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Ilmiawan, Muhammad In'am
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Hubungan antara tumor-infiltrating lymphocytes dengan parameter klinikopatologi pada kanker kolorektal Trianto, Heru Fajar; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Hartono, Henky; Ftrianingrum, Iit; Lestari, Desriani
Majalah Kedokteran Andalas Vol. 46 No. 4 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p949-958.2023

Abstract

Latar Belakang: Kanker kolorektal termasuk dalam keganasan terbanyak di dunia. Berbagai faktor turut mempengaruhi prognosis dari kanker salah satunya sistem imun. Sistem imun di sekitar tumor memiliki pengaruh terhadap progesivitas sel kanker. Salah satu sistem imun yang dapat diamati adalah Tumor-infiltrating lymphocytes (TIL). Tujuan: Penelitian ini bertujuan untuk membuktikan adanya hubungan antara TIL dengan berbagai parameter klinikopatologi pada kanker kolorektal. Metode : Penelitian ini menggunakan desain potong lintang. Subjek penelitian berupa 38 sampel blok parafin dan slide hematoksilin-eosin (HE) serta data klinikopatologi yang berasal dari sediaan operasi kanker kolorektal pada Laboratorium Patologi Anatomi RSUD Dr. Soedarso periode Januari – Desember 2020. Penilaian jumlah TIL dibagi menjadi tiga kelompok yaitu ringan (0-10%), sedang (11-59%), dan berat (60-100%). Hasil: Hasil penelitian menunjukkan bahwa jumlah TIL terbanyak adalah TIL berat yaitu sebanyak 16 kasus (42,1%). Hasil uji korelasi Spearman menunjukkan hubungan antara jumlah TIL dengan derajat diferensiasi, stadium Dukes dan stadium p TNM dengan nilai p<0,005. Tidak terdapat hubungan antara jumlah TIL dengan ukuran tumor, status metastasis kelenjar getah bening, status metastasis jauh, dan lokasi tumor. Kesimpulan: Terdapat hubungan antara jumlah TIL dengan derajat keganasan, stadium Dukes dan stadium pTNM yang merupakan faktor-faktor prognosis pada kanker kolorektal.
Hubungan Status Hidrasi Dan Intensitas Latihan Terhadap VO2Max Pada Atlet Basket Fakultas Kedokteran Universitas Tanjungpura Ronaldo, Andriano; Fathoni, Izzuddin; Ilmiawan, Muhammad In'am
Majalah Kedokteran Andalas Vol. 46 No. 4 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p1025-1035.2023

Abstract

Tujuan: Mengetahui hubungan status hidrasi dan intensitas latihan terhadap VO 2 Max pada atlet basket Fakultas Kedokteran Universitas Tanjungpura. Metode: Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross sectional . Subjek dari penelitian ini berjumlah 15 atlet Fakultas Kedokteran Universitas Tanjungpura yang sesuai dengan kriteria inklusi. Pada penelitian ini dilakukan pengumpulan identitas responden, frekuensi latihan, durasi latihan, pengukuran berat badan berdasarkan kriteria dari National Athletic Trainers' Association , pengukuran tinggi badan, pengukuran VO 2 Max menggunakan metode rockport jogging1,6 km dan diberikan kuesioner skala Borg RPE. Hasil: sebanyak 8 orang (53,3%) mengalami dehidrasi ringan, intensitas latihan ringan 9 orang (60%), dan 8 orang (53,3%) dengan VO 2 Max kurang. Hasil uji korelasi spearman antara status hidrasi terhadap tingkat VO 2 Max menunjukkan nilai signifikansi sebesar 0,036 dan angka koefisien korelasi sebesar 0,545 yang menunjukkan terdapat korelasi positif dengan korelasi kuat. Kemudian antara intensitas latihan terhadap tingkat VO 2 Max menunjukkan nilai signifikansi 0,248 yang menunjukkan tidak terdapat korelasi. Kesimpulan: Terdapat hubungan searah antara tingkat status hidrasi terhadap VO 2Max dan tidak terdapat hubungan antara intensitas latihan terhadap VO 2 Max pada keranjang atlet Fakultas Kedokteran Universitas Tanjungpura.
Differentiation of Microvessel Density Based on The Breast Cancer Patient Characteristics Including Age, Stage, Tumor Size, and Lymph Node Metastasis Salsabila, Tasya; Pratiwi, Sari Eka; Trianto, Heru Fajar; Ilmiawan, Muhammad In'am; Lestari, Desriani; Fitrianingrum, Iit; Hartono, Henky
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1041

Abstract

Background: Breast cancer is the most common malignant tumor in the world and Indonesia. One well-known prognostic marker is microvessel density (MVD), the numerical value of angiogenesis. In recent years, it has been recognized that tumor growth depends on angiogenesis. Therefore, this study aimed to determine the differentiation of MVD based on the breast cancer patients' characteristics including age, stage, tumor size, and lymph node metastasis in the Anatomical Pathology Laboratory of Soedarso Hospital. Methods: This research was an observational study with a cross-sectional approach. The study was conducted by observing the slides of Hematoxylin-Eosin (HE) in breast cancer patients. Samples were taken using the total sampling technique. The samples were observed by two observers. 51 tissue preparations met the inclusions and exclusions criteria. MVD cut-off points are taken by calculating the median. Research analysis was using the Kruskal-Wallis test in SPSS version 24. Results: All samples of this study were women and had invasive ductal carcinoma. Breast cancer tends to occur in patients aged 48-53 years, has stage III, lymph node metastasis (N2). The patients have a low MVD rate but have a large tumor size (T4). Kruskal Wallis test showed that there was a differentiation of MVD based on age (p = 0.029). While, there was no differentiation of MVD based on stage (p=0.974), tumor size (0.069), and lymph node metastasis (0.571). Conclusions: There was a differentiation of MVD based on the age of breast cancer patients in the Anatomical Pathology Laboratory at Soedarso Hospital.
Necrosis area, Tumor Size, and Lymph Node of Breast Cancer Laili, Kharima; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Trianto, Heru Fajar; Fitrianingrum, Iit
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1121

Abstract

Background: Breast cancer is the leading cause of cancer deaths in women worldwide in 2020. The high mortality rate is often influenced by various reasons, one of which is patients's prognosis. One of the prognostic factors is necrosis area, caused by hypoxic tumor tissue that can affect tumor growth and metastasis. Therefore, this study aims to determine the relationship between necrosis area with tumor size and lymph node metastasis in breast cancer patients. Methods: This study was an observational analytic with a cross-sectional approach. This research was conducted at the Anatomical Pathology Laboratory of Dr Soedarso Pontianak General Hospital and the Microscopy Laboratory of the Faculty of Medicine Tanjungpura University from September until November 2022. The study sample was 55 slides of Formalin-Fixed Paraffin-Embedded (FFPE). The study was conducted by observing the preparations under a microscope and then analyzed using ImageJ and SPSS software. The independent variable in this study was the necrosis area in the tumor microenvironment, and the dependent variables were tumor size and lymph node metastasis in breast tissue. Results: All study samples were female patients with invasive ductal carcinoma. Breast cancer tends to occur in patients aged 48-55 years. The highest percentage of necrosis area was 21% and the most diagnosed breast tumor size and lymph node metastasis were stage T4 and stage N2. Spearman's rho correlation test showed that there was no relationship between necrosis area and tumor size (p = 0.122; r = 0.16) and lymph node metastasis (p = 0.637; r = 0.18). Conclusions: There is no correlation between necrosis area with tumor size and lymph node metastasis of breast cancer patients in the Anatomical Pathology Laboratory at Dr Soedarso Pontianak General Hospital.
Co-Authors ., Hardianto Abror Irsan Alex Alex Aswada, Dias Arivia Efrem, Deo Gratias Ery Hermawati Fathoni, Izzuddin Ftrianingrum, Iit Handini, Mitra Hartono, Henky Hengky Hartono Laili, Kharima Lestari, Desriani Mahyarudin, Mahyarudin Mardhia, Mardhia Nugraha, Muhammad Fikri Parinding, Vinny Vania Putranda, Muhammad Afia Akbar Rini Andriani Ronaldo, Andriano Salsabila, Tasya Sandy A.K., Risky Sari Eka Pratiwi Siddiq, Andri Muhrim Trianto, Heru Fajar Uswatun Hasanah