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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Biopendix: Jurnal Biologi, Pendidikan dan Terapan BIOEDUPAT: Pattimura Journal of Biology and Learning Jurnal INKOFAR Jurnal Sains dan Kesehatan
Mayuri, Nindya Sekar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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PEMANFAATAN MIKROBA ENDOFIT ASAL TANAMAN OBAT SEBAGAI SUMBER BAHAN OBAT Mayuri, Nindya Sekar
Jurnal Inkofar Vol 8, No 1 (2024)
Publisher : Politeknik META Industri Cikarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46846/jurnalinkofar.v8i1.354

Abstract

Tingginya permintaan obat yang berasal dari tanaman obat dengan keterbatasan tanaman dalam waktu tumbuh dan ketersedian tanaman tersebut di alam, menjadikan produksi senyawa metabolit dari tanaman obat sangat terbatas sehingga diperlukan pencarian senyawa baru dengan efektivitas yang lebih baik. Mikroba Endofit merupakan mikroba yang hidup membentuk koloni di dalam jaringan tanaman tanpa merugikan tanaman inang. Setiap tanaman dapat mengandung beberapa mikroba endofit yang berpotensi menghasilkan metabolit sebagai akibat koevolusi atau terjadi transfer genetik dari tanaman inang kepada mikroba endofit. Pemanfaatan mikroba endofit asal tanaman obat untuk memproduksi metabolit yang dihasilkan oleh tanaman obat merupakan salah satu solusi alternatif untuk memproduksi obat tanpa terkendala waktu tumbuh dan ketersedian tanaman obat serta resistensi mikroba.
PEMANFAATAN MIKROORGANISME PENGHASIL KOLAGEN SEBAGAI PENGGANTI KOLAGEN BABI DALAM SKIN CARE HALAL Mayuri, Nindya Sekar; Dianah, Pepin Nur; Asifadilah, Ayu
Jurnal Inkofar Vol 8, No 2 (2024)
Publisher : Politeknik META Industri Cikarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46846/jurnalinkofar.v8i2.331

Abstract

Collagen is a protein material that has tensile strength and a fiber-shaped structure, and is found in many higher vertebrates with an amount of around 25-30% of the protein that makes up the body. Currently, collagen is widely used as a basic ingredient in beauty products. The collagen that is most widely marketed generally comes from the skin and bone tissue of cows or pigs, the safety and halal of which need to receive more attention, so an alternative source of collagen that is safe and halal is needed to replace pork collagen. One alternative that can be used is to use collagen-producing microorganisms. This research uses library research (Library Research) with documentation methods to analyze library results. The results of the analysis show that the bacteria Streptococcus pyrogenes is a potential bacteria that can be used to replace pork collagen. Recombinant technology by manipulating the hCol gene as human collagen and bCol as recombinant bacterial collagen Scl2. This manipulation can optimize molecular and biological properties. Apart from that, to increase the stability of the S.pyrogenes Scl2 bacterial collagen, the insertion of hydroxyproline was carried out by combining direct co-translation of modified amino acids using the codon for proline in inserting the gene construction. This GMO (Genetically Modified Organism) product is certainly halal because it does not use ingredients containing pork.
Effectiveness of Sengon Ethyl Acetate Extract and Bamboo Liquid Smoke as Disinfectants Anisa, Divia; Marlina, Rina; Juniar, Fadia Rahma; Nurjaman, Deni; Fadhila, Feldha; Mayuri, Nindya Sekar; Rumidatul, Alfi
BIOEDUPAT: Pattimura Journal of Biology and Learning Vol 5 No 1 (2025): Bioedupat : Pattimura Journal of Biology and Learning
Publisher : Program Studi Pendidikan Biologi, Pascasarjana, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/bioedupat.v5.i1.pp287-293

