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All Journal Biomedical Journal of Indonesia Pendas : Jurnah Ilmiah Pendidikan Dasar IIJSE Jurnal kiprah pendidikan Jurnal Inovatif Mahasiswa Manajemen
Khairunnisa, Rahma
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Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences Other

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A Refined Saccharomyces Cerevisiae-Induced Pyrexia Model In Rats For Specific Antipyretic Preclinical Screening Putra, Oktavian Arya; Wardhani, Bantari Wisynu Kusuma; Riska, Riska; Ramadhan, Nuzula Rijal Nur; Pamungkas, Fajrin Yudha; Al Baariq, Hisyam Nabil Najmuddin; Wahyuningtias , Dita Sheila Putri; Khairunnisa, Rahma; Ulhaq, Oktania Dhiya; Azis, Nurul Magfirah; Guselsa, Fricelia Aura; Siregar, Tika Hafzara; Khairullah, Aswin Rafif
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.265

Abstract

Introduction. A fever-specific, reliable animal model is necessary to screen the antipyretic activity of pharmacological agents, especially to differentiate their action from broad anti-inflammatory activity. The present investigation was directed towards standardizing the yeast-induced pyrexia model in Sprague Dawley rats for screening the antipyretic activity of paracetamol. Methods. Male Sprague Dawley rats were placed into three groups (5 each): normal control, pyrexia-induced untreated, and paracetamol-treated. Pyrexia was induced by subcutaneous injection of 40% aqueous suspension of Saccharomyces cerevisiae (10 mL/kg b.w.). Paracetamol-treated rats were given a single oral dose of 150 mg/kg following pyrexia induction. Rectal temperature was measured at intervals of 30 minutes for 180 minutes. Results. Saccharomyces cerevisiae injection elicited a satisfactory febrile response in both pyrexia-induced groups. In the paracetamol-treated group, there was a considerable decrease in rectal temperature from 90 minutes, and the difference was statistically significant (p < 0.05) when compared with the untreated group. The model was able to distinguish the antipyretic effect of paracetamol from natural thermoregulatory fall in controls. Conclusion. This S. cerevisiae pyrexia model in mice is a specific and reproducible platform for antipyretic drug evaluation. The ability to dissociate antipyretic mechanisms from accompanying inflammatory processes is what makes it an acceptable model for future pharmacological screens. The addition of fever-specific biomarkers, i.e., hypothalamic metabolites and PGE₂, is suggested to also offer mechanistic insight and translational value.
Peran Layanan Bimbingan Pribadi Terhadap Karakter Kejujuran Anak Khairunnisa, Rahma; Ayu, Elina Nurni; Maulidya, Riska; Herinawati; Hopeman, Teofilus Ardian
Jurnal Kiprah Pendidikan Vol. 3 No. 1 (2024): Jurnal Kiprah Pendidikan | Januari 2024
Publisher : Program Studi Pendididikan Guru Sekolah Dasar Fakultas Keguruan dan Ilmu Pendidikan Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33578/kpd.v3i1.217

Abstract

Penelitian ini bertujuan untuk mengetahui peran layanan bimbingan pribadi terhadap karakter kejujuran anak. Subjek penelitian sebanyak 2 anak SD kelas V MI Cibolang kaler dengan menggunakan teknik random sampling. Metode yang digunakan pada penelitian ini yaitu studi kasus dengan pendekatan kualitatif. Teknik pengumpulan data dilakukan secara triangulasi melalui observasi, wawancara dan dokumentasi. Hasil penelitian menunjukan bahwa layanan bimbingan pribadi memiliki pengaruh positif terhadap karakter kejujuran anak. Melalui observasi, ditemukan bahwa anak-anak yang menerima layanan bimbingan pribadi lebih cenderung menunjukkan perilaku jujur dalam berbagai situasi. Wawancara dengan anak-anak dan dokumentasi aktivitas bimbingan menegaskan peran signifikan layanan tersebut dalam membentuk nilai-nilai kejujuran. Implikasi dari penelitian ini dapat memberikan pandangan yang lebih jelas tentang pentingnya integrasi layanan bimbingan pribadi dalam pendidikan anak untuk mengembangkan karakter kejujuran sejak dini.
IMPLEMENTASI PEMBELAJARAN STEAM PADA MATERI IPA UNTUK MENINGKATKAN MINAT BELAJAR SISWA Khairunnisa, Rahma; Sheryl Mutiara Putri
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 3 (2025): Volume 10 No3 September, 2025
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i3.31099

