Article Per Year (5 Year)
p-Index From 2021 - 2026
1.671
P-Index
This Author published in this journals
All Journal Jurnal Biosains Pascasarjana Jurnal Analis Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Poltekita : Jurnal Ilmu Kesehatan Jaringan Laboratorium Medis Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Academic Hospital Journal E-Amal: Jurnal Pengabdian Kepada Masyarakat
Kuncara, Rachmad Bayu
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Hubungan Kadar Vitamin D3 Dengan Derajat Kepositifan BTA Pada Penderita Tuberkulosis Paru Kuncara, Rachmad Bayu; Istiqomah, Anisa; Hartono, Rodhi; Priyatno, Djoko
Jurnal Analis Kesehatan Vol. 12 No. 2 (2023): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v12i2.3925

Abstract

Tuberkulosis paru adalah penyakit menular yang disebabkan bakteri Mycobacterium tuberculosis (MTB). Pemeriksaan mikroskopis Bakteri Tahan Asam (BTA) merupakan pemeriksaan yang penting untuk membantu diagnosis tuberculosis paru. Penderita tuberculosis paru dapat mengalami peningkatan jumlah BTA apabila mengalami defisiensi vitamin D. Vitamin D dapat menghambat multiplikasi MTB dalam makrofag dengan induksi peptida anti mikroba. Penelitian ini bertujuan untuk mengetahui hubungan kadar vitamin D3 dengan derajat kepositifan bakteri tahan asam pada penderita tuberkulosis paru. Jenis penelitian ini adalah observasional analitik dengan desain cross sectional. Sampel penelitian sebanyak 30 responden diambil dari Puskesmas Bangetayu, Puskesmas Tlogosari Wetan, dan Puskesmas Kedungmundu di Kota Semarang. Sampel tersebut diperiksa BTA secara mikroskopis dan pemeriksaan vitamin D3 dilakukan dengan metode Enzym Linked Immunosorbent Assay (ELISA). Hasil pemeriksaan BTA menunjukan sebanyak 12 (40,0%) penderita dengan hasil scanty, sebanyak 7 (23,3%) penderita positif 1, sebanyak 7 (23,3%) penderita positif 2 dan 4 (13,4%) penderita positif 3. Hasil pemeriksaan vitamin D menunjukan sebanyak 23 (76,7%) penderita dengan status defisiensi, 5 (76,7%) penderita dengan status insufisiensi dan 2 (6,7%) penderita dengan status sufisiensi. Data tersebut dianalisa secara statiskik menggunakan uji Spearman dengan hasil p-Value = 0,023 (p< 0,05) sehingga dapat disimpulkan terdapat hubungan kadar vitamin D3 dengan derajat kepositifan BTA pada penderita tuberculosis paru.
Edukasi Masyarakat sebagai Pengawas Menelan Obat (PMO) untuk Meningkatkan Kepatuhan Pengobatan Tuberkulosis Putri, Adita Puspitasari Swastya; Duri, Iin Desmiany; Kuncara, Rachmad Bayu; Auliya, Qurrotu A’yuni
Abdimas Galuh Vol 6, No 2 (2024): September 2024
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v6i2.14905

Abstract

Tuberkulosis merupakan penyakit menular penyebab kematian terbanyak, termasuk di Indonesia. Jawa Tengah menempati posisi tertinggi kedua dengan jumlah kasus terbanyak. Penyakit tuberkulosis dapat disembuhkan dengan melakukan pengobatan secara rutin dan teratur. Keberhasilan pengobatan tuberkulosis didukung oleh adanya peran Pengawas Menelan Obat (PMO) yang memantau dan mengingatkan penderita tuberkulosis untuk meminum obat secara rutin dan teratur hingga tuntas. Tujuan kegiatan ini adalah meningkatkan pengetahuan masyarakat melalui edukasi masyarakat sebagai PMO untuk meningkatkan kepatuhan pengobatan tuberkulosis di Kelurahan Penggaron Kidul Kecamatan Pedurungan Kota Semarang. Kegiatan yang dilakukan adalah edukasi kesehatan berupa penyuluhan dengan metode ceramah, tanya jawab, dan diskusi. Peserta diberikan leaflet tentang PMO sebagai media promosi kesehatan. Kegiatan di awali dengan pengerjaan soal pretest dan di akhiri dengan posttest untuk mengukur tingkat pemahaman peserta. Berdasarkan hasil kegiatan diketahui bahwa ada perbedaan antara tingkat pengetahuan peserta sebelum dan sesudah dilakukan edukasi. Terjadi peningkatan pemahaman warga masyarakat RT.06 RW.03 di Kelurahan Penggaron Kidul Kecamatan Pedurungan Kota Semarang yang cukup signifikan terhadap rata-rata nilai peserta. Peserta dapat menyebarkan seluruh informasi tentang PMO kepada keluarga dan masyarakat lain disekitarnya dengan menggunakan leaflet sebagai media promosi kesehatan.
PELATIHAN TEKNIK PENGAMBILAN, PENGEPAKAN DAN PENGIRIMAN SPESIMEN DAHAK (SPUTUM) UNTUK DIAGNOSIS TUBERKULOSIS BAGI KADER KESEHATAN DI KELURAHAN SENDANG MULYO Kuncara, Rachmad Bayu; Hadipranoto, Ichsan; Afriansya, Roni; Sulistyasmi, Wiwit
E-Amal: Jurnal Pengabdian Kepada Masyarakat Vol 4 No 2: Mei-Agustus 2024
Publisher : LP2M STP Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47492/eamal.v4i2.3213