Abstract

The absence of environmental sanitation can influence the transmission of infectious diseases, exemplified as toilets tainted with dangerous microbes. Prevention typically employs disinfectants; nevertheless, their adverse effects might lead to skin and respiratory discomfort. Flavonoids, tannins, and saponins in sengon wood possess antibacterial properties and can serve as alternative materials. The study aimed to assess the efficacy of combining sengon wood extract and bamboo stem liquid smoke as a disinfectant. The experimental methodology employed in vitro testing through an inhibitory assay and in vivo testing utilizing a swab on the surface, assessing the effects pre- and post-swabbing. The in vitro results indicated that the most substantial inhibitory zone was observed with a 40:60 ratio for Salmonella typhimurium ATCC 25241, measuring 11.8 mm; for Candida albicans ATCC 10231, a 30:70 ratio yielded 5.33 mm; and for Aspergillus flavus ATCC 9643, a 30:70 ratio resulted in 5.5 mm. In vivo, swabs from the table yielded an average reduction of 92% in bacterial colonies and 73% in fungal colonies. Conclusion: The amalgamation of sengon twig wood extract and bamboo stem liquid smoke exhibits potential as a disinfectant. Keywords: Liquid smoke, bamboo sticks, disinfectant, sengon wood
Efektivitas Ekstrak Kayu Sengon (Falcataria moluccana) dan Asap Cair Batang Bambu (Bambusa sp) sebagai Disinfektan: Effectiveness of Sengon Wood Extract (Falcataria moluccana) and Bamboo Stem Liquid Smoke (Bambusa sp) as Disinfectants Anisa, Divia; Marlina, Rina; Juniar, Fadia Rahma; Nurjaman, Deni; Fadhila, Feldha; Mayuri, Nindya Sekar; Rumidatul, Alfi
Jurnal Sains dan Kesehatan Vol. 7 No. 2 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i2.2431

Abstract

Lack of cleanliness of the surrounding environment can influence the spread of infectious diseases, such as toilets being contaminated by pathogenic microorganisms. It is common for prevention to use disinfectants, but the negative impact of using them can cause skin and respiratory irritation. The objective of this research is to determine the effectiveness of the combination of sengon twig wood extract and bamboo stem liquid smoke as a disinfectant. The method of this research is uses an experimental design where testing is carried out in vitro using an inhibition test and in vivo using a swab on a table by looking at the effects before and after the swab. Results: In vitro, the largest inhibition zone was formed in a combination ratio of 40:60 for Salmonella typhimurium ATCC 25241 of 11.8 mm; Candida albicans ATCC 10231 in comparison 30:70 was 5.33 mm; Aspergillus flavus ATCC 9643 in a ratio of 30:70 of 5.5 mm. In vivo, using swabs on the table, the average reduction in the number of bacterial colonies was 92% and in fungi the average was 73%. The combination of sengon twig wood extract and bamboo stem liquid smoke has the potential to be a disinfectant Keywords:          Liquid smoke, bamboo sticks, disinfectant, sengon twigs   Abstrak Kurangnya kebersihan lingkungan sekitar dapat mempengaruhi penyebaran penyakit infeksi, seperti toilet yang tercemari oleh mikroorganisme patogen.  Lumrahnya pencegahan menggunakan disinfektan, namun dampak negatif penggunaanya dapat menyebabkan iritasi kulit dan pernafasan. Tujuan penelitian ini untuk mengetahui efektivitas kombinasi ekstrak kayu ranting sengon dan asap cair batang bambu sebagai disinfektan. Metode penelitian ini menggunakan desain eksperimental dimana dilakukan pengujian secara in vitro menggunakan uji daya hambat dan in vivo menggunakan swab pada meja dengan melihat efek sebelum dan setelah swab. Secara in vitro terbentuk zona hambat paling besar pada kombinasi perbandingan 40:60 untuk Salmonella typhimurium ATCC 25241 sebesar 11.8 mm; Candida albicans ATCC 10231 di perbandinga 30:70 sebesar 5.33 mm; Aspergillus flavus ATCC 9643 di perbandingan 30:70 sebesar 5.5 mm. In vivo melalui swab pada meja diperoleh nilai rata-rata penurunan jumlah koloni bakteri  sebesar 92% dan pada jamur rata-rata sebesar 73%. Kombinasi ekstrak kayu ranting sengon dan asap cair batang bambu berpotensi sebagai disinfektan Kata Kunci:         Asap cair, batang bambu, disinfektan, kayu ranting sengon  
GAMBARAN ANGKA LEMPENG TOTAL BAKTERI PADA BEDAK USIA 12 BULAN SETELAH DIGUNAKAN Mayuri, Nindya Sekar; Yusuf, Nabila Islami; Mareta Hera Siswana, Dwi Risyani; Tantiani, Aisyah Putri; Hafid, Naila Akfalia
Jurnal Inkofar Vol 9, No 1 (2025)
Publisher : Politeknik META Industri Cikarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46846/jurnalinkofar.v9i1.421

