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All Journal Jurnal Kedokteran MNJ (Malang Neurology Journal) Jurnal Biologi Tropis Jurnal Ilmu Kedokteran dan Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan UMI Medical Journal Jurnal Abdi Insani International Journal of Public Health Excellence (IJPHE)
Wiracakra, I Gusti Lanang Krisna
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Efek Pemberian Ekstrak Daun Srikaya (Annona squamosal L) terhadap Kadar SGOT dan SGPT pada Tikus (Rattus norvegicus) yang Diinduksi Karbon Tetraklorida(CCL4) Wiracakra, I Gusti Lanang Krisna; Nurhidayati, Nurhidayati; Padauleng, Novrita; Rizki, Mohammad
Jurnal Kedokteran Vol 6 No 2.1 (2017)
Publisher : Faculty of Medicine Universitas Mataram

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Abstract

Latar belakang:Kerusakan hepar dapat disebabkan oleh radikal bebas yaitu CCl4. Daun srikaya (Annona squamosa L) mengandung senyawa flavonoid yang merupakan antioksidan dan berpotensi melindungi hepar terhadap kerusakan. Penelitian ini dilakukan untuk mengetahui efek pemberian ekstrak daun srikaya (Annnona squamosal L) terhadap kadar SGOT dan SGPT tikus yang diinduksi CCl4. Metodologi penelitian: Penelitian ini merupakan studi eksperimental dengan rancangan post-test only control group design. Duapuluh ekor tikus dibagi dalam 4 kelompok, 2 kelompok kontrol dan 2 kelompok perlakuan.kontrol positif diberikan CCL4 10% 1 ml/kgBB, kontrol negatif diberikan minyak zaitun 1 ml/kgBB, perlakuan 1 diberi CCl4 dan ekstrak daun srikaya dosis 300 mg/kgBB, serta perlakuan 2 diberi CCl4 dan ekstrak daun srikaya dosis 350 mg/kgBB Hasil:Nilai rerata SGOT dan SGPT kontrol positif tertinggi diantara semua kelompok dan rerata perlakuan 2 terendah diantara semua kelompok. Uji One-way ANOVA terdapat signifikansi (<0,05) pada kadar SGPT, sedangkan pada kadar SGOT tidak signifikan (p>0,05). Uji Post Hoc (LSD) terdapat perbedaan yang bermakna (p<0,05) kadar SGPT perlakuan dua terhadap kontrol positif. Tidak terdapat perbedaan yang bermakna antara kelompok perlakuan 2 dan perlakuan 1. Simpulan:Potensi efek hepatoprotektor ditemukan pada kelompok perlakuanyang diberi ekstrak daun srikaya dengan dosis 300 mg/kgBB dan 350 mg/kgBB
A RARE CASE OF CARDIOEMBOLIC STROKE IN PATIENT WITH CARDIAC MYXOMA: CASE REPORT Wiracakra, I Gusti Lanang Krisna; Putri, Setyawati Asih
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 10 (2023): volume 10 Nomor 10
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i10.10918

Abstract

Abstract: A Rare Case of Cardioembolic Stroke in Patient with Cardiac Myxoma: Case Report. Cardiac myxoma is a condition where there is a tumor in the heart chambers, which is a rare cause of cardioembolic strokes in patients. The purpose of this case report is to convey a case that is rarely found in daily clinical practice as well as the stages of diagnosis and management of this case. A 42-year-old woman came with a sudden loss of consciousness, and after the patient regained consciousness, there was a neurological deficit. Based on the anamnesis, there was no history or risk factors for stroke in the patient. Through additional physical and supporting examinations, the patient was diagnosed with a cardioembolic stroke accompanied by cardiac myxoma. The patient received stroke therapy such as antiplatelet administration and physiotherapy to improve the condition of the patient's neurological deficits. After passing the treatment period, the patient's condition improved but still required further treatment.
The Effectiveness of Using Laser Therapy on Outcome of Carpal Tunnel Syndrome Patients : A Literature Review Tjahyanto, Teddy; Mayung, Claraiva; Yohanes, Guntur; Erwin, Ferdinand; Wiracakra, I Gusti Lanang Krisna
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 1 (2023): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i1.523

