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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Medical and Health Journal Linggamas: Jurnal Pengabdian Masyarakat
Ihtiaringtyas, Suci
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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POTENTIAL OF PLANT-DERIVED ANTIMICROBIAL COMPOUND AGAINS MULTI-DRUG RESISTANT TUBERCULOSIS (MDR-TB): A LITERATUR REVIEW Pauzi, Rizqi Yanuar; Ihtiaringtyas, Suci; Wahyudin, Wahyudin
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.10459

Abstract

Antibiotic resistance is currently a global challenge, especially in the healthcare. Tuberculosis is a disease caused by Mycobacterium tuberculosis that has developed to resistant strains against antibiotic. Multi-drug resistant tuberculosis (MDR-TB) is a Mycobacterium strain that is resistant to first-line TB drugs such as isoniazid and rifampicin. More than 10 million people suffer from TB every year, while MDR-TB sufferers in 2022 about 410,000 people. Treatment for MDR-TB patients has side effects in the form of toxicity. Plant-derived antimicrobial compounds have the potential to inhibit the growth of MDR-TB so they can be used as alternative treatments. Recent studies discuss several potential plant compounds against MDR-TB in a country. This article presents several antimicrobial compounds from various plant species from various countries against MDR-TB. The results of the study showed that around 20 compounds from various plant species had the potential to inhibit MDR-TB. These compounds can be developed further, especially by examining their side effects on the body so that they can be used as an alternative treatment for MDR-TB.
KAJIAN LITERATUR: BIOPROSPEKSI TANAMAN DLINGO (Acorus calamus L) SEBAGAI ANTINYAMUK Ihtiaringtyas, Suci; Pauzi, Rizqi Yanuar
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.10961

Abstract

Acorus calamus, also known as sweet flag or calamus, is a water-loving shrub that grows in swampy areas and along the edges of water bodies in various parts of the world. This plant is renowned for its rhizomes, which are used in various traditional medicinal practices. Additionally, the plant contains secondary metabolites that have the potential to act as mosquito repellents. This research aims to explore the prospects of Acorus calamus L. as an anti-mosquito agent. The methodology employed is a Systematic Literature Review design. The literature review involved searching for articles using the Google Scholar database, including both national and international journal articles. The research findings suggest promising biological prospects as an anti-mosquito agent. This includes inducing mortality in larval stages as well as acting as a repellent for adult mosquitoes. These effects are attributed to the presence of bioactive compounds such as asarone, colamenole, calamin, colameon, and methyl eugenol. The most abundant chemical component is asarone (82%), an active compound with antifeedant properties that inhibit insect growth. Furthermore, Acorus calamus contains other secondary metabolites like alkaloids, saponins, flavonoids, phenols, tannins, steroids, and terpenoids. These compounds can enter the mosquito through respiratory contact and digestive toxicity, leading to mosquito mortality. Additionally, these compounds obstruct the chemical receptors (chemoreceptors) found in mosquito palps and antennae, causing mosquitoes to avoid feeding on blood. This review article aims to provide insights into the potential of Acorus calamus L as an anti-mosquito agent.
EKSTRAK TUMBUHAN SEBAGAI AGEN ANTIMIKROBA UNTUK METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA): REVIEW Pauzi, Rizqi Yanuar; Septiya, Lia; Ihtiaringtyas, Suci; Wahyudin, Wahyudin
Medical and Health Journal Vol 4 No 1 (2024): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.4.1.12282

Abstract

Plant extracts have become an intriguing subject of research in the search for effectiveantimicrobial agents against Methicillin-Resistant Staphylococcus Aureus (MRSA), which is a global health issue due to its resistance to various antibiotics. Several studies have shown that compounds such as alkaloids and polyphenols in plants are responsible for their antimicrobial properties. Extracts from plants such as Azadirachta indica, Psidium guajava, and Rhamnus californica have demonstrated antibacterial activity against MRSA. Other research indicates that compounds like Psorothatin C from Psorothamnus fremontii are also effective against MRSA. The main challenge in managing MRSA infections is resistance to conventional antibiotics like vancomycin. Therefore, further research on plant extracts and synthetic compounds with antimicrobial activity against MRSA could provide significant contributions to the development of new therapies. Approaches involving the combination of plant extracts with conventional antibiotics also show potential in enhancing treatment effectiveness. A deep understanding of the mechanisms of action of these plant extracts is crucial for developing effective treatment strategies, and with further research, plant extracts could become an important alternative in addressing MRSA infections that are resistant to antibiotics.
STUDI LITERATUR: POTENSI BUAH PARIJOTO (Medinilla speciosa) SEBAGAI ANTIMALARIA Ihtiaringtyas, Suci; Pauzi, Rizqi Yanuar; Setyanto, Muhamad Rifqy
Medical and Health Journal Vol 4 No 1 (2024): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.4.1.12805