Abstract

The high number of powder users and the side effects caused by using powder that contains bacteria, then research is needed related to the Total Plate Count of bacteria in powder aged 12 months after use. The research method used in this study is an experimental method. The powder sample used was 12 months old after the powder was used without using a particular brand. The results of the calculation of the number of bacterial colonies showed that the sample with the highest number of colonies was sample S as much as 7.9 x 10^3 cfu/gram then sample W as much as 5.5 x 10^2 cfu/gram and sample L as much as <3.0 x 10^2 cfu/gram. As for the WB sample, there was no bacterial growth the same as the control, namely <1.0 x 10^1 cfu/gram. The color of the bacterial colonies that were successfully isolated was mostly white and 1 colony was clear. While for the shape of the colony consists of Spindle, Irregular, Punctiform, Circular. For the elevation of all bacterial colonies is Convex with margins consisting of Entire and Endulate. 
FORMULASI DAN EVALUASI SABUN PADAT MINYAK ADAS BINTANG (Illicium verum) DENGAN VARIASI KONSENTRASI MINYAK KELAPA, MINYAK SAWIT DAN MINYAK ZAITUN Azzahra, Fauzia; Ramadhani, Intan Puspita; Fitriani, Rima; Mayuri, Nindya Sekar
Jurnal Inkofar Vol 9, No 1 (2025)
Publisher : Politeknik META Industri Cikarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46846/jurnalinkofar.v9i1.458

Abstract

Soap bar is a cleansing preparation created by the saponification reaction. The qualities of soap bars vary depending on the oil composition. Furthermore, additional materials, such as essential oils, could be added to boost the product's value and benefits. The aim of this study is to generate good-quality soap bars using Illicium verum as active ingredients and varying oil concentrations applying the cold process method. The developed soap bar was then examined for its organoleptic properties, pH, moisture content, foam stability, and free fatty acid. On the 7th day, F1, F2, and F3 had pH values of 10.36 ± 0.012, 10.30 ± 0.038, and 10.15 ± 0.095, moisture content (%) of 5.21 ± 0.16, 4.76 ± 0.40, and 7.80 ± 0.58, foam stability (%) of 89.4 ± 0.06, 72.9 ± 0.07, and 74.8 ± 0.10, and free fatty acid (%) of 0.342 ± 0.024, 0.301 ± 0.024, and 0.328 ± 0, respectively. On the 14th day, F1, F2, and F3 had pH values of 10.09 ± 0.121, 10.29 ± 0.015, and 10.18 ± 0.067, moisture content of 4.55 ± 0.46, 3.49 ± 0.29, and 6.67 ± 0.29, foam stability of 91.3 ± 0.02, 91.7 ± 0.05, and 86.2 ± 0.04, and free fatty acid of 0.478 ± 0.063, 0.586 ± 0.046, and 0.560 ± 0.024, respectively. Both the results from the 7th and 14th days comply with the specifications. The variation in oil concentration influences soap bar qualities such as organoleptic, moisture content, and pH.Keywords : Soapbar, Illicium verum, Coconut oil, Palm oil, Olive oil
Effectiveness of Tea Twig Liquid Smoke (Camellia sinensis) as an Antiseptic against Microbes in Vivo and In Vitro Ni'am, Ayu Rahayu Nurul; Arrsy, Aulia Nur; Zahroh, Salsabila; Fadhila, Feldha; Mayuri, Nindya Sekar; Rumidatul, Alfi
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 12 No 2 (2025): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol12issue2page94-101

Abstract

Transmission of microorganisms that cause disease in humans occurs directly or indirectly. Prevention efforts can use antiseptics. The content of liquid smoke compounds in tea twigs has the potential to be an antiseptic. The purpose of this study was to determine the effectiveness of liquid smoke from tea twigs (Camellia sinensis) on microbial growth in vitro using the inhibition test method and in vivo swab test on the palms. In the in vitro test, the most effective results were grade 2 liquid smoke with a concentration of 75% with an inhibition zone diameter of 18.1 mm (E. coli ATCC 25922), 15.6 mm (S. aureus ATCC 25923), 32.3 mm (A. flavus ATCC 9643), 4.3 mm (C. albicans ATCC 10231). The results of the in vivo test showed effectiveness in reducing the number of bacterial colonies by an average of 88.33%, and fungal colonies by an average of 91.52%. From the entire questionnaire data, the parameters of aroma, color, dryness are in the criteria of liking and do not cause side effects on the skin. The results of the study showed that liquid smoke from tea twigs has the potential as an antiseptic.
Effectiveness as a Disinfectant of Ethyl Acetate Extracted from Sengon Twig Bark (Falcataria Moluccana) and Bamboo Stem Liquid Smoke (Bambusa sp.) Nabila, Hasna Putri; Yuliani, Septa; Alifah, Aqil; Qomariah, Annisa Nur; Sugara, Yuliannisa; Rumidatul, Alfi; Fadhila, Feldha; Mayuri, Nindya Sekar
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 8 (2025): Volume 12 Nomor 8
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i8.19621