Abstract

Tuberkulosis merupakan penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis complex (MTBC). Strategi DOTS adalah pengawasan langsung pengobatan jangka pendek dengan keharusan setiap pengelola program tuberkulosis untuk memfokuskan perhatian (direct attention) dalam usaha menemukan penderita dengan pemeriksaan mikroskop. Tujuan dari kegiatan ini adalah peningkatan pengetahuan kader tentang teknik pengambilan, pengepakan dan pengiriman spesimen dahak (sputum) untuk diagnosis tuberkulosis bagi kader kesehatan di Kelurahan Sendang Mulyo. Metode: melakukan intervensi dengan meningkatkan pengetahuan kader kesehatan dengan memberikan penyuluhan teknik pengambilan, pengepakan dan pengiriman spesimen dahak. Hasil: terjadi peningkatan pengetahuan kader sebesar 70% dalam mengetahui tentang teknik pengambilan, pengepakan dan pengiriman spesimen dahak.
Derajat Aglutinasi pada Pemeriksaan Golongan Darah Metode Tabung Berdasarkan Masa Simpan Test Sel A dan Test Sel B Hari Ke-0, Ke-2, Ke-4, Ke-6 dan Ke-8 Zatalini, Karinta Syifa; Kuncara, Rachmad Bayu; Sugihantono, Anung
Jaringan Laboratorium Medis Vol 6, No 2 (2024): November 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i2.11733

Abstract

Blood group examination is an examination that aims to determine the type of blood group. Cell test is a blood group examination reagent used to detect antibodies in the serum being examined. The long shelf life of cell tests that can only last for two days is considered less effective for agencies with a high level of blood services. The purpose of this study was to describe the degree of agglutination in blood group examination with cell test A and B stored on the 0th, 2nd, 4th, 6th, and 8th days. This study is a descriptive study with a Quasi Experimental research design. Test cell A and test cell B were made from red blood cell specimens of 3 blood type A and 3 blood type B respectively. Test cells are stored in a refrigerator with a temperature of 2-6° C. Test cells were then examined on the 0th, 2nd, 4th, and 6th day of storage. Calculation of samples and repetitions using the Federer formula with the number of treatments in this study is 5 treatments. Based on the calculation, one sample of test cell A and test cell B was obtained with five repetitions of each examination. The results showed that on the 0th, 2nd, 4th, and 6th day of cell test storage, the results of blood type examination were obtained, namely the degree of agglutination 4+ with erythrocytes in the cell test clumping into one bond, cells forming large agglutination with clear supernatant. On the 8th day of storage, the result of agglutination degree is 3+ with erythrocytes in test cells not clumping perfectly, there are erythrocyte granules and cloudy supernatant. Based on the results of the study, it is concluded that test cell A and test cell B can be used optimally until day 6 storage.
Perbedaan Kadar Vitamin D3 pada Penderita Tuberkulosis Paru Sebelum dan Sesudah Satu Bulan Terapi Obat Anti Tuberkulosis Kuncara, Rachmad Bayu; Najiah, Dewina Zumrotin
Jaringan Laboratorium Medis Vol 6, No 1 (2024): May 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i1.11379