Abstract

Carpal Tunnel Syndrome (CTS) is a neuropathy caused by compression of the median nerve that passes through the carpal tunnel structure in the wrist. If the CTS condition is not treated, complications will occur such as irreversible damage to the median nerve resulting in permanent impairment and disability, chronic wrist pain, and muscle atrophy and weakness. Currently there are various CTS therapies such as splinting , local injection of corticosteroids, oral medications such as prednisone, physical therapy such as carpal bone mobilization, ultrasound therapy , and nerve glides exercises , as well as surgical therapy. However, these various therapies have not provided optimal results and there are complications such as neuromas, hypertrophic wounds, dysesthesia, wrist joint stiffness, and the inability of various to reduce CTS symptoms. Therefore, more effective therapy with minimal side effects is needed. Therefore, in this literature review, an analysis of the effect of laser therapy on various outcomes of CTS patients as an innovative therapy was carried out. Study searches were performed on various databases such as Pubmed, ScienceDirect , Directory of Open Access Journal , Epistemonikos, and Cochrane Library . From the search results obtained a total of 389 studies. The 7 studies that met the inclusion and exclusion criteria were the studies that were analyzed in this literature review. Various types of laser therapy showed better outcome results than the control group, with LLLT laser therapy showing the best results in various outcomes in CTS patients. LLLT laser therapy also shows better results when combined with other types of therapy. No adverse events were reported with any type of laser therapy in all inclusion studies. Therapy is the newest type of innovative therapy with better effects and minimal side effects compared to conventional therapy in CTS patients.
Gangguan Keseimbangan Akibat Penyakit Dekompresi kholida, Baiq Hilya; Hunaifi, Ilsa; Lestari, Diayanti Tenti; Kurniawan, Theophany Margareta; Annisa, Wardha Novia; Agistany, Nur Feby Febiana; Wiracakra, I Gusti Lanang Krisna
UMI Medical Journal Vol 9 No 2 (2024): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v9i2.308

Abstract

Latar belakang: Decompression Sickness (DCS) adalah penyakit multisistem disebabkan oleh gelembung gas terlarut yang terbentuk dalam darah dan jaringan selama atau pasca penurunan tekanan lingkungan mendadak. Isi: Insiden DCS jarang terjadi, hanya sekitar 3 kasus per 10.000 penyelaman. Insidennya meningkat pada nelayan penyelam tradisional. Inner Ear Barotrauma (IEB) merupakan suatu kerusakan jaringan fisik yang terjadi akibat ketidakseimbangan antara tekanan udara pada ruang telinga tengah dan telinga dalam. Alternobaric vertigo (AV) merupakan suatu kondisi kejadian vertigo sementara yang biasanya akan berkembang saat naik atau melakukan manuver valsava. Faktor risiko lainya pada AV meliputi paparan kebisingan saat melakukan penyelaman. Review ini menggunakan Inner Ear Disorders in SCUBA Divers: A Review sebagai panduan dalam menyusun artikel. Penelusuran menggunakan Google Scholar, Pubmed, dan Plos One. Kesimpulan: Decompression Sickness (DCS) dapat menyebabkan Gangguan keseimbangan pada IEB, Inner Ear Decompression Sickness, dan AV.
SLEEP DISORDERS AND DIVING-ASSOCIATED DECOMPRESSION SICKNESS Harahap, Herpan Syafii; Indrayana, Yanna; Afif, Zamroni; Landapa, Raditya Rachman; Ismiana, Baiq Holisatul; Gea, Endah Irnanda Ulfa; Wiracakra, I Gusti Lanang Krisna
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.09

Abstract

Decompression sickness is considered as an important complication of deep diving. Since the trend of diving activities is increasing throughout the world and is dominated by novice divers, the incidence of decompression sickness should be high. Severe form of decompression sickness can cause damage to the central nervous system with varying manifestations of mild to severe neurological deficits. Recent studies show that sleep disorders need to be considered as an important consequence of decompression sickness. However, the pathophysiology of decompression sickness-associated sleep disorders is currently not well understood. Since sleep disorders are associated with dysfunction of anatomical structures and the neurotransmitter systems in the brain that regulate the sleep-wakefulness cycle, decompression sickness-associated sleep disorders can be postulated to be related to dysfunction of these two regulators of sleep-wakefulness cycle. Sleep disorders found in patients with decompression sickness are more likely to occur in type 2 decompression sickness and may be found in the form of insomnia, hypersomnia, circadian rhythm disorders, obstructive sleep apnea, and narcolepsy. This review aims to discuss the pathophysiology of sleep disorders and decompression sickness as well as possible mechanisms underlying sleep disorders in decompression sickness through theoretical approaches and the results of available studies. In conclusion, decompression sickness-related sleep disorders are thought to involve two pathological conditions in the brain, namely structural lesions and dysfunction of the neurotransmitter system in the brain.
GANGGUAN NEUROPATI AKIBAT PENYELAMAN (NEUROPATHIC DISORDER AFTER UNDERWATER DIVING) Hunaifi, Ilsa; Harahap, Herpan Syafii; Landapa, Raditya Rachman; Ismiana, Baiq Holisatul; Ulfa Gea, Indah Ernanda; Wiracakra, I Gusti Lanang Krisna
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 2 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Indonesia memiliki ribuan pulau. Hal ini berdampak pada meningkatnya kegiatan penyelaman bawah laut. Penyelaman yang tidak sesuai prosedur dapat menimbulkan gangguan kesehatan berupa penyakit dekompresi yang salah satunya mengakibatkan neuropati. Emboli gas nitrogen menimbulkan respons inflamasi sistemik yang dapat memicu kerusakan pada saraf perifer. Faktor risiko gangguan dekompresi antara lain kurang pengalaman dalam menyelam, melakukan penyelaman berulang kali dalam waktu yang sama, tidak mematuhi prinsip-prinsip penyelaman dan sering kali melakukan yo-yo diving. Gangguan saraf perifer yang dapat terjadi berupa sindroma terowongan carpal, neuropati nervus peroneus, neuropati nervus ulnaris, mononeuritis multiplex. Pemeriksaan elektrodiagnostik menunjukkan adanya demielinisasi yang ditandai dengan peningkatan kecepatan hantar saraf. Pemberian terapi hiperbarik oksigen sesuai standar Angkatan Laut Amerika (United State Navy Treatment) menjadi standar dalam pengobatan penyakit dekompresi disertai dengan pemberian terapi simptomatik dapat memperbaiki gejala gangguan saraf tepi. Kata kunci: dekompresi, emboli gas nitrogen, neuropati, penyelaman, saraf perifer DOI : 10.35990/mk.v8n2.p198-208
PELATIHAN DETEKSI DINI NEUROPATI AKIBAT KEMOTERAPI Hunaifi, Ilsa; Primayanti, Ika; Sapta Wardhani, Indah; Briliansy, Briliansy; Anggoro, Joko; Setyawati, Indri; Fesmia, Herodya Lajunee; Ismiana, Baiq Holisatul; Wiracakra, I Gusti Lanang Krisna; Gea, Endah Irnanda Ulfa; Jacob, Lusye Diana; Putri, Siti Noururrifqiyati Juna; Wardi, Bq. Prita Riantiani; Suryani, ⁠Dini; Andiyani, Dinda Zahra Putri
Jurnal Abdi Insani Vol 12 No 9 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i9.2843

Abstract

Cancer is currently a disease that is experiencing significant growth. This has resulted in the number of chemotherapy administrations reaching 9.8 million to 15 million people and increasing by 53%. One of the side effects that can be caused is peripheral nerve disorders called Chemotherapy-Induced Peripheral Neuropathy (CIPN). In connection with the increasing number of cancer patients undergoing chemotherapy and the severe impact on peripheral nerves due to chemotherapy, early detection is very important to prevent severe complications. This training aims to improve the knowledge and skills of medical personnel in the early detection of chemotherapy-induced neuropathy in order to improve the quality of life of patients and reduce complications and disabilities due to neuropathy. This training was carried out in collaboration with the West Nusa Tenggara Province General Hospital and was attended by 62 nurses. The series of training activities included delivering materials and direct practice to patients. Evaluation of participant knowledge was through a pre-test using the Kahoot application and a post-test using the Plataran Sehat application with a pre-test completion time of 5 minutes. The average pre-test score was 59.35, while the average post-test score was 79.35. The simulation sessions are conducted directly with patients using a neuropathy screening questionnaire, accompanied by a physician. The presentation of the material and the simulation sessions are highly beneficial in neuropathy screening, allowing early detection of neuropathy symptoms and prompt treatment.
Unraveling Cerebral Stenosis: Current Insights Into Diagnosis and Neurointervention Management Kholida, Baiq Hilya; Wiracakra, I Gusti Lanang Krisna; Gea, Endah Irnanda Ulfah
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10074

Abstract

Intracranial atherosclerotic stenosis (ICAS) represents a major cause of ischemic stroke worldwide, particularly among Asian, African, and Hispanic populations. Atherosclerosis is the primary underlying pathology, and severe symptomatic stenosis (70–99%) is associated with up to a 25% risk of recurrent stroke within two years. Accurate diagnosis and optimal management are critical to improving outcomes and preventing recurrence. A comprehensive literature review was conducted using Google Scholar, PubMed, and ScienceDirect databases for studies published between 2012 and 2025. Relevant articles addressing the etiology, pathophysiology, diagnostic imaging, and therapeutic approaches to ICAS were analyzed and synthesized. ICAS is strongly associated with modifiable risk factors; hypertension, diabetes mellitus, dyslipidemia, and smoking as well as non-modifiable factors such as age, sex, and ethnicity. Diagnostic confirmation relies on neuroimaging modalities including CTA, MRA, and digital subtraction angiography (DSA), with DSA remaining the gold standard. Aggressive best medical therapy (BMT), consisting of dual antiplatelet therapy, statins, risk-factor control, and lifestyle modification, significantly reduces stroke recurrence. Endovascular revascularization and surgical procedures such as encephaloduroarteriosynangiosis (EDAS) may be considered for selected high-grade or refractory cases. ICAS remains a leading cause of recurrent ischemic stroke. Early detection through advanced imaging and comprehensive, individualized managementprimarily with medical therapy, supplemented by endovascular or surgical intervention when indicated offers the best outcomes for affected patients.
Co-Authors Afif, Zamroni Agistany, Nur Feby Febiana Andiyani, Dinda Zahra Putri Anggoro, Joko Annisa, Wardha Novia Briliansy, Briliansy Erwin, Ferdinand Fesmia, Herodya Lajunee Gea, Endah Irnanda Ulfa Gea, Endah Irnanda Ulfah Herpan Syafii Harahap Ilsa Hunaifi, Ilsa Indrayana, Yanna Ismiana, Baiq Holisatul Jacob, Lusye Diana kholida, Baiq Hilya Kurniawan, Theophany Margareta Landapa, Raditya Rachman Lestari, Diayanti Tenti Mayung, Claraiva Nurhidayati Nurhidayati Padauleng, Novrita Primayanti, Ika Putri, Setyawati Asih Putri, Siti Noururrifqiyati Juna Rizki, Mohammad Sapta Wardhani, Indah Setyawati, Indri Suryani, ⁠Dini Tjahyanto, Teddy Ulfa Gea, Indah Ernanda Wardi, Bq. Prita Riantiani Yohanes, Guntur