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Halimah Pagarra
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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EKSPRESI GEN P53 PADA PTERIGIUM PRIMER DAN PTERIGIUM REKUREN Ratih Natasha; Sitti Rukiyah Syawal; Halimah Pagarra; Arifin Seweng
Green Medical Journal Vol 1 No 1 (2019): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (654.825 KB) | DOI: 10.33096/gmj.v1i1.20

Abstract

Tujuan penelitian untuk mengetahui dan membandingkan ekspresi P53 mutan pada pterigium primer dan pterigium rekuren. Metode Penelitian ini merupakan penelitian analitik observasional cross sectional study dengan 19 sampel pterigium primer dan 19 sampel pterigium rekuren. Data diperoleh dengan cara pengambilan jaringan pterigium kemudian dilakukan pemeriksaan imunohistokimia. Hasil Penelitian ini dilakukan selama 5 bulan dengan 19 sampel pterigium primer dan 19 sampel pterigium rekuren. Dari keseluruhan data menunjukkan bahwa P53 ekspresi pterigium primer dan rekuren rata-rata 191,6 sementara ada 38,3 untuk pterigium primer dan 344,8 untuk pterigium rekuren. Ada perbedaan yang signifikan antara ekspresi P53 primer dan P53 ekspresi pterygium berulang dengan (P = 0,000). Kesimpulannya tidak ada perbedaan signifikan pada ekspresi P53 berdasarkan stadium pterigium meskipun ada kecenderungan ekspresi P53 semakin kecil dengan meningkatnya stadium pterigium.
Blind Painful Eye Revealing Spontaneously Regressed Retinoblastoma in Young Patient Hadijah Hadijah; Halimah Pagarra; Suliati P. Amir; Andi Pratiwi
Majalah Oftalmologi Indonesia Vol 47 No 2 (2021): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v47i2.100298

Abstract

Purpose: Spontaneous regression is a rare but well-known feature of retinoblastoma, which is predicted in approximately 2 of every 100 cases. Unilateral, unifocal spontaneous regression of retinoblastoma is infrequent; bilateral multifocal spontaneous regression of retinoblastoma is even more extraordinary. In many of the previously reported cases, the eye (or eyes) containing the spontaneously regressed tumor has been phthisical and blind. Herein, we describe the case of a young woman with unilateral, spontaneously regressed retinoblastoma (RB), with inflamed, blind, and phthisis in the left eye as an uncommon presentation of spontaneously regressed retinoblastoma Methods: This is a case report: An 18-year-old woman came to the outpatient clinic with a chief complaint of pain in the left eye since 1 month prior and a history of dysfunctional “cat’s” eye since childhood. Results: Exotropia and atrophy bulbi was noticed in the left eye. Anterior segment examination revealed signs of inflammation including conjunctival hyperemia, shallow anterior chamber, rubeosis iridis, and posterior synechia with white “chalky” mass suggestive calcification. B-scan ultrasonography showed a point like lesion and solitary solid intraocular mass with calcification in vitreus. Orbital computed tomography scan (CT-Scan) showed atrophy of the left eye with intraocular calcification without optic nerve and extraocular muscle involvement. Enucleation and histopathology examination were done and revealed undifferentiated retinoblastoma beyond the sign of metastasis in other parts of the eye. Conclusion: Blind painful eye may present as the main feature of spontaneously regressed retinoblastoma that possibly caused by an inflammatory reaction.
UNUSUAL CASE OF A METAL FOREIGN OBJECT IN ORBITOCRANIAL INJURY: UNLOCKING THE MACCARTY KEYHOLE Rahman, Fadiah Gazzani; Pratiwi, Andi; Halimah Pagarra; Suliati P. Amir
Majalah Oftalmologi Indonesia Vol 51 No 2 (2025): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v51i2.101859

Abstract

Introduction. Penetrating orbitocranial injuries are quite rare but very fatal if left untreated. Various metal objects have been reported as foreign bodies that have penetrated the orbit. However, unusual objects such as motorcycle locks have never been reported before. Case Illustration. A 14-year-old boy was brought to the emergency room with a motorcycle lock embedded in his left temporal region. Examination of the left eye showed decreased vision, clear serous ciliary secretions, conjunctival hyperemia, chemosis, and relative afferent pupillary defect. Investigations using a 3D Head MSCT Scan revealed the presence of a metal object that penetrates the left optic nerve, the rectus lateralis muscle, and the frontal process of the left zygoma bone in the left temporal region, which is located around the MacCarty keyhole. The operation in the form of exploration and foreign object removal was then carried out in collaboration with the neurosurgeon. No postoperative complications were reported, but the patient had restricted movement of the left eye. Discussion. Penetrating orbitocranial injury should be treated as an emergency. Diagnosis should include comprehensive ophthalmological and neurological examinations. CT Scan continues to be the best cranial imaging technique. In this case, the motorcycle lock penetration was around the MacCarty keyhole, a structure that is frequently used to enter both the orbit and the frontal fossa, which located 7 mm superior and 5 mm posterior to the frontozygomatic suture. An appropriate surgical strategy is mandatory for removing the object because it may lead to serious consequences, including cerebral, infectious, vascular complications, and even death. Conclusion. Metal foreign objects such as motorcycle lock was considered unusual, particulary when it unlock an important landmark such as MacCarty keyhole. This case emphasizes the significance of a surgical strategy based on accurate anatomical tracking.
Co-Authors Andi Pratiwi Arifin Seweng Hadijah Hadijah Pratiwi, Andi Rahman, Fadiah Gazzani Ratih Natasha Sitti Rukiyah Syawal Suliati P. Amir