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NARKOLEPSI: PATOFISIOLOGI, DIAGNOSIS DAN MANAJEMEN sahidu, ghalvan; Afif, Zamroni
Jurnal Kedokteran Vol 9 No 1 (2020): Jurnal Kedokteran Vol 9 No 1 2020
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v9i1.401

Abstract

Narkolepsi telah dikenal lama oleh profesi medis. Narkolepsi sangat mengganggu karena tidur dan bangun menjadi tidak teratur. Cataplexy adalah sebuah gejala yang paling sering dikaitkan dengan narkolepsi, meski ada banyak gejala lainnya yang menyertai penyakit gangguan tidur. Narkolepsi dengan cataplexy (tipe 1) bisa langsung didiagnosis. Diagnosa narkolepsi tanpa cataplexy (tipe 2) sering sulit karena hasil diagnosanya perlu diuji dan batasannya pun perlu dipahami. Narkolepsi sering dianggap pemicu terjadinya komorbiditas multipel.
SLEEP DISORDERS AND DIVING-ASSOCIATED DECOMPRESSION SICKNESS Harahap, Herpan Syafii; Indrayana, Yanna; Afif, Zamroni; Landapa, Raditya Rachman; Ismiana, Baiq Holisatul; Gea, Endah Irnanda Ulfa; Wiracakra, I Gusti Lanang Krisna
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.09

Abstract

Decompression sickness is considered as an important complication of deep diving. Since the trend of diving activities is increasing throughout the world and is dominated by novice divers, the incidence of decompression sickness should be high. Severe form of decompression sickness can cause damage to the central nervous system with varying manifestations of mild to severe neurological deficits. Recent studies show that sleep disorders need to be considered as an important consequence of decompression sickness. However, the pathophysiology of decompression sickness-associated sleep disorders is currently not well understood. Since sleep disorders are associated with dysfunction of anatomical structures and the neurotransmitter systems in the brain that regulate the sleep-wakefulness cycle, decompression sickness-associated sleep disorders can be postulated to be related to dysfunction of these two regulators of sleep-wakefulness cycle. Sleep disorders found in patients with decompression sickness are more likely to occur in type 2 decompression sickness and may be found in the form of insomnia, hypersomnia, circadian rhythm disorders, obstructive sleep apnea, and narcolepsy. This review aims to discuss the pathophysiology of sleep disorders and decompression sickness as well as possible mechanisms underlying sleep disorders in decompression sickness through theoretical approaches and the results of available studies. In conclusion, decompression sickness-related sleep disorders are thought to involve two pathological conditions in the brain, namely structural lesions and dysfunction of the neurotransmitter system in the brain.
COGNITIVE FUNCTION PROFILE IN OBSTRUCTIVE SLEEP APNEA PATIENTS: WHICH IS MORE LIKELY TO DEVELOP? Wardani, Rachmawati; Afif, Zamroni
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.04

Abstract

Background: Obstructive sleep apnea (OSA) is a condition that arises from repeated episodes of upper airway collapse and obstruction during sleep that are associated with waking events with or without oxygen desaturation. OSA can cause a decrease in cognitive function. There are several neurocognitive areas of the brain that OSA and sleep deprivation can affect differently. Objective: The aim of this study is to determine the profile of cognitive disorders in OSA patients at dr. Saiful Anwar General Hospital from 2017 to 2022. Methods: This is an observational descriptive study of the results of Polysomnography and Mini-Mental State Examination (MMSE) of patients with OSA at dr. Saiful Anwar General Hospital during the period January 2017 - April 2022. Results: Results: Among the 100 subjects of the study, there were 63 men (63%) and 37 women (37%). The age distribution was as follows: 20 individuals were under 25 years old (20%), 36 people were between 25 and 45 years old (36%), 24 people were between 46 and 60 years old (24%), and 20 people were over 60 years old (20%). 12 individuals (12%) had an elementary education, 17 individuals (17%) had a junior high school education, 36 individuals (36%) had a senior high school education, and 34 individuals (34%) had an undergraduate education, according to the most recent education subject. According to the study participants' cognitive function profiles, 93 individuals (93%) had normal cognitive function, 5 individuals (5%) had mild cognitive function impairment, 2 individuals (2%) had moderate cognitive impairment, and none of the study participants had severe cognitive impairment. Conclusion: Most cognitive function profiles were normal, and the majority of OSA patients at dr. Saiful Anwar General Hospital are men. Few people acquired mild to moderate cognitive deficits and no severe cognitive impairment was seen.
Tingkat Pengetahuan Masyarakat Di Kota Malang Tentang Obstructive Sleep Apnea Djajalaksana, Susanthy; Afif, Zamroni; Muhammad, Iqbal; Dini, Zata; Pratiwi, Eka
JURNAL WACANA KESEHATAN Vol 10, No 1 (2025): Juli
Publisher : AKPER Dharma Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52822/jwk.v10i1.678

Abstract

Obstructive Sleep Apnea Syndrome (OSA) merupakan masalah kesehatan masyarakat yang sering terjadi dan dapat menimbulkan berbagai masalah kesehatan jangka panjang. Oleh karena itu, perlu dilakukan penelitian tentang tingkat pengetahuan masyarakat di puskesmas Kota Malang tentang OSA sebagai upaya preventif untuk deteksi dini dan penatalaksanaan dini OSA. Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross-sectional. Penelitian ini menggunakan teknik quota sampling dengan jumlah subjek sebanyak 100 subjek. Tingkat pengetahuan masyarakat diukur menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya kemudian dibagi menjadi baik, sedang dan buruk. Analisis statistik menggunakan korelasi Pearson dengan tingkat signifikansi p<0,05. subjek berjumlah 100 orang yang terdiri dari 52% laki-laki dan 48% perempuan. Sebagian besar subjek berusia < 50 tahun (80%) dengan tingkat pendidikan sarjana (76%). Tingkat pengetahuan tidak berkorelasi dengan jenis kelamin (r = -0,041, p = 0,682), usia (r = 0,144, p = 0,151), dan tingkat pendidikan (r = 0,109, p = 0,282). Pada penelitian ini didapatkan sebagian besar tingkat pengetahuan subjek baik dan tidak berkorelasi dengan jenis kelamin, usia, dan tingkat pendidikan.Kata Kunci: Tingkat Pengetahuan, Obstructive Sleep Apnea, Masyarakat Kota Malang.