Article Per Year (5 Year)
p-Index From 2020 - 2025
1.513
P-Index
This Author published in this journals
All Journal Jaringan Laboratorium Medis Academic Hospital Journal
Setyaji, Yoki
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 9 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 9 Documents
Search

 1 
Gambaran Stabilitas Pooled plasma CPDA Sebagai Bahan Kontrol Kualitas Pemeriksaan Asam Urat Pada Uji Presisi Within run dan Between day Setyaji, Yoki; Duri, Iin Desmiany; Setyowatiningsih, Lilik
Jaringan Laboratorium Medis Vol 6, No 2 (2024): November 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i2.10933

Abstract

The quality of laboratory test results is ensured by implementing quality control measures, which usually require control materials. The high cost of commercial control materials poses a challenge for laboratory quality control. Commonly, laboratory control materials are commercial control serums derived from animal serum that undergoes lyophilization during manufacturing. This study aims to assess the stability of CPDA pooled plasma that has been frozen for 60 days, using precision tests both within-run and between-day. Methods: This experimental research utilized CPDA pooled plasma samples from hematology laboratory waste at Poltekkes Kemenkes Semarang. The samples were frozen at -20℃ for 60 days. Quality control (QC) analysis was conducted using within-run and between-day precision tests without replication, to determine the standard deviation (SD) and coefficient of variation (CV). The results were then statistically analyzed using a one-way ANOVA to assess the difference in CPDA pooled plasma stability between the within-run and between-day precision tests. The QC results for within-day and between-day precision were as follows: the average for within-day was 4.066 and for between-day 3.2785; SD for within-day was 0.20 and for between-day 0.09; CV for within-day was 4.9% and for between-day 2.9%. The one-way ANOVA test showed a significance value of 0.316, indicating no significant difference between the within-day and between-day QC methods in terms of precision testing. Conclusion: CPDA pooled plasma remains stable in maintaining the precision of QC results for uric acid using the enzymatic colorimetric method (end-point) after 60-80 days of storage and can be used as an alternative to commercial control materials in uric acid QC testing.
Profil SGOT, SGPT, dan Kreatinin Pada Pasien MDR TB di RS KRMT Wongsonegoro Semarang Surati, Surati; Khairunnisa, Afifah; Setyaji, Yoki; Maulana, Mochamad Rizal
Jaringan Laboratorium Medis Vol 6, No 1 (2024): May 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i1.10951

Abstract

Tuberculosis (TB) is an infectious disease caused by infection with the bacterium Mycobacterium tuberculosis. Tuberculosis apabila is not treated immediately or the treatment is not complete can result in complications leading to death. Multidrugs resistant tuberculosis (MDR-TB) is one of the complications where the germ Mycobacterium tuberculosis can no longer bekilled with several Anti-Tuberculosis Drugs (OAT). The prevalence of MDR-TB cases in Semarang City has increased from 35 cases in 2017 to 79 cases in 2018. MDR-TB therapy takes a longer time, which is about 18-24 months. Prolonged exposure to drugs can affect body functions, especially the kidneys and liver organs which play a role in the process of removing toxins and metabolic waste. This study aims to determine the health profile of the kidney and liver organs of MDR TB sufferers through the SGOT SGPT and Creatinine parameters and describe them based on age and age range. This research is adescriptive quantitative research with a cross-sectional approach. Sampling using total samples of 18 patients. The results showed that 33% (n= 6) of patients had increased levels of SGOT and SGPT, while examination of creatinine levels showed that 33% of patients had kidney problems. Men have upnormal SGOT and SGPT levels of 40% ( n=4) compared to women, which is 25% (n=2), while upnormal creatinine levels in men are 40% (n=4) while in women it is 50% (n = 8). Patients over the age of 46 years have the most levels of SGOT SGPT and upnormal creatinine, which is 61% (n=4). The results showed that age and gender had an effect on increasing SGOT SGPT and Creatinine levels in MDR-TB patients.
Perbedaan Kadar TNF-α pada Penderita Tuberkulosis Paru Sebelum dan Sesudah Satu Bulan Terapi Obat Anti Tuberkulosis Kuncara, Rachmad Bayu; Purlinda, Devi Etivia; Setyaji, Yoki; Sulistyasmi, Wiwit
Jaringan Laboratorium Medis Vol 7, No 1 (2025): May 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v7i1.12789

