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All Journal HAYATI Journal of Biosciences Nurse Media Journal of Nursing Sari Pediatri Paediatrica Indonesiana Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Archives of Pediatric Gastroenterology, Hepatology, and Nutrition The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Nina Dwi Putri
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Medicine & Pharmacology Neuroscience Nursing

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Protokol Evaluasi Infeksi Jamur dan Parasit Pre dan Pasca-Transplantasi Hati pada Anak Mulya Rahma Karyanti; Nina Dwi Putri; Hanifah Oswari
Sari Pediatri Vol 21, No 6 (2020)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp21.6.2020.394-400

Abstract

Infeksi jamur menjadi penyebab morbiditas dan mortalitas paling penting pada pasien pasca-transplantasi hati yang mendapat beberapa imunosupresan. Candida species dan Aspergillus species adalah infeksi jamur paling invasif. Infeksi Candida species dilaporkan menjadi etiologi penyebab infeksi jamur tertinggi pada transplantasi hati. Selain infeksi jamur, parasit juga dilaporkan menjadi penyebab infeksi pada transplantasi hati khususnya pada pasien berasal dari daerah endemis. Artikel ini bertujuan untuk membuat protokol evaluasi infeksi jamur dan parasit pada transplantasi hati anak.
Protokol Evaluasi Infeksi Bakteri Pre- dan Pasca-Transplantasi Hati Anak Mulya Rahma Karyanti; Nina Dwi Putri; Hanifah Oswari
Sari Pediatri Vol 21, No 1 (2019)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (455.109 KB) | DOI: 10.14238/sp21.1.2019.66-72

Abstract

Infeksi pre- dan pasca-transplantasi hati dipengaruhi oleh gangguