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All Journal JURNAL BIOMEDIK Jurnal Keperawatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kesehatan Tambusai Jurnal Impresi Indonesia Heca Journal of Applied Sciences Malacca Pharmaceutics Grimsa Journal of Science Engineering and Technology
Manampiring, Aaltje Ellen
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Journal : Grimsa Journal of Science Engineering and Technology

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In Vitro Analysis of Anti-Inflammatory Effects of Purple Chrysanthemum (Chrysanthemum morifolium) Leaf Extract Nastiti, Gemi; Fatimawali, Fatimawali; Budiarso, Fona Dwiana Hermina; Manampiring, Aaltje Ellen; Kepel, Billy Johnson; Bodhi, Widdhi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.70

Abstract

Chronic inflammatory diseases are the most significant cause of death in the world and pose the greatest threat to human health. Treatment of inflammation is usually done by taking anti-inflammatory drugs that have dangerous side effects in long-term use. Chrysanthemum is the largest horticultural commodity in North Sulawesi that also holds great potential in the world of health. Based on its phytochemical content, purple chrysanthemum leaves have potential as an anti-inflammatory agent. This study aimed to analyze the anti-inflammatory activity of ethanol extract of purple chrysanthemum leaves using the red blood cell membrane stabilization method. This study used an in vitro laboratory experimental method using rat blood. The anti-inflammatory activity of the extract was tested using the red blood cell membrane stabilization method at 4 concentration series, namely 50 ppm, 100 ppm, 200 ppm, and 400 ppm, then measured on a UV-Vis spectrophotometer. The results of phytochemical screening showed that the ethanol extract of purple chrysanthemum (Chrysanthemum morifolium) leaves contains active compounds such as flavonoids, alkaloids, tannins, steroids, and phenolics. The ethanol extract of purple chrysanthemum leaves exhibits anti-inflammatory activity, with higher extract concentrations demonstrating stronger anti-inflammatory effects. The stability percentage values obtained at 50, 100, 200, and 400 ppm were 28.87%, 41.85%, 47.41%, and 64.15% with an IC50 of 235.88 ppm and a correlation coefficient of 0.94.
Antioxidant Potential of Yellow Chrysanthemum (Chrysanthemum indicum) Leaves: In Vitro Analysis Using DPPH and FRAP Techniques Ley, Gabriella Therezia Ley; Kepel, Billy Johnson; Fatimawali, Fatimawali; Manampiring, Aaltje Ellen; Budiarso, Fona Dwiana Hermina; Bodhi, Widdhi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.68

Abstract

The shift from infectious diseases to non-communicable diseases (NCDs), driven by aging and unhealthy lifestyles, has led to an increase in degenerative diseases. The World Health Organization (WHO) reported that NCDs account for 74% of global deaths. An imbalance between free radicals and antioxidants contributes to the progression of these diseases, highlighting the need for research on plant-derived antioxidants. Secondary metabolites, particularly phenolic and flavonoid compounds, are abundant in Chrysanthemum indicum and are known for their potential antioxidant properties. This study aims to identify the secondary metabolites and evaluate the antioxidant activity of yellow chrysanthemum (Chrysanthemum indicum) leaves using two methods: Ferric Reducing Antioxidant Power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The extraction process was performed using the reflux method with 96% ethanol as the solvent. Antioxidant activity was assessed using the DPPH and FRAP methods, with absorbance measurements conducted via UV-Vis spectrophotometry. Phytochemical screening revealed the presence of phenols, flavonoids, tannins, steroids/triterpenoids, and alkaloids in the ethanol extract of yellow chrysanthemum leaves. The antioxidant activity assay using the DPPH method indicated a value of 64.34 ppm, signifying strong antioxidant activity. In contrast, the FRAP method showed weak antioxidant activity, with an IC50 value of 187.13 ppm.
Co-Authors Fatimawali . Fona Budiarso Gemi Nastiti Hermina Budiarso, Fona Dwiana Jimmy Posangi Kepel, Billy Johnson Ley, Gabriella Therezia Ley Malino, Angeline Priscillia Mawikere, Yolanda Niode, Nurdjannah Jane Roring, Natalia Megawati Rumangu, Chrisa P. Saragih, Nathin Loria , Subadio, Nathanael Yngwie Christian Toar, Juwita M. Welong, Seftian Surya Widdhi Bodhi Wijaya, Natalya