Abstract

Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Patients diagnosed with pulmonary tuberculosis undergo Anti-Tuberculosis Drug (OAT) therapy for six months. In the first two months, known as the intensive phase, patients receive a combination of OATs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. TNF-α is a pro-inflammatory cytokine that plays a crucial role in granuloma formation to contain the spread of Mycobacterium tuberculosis. This study aims to determine the difference in TNF-α levels in pulmonary tuberculosis patients before and after one month of OAT therapy. The study used an observational analytic design with a prospective cohort approach without comparison. A total of 17 newly diagnosed pulmonary tuberculosis patients at Bangetayu, Kedungmundu, and Tlogosari Wetan Health Centers, Semarang City, were included. TNF-α levels in serum samples were measured using the ELISA method. The mean TNF-α level before OAT therapy was 110.09±100,48 pg/mL, while after one month of therapy, it decreased to 90,05±60,12 pg/mL. The statistical analysis using the Mann-Whitney test yielded a p-value of 0.228 (p 0.05), indicating that there was no statistically significant difference in TNF-α levels before and after one month of anti-tuberculosis drug (OAT) therapy. However, the mean TNF-α levels showed a decreasing trend, which, although not statistically significant, may suggest an initial immunological response to the treatment. The researcher recommends further studies with a larger sample size and longer observation period—such as until the end of the intensive phase or the completion of therapy—in order to obtain more representative and statistically significant results regarding TNF-α dynamics during tuberculosis treatment.
Description Of Giving Blood Supplement Tablets To Donor Haemoglobin Levels in PMI Banyumas Regency Febriana, Gita Dwi; Setyaji, Yoki
Academic Hospital Journal Vol 7, No 2 (2025)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v7i2.106000

Abstract

Background: Based on data from the Banyumas Regency PMI for August 2023, it is stated that there are 182 requests for blood products every day, but can only fulfil the demand for blood products at 152 blood bags/day, which means that in one day, the Banyumas Regency PMI still lacks 30 blood bags of blood. Everyday. Therefore, this is the background for UDD PMI Kab. Banyumas to provide additional blood supplements of Fe 60 mg and Folic Acid 0.4 mg to donors who failed due to low haemoglobin levels, namely < 12.5 gr/dL. Giving blood supplement tablets is considered to be able to increase haemoglobin levels more quickly than other vitamin supplements because they contain Fe or iron. The purpose of this study was to determine the increase in haemoglobin levels before and after giving blood supplements to blood donors in UDD PMI Banyumas.Method: This quantitative research uses an analytical observational method (Cross-Sectional Study), with a Purposive sampling technique using the Slovin Formula, resulting in 24 samples. Of the 24 prospective blood donors who failed the HB screening selection, they were given treatment with blood supplements of 5 tablets, which were consumed once a day.Result:  The average result of checking the haemoglobin level before administering the blood supplement was 11.48 gr/dL. After taking the blood supplement, the donor checked the haemoglobin level again, and the average haemoglobin level was 12.57 gr/dL. Based on the results of pre- and post-blood supplement examinations, the results showed an average increase in haemoglobin levels of 1.09 gr/dL.Conclusion: Prospective blood donors who consumed blood supplement tablets, namely Fe 12.45 mg and Folic Acid 0.5 mg, 1 tablet per day for 5 days, experienced an average increase in haemoglobin levels of 1.09 gr/dL.
Hemoglobin Levels in PRC Blood Products Before and After Shelf Life Period Ranika Puteri, Orchelanesya Avrilia; Setyaji, Yoki; Setyowatiningsih, Lilik
Academic Hospital Journal Vol 7, No 2 (2025)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v7i2.106350