Abstract

Pulmonary tuberculosis is an infectious disease caused by infection with the bacteria Mycobacterium tuberculosis. Patients diagnosed with pulmonary tuberculosis will receive Anti-Tuberculosis Drug (OAT) therapy for six months. In the first two months or what is called the intensive phase, the patient will be given a combination of OAT in the form of rifampicin, isoniazid, ethambutol and pyrazinamide. Several types of anti-tuberculosis drugs have the potential to affect vitamin D3 metabolism, either by interfering with absorption, metabolism or changing the action of vitamin D3. The long-term treatment process for pulmonary tuberculosis also results in a decrease in vitamin D3 levels in the blood. This study aims to determine the difference in vitamin D3 levels in pulmonary tuberculosis sufferers before and after one month of anti-tuberculosis drug therapy. This type of research is descriptive observational with a prospective cohort design without comparison. The total sample was 16 newly diagnosed pulmonary tuberculosis sufferers at the Bangetayu, Kedungmundu and Tlogosari Wetan Health Centers, Semarang City. Vitamin D3 levels in serum samples were examined using the ELISA method. The mean vitamin D3 level before OAT therapy was 19.00 ± 10.45 ng/mL, the level decreased after OAT therapy, namely 18.51 ± 4.74 ng/mL. These results indicate that administration of anti-tuberculosis drugs may have an effect on vitamin levels.
Perbedaan Kadar TNF-α pada Penderita Tuberkulosis Paru Sebelum dan Sesudah Satu Bulan Terapi Obat Anti Tuberkulosis Kuncara, Rachmad Bayu; Purlinda, Devi Etivia; Setyaji, Yoki; Sulistyasmi, Wiwit
Jaringan Laboratorium Medis Vol 7, No 1 (2025): May 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v7i1.12789

Abstract

Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Patients diagnosed with pulmonary tuberculosis undergo Anti-Tuberculosis Drug (OAT) therapy for six months. In the first two months, known as the intensive phase, patients receive a combination of OATs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. TNF-α is a pro-inflammatory cytokine that plays a crucial role in granuloma formation to contain the spread of Mycobacterium tuberculosis. This study aims to determine the difference in TNF-α levels in pulmonary tuberculosis patients before and after one month of OAT therapy. The study used an observational analytic design with a prospective cohort approach without comparison. A total of 17 newly diagnosed pulmonary tuberculosis patients at Bangetayu, Kedungmundu, and Tlogosari Wetan Health Centers, Semarang City, were included. TNF-α levels in serum samples were measured using the ELISA method. The mean TNF-α level before OAT therapy was 110.09±100,48 pg/mL, while after one month of therapy, it decreased to 90,05±60,12 pg/mL. The statistical analysis using the Mann-Whitney test yielded a p-value of 0.228 (p 0.05), indicating that there was no statistically significant difference in TNF-α levels before and after one month of anti-tuberculosis drug (OAT) therapy. However, the mean TNF-α levels showed a decreasing trend, which, although not statistically significant, may suggest an initial immunological response to the treatment. The researcher recommends further studies with a larger sample size and longer observation period—such as until the end of the intensive phase or the completion of therapy—in order to obtain more representative and statistically significant results regarding TNF-α dynamics during tuberculosis treatment.
The Role of TNF-α (Tumor Necrosis Factor-alpha) in Pulmonary Tuberculosis Sulistyasmi, Wiwit; Fuzianingsih, Eka Noviya; Kuncara, Rachmad Bayu
Academic Hospital Journal Vol 7, No 2 (2025)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v7i2.106190

Abstract

Background: Tuberculosis (TB) remains a primary global health concern, with Indonesia accounting for approximately 10% of international cases. Tumor necrosis factor-alpha (TNF-α) plays a crucial role in the immune response against Mycobacterium tuberculosis, particularly in pulmonary tuberculosis (TB).Method: This article is a narrative literature review that examines the role of tumor necrosis factor-alpha (TNF-α) in pulmonary tuberculosis.Result:  This pro-inflammatory cytokine is essential for activating macrophages, promoting phagolysosome fusion, and supporting the formation and maintenance of granulomas—immune structures critical for containing infection. However, dysregulated TNF-α expression can be detrimental: excessive levels contribute to inflammation and lung tissue damage, while insufficient production—such as that induced by TNF-α inhibitor therapy—can lead to reactivation of latent TB. This narrative review examines the biosynthesis, immunological functions, and regulatory mechanisms of TNF-α in the context of pulmonary tuberculosis, highlighting its dual role in protective immunity and immunopathology.Conclusion: A deeper understanding of TNF-α modulation may inform the development of targeted, host-directed therapies that improve treatment outcomes while minimizing tissue damage.
Education and Training Empowerment for Posbindu Cadres to Prevent Non-Communicable Diseases in Sendangmulyo Village, Semarang City Qomariah, Nurul; Widiyanto, SY. Didik; Wikandari, Ririh Jatmi; Kuncara, Rachmad Bayu
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 2 No. 2 (2024): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v2i2.166