Abstract

Science learning at the elementary school level often faces challenges in fostering students’ learning interest. Conventional methods that rely on memorization are considered less effective in cultivating curiosity and active engagement. The STEAM approach emerges as an innovative solution by integrating multiple disciplines in a contextual and project-based manner. This study aims to examine the implementation of STEAM-based learning in elementary science education to enhance students’ learning interest, as well as to identify the challenges in its application. This review employs a qualitative method using a Systematic Literature Review (SLR) approach guided by the PRISMA protocol. Data were obtained from 20 national and international scholarly articles published between 2020 and 2025 that met inclusion criteria: focusing on STEAM implementation in science learning, containing empirical data, and being fully accessible. The results indicate that STEAM is effective in increasing learning interest through creative, collaborative, and experience-based learning activities. Students became more active, motivated, and demonstrated a deeper understanding of science concepts. However, challenges such as limited teacher training, inadequate infrastructure, and curriculum readiness remain significant obstacles. Therefore, improving teacher competencies, developing flexible curricula, and providing adequate facilities are essential efforts to optimize STEAM implementation in elementary schools. This review is limited by its scope and publication range, thus further research with broader and deeper exploration is recommended.
The The Impact of Work Value and Satisfication on Employee Engagement at Lazismu Sunggal Service Office Khairunnisa, Rahma; Lubis, Muhammad Arifin
Indonesian Interdisciplinary Journal of Sharia Economics (IIJSE) Vol 7 No 3 (2024): Sharia Economics
Publisher : Sharia Economics Department Universitas KH. Abdul Chalim, Mojokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31538/iijse.v7i3.5690

Abstract

This study examines the impact of work values ​​and job satisfaction on employee engagement at the Lazismu Sunggal service office. This study aims to address the problem of low employee engagement in this social service organization, which is very important to achieve organizational goals and improve employee performance. This study uses a qualitative research design with a case study approach, focusing on employees who have worked at Lazismu Sunggal for at least one year. Data were collected through semi-structured interviews with 3 employees, observation, and documentation. The findings of the study indicate a significant relationship between work values, job satisfaction, and employee engagement. Employees who align their work values ​​with organizational goals tend to be more satisfied and engaged in their jobs. This study concludes that increasing work values ​​and job satisfaction can significantly increase employee engagement, thereby contributing to the effectiveness and efficiency of the organization in managing zakat, infaq, and shadaqah funds.
PENGARUH CAPITAL ADEQUACY RATIO, LOAN TO DEPOSIT RATIO DAN NON PERFORMING LOAN TERHADAP CADANGAN KERUGIAN PENURUNAN NILAI PADA PERBANKAN BADAN USAHA MILIK NEGARA TAHUN 2019 – 2023 Khairunnisa, Rahma; Simamora, Saur Costanius
Jurnal Inovatif Mahasiswa Manajemen Vol 4 No 3 (2024): Jurnal Inovatif Mahasiwa Manajemen
Publisher : Feb Universitas Dirgantara Marsekal Suryadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35968/r5zb4f03

Abstract

Penelitian ini bertujuan untuk menguji Capital Adequacy Ratio, Loan to Deposit Ratio, dan Non Performing Loan terhadap Cadangan Kerugian Penurunan Nilai Pada Perbankan Badan Usaha Milik Negara (BUMN) Tahun 2019-2023. Variabel independen dalam penelitian ini adalah Capital Adequacy Ratio, Loan to Deposit Ratio, dan Non Performing Loan, sedangkan variabel dependen dalam penelitian ini adalah Cadangan Kerugian Penurunan Nilai. Metode penelitian ini adalah kuantitatif. Penelitian ini menggunakan metode purposive sampling yaitu Teknik sampling dengan menentukan sampel dengan pertimbangan tertentu dan terdapat 6 perbankan BUMN. Hasil penelitian ini menunjukkan bahwa: (1) CAR berpengaruh signifikan terhadap CKPN; (2) LDR tidak berpengaruh dan signifikan terhadap CKPN; (3) NPL berpengaruh signifikan terhadap CKPN;(4)CAR,LDR,NPL berpengaruh signifikan secara simultan terhadap CKPN.
Co-Authors Al Baariq, Hisyam Nabil Najmuddin Ayu, Elina Nurni Azis, Nurul Magfirah Guselsa, Fricelia Aura Herinawati Hopeman, Teofilus Ardian Khairullah, Aswin Rafif Lubis, Muhammad Arifin Maulidya, Riska Pamungkas, Fajrin Yudha Putra, Oktavian Arya Ramadhan, Nuzula Rijal Nur Riska Riska Saur Costanius Simamora, Saur Costanius Sheryl Mutiara Putri Tika Hafzara Siregar Ulhaq, Oktania Dhiya Wahyuningtias , Dita Sheila Putri Wardhani, Bantari Wisynu Kusuma