Abstract

Background: PRC is a component found in living creatures, which plays an important role in transporting oxygen and metabolic products to body tissues. PRC transfusion is indicated at Hb levels < 7.0 g/dl, especially in patients with acute anemia. In the transfusion process, before there is a request for blood to be transfused, the blood will be stored in a blood bank. A good blood storage process is needed to maintain the quality of blood products so that they are safe for transfusion. During the storage process, hemoglobin levels in the blood can change. The longer blood is stored, the more red blood cells become fragile and lyse, thereby increasing the concentration of hemoglobin in the blood. This study aims to determine and describe the description of hemoglobin levels in pre- and post-PRC blood products during the shelf life at UDD PMI Rembang Regency.Method: This type of research uses analytical descriptive research and a research design with purposive sampling techniques. The samples used in this study were 30 bags of PRC blood, which met the inclusion and exclusion criteria.Result:  The results of this study showed an increase in hemoglobin levels, with the average pre-storage hemoglobin level being 14.99 g/dl, while the average post-storage hemoglobin level was 17.5 g/dl.Conclusion: In this study, there was an average increase in hemoglobin levels of 2.51 g/dl or 16.74%. This could be caused by temperature, storage time, and anticoagulants.
Validasi Jarak pada Pneumatic Tube System terhadap Hasil Pemeriksaan Trombosit (PLT) dan Kalium Setyaji, Yoki; Novitasari, Tri; Muktianafi, Inggil Tunjung; Anggreini, Shintia Dini; Palupi, Norma Agustin
Jaringan Laboratorium Medis Vol. 4 No. 1 (2022): May 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i1.8488

Abstract

Pneumatic tube system (PTS) is a sample transport medium that is widely used in hospitals. Samples sent using PTS may be shaken due to the varying speed and air pressure in the PTS. The use of PTS can affect the examination of platelet counts and potassium levels. The installation of PTS at the Gadjah Mada University Academic Hospital was carried out in May 2020 in the Yudistira, Arjuna, Kresna and Nakula buildings. Delivery of laboratory samples at RSA UGM every day can be done from buildings with different distances. Every hospital that uses PTS is advised to validate PTS and investigate blood specimens for the possibility of hemolysis and laboratory results. The purpose of this study was to validate the PTS distance as a transport medium for laboratory examinations. This research is an experimental research which is a follow-up study using 30 samples. Samples were taken twice and sent with the PTS from two different distances, namely YD 2 and IGD. The statistical test will use a paired sample t-test. The data will be analyzed with the help of Prima Graph 8 Statistical Software with a significance level of 5%. The results of the analysis showed that there was no difference in the results of the examination of platelets and potassium sent from YD 2 or from the ER.
Gambaran Stabilitas Pooled plasma CPDA Sebagai Bahan Kontrol Kualitas Pemeriksaan Asam Urat Pada Uji Presisi Within run dan Between day Setyaji, Yoki; Duri, Iin Desmiany; Setyowatiningsih, Lilik
Jaringan Laboratorium Medis Vol. 6 No. 2 (2024): November 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i2.10933

Abstract

The quality of laboratory test results is ensured by implementing quality control measures, which usually require control materials. The high cost of commercial control materials poses a challenge for laboratory quality control. Commonly, laboratory control materials are commercial control serums derived from animal serum that undergoes lyophilization during manufacturing. This study aims to assess the stability of CPDA pooled plasma that has been frozen for 60 days, using precision tests both within-run and between-day. Methods: This experimental research utilized CPDA pooled plasma samples from hematology laboratory waste at Poltekkes Kemenkes Semarang. The samples were frozen at -20℃ for 60 days. Quality control (QC) analysis was conducted using within-run and between-day precision tests without replication, to determine the standard deviation (SD) and coefficient of variation (CV). The results were then statistically analyzed using a one-way ANOVA to assess the difference in CPDA pooled plasma stability between the within-run and between-day precision tests. The QC results for within-day and between-day precision were as follows: the average for within-day was 4.066 and for between-day 3.2785; SD for within-day was 0.20 and for between-day 0.09; CV for within-day was 4.9% and for between-day 2.9%. The one-way ANOVA test showed a significance value of 0.316, indicating no significant difference between the within-day and between-day QC methods in terms of precision testing. Conclusion: CPDA pooled plasma remains stable in maintaining the precision of QC results for uric acid using the enzymatic colorimetric method (end-point) after 60-80 days of storage and can be used as an alternative to commercial control materials in uric acid QC testing.
Profil SGOT, SGPT, dan Kreatinin Pada Pasien MDR TB di RS KRMT Wongsonegoro Semarang Surati, Surati; Khairunnisa, Afifah; Setyaji, Yoki; Maulana, Mochamad Rizal
Jaringan Laboratorium Medis Vol. 6 No. 1 (2024): May 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i1.10951

Abstract

Tuberculosis (TB) is an infectious disease caused by infection with the bacterium Mycobacterium tuberculosis. Tuberculosis apabila is not treated immediately or the treatment is not complete can result in complications leading to death. Multidrugs resistant tuberculosis (MDR-TB) is one of the complications where the germ Mycobacterium tuberculosis can no longer bekilled with several Anti-Tuberculosis Drugs (OAT). The prevalence of MDR-TB cases in Semarang City has increased from 35 cases in 2017 to 79 cases in 2018. MDR-TB therapy takes a longer time, which is about 18-24 months. Prolonged exposure to drugs can affect body functions, especially the kidneys and liver organs which play a role in the process of removing toxins and metabolic waste. This study aims to determine the health profile of the kidney and liver organs of MDR TB sufferers through the SGOT SGPT and Creatinine parameters and describe them based on age and age range. This research is adescriptive quantitative research with a cross-sectional approach. Sampling using total samples of 18 patients. The results showed that 33% (n= 6) of patients had increased levels of SGOT and SGPT, while examination of creatinine levels showed that 33% of patients had kidney problems. Men have upnormal SGOT and SGPT levels of 40% ( n=4) compared to women, which is 25% (n=2), while upnormal creatinine levels in men are 40% (n=4) while in women it is 50% (n = 8). Patients over the age of 46 years have the most levels of SGOT SGPT and upnormal creatinine, which is 61% (n=4). The results showed that age and gender had an effect on increasing SGOT SGPT and Creatinine levels in MDR-TB patients.
Perbedaan Kadar TNF-α pada Penderita Tuberkulosis Paru Sebelum dan Sesudah Satu Bulan Terapi Obat Anti Tuberkulosis Kuncara, Rachmad Bayu; Purlinda, Devi Etivia; Setyaji, Yoki; Sulistyasmi, Wiwit
Jaringan Laboratorium Medis Vol. 7 No. 1 (2025): May 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v7i1.12789

Abstract

Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Patients diagnosed with pulmonary tuberculosis undergo Anti-Tuberculosis Drug (OAT) therapy for six months. In the first two months, known as the intensive phase, patients receive a combination of OATs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. TNF-α is a pro-inflammatory cytokine that plays a crucial role in granuloma formation to contain the spread of Mycobacterium tuberculosis. This study aims to determine the difference in TNF-α levels in pulmonary tuberculosis patients before and after one month of OAT therapy. The study used an observational analytic design with a prospective cohort approach without comparison. A total of 17 newly diagnosed pulmonary tuberculosis patients at Bangetayu, Kedungmundu, and Tlogosari Wetan Health Centers, Semarang City, were included. TNF-α levels in serum samples were measured using the ELISA method. The mean TNF-α level before OAT therapy was 110.09±100,48 pg/mL, while after one month of therapy, it decreased to 90,05±60,12 pg/mL. The statistical analysis using the Mann-Whitney test yielded a p-value of 0.228 (p > 0.05), indicating that there was no statistically significant difference in TNF-α levels before and after one month of anti-tuberculosis drug (OAT) therapy. However, the mean TNF-α levels showed a decreasing trend, which, although not statistically significant, may suggest an initial immunological response to the treatment. The researcher recommends further studies with a larger sample size and longer observation period—such as until the end of the intensive phase or the completion of therapy—in order to obtain more representative and statistically significant results regarding TNF-α dynamics during tuberculosis treatment.
Co-Authors Anggreini, Shintia Dini Duri, Iin Desmiany Febriana, Gita Dwi Khairunnisa, Afifah Kuncara, Rachmad Bayu Maulana, Mochamad Rizal Muktianafi, Inggil Tunjung Novitasari, Tri Palupi, Norma Agustin Purlinda, Devi Etivia Ranika Puteri, Orchelanesya Avrilia Setyowatiningsih, Lilik Surati Surati Wiwit Sulistyasmi