Abstract

The purpose of this PPDM is to strengthen the cadre of Posbindu PTM officers in 3 RW of Sendangmulyo village in order to provide optimal health services and how to increase awareness of their own health and family, so as to reduce the number of NCD patients. The targets of PPDM are cadres of Posbindu PTM Officers in RW 15, 20 and 24 Sendangmulyo urban villages, Tembalang sub-district, Semarang City. The method used is education, training 15 cadres of Posbindu PTM officers, to be implemented during Posbindu PTM in their RW routinely in the form of health counseling) and providing services for checking blood pressure, weight, height, abdominal circumference, cholesterol, uric acid and blood sugar, as well as consulting services about complaints felt by residents, then conducted monitoring and evaluation by pengabdi related to improving the quality of health services carried out by cadres of Posbindu PTM officers after being trained. The results obtained are that residents feel more able to know their health conditions so that they can improve their health conditions on the basis of direction, advice from officers at table 5 and the quality of service is getting faster, dexterous, and looks skilled in the use of tools.  
Pemberdayaan Masyarakat tentang Tuberkulosis serta Pelatihan Etika Batuk di Kelurahan Sendang Mulyo: Community Empowerment about Tuberculosis and Cough Ethics Training in Sendang Mulyo Afriansya, Roni; Budiharjo, Teguh; Afrianti, Dina; Widodo, Widodo; Kuncara, Rachmad Bayu
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 8 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i8.7021

Abstract

Tuberculosis control requires synergy between the government and the community. The success of TB control in an area is inseparable from the role of the community, which can be pursued by empowering the community. Community empowerment in TB control is to foster awareness, ability and willingness in breaking the chain of TB transmission. This activity aims to increase the knowledge and ability of the community in breaking the chain of TB transmission. The method of activity is carried out by providing counseling and training directly to the community. The results of the activity showed an increase in knowledge and ability of the community in understanding about TB. Direct counseling on TB and direct training on how to cough properly have a good and effective impact in increasing the knowledge and abilities of the community. It is recommended that empowerment activities by providing direct material about TB and direct training on how to cough properly be carried out more intensively and also involve health cadres.
DIFFERENCES IN INTERFERON GAMMA LEVELS IN TREATMENT OF TUBERCULOSIS IN INTENSIVE PHASE AND ADVANCED PHASE Kuncara, Rachmad Bayu; SY. Didik Widiyanto; Ririh Jatmi Wikandari; Wiwit Sulistyasmi
Jurnal Biosains Pascasarjana Vol. 26 No. 1 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i1.2024.72-76

Abstract

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis complex (MTBC). Anti-tuberculosis drugs given to active TB sufferers consist of 3 or 4 combinations. Tuberculosis treatment is divided into intensive phase treatment (2 weeks) and continuation phase (16 weeks / 4 months). Interferon gamma (IFN γ) is a protein belonging to the cytokine family which plays a role in eliminating MTB bacteria through a cell-mediated immunity mechanism. The aim of this study was to analyze differences in gamma interferon levels in the intensive phase and advanced phase of tuberculosis treatment. This research method is an analytical observational study with a cross-sectional design (cross sectional study). The research design used was a randomized post test only control group design. Data were analyzed using the Kruskal Wallis test with statistical test results obtained with a p value of 0.033 (> 0.05), meaning there was a difference in IFN γ levels in the intensive phase and advanced phase of tuberculosis treatment.
Co-Authors Anung Sugihantono Auliya, Qurrotu A’yuni Dina Afrianti1 Djoko Priyatno, Djoko Duri, Iin Desmiany Fuzianingsih, Eka Noviya Hadipranoto, Ichsan Istiqomah, Anisa Lilik Setyowatiningsih Najiah, Dewina Zumrotin Nurul Qomariah Purlinda, Devi Etivia Putri, Adita Puspitasari Swastya Ririh Jatmi Wikandari Rodhi Hartono Roni Afriansya Setyaji, Yoki SY. Didik Widiyanto Teguh Budiharjo, Teguh Widiyanto, SY. Didik Widodo Widodo Wiwit Sulistyasmi Zatalini, Karinta Syifa