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Purlinda, Devi Etivia
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Public Health

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Kasus Reaksi Transfusi pada Pasien Penerima Donor Darah di RSUD Sayang Kabupaten Cianjur Periode 2020-2022 Purlinda, Devi Etivia; Nurhamida, Tsani Nisa
Jaringan Laboratorium Medis Vol 6, No 1 (2024): May 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i1.9899

Abstract

Blood transfusions must be performed based on appropriate indications, selecting the correct volume and type of component, and administered at the right time. The risk of transfusion reactions is inherent in nearly every transfusion process and can manifest clinical symptoms in patients. Hospitals must conduct oversight of the blood transfusion process, known as hemovigilance, to prevent transfusion reactions and enhance the safety of blood services. This study aims to determine the number of transfusion reaction cases in blood donor recipients at RSUD Sayang, Cianjur Regency, during the period from 2020 to 2022. This qualitative research utilizes a total sampling technique. The population comprises all blood donor recipients at RSUD Sayang, Cianjur Regency, from 2020 to 2022. The sample includes medical records data of transfusion reaction cases in blood donor recipients at RSUD Sayang, Cianjur Regency, from 2020 to 2022. The results indicate 35 cases of transfusion reactions. The majority of transfusion reaction cases in blood donor recipients were acute category I (mild) reactions, totaling 21 cases (60%). Patients with a history of previous transfusions predominantly experienced category I (mild) and category II (moderate) reactions, each with 12 cases (57.1%). Most acute reaction cases were category I (mild), with 20 cases (57.1%), occurring during transfusions with Packed Red Cells (PRC). The majority of acute transfusion reactions occurred after the administration of the first blood bag, with 17 cases (48.6%), and these reactions were primarily category I (mild).
Perbedaan Kadar TNF-α pada Penderita Tuberkulosis Paru Sebelum dan Sesudah Satu Bulan Terapi Obat Anti Tuberkulosis Kuncara, Rachmad Bayu; Purlinda, Devi Etivia; Setyaji, Yoki; Sulistyasmi, Wiwit
Jaringan Laboratorium Medis Vol 7, No 1 (2025): May 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v7i1.12789

Abstract

Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Patients diagnosed with pulmonary tuberculosis undergo Anti-Tuberculosis Drug (OAT) therapy for six months. In the first two months, known as the intensive phase, patients receive a combination of OATs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. TNF-α is a pro-inflammatory cytokine that plays a crucial role in granuloma formation to contain the spread of Mycobacterium tuberculosis. This study aims to determine the difference in TNF-α levels in pulmonary tuberculosis patients before and after one month of OAT therapy. The study used an observational analytic design with a prospective cohort approach without comparison. A total of 17 newly diagnosed pulmonary tuberculosis patients at Bangetayu, Kedungmundu, and Tlogosari Wetan Health Centers, Semarang City, were included. TNF-α levels in serum samples were measured using the ELISA method. The mean TNF-α level before OAT therapy was 110.09±100,48 pg/mL, while after one month of therapy, it decreased to 90,05±60,12 pg/mL. The statistical analysis using the Mann-Whitney test yielded a p-value of 0.228 (p 0.05), indicating that there was no statistically significant difference in TNF-α levels before and after one month of anti-tuberculosis drug (OAT) therapy. However, the mean TNF-α levels showed a decreasing trend, which, although not statistically significant, may suggest an initial immunological response to the treatment. The researcher recommends further studies with a larger sample size and longer observation period—such as until the end of the intensive phase or the completion of therapy—in order to obtain more representative and statistically significant results regarding TNF-α dynamics during tuberculosis treatment.
Biokimia Mycobacterium Tuberculosis yang Diberi Perlakuan Obat Anti TB Isoniazid Karlina, Elly; Widodo, Widodo; Purlinda, Devi Etivia
Jaringan Laboratorium Medis Vol. 1 No. 2 (2019): November 2019
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v1i2.5871