Abstract

Malaria is one of the deadliest infectious diseases in the world. It is caused by the parasite Plasmodium spp. and transmitted through the bites of female Anopheles mosquitoes. This disease remains a significant global health problem, particularly in tropical and subtropical regions. Approximately 41% of the world's population is at risk of malaria infection. Artemisinin-based Combination Therapy (ACT) remains the gold standard for malaria treatment, but resistance is beginning to develop, necessitating alternative treatments from natural sources found in plants. Parijoto (M. speciosa) is an exotic fruit native to Indonesia that grows abundantly in mountainous areas. The fruit has been widely used by local communities to treat various ailments, including mouth ulcers, inflammation, and diarrhea. Numerous studies have been conducted to prove the effectiveness of this plant's fruit as an alternative natural remedy. This study aims to investigate the potential of parijoto fruit (M. speciosa) as an antimalarial agent. The method used is a literature review with a Systematic Literature Review design. Articles were sourced from the Google Scholar database, including both national and international journal articles. Based on the research findings, parijoto fruit has been proven to contain bioactive compounds, including phenolics, flavonoids, saponins, tannins, alkaloids, cardenolides, and glycosides. These secondary metabolite compounds in the plant have been shown to possess antioxidant, antidiabetic, antimicrobial, anticancer, and other beneficial activities. It is hoped that the secondary metabolite compounds contained in parijoto fruit (M. speciosa) have the potential to serve as antimalarial agents.
COMPARISON OF THE EFFECTIVENESS OF SKIN SWAB AND SKIN SCRAPING TECHNIQUES FOR SCABIES DIAGNOSIS Ihtiaringtyas, Suci; Susiawan, Lieza Dwianasari; Sari, Octavia Permata; Firinda, Rizma Haidif
Medical and Health Journal Vol 4 No 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.4.2.14686

Abstract

Scabies is a skin disease caused by an infestation of the mite Sarcoptes scabiei var. hominis. This disease often mimics other skin conditions, earning it the nickname "The Great Imitator." Four main signs (cardinal signs) of scabies infestation are recognized: intense itching at night (pruritus nocturna), group infections affecting multiple individuals, burrows accompanied by papules or vesicles, and the presence of mites on the patient’s lesions. Atypical scabies has several rare and difficult-to-recognize forms, which can lead to misdiagnosis. Accurate diagnosis is crucial to prevent further spread and complications.Several diagnostic methods can be employed to confirm this disease. Two diagnostic techniques commonly used are skin swab and skin scraping; however, the comparative effectiveness of these methods has not been extensively studied. This study aims to compare the effectiveness of these two techniques in detecting scabies. The research design used in this study is observational with a cross-sectional approach and a full-sampling method. The test subjects were scabies-infected rabbit obtained from the Research Laboratory of the Faculty of Medicine, Jenderal Soedirman University.A total of 8 samples were collected: 4 samples using the skin swab technique and 4 samples using the skin scraping technique. Samples were taken from active lesion areas using the skin swab technique with transparent adhesive tape and the skin scraping technique with a sterile scalpel. The collected samples were examined under a microscope to detect mites, eggs, or their feces. The results showed no statistically significant difference between the outcomes of the skin swab and skin scraping methods, with a p-value of 0.448 (p > 0.05). Both techniques were equally effective in diagnosing scabies in rabbit.Additionally, the skin swab technique was more comfortable for patients and minimized the risk of injury. In conclusion, the skin swab technique can serve as a safer and more effective alternative to skin scraping, particularly for diagnosing scabies in sensitive lesion areas. This study is expected to assist medical practitioners in selecting the optimal diagnostic method for scabies.
Implementasi Edukasi Gizi Interaktif sebagai Upaya Pencegahan Komplikasi Penyakit Kronis pada Lansia di Posyandu Mawar IV Desa Purwosari Wisesa, Sindhu; Sari, Octavia Permata; Candrawati, Susiana; Wicaksono, Madya Ardi; Ihtiaringtyas, Suci; Soraya, Aristi Intan
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.14367

