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All Journal HAYATI Journal of Biosciences Sari Pediatri Paediatrica Indonesiana Archives of Pediatric Gastroenterology, Hepatology, and Nutrition
Hafifah, Cut Nurul
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Health Professions Medicine & Pharmacology

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Mid-upper arm circumference as an indicator of nutritional status improvement in children aged 6-59 months with severe acute malnutrition Putri, Trivani; Prasetyadi, Yosafat Lambang; Ibrahim, Naufal Arkan Abiyyu; Hafifah, Cut Nurul
Paediatrica Indonesiana Vol. 64 No. 4 (2024): July 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.4.2024.300-4

Abstract

Background The prevalence of severe acute malnutrition (SAM) in Indonesia remains high, especially in children with pre-existing chronic disease. These children often present with conditions that could interfere with weight measurements, such as edema or organomegaly. Mid-upper arm circumference (MUAC) is a potential indicator of nutritional status improvement. Objective To analyze the correlation between MUAC and body weight as parameters for nutritional improvement in children with SAM. Methods We performed registry analysis of patients admitted to the Pediatric Ward, Cipto Mangunkusumo Hospital, Jakarta, Indonesia from November 2016 to December 2020. We included children aged 6-59 months who were severely wasted (z-score <-3 on the WHO weight-for-height growth chart), had no conditions that could alter weight measurement, and had a 7-day minimum hospital stay. Patients with missing body weight and/or MUAC data were excluded. MUAC and weight increment between admission and discharge were analyzed using bivariate correlation and linear regression analyses. Results Out of 4,746 pediatric inpatients, 1,996 presented with SAM. Of these, 124 were eligible for analysis. Subjects’ median age was 18 (IQR 11-32) months and median length of stay was 16 days (IQR 9-29 days). Weight increment (g/kg/day) and MUAC increment (mm/day) were independently and significantly correlated (P<0.001; Spearman’s rho=0.414). An adequate weight increment of 5-10 g/kg/day was equivalent to a MUAC increment of 0.319-0.439 mm/day (P<0.001; R=0.374). Conclusion MUAC increment has a moderate positive correlated with weight increment. MUAC is a useful parameter of nutritional status improvement in SAM patients, especially in patients with conditions that could interfere with weight measurement.
Gut Microbiota Profile of Infants with Breastfeeding and Mixed Feeding Patterns Kusumaningrum, Tina; Tafroji, Wisnu; Gultom, Septiani Madonna; Putri, Nina Dwi; Hafifah, Cut Nurul; Safari, Dodi
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.530-538

Abstract

We explore the gut microbiota profiles of 103 stool samples collected from infants at the age of 4 and 6 months in Jakarta, Indonesia. We performed 16S rRNA gene sequencing with Illumina MiSeq to identify the diversity, structure, and composition of the gut microbiota from those stool samples. Among 103 stool samples, 55 and 48 samples were collected from infants with breastfeeding and mixed feeding patterns, respectively. We found that the most abundant bacteria were Bifidobacteriales from the phylum of Actinobacteria (43.05%), Lactobacillales from the phylum of Firmicutes (28.39%), and Enterobacterales from the phylum of Proteobacteria (13.75%). The alpha and beta diversity analysis showed that the association between feeding patterns and differences in the microbial communities was not statistically significant (p-value >0.05). Our study did not show a difference in the gut microbiota pattern between the two feeding pattern groups. This result contributed to the variety of the world gut microbiota profile data in infants.
Sindrom Nefrotik Monogenik: Pendekatan Klinis dan Diagnosis Fahlevi, Reza; Trihono, Partini Pudjiastuti; Muktiarti, Dina; Wahidiyat, Pustika Amalia; Hidayati, Eka Laksmi; Hafifah, Cut Nurul
Sari Pediatri Vol 26, No 3 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.3.2024.189-96

Abstract

Sindrom nefrotik merupakan penyakit ginjal yang sering ditemukan pada anak-anak, dengan insiden 1-3 per 100.000 anak di bawah usia 16 tahun. Sekitar 10-20% anak dengan sindrom nefrotik mengalami sindrom nefrotik resisten steroid (SNRS), dan 10-30% dari kasus ini disebabkan oleh kelainan genetik. Pada SNRS monogenik, terdapat dua jenis yaitu sindromik (dengan gejala ekstra-renal) dan non-sindromik (tanpa gejala ekstra-renal). Penanganan SNRS memerlukan pendekatan klinis yang berbeda tergantung pada etiologi genetiknya. Pemeriksaan genetik, termasuk gen tunggal, panel multigen, dan genomik komprehensif, dapat mengidentifikasi varian patogenik, menetapkan diagnosis yang akurat, menyesuaikan terapi (termasuk penghentian terapi imunosupresan dan pemberian terapi yang lebih spesifik) konseling genetik, serta penanganan komprehensif terhadap manifestasi ekstra-renal terkait. Oleh karena itu, pendekatan klinis yang efektif harus didasarkan pada hasil pemeriksaan genetik untuk pengelolaan yang optimal dan konseling yang lebih tepat.
Bone Mineral Disorders in Children with Predialysis Chronic Kidney Disease Correlates with Short Stature Rania, Ghina; Puspitasari, Henny Adriani; Hidayati, Eka Laksmi; Hafifah, Cut Nurul
Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Vol. 3 No. 1 (2024): APGHN Vol. 3 No. 1 February 2024
Publisher : The Indonesian Society of Pediatric Gastroenterology, Hepatology, and Nutrition