Abstract

Mycobacterium tuberculosis exposed to Isoniazid experienced drug resistance due to morphological and selection factors, with Isoniazid concentrations of 0.5 μg / ml with a contact time of 24 hours, 48 hours, 72 hours, 96 hours, the results obtained in testing for NaCl 5% Kruskal wallis obtained sig 0.005 results there is a treatment effect on growth While in the semi-quantitative catalase test, a sig value of 0.007 was obtained with p <0.01 so it can be concluded that there is a significant influence between the duration of isoniazid exposure. resistance occurs due to the selection of strains that are resistant to treatment during the therapy process at 96 hours exposure with a percentage of 2%. In the exposure process it can be concluded that it will change the resistance to 5% NaCl, changes in Catalase test results and also causes strain selection that is resistant to isoniazid 0.5 µg / ml.
Kadar Asam Urat Pasien Diabetes Melitus Tipe 2 Ramadhanti, Linda; Purlinda, Devi Etivia
Jaringan Laboratorium Medis Vol. 3 No. 2 (2021): November 2021
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v3i2.8026

Abstract

Patients with type 2 diabetes mellitus are about 90% of all cases of DM in the world. Type 2 diabetes is caused by the body's inability to respond properly to insulin or is called insulin resistance. Insulin resistance causes hyperglycemia and hyperinsulinemia which results in decreased function of uric acid excretion in the kidney tubules, and causes an increase in uric acid in the blood or hyperuricemia. This type of research is descriptive, with a cross sectional approach in May for 5 days from May 17 to May 21 2019. The research sample is type 2 DM outpatients, at Dr. Hospital. Adhyatma MPH consisted of 24 people who were taken based on total sampling who agreed to the informed consent, were over 20 years old, had no history of gout, and fasted for 10-12 hours. The purpose of this study was to determine the uric acid levels of type 2 DM outpatients based on gender, age, and blood pressure at Dr. Hospital. Adhyatma MPH. The results showed that normal uric acid levels in type 2 DM outpatients were 14 people (58.3%) and hyperuricemia 10 people (41.6%). 7 patients (29%) each had normal urate levels. The highest normal uric acid levels were in patients aged over 55 years as many as 9 people (37.5%) and 10 people with hypertension (41.7%). The most hyperuricemia occurred in 6 female patients (25%), 6 patients over 55 years old (25%) and 6 patients with hypertension (25%).
Perbandingan Berbagai Metode Pengecatan Spora pada Bacillus Cereus Widodo, Widodo; Purlinda, Devi Etivia; Riadi, Ahmad
Jaringan Laboratorium Medis Vol. 4 No. 2 (2022): November 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i2.8493

Abstract

Endospores are formed by members of several genera of gram-positive bacteria, such as Bacillus and Clostridium. The spores are very resistant structurally; withstand the temperature of boiling water for two hours or more. They contain very little water and show very few chemical reactions. The favorable external environment will cause the spores to break down and the vegetative cells to appear to grow and reproduce. Identification of endospore-forming pathogens is important in food and medical microbiology. However, the spores contain multiple protective layers, which cannot be easily penetrated by simple staining or Gram staining techniques. Therefore, it is necessary to apply heat to help penetrate the color, with various methods of Gram stain, fluorescent spore painting, Schaeffer and Fulton spore painting and Client's spore painting method. The results of the fluorescent painting method have better results but require much more expensive equipment using a fluorescent microscope considering the facilities that must be provided for the Schaeffer and Fulton painting method as an alternative if they do not have these facilities.
Korelasi Kadar Kolesterol Total dan Tekanan Darah pada Orang Dewasa di Bangetayu Kota Semarang Wikandari, Ririh Jatmi; Purlinda, Devi Etivia; Ichsan, Burhanudin
Jaringan Laboratorium Medis Vol. 5 No. 1 (2023): May 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i1.9379

Abstract

Non-communicable diseases (NCDs) are the largest contributor to death in the world. The prevalence of NCDs tends to increase. Hypertension is one of the non-communicable diseases with the largest proportion in Semarang. High cholesterol levels will accumulate in  the arteries, causing the arteries to stiffen, so the heart tries hard to pump blood through these blood vessels, and can cause blood pressure to rise (hypertension). Some risk factors that can increase blood pressure, such as high salt intake, overweight or obesity, alcohol consumption, lack of physical activity, stress and smoking. Lack of physical activity can increase cholesterol levels in the body which is a risk factor for cardiovascular disease (coroner's heart disease dan stroke). Age affects the occurrence of hypertension. With age the risk of developing hypertension is greater. The purpose of the study was to determine the relationship between cholesterol and blood pressure in adults in Bangetayu, Semarang City. This study uses a cross-sectional approach. Research samples are in the community of  Bangetayu Kota Semarang. Research Tools and Materials include lanceolate, alcohol swab, cholesterol strips, digital sphygmomanometers, POCT cholesterol and capillary blood.  Research data obtained from the results of checking cholesterol levels and blood pressure. The results of this study were processed using SPSS 20 software with data analysis using Chi Square (α=5%) and presented descriptively about the relationship of cholesterol levels with blood pressure in adults. The results of statistical analysis show a p-value > 0.05 which means that there is no significant relationship between variables and vice versa. The results showed that there was no relationship between blood pressure and cholesterol.
Kasus Reaksi Transfusi pada Pasien Penerima Donor Darah di RSUD Sayang Kabupaten Cianjur Periode 2020-2022 Purlinda, Devi Etivia; Nurhamida, Tsani Nisa
Jaringan Laboratorium Medis Vol. 6 No. 1 (2024): May 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i1.9899

