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All Journal Jurnal Kedokteran Diponegoro International Journal of Artificial Intelligence Research Diponegoro International Medical Journal (DIMJ)
Afriliana, Liza
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Computer Science & IT Electrical & Electronics Engineering Medicine & Pharmacology Neuroscience

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THE EFFICACY OF TOPICAL CLINDAMYCIN GEL ON SEVERITY DEGREE OF ACNE VULGARIS AMONG FEMALE COLLEGE STUDENTS Hapsari, Rani Puspita; Widayati, Retno Indar; Afriliana, Liza; Hadi, Purnomo
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.391 KB)

Abstract

Background: Acne vulgaris is a chronic inflammatory disease in the pilosebaceous follicle of the skin as the result of Propionibacterium acnes colonization. Clindamycin is an antibiotic that is effective against most gram-positive anaerobic bacteria such as the strain of  Propionibacterium sp. Clindamycin in topical form inhibits P. acnes lipase enzyme resulting in the decrease of free fatty acid on the skin surface and the decrease of the Propionibacterium acnes population.  Aim: To know the effect of topical clindamycin gel application on the severity degree of acne vulgaris among female college students of Diponegoro University. Methods: The study has done on 34 female college students of Diponegoro University who were diagnosed with Acne Vulgaris. All of the subjects underwent a face skin examination where the acne lesions were counted before and after the treatment. The treatment given was the application of clindamycin topical gel once a day for four weeks. The counted acne lesions were classified into the severity degree of acne vulgaris by Plewig and Kligman. The study compared the severity degree of acne vulgaris before and after the treatment. Statistical analysis of this study used the Wilcoxon test. Result: The result of pre and post-treatment data showed a significant decrease in the severity degree of acne vulgaris after the treatment application (p=0.000). The decrease of severity degree was marked by the decrease of acne lesion count after having four weeks of treatment. This significant result indicated an effective recovery of acne vulgaris after being given the treatment of topical clindamycin. The antibiotic and anti-inflammation effects of clindamycin were discovered effectively healing the lesions of acne vulgaris, therefore, decreasing its severity. Conclusion: Topical clindamycin can effectively reduce the severity degree of acne vulgaris among female college students of Diponegoro University.
EFFECT OF NURSE CARING BEHAVIOR AND COMMUNICATION ON INPATIENTS SATISFACTION Afriliana, Liza; Suryawati, Chriswardani; Dwiantoro, Luky
International Journal of Artificial Intelligence Research Vol 6, No 1.1 (2022)
Publisher : STMIK Dharma Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29099/ijair.v6i1.1.513

Abstract

Background: Patient satisfaction is very important in health services in hospitals. A decrease in patient satisfaction will have an impact on a decrease in the number of patients in the hospital. Caring and communication behavior are examples of attitudes that must be considered in nursing care for patients.Purpose: This study aimed to evaluate the effect of caring behavior and nurse communication on inpatient satisfaction.Methods: This cross-sectional study involved 125 inpatients at Puri Asih Hospital Salatiga, Indonesia. Patients who fit the inclusion and exclusion criteria were taken by purposive sampling method. The caring behavior questionnaire used the Caring Dimension Inventory (CDI) instrument, nurse communication was assessed by the Nurse Quality of Communication with Patient Questionnaire (NQCPQ), and patient satisfaction by the La Monica Oberst patient satisfaction scale (LOPSS) in the Indonesian version. The Chi-square test and logistic regression were used in this study.Results: Caring behavior and nurse communication significantly affect patient satisfaction (p < 0.001). Caring behavior and good nurse communication can protect against low patient satisfaction by 69% each (OR = 0.31, 95% CI: 0.134-0.721).Conclusion: Good caring behavior and communication can prevent patient dissatisfaction. Caring behavior and nurse communication must be continuously improved to increase patient satisfaction.
THE EFFECT OF DAYAK ONION (ELEUTHERINE PALMIFOLIA) EXTRACT CREAM APPLICATION ON SERUM INTERLEUKIN-6 LEVELS: AN EXPERIMENTAL STUDY IN UVB-INDUCED MALE WISTAR RATS Choirunnisa, Armadina Fitra; Afriliana, Liza; Damayanti, Galih Sari; Widyawati, Widyawati
Diponegoro International Medical Journal Vol 6, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i2.29701

Abstract

Background: Indonesia receives intense ultraviolet B (UVB) exposure. Prolonged exposure to (UVB) radiation is a major environmental factor contributing to oxidative stress and skin inflammation through the overproduction of reactive oxygen species (ROS) and subsequent upregulation of pro-inflammatory cytokines, including interleukin-6 (IL-6). Eleutherine palmifolia, traditionally used in Indonesian herbal medicine, contains abundant flavonoids and phenolic compounds with documented antioxidant and photoprotective properties. Its ability to absorb UV rays and neutralizing ROS suggests potential efficacy as a topical agent for mitigating UVB-induced inflammatory responses. Objective: This study aimed to evaluated the effect of Eleutherine palmifolia extract cream at various concentrations (10%, 15%, 20%) on serum IL-6 levels in UVB-induced male Wistar rats. Methods: A true experimental design with post-test only control group was conducted using 36 male Wistar rats randomly assigned to four groups: control (placebo), P1 (10%), P2 (15%), and P3 (20%). The cream was applied 20 minutes before UVB exposure and again 4 hours after irridation, three times per week for 30 days. Serum IL-6 levels were measured using ELISA. Statistical analysis was performed using Shapiro–Wilk, Levene’s test, one-way ANOVA, and LSD post-hoc test. Results: Mean IL-6 levels (pg/mL): control 1.63; P1 1.59; P2 1.65; P3 1.57. ANOVA indicated a significant differences among groups (p = 0.047). Post-hoc analysis showing a significant difference only between P2 and P3 groups (p = 0.012). Conclusion: The 20% Eleutherine palmifolia cream showed the strongest anti-inflammatory effect, significantly lowering IL-6 compared with 15%, while other group differences were not significant.
Incidence and Associated Factors of Occupational Contact Dermatitis in Wood Furniture Finishing Workers faustinawati, belinda; Malik, Diah Adriani; Afriliana, Liza
Diponegoro International Medical Journal Vol 6, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i2.28408

Abstract

Background: Occupational contact dermatitis (OCD) is a prevalent skin disease caused by workplace exposure to exogenous agents. Wood furniture finishing workers are at high risk due to significant contact with allergens and irritants, yet specific research on this group remains limited.Objective: To determine the incidence rate of OCD and analyze its associated factors among wood furniture finishing workers.Methods: An observational analytical study with a cross-sectional design was conducted involving 36 wood furniture finishing workers. Data on potential risk factors were collected using a modified Nordic Occupational Skin Questionnaire (NOSQ)-2002. The diagnosis of OCD was established using the Mathias criteria. A patch test was performed with four common industrial allergens (Formaldehyde 1%, Isothiazolinone 0.2%, Cobalt Chloride 1%, and Colophony 20%) to identify specific sensitisations. Data were analyzed using Mann-Whitney, Fisher's exact, and logistic regression tests.Results: The incidence rate of OCD was 58.3% (21 of 36 subjects). Positive patch test results were found in 20 subjects (55.5%), with Cobalt Chloride 1% being the most frequent sensitizer (44.4%), followed by Colophony 20% (30.5%), Formaldehyde 1% (19.4%), and Isothiazolinone 0.2% (13.8%). Univariate analysis identified younger age (p=0.012), shorter length of work (p=0.001), and a history of atopic dermatitis (p<0.001) as significant risk factors. Multivariate logistic regression analysis confirmed that younger age was the strongest predictor for OCD (OR 1.086; 95% CI 1.018–1.158; p=0.012).Conclusion: Wood furniture finishing workers exhibit a high incidence of OCD. Younger age, shorter work duration, and a history of atopic dermatitis are significant associated factors. These findings highlight the need for targeted preventive strategies, including worker education and improved safety measures in the furniture finishing industry.
Effect of Topical Dayak Onion (Eleutherine palmifolia) Cream on Epidermal Thickness in UVB-Exposed Male Wistar Rats: An Experimental Study Setyanegari, Aditya Putri; Damayanti, Galih Sari; Afriliana, Liza; Karlowee, Vega
Diponegoro International Medical Journal Vol 6, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i2.29621

Abstract

Background: Exposure to ultraviolet B (UVB) radiation, particularly in tropical regions like Indonesia, can cause skin damage characterized by increased epidermal thickness due to keratinocyte hyperproliferation, contributing to photoaging. Natural photoprotective agents rich in antioxidants such as Dayak onion (Eleutherine palmifolia) extract are expected to mitigate these effects. Objective: This study aims to evaluate the effect of applying Dayak onion extract cream at varying concentrations on epidermal thickness of UVB-induced male Wistar rat skin. Methods: This study was a true experimental study with a post-test only control group design. A total of 36 male Wistar rats were randomly divided into four groups: a control group (given placebo cream) and three treatment groups given Dayak onion extract cream at concentrations of 10%, 15%, and 20%. UVB exposure was carried out every two days for 30 days, along with application of the cream before and after UVB radiation. Epidermal thickness was analyzed through histopathological examination using Hematoxylin-Eosin staining and observed under 400x magnification. Results: Statistical analysis showed significant differences (p < 0,05) in epidermal thickness between the control group and the treatment groups. The mean epidermal thickness in the treatment groups was lower than that of the control group, with the greatest reduction observed in the 20% concentration group, followed by the 15% and 10% groups. There was no significant difference between the 15% and 20% concentrations. Conclusion: Application of Dayak onion extract cream is effective in reducing epidermal thickness, with a concentration of 20% providing optimal protective effects. These findings support the potential of Dayak onion as a natural photoprotective agent.Keywords: Dayak onion, Eleutherine palmifolia, epidermal thickness, photoaging, antioxidant
Co-Authors Choirunnisa, Armadina Fitra Damayanti, Galih Sari Diah Adriani Malik Dwiantoro, Luky Faustinawati, Belinda Hapsari, Rani Puspita Karlowee, Vega Purnomo Hadi Retno Indar Widayati Setyanegari, Aditya Putri Widyawati Widyawati