Abstract

Hampir seluruh populasi lansia memiliki setidaknya satu penyakit kronis. Penyakit kronis dan komplikasinya menyebabkan penurunan produktivitas dan kualitas hidup, serta meningkatkan beban ekonomi. Asupan gizi seimbang terbukti mencegah komplikasi penyakit kronis. Program Pengabdian kepada Masyarakat (PKM) ini bertujuan untuk meningkatkan kesadaran asupan gizi seimbang pada lansia melalui edukasi interaktif menggunakan model makanan. Kegiatan dilaksanakan pada tanggal 2 Agustus 2024 di Desa Purwosari yang dihadiri oleh 40 lansia dan kader Posyandu. Hasil pretest dan posttest menunjukkan peningkatan pengetahuan secara signifikan pada lansia yang mengikuti kegiatan PkM. Edukasi gizi berperan krusial dalam mengubah pola pikir dan perilaku masyarakat terkait asupan makanan. Penggunaan model makanan membantu peserta memahami porsi yang tepat, serta meningkatkan minat dan retensi informasi, sehingga diharapkan melalui program ini, lansia di Desa Purwosari dapat memperbaiki pola makan dan mencegah komplikasi penyakit kronis.
Skabies di Antara Penyakit Kulit: Studi Prevalensi di Klinik Pratama Soedirman Tahun 2024 Firinda, Rizma Haidif; Wicaksono, Madya Ardi; Sinensis, Rizki Amelia; Nafiisah, Nafiisah; Kusdaryanto, Wahyu Dwi; Ihtiaringtyas, Suci
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.84-89

Abstract

Scabies is a skin disease caused by infestation of the parasitic mite Sarcoptes scabiei, which penetrates the skin and reproduces by laying eggs. Although often regarded as a common and non-severe condition, scabies is classified as a neglected skin disease on a global scale. This study aims to determine the prevalence of scabies in relation to the total number of skin diseases diagnosed at the Soedirman Primary Outpatient Clinic. A descriptive research method was employed, utilizing patient medical records from March to September 2024. Data were collected based on ICD-10 diagnostic codes, including both scabies and other dermatological conditions. The results showed that there were 13 recorded cases of scabies (5.05%) out of a total of 257 diagnosed skin diseases. This prevalence closely aligns with the national prevalence of scabies in Indonesia. Variations in prevalence may be influenced by social and environmental factors, with higher transmission rates occurring in densely populated areas and among individuals with frequent close contact. Preventive measures include health education, personal hygiene, and improved environmental sanitation.
Integrasi Edukasi Mikrobiota Usus, Skrining Antropometri, dan Pemanfaat Probiotik sebagai Upaya Pencegahan Stunting di Desa Watuagung Pauzi, Rizqi Yanuar; Ihtiaringtyas, Suci; Yunika, Novia; Nur’aini, Indah; Oliviany, Windy
Linggamas: Jurnal Pengabdian Masyarakat Vol 3 No 1 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.3.1.17703

Abstract

Prevalensi stunting di Desa Watuagung, Kabupaten Banyumas (18,58%), masih menjadi masalah gizi kronis yang signifikan. Salah satu faktor penyebab yang teridentifikasi adalah rendahnya pengetahuan masyarakat mengenai gizi seimbang dan peran mikrobiota usus dalam optimalisasi penyerapan nutrisi. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan ibu balita dan keterampilan kader Posyandu serta melakukan deteksi dini stunting sebagai upaya pencegahan. Metode yang diterapkan adalah participatory action research yang melibatkan 48 ibu balita dan 11 kader Posyandu. Intervensi terdiri dari tiga kegiatan utama: (1) penyuluhan interaktif mengenai stunting, gizi seimbang, dan peran mikrobiota usus; (2) pelatihan dan pendampingan kader dalam melakukan pengukuran antropometri standar; serta (3) skrining status gizi pada 38 balita. Peningkatan pengetahuan diukur menggunakan pre-test dan post-test, sedangkan status gizi dianalisis berdasarkan standar WHO Child Growth Standards. Hasil pre-test dan post-test menunjukkan terjadi peningkatan pengetahuan peserta secara signifikan, dengan skor rata-rata naik dari 85,22 menjadi 92,61 dan nilai N-Gain sebesar 0,50 yang termasuk kategori efektivitas sedang. Hasil skrining antropometri pada 38 balita menunjukkan prevalensi stunting (TB/U <-2 SD) yang tinggi, yaitu sebesar 45% (17 anak), dan underweight (BB/U <-2 SD) sebesar 24% (9 anak). Adapun prevalensi wasting (BB/TB <-2 SD) lebih rendah, yaitu 6% (2 anak). Edukasi terstruktur dan deteksi dini melalui pemberdayaan kader terbukti efektif sebagai strategi awal pencegahan stunting. Tingginya angka stunting yang ditemukan menegaskan urgensi intervensi lanjutan berbasis data skrining yang akurat.
Co-Authors Firinda, Rizma Haidif Kusdaryanto, Wahyu Dwi Madya Ardi Wicaksono, Madya Ardi Nafiisah, Nafiisah Nur’aini, Indah Octavia Permata Sari, Octavia Permata Oliviany, Windy Pauzi, Rizqi Yanuar Septiya, Lia Setyanto, Muhamad Rifqy Sinensis, Rizki Amelia Soraya, Aristi Intan Susiana Candrawati Susiawan, Lieza Dwianasari Wahyudin Wahyudin Wisesa, Sindhu Yunika, Novia