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58427/apghn.3.1.2024.12-23

Abstract

Background: The increasing prevalence of malnutrition and growth impairment among children with CKD could impact the prognosis and the preferred intervention. Therefore, this study aimed to identify the nutritional status of children with CKD and its relating factors. Method: A cross-sectional study was conducted in a tertiary, national-referral teaching hospital in Jakarta. Sociodemographic and laboratory data were obtained from medical records. Body weight and height of participants were measured using digital scale and stadiometer, respectively. Growth and nutritional status indicators such as BMI-for-age, weight-for-height, height for age, and weight for age were quantified and plotted using WHO Anthro and Anthroplus application. Result: A total of 18 participants aged 3-17 years old with CKD stage 3 – 5 were included in this study. BMI measurements showed a z-score average of -1.02, while the mean z-score for height-for-age was of -2.71. Our study demonstrated a significant association between the height-for-age and mineral bone in children with CKD (p = 0.005). However, we found no association between mineral bone disorder with other indicators of nutritional status. Furthermore, our study also found no significant relation between nutritional status and other influencing factors including the stage of CKD, duration of CKD, age, gender, primary etiological factor, hypertension, anemia, age, familial economic status, disease duration, and parental education level demonstrates no significant correlation (p > 0.05). Conclusion: Children with stage 3 – 5 CKD in the pre-dialysis phase are shown to be underweight and short statured but with normal nutritional status. Mineral bone disorder was revealed to be significantly associated with height-for-age in children with CKD.
Obesitas dan Risiko Penyakit Ginjal pada Anak Fahlevi, Reza; Ulfa, Maryam; Hafifah, Cut Nurul; Pardede, Sudung Oloan; Trihono, Partini Pudjiastuti
Sari Pediatri Vol 26, No 1 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.1.2024.63-8

Abstract

Obesitas pada anak makin meningkat dan menimbulkan berbagai permasalahan kesehatan di dunia. Umumnya anak dengan obesitas cenderung akan mengalami obesitas pula pada saat remaja dan dewasa yang menyebabkan peningkatan risiko mortalitas dan morbiditas. Berdasarkan data Badan Kesehatan Dunia (WHO), anak berusia di bawah 5 tahun yang mengalami overweight atau obesitas sebanyak 39 juta anak. Obesitas merupakan suatu kondisi patologis penumpukan energi dalam bentuk lemak. Bersamaan dengan itu, tubuh mengalami berbagai perubahan yang menyebabkan gangguan fungsi organ. Hal tersebut terjadi karena perubahan sistemik pada hemodinamik, metabolik, dan lipotoksisitas. Kondisi ini menyebabkan tubuh anak yang obes mengalami peningkatan kadar stres oksidatif dan faktor inflamasi disertai penurunan kadar antioksidan, yang kemudian berdampak terhadap terjadinya resistensi insulin, disfungsi endotel, serta kerusakan struktur jaringan, dan fungsi organ, salah satunya ginjal. Penyakit ginjal yang banyak ditemukan terkait dengan obesitas pada anak, di antaranya adalah: hipertensi, glomerulopati, tubulopati, batu ginjal, infeksi saluran kemih, keganasan, hingga penyakit ginjal stadium akhir, atau gagal ginjal. Tulisan ini membahas obesitas pada anak dan risiko penyakit ginjal yang dapat terjadi. Dengan demikian diharapkan tenaga kesehatan dan pemangku kebijakan dapat menerapkan upaya pencegahan obesitas sedini mungkin, sebelum menimbulkan komplikasi yang mengenai berbagai organ tubuh, termasuk ginjal.
Co-Authors Dina Muktiarti, Dina Eka Laksmi Hidayati, Eka Laksmi Gultom, Septiani Madonna Henny Adriani Puspitasari, Henny Adriani Ibrahim, Naufal Arkan Abiyyu Kusumaningrum, Tina Nina Dwi Putri Pardede, Sudung Oloan Partini Pudjiastuti Trihono, Partini Pudjiastuti Prasetyadi, Yosafat Lambang Pustika Amalia Wahidiyat, Pustika Amalia Putri, Trivani Rania, Ghina REZA FAHLEVI Safari, Dodi Tafroji, Wisnu Ulfa, Maryam