Abstract

Blood transfusions must be performed based on appropriate indications, selecting the correct volume and type of component, and administered at the right time. The risk of transfusion reactions is inherent in nearly every transfusion process and can manifest clinical symptoms in patients. Hospitals must conduct oversight of the blood transfusion process, known as hemovigilance, to prevent transfusion reactions and enhance the safety of blood services. This study aims to determine the number of transfusion reaction cases in blood donor recipients at RSUD Sayang, Cianjur Regency, during the period from 2020 to 2022. This qualitative research utilizes a total sampling technique. The population comprises all blood donor recipients at RSUD Sayang, Cianjur Regency, from 2020 to 2022. The sample includes medical records data of transfusion reaction cases in blood donor recipients at RSUD Sayang, Cianjur Regency, from 2020 to 2022. The results indicate 35 cases of transfusion reactions. The majority of transfusion reaction cases in blood donor recipients were acute category I (mild) reactions, totaling 21 cases (60%). Patients with a history of previous transfusions predominantly experienced category I (mild) and category II (moderate) reactions, each with 12 cases (57.1%). Most acute reaction cases were category I (mild), with 20 cases (57.1%), occurring during transfusions with Packed Red Cells (PRC). The majority of acute transfusion reactions occurred after the administration of the first blood bag, with 17 cases (48.6%), and these reactions were primarily category I (mild).
Perbedaan Kadar TNF-α pada Penderita Tuberkulosis Paru Sebelum dan Sesudah Satu Bulan Terapi Obat Anti Tuberkulosis Kuncara, Rachmad Bayu; Purlinda, Devi Etivia; Setyaji, Yoki; Sulistyasmi, Wiwit
Jaringan Laboratorium Medis Vol. 7 No. 1 (2025): May 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v7i1.12789

Abstract

Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Patients diagnosed with pulmonary tuberculosis undergo Anti-Tuberculosis Drug (OAT) therapy for six months. In the first two months, known as the intensive phase, patients receive a combination of OATs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. TNF-α is a pro-inflammatory cytokine that plays a crucial role in granuloma formation to contain the spread of Mycobacterium tuberculosis. This study aims to determine the difference in TNF-α levels in pulmonary tuberculosis patients before and after one month of OAT therapy. The study used an observational analytic design with a prospective cohort approach without comparison. A total of 17 newly diagnosed pulmonary tuberculosis patients at Bangetayu, Kedungmundu, and Tlogosari Wetan Health Centers, Semarang City, were included. TNF-α levels in serum samples were measured using the ELISA method. The mean TNF-α level before OAT therapy was 110.09±100,48 pg/mL, while after one month of therapy, it decreased to 90,05±60,12 pg/mL. The statistical analysis using the Mann-Whitney test yielded a p-value of 0.228 (p > 0.05), indicating that there was no statistically significant difference in TNF-α levels before and after one month of anti-tuberculosis drug (OAT) therapy. However, the mean TNF-α levels showed a decreasing trend, which, although not statistically significant, may suggest an initial immunological response to the treatment. The researcher recommends further studies with a larger sample size and longer observation period—such as until the end of the intensive phase or the completion of therapy—in order to obtain more representative and statistically significant results regarding TNF-α dynamics during tuberculosis treatment.
Co-Authors Ahmad Riadi Elly Karlina Ichsan, Burhanudin Kahar, Fitriani Kuncara, Rachmad Bayu Nurhamida, Tsani Nisa Putri, Nanik Aryani Ramadhanti, Linda Ririh Jatmi Wikandari Setyaji, Yoki Widodo Widodo Wiwit Sulistyasmi