under 12 years old were found, with the majority is Unpalpable Unilateral UDT, patient come from the Malang area and have received antenatal care from midwives. The data obtained can be used as a database for enhancing the standard of care. Keywords : Clinical profile, UDT, Malang
SCREENING AND FACTOR ANALYSIS OF DELAYED TREATMENT OF UNDESCENDED TESTIS (UDT) IN EARLY CHILDHOOD Subrata, Gabriella; Daryanto, Besut; Nurhadi, Pradana
Indonesian Journal of Urology Vol 32 No 1 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i1.1025

Abstract

Objective: To determine the prevalence of undescended testis (UDT) cases in the integrated health service post of the Wagir health center working area, the level of parental knowledge of UDT disorders, and to find out what factors affect the delay in UDT treatment. Materials and Methods: Physical examination by a urology specialist education doctor and distributing questionnaires to parents of toddlers with UDT disorders which were then analyzed with SPSS software using the chi square method followed by the binary logistic regression method. Result : Factors that were found to significantly affect the delay in UDT treatment included antenatal care history (sig. = 0.023) and parental knowledge about UDT (sig.=0.044). Factors found to be less significant in influencing the delay in UDT treatment included affordability of health facilities, insurance ownership, parents' monthly income, latest education, and family history. Conclusion: The prevalence of this with the majority of the population having poor knowledge about UDT. The factors that most influence the delay in treatment are antenatal care history and parental knowledge about UDT Keywords: Undescended Testis (UDT), Delayed Treatment, Parental Knowledge, Delayed Factors Objective: This study aims to determine the prevalence of undescended testis (UDT) cases in the integrated health service post of the Wagir health center working area, the level of parental knowledge of UDT disorders, and to find out what factors affect the delay in UDT treatment. Material & Methods: Physical examination by a urology specialist education doctor and distributing questionnaires to parents of toddlers with UDT disorders which were then analyzed with SPSS software using the chi square method followed by the binary logistic regression method. Results: Factors that were found to significantly affect the delay in UDT treatment included antenatal care history (sig. = 0.023) and parental knowledge about UDT (sig.=0.044). Factors found to be less significant in influencing the delay in UDT treatment included affordability of health facilities, insurance ownership, parents' monthly income, latest education, and family history. Conclusion: The prevalence of this with the majority of the population having poor knowledge about UDT. The factors that most influence the delay in treatment are antenatal care history and parental knowledge about UDT. Keywords: Undescended Testis (UDT), parental knowledge, physical examination
Effect of selective androgen receptor modulator RAD140 on prostate and testosterone levels in Wistar strain rats with bilateral orchidectomy Budaya, Taufiq Nur; Nurhadi, Pradana; Anita, Kenty Wantri; Nugroho, Prasetyo; Dhani, Fauzan Kurniawan
Medical Journal of Indonesia Vol. 33 No. 2 (2024): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247289

Abstract

BACKGROUND Selective androgen receptor modulators (SARMs) have been investigated as a potential treatment for hypogonadism, a condition characterized by low testosterone levels in men. The idea is to provide therapeutic benefits similar to traditional testosterone replacement therapy. However, research in this area is still in its early stages, and more extensive studies are needed to establish the efficacy of SARM. This study aimed to determine the impact of SARM RAD140 on testosterone levels, fibromuscular stroma, and prostate mass in rats undergoing bilateral orchidectomy. METHODS This was an in vivo study using posttest-only control group design in rats (Rattus norvegicus). The positive and negative control groups consisted of rats with and without bilateral orchidectomy, respectively. The treatment groups were rats given SARM RAD140 with and without orchidectomy. Testosterone levels, histopathology, and prostate mass were examined at the end of week 6, and the quantitative data were analyzed using one-way ANOVA. RESULTS This study found no difference in prostate mass (0.598 [0.05] g versus 0.590 [0.07] g, p = 0.984), fibromuscular stroma ratio (0.483 [0.094] versus 0.463 [0.057], p = 0.984), and testosterone level (0.006 [0.005] ng/dl versus 0.014 [0.004] ng/dl, p = 0.098) compared to positive control with orchidectomy and SARM RAD140 administration 6 weeks after treatment. CONCLUSIONS There were no differences in testosterone levels, prostate mass, or the ratio of fibromuscular stroma to epithelium area in rats undergoing bilateral orchidectomy and placebo surgery with the administration of SARM RAD140.
Co-Authors Akbar, Fariz Kemal Alfandy, Tommy N. Anderson, Vincent Enrico Balafif, Muhammad Firas Clark Rizqullah Suhermanto, Muhammad Dhani, Fauzan K. Dhani, Fauzan Kurniawan Faida, Nova Auliyatul Henrizal, Fenni Husein, Rahmat Kenty Wantri Anita, Kenty Wantri Kurnia Penta Seputra Kusworini Handono Lalchanzani , Jawaharlal Akbar Lukman Hakim Paksi Satyagraha Permata , Angeline Asti Shiela Prasetyo Nugroho Purnomo, Athaya F. Putra, Fikri Alam Riza Rachman, Manarul Iman Alfafa Rachmat Setiawan, Ilham Samudra, Fathan Satria Satria, Hikmat Satriawan , Ilham Setiawan, Ilham Rachmat Subrata, Gabriella Sulistyanti, Rachma Fitri Sunaryo Hardjowijoto Tarmono Djojodimedjo Taufiq Nur Budaya Vilado, Irene Yasmina