Abstract

Penyakit infeksi yang disebabkan oleh mikroba patogen masih menjadi suatu masalah kesehatan utama di seluruh dunia. Pada umumnya, pencegahan dilakukan dengan penyemprotan disinfektan berbahan dasar kimia, namun penggunaananya dapat menimbulkan kerusakan kulit sehingga diperlukan alternatif lain, salah satunya dengan menggunakan bahan alami yaitu ekstrak etil asetat kulit ranting sengon (Falcataria moluccana) dan batang bambu (Bambusa sp.). Mengetahui efektivitas antimikroba ekstrak etil asetat kulit ranting sengon (Falcataria moluccana) dan asap cair batang bambu (Bambusa sp.) sebagai disinfektan. Menggunakan rancangan eksperimental. Data diambil dari 5 perlakuan pada metode difusi menggunakan campuran ekstrak etil asetat kulit ranting sengon (Falcataria moluccana) dan asap cair batang bambu (Bambusa sp.) dengan masing-masing perbandingan 50:50, 40:60, 30:70, 20:80, 10:90 kemudian hasil terbaik dilakukan uji swab pada meja. Pada metode difusi didapatkan hasil terbaik yaitu pada perbandingan 40:60 dan 20:80. Uji swab menghasilkan persentase penurunan bakteri sebesar 78,93% dan persentase penurunan jamur sebesar 83,27%. Ekstrak etil asetat kulit ranting sengon (Falcataria moluccana) dan asap cair batang bambu (Bambusa sp.) memiliki sifat antimikroba sehingga dapat dijadikan sebagai disinfektan.
Utilization of Roots of Muli Banana Plants (Musa acuminata Linn.) as Antibiotics and Antiseptics Nainggolan, Ribka Debora; Handayani, Kusuma; Mayuri, Nindya Sekar; Rumidatul, Alfi
BIOEDUPAT: Pattimura Journal of Biology and Learning Vol 5 No 2 (2025): Bioedupat : Pattimura Journal of Biology and Learning
Publisher : Program Studi Pendidikan Biologi, Pascasarjana, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/bioedupat.v5.i2.pp335-344

Abstract

Diseases caused by bacteria can usually be combated by administering antibiotics and using antiseptics. However, there are some groups of pathogens, such Escherichia coli as well as Staphylococcus aureus, which are highly resistant to the antibiotics amoxicillin, penicillin, tetracycline and chloramphenicol. One of the efforts to control these bacteria is by using bioactive compounds derived from plants. Banana plants contain secondary metabolite compounds flavonoids, saponins, and tannins that can act as anti-infective agents, including muli banana (Musa acuminata Linn.). Banana plant roots as natural ingredients can be an alternative to antiseptics because they contain antibacterial compounds with milder side effects than long-term use of alcohol-based antiseptics that can reduce skin moisture. This study was conducted to determine the efficacy of banana muli root extract (M. acuminata Linn.) as an antibiotic and antiseptic. The hypothesis in this study is that the root extract at a certain concentration is thought to have effectiveness as an antibiotic (E. coli) and antiseptic (S. aureus). In this study, the Kirby-Bauer method was applied by agar diffusion and the results of the inhibition zone test were formed around the paper disc. The results showed that the optimum efficacy of muli banana root extract (M. acuminata Linn.) as an antibiotic (E. coli ATCC 25922) was at a concentration of 95% (2.96 mm) and as an antiseptic (S. aureus ATCC 25923) at a concentration of 75% (9.1 mm).
Co-Authors Alifah, Aqil Anisa, Divia Arrsy, Aulia Nur Asifadilah, Ayu Dianah, Pepin Nur Fadhila, Feldha Fauzia Azzahra, Fauzia Fitriani, Rima Hafid, Naila Akfalia Juniar, Fadia Rahma Kusuma Handayani, Kusuma Mareta Hera Siswana, Dwi Risyani Nabila, Hasna Putri Nainggolan, Ribka Debora Ni'am, Ayu Rahayu Nurul Nurjaman, Deni Qomariah, Annisa Nur Ramadhani, Intan Puspita Rina Marlina Rumidatul, Alfi Sugara, Yuliannisa Tantiani, Aisyah Putri Yuliani, Septa Yusuf, Nabila Islami Zahroh, Salsabila