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All Journal HAYATI Journal of Biosciences Progressive Physics Journal Faraday: Journal of Fundamental Physics, Research, and Applied Science
Santika, Arum Sinda
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Agriculture, Biological Sciences & Forestry Astronomy Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Electrical & Electronics Engineering Energy Health Professions Materials Science & Nanotechnology Physics

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Preliminary Investigation of pH-Dependent Optical Properties of Curcumin-Derived Carbon Dots Santika, Arum Sinda; Permatasari, Fitri Aulia; Iskandar, Ferry
Progressive Physics Journal Vol. 6 No. 1 (2025): Progressive Physics Journal
Publisher : Program Studi Fisika, Jurusan Fisika, FMIPA, Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/ppj.v6i1.1522

Abstract

Carbon dots (CDs) are photoluminescent nanoparticles smaller than 10 nm with excellent optical properties, including high photostability, UV and visible light absorption, water solubility, low toxicity, and good biocompatibility. These features make them attractive for biomedical, optoelectronic, and catalytic applications. Curcumin, a polyphenol from turmeric, possesses anti-inflammatory, antibacterial, anticancer, and antiviral properties, but its poor water solubility limits its biomedical use. In this study, CDs were synthesized from curcumin and urea via a solvothermal method at 140 °C for 180 minutes to improve curcumin's solubility. The effect of pH on the optical properties of CDs was investigated by adjusting acidity with citric acid and alkalinity with NaOH. UV-Vis and photoluminescence (PL) spectroscopy revealed that the optical properties of CDs are strongly influenced by pH, likely due to the presence of keto-enol tautomerism in curcumin. The pH sensitivity of these curcumin-derived CDs highlights their potential for biomedical applications such as photothermal therapy, bioimaging, drug delivery, and antiviral agents.
Implant Design Femur Bone using CAD Computation with Variation in Implant Plate Length Az Zahra, Ladya Cheril; Sudrajat, Oka Akbar; Santika, Arum Sinda; Ernawati, Dira; Sujiwa, Akbar
Faraday: Journal of Fundamental Physics, Research, and Applied Science Vol. 1 No. 1 (2025): Faraday: Journal of Fundamental Physics, Research, and Applied Science
Publisher : Universitas Pembangunan Nasional "Veteran" Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/faraday.v1i1.9

Abstract

Femoral fractures are among the most common and severe musculoskeletal injuries, necessitating effective and reliable treatment strategies. This study explores the biomechanical performance of femur implants by evaluating the effects of material selection and implant design using the finite element method (FEM). Three biocompatible materials—titanium alloy Ti-6Al-4V, stainless steel, and PEEK—were analyzed under linear elastic isotropic conditions. Implant designs varied in length (10.02 mm, 13.37 mm, and 15.60 mm) with a fixed head thickness of 3 mm. Simulations assessed stress distribution, deformation, and overall structural performance under physiological loading conditions. Results demonstrated that implant length significantly affects mechanical behavior. The 15.60 mm implants exhibited the most uniform stress distribution and minimal deformation, indicating superior mechanical stability. In contrast, shorter implants (e.g., 10.02 mm) showed increased stress concentrations and deformation, suggesting a higher risk of mechanical failure. Among the materials tested, Ti-6Al-4V outperformed others due to its favorable combination of strength and biocompatibility. The study concludes that longer implants made from titanium alloy provide improved structural integrity, offering safer and more durable options for femoral fracture repair. These findings contribute to the optimization of implant design for enhanced clinical outcomes in orthopedic applications
Review: Characterization of Optical and Structural Properties of Carbon Nanodots (CNDs) from Biomass Waste by Microwave Method Putriana, Ima; Aruan, Nenni Mona; Riskiarna, Reffany Choiru; Fauziyah, Nur Aini; Santika, Arum Sinda
Faraday: Journal of Fundamental Physics, Research, and Applied Science Vol. 1 No. 2 (2025): Faraday: Journal of Fundamental Physics, Research, and Applied Science
Publisher : Universitas Pembangunan Nasional "Veteran" Jawa Timur

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Abstract

This review focuses on examining the synthesis and characterization of Carbon Nanodots (CNDs) from the utilization of Tandan Kosong Kelapa Sawit (TKKS) using the microwave method as an environmentally friendly approach. The resulting CNDs were characterized for their optical and structural properties to evaluate their potential application in the field of biosensors. The synthesis process involves carbonizing TKKS at 500℃ for 3 hours, followed by activation using a microwave at 450 Watts for 15 minutes. UV-Vis characterization shows an absorption peak at 280 nm, which indicates n-π* (C=O) and π-π* (C=C). Meanwhile, FTIR characterization aims to determine the presence of the carbonyl C=O functional group at 1990,98 cm-1 and the aromatic C=C bond at 1416,2 cm-1. The CNDs from TKKS exhibit photoluminescent properties and surface functional groupss that enhance adsorption performance and chemical reactivity. This research offers an efficient and sustainable method for synthesizing CNDs, while also being a breakthrough in utilizing biomass wate, particularly TKKS. The findings have the potential for developing carbon materials in environmental and energi applications.
Development of a Fluorescence Immunoassay Based on Curcumin Carbon Dots-labeled IgY Antibodies for SARS-CoV-2 Detection Rachmadani, Nisa Amanda; Soetomo, Meilisa Keizia; Taharuddin, Audrey Angelina Putri; Santika, Arum Sinda; Abdillah, Oktaviardi Bityasmawan; Permatasari, Fitri Aulia; Iskandar, Ferry; Rachmawati, Heni; Fibriani, Azzania
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.44-57

Abstract

Carbon dots (CDs) are widely utilized in biomedical applications as fluorescent labels for imaging and diagnostics due to their excellent biocompatibility and superior optical properties. These advantages often make CDs a substitute for organic fluorescent dyes, which suffer from low emission intensity and poor photostability when interacting with biomolecules. Moreover, carbon-based materials are eco-friendly and can be synthesized from natural sources, such as curcumin, a chromophore compound abundantly available in Indonesia. Therefore, this study conducted a preliminary investigation on curcumin CDs-labeled IgY antibodies (IgY-cur CDs) for fluorescence immunoassay of SARS-CoV-2 in rapid test applications. The synthesis of the fluorescent label involved a carbodiimide coupling reaction using EDC/NHS agents to conjugate IgY antibodies with curcumin CDs. The IgY-cur CDs conjugate was confirmed to detect antigens through FRET immunosensor mechanisms, showing a significant increase in fluorescence intensity with increasing antigen concentrations (p < 0.05), with a minimum sample concentration of 10 ng. Furthermore, the IgY-CDs cur conjugate was applied as a reporter in a fluorescence-based LFIA using a sandwich assay format. The test strip successfully detected synthetic multiepitope SARS-CoV-2 antigens with an estimated detection limit of 54.28 µg and nasopharyngeal samples from confirmed COVID-19 patients within 35 minutes of operation. The test strip was evaluated to be stable under cold storage at 4°C for up to 3 weeks. In conclusion, curcumin CDs-labeled IgY antibodies demonstrate promising potential for further development as fluorescent labels in rapid diagnostic applications targeting SARS-CoV-2.
Co-Authors Abdillah, Oktaviardi Bityasmawan Akbar Sujiwa Aruan, Nenni Mona Az Zahra, Ladya Cheril Dira Ernawati Ferry Iskandar Fibriani, Azzania HENI RACHMAWATI Nur Aini Fauziyah Permatasari, Fitri Aulia Putriana, Ima Rachmadani, Nisa Amanda Riskiarna, Reffany Choiru Soetomo, Meilisa Keizia Sudrajat, Oka Akbar Taharuddin, Audrey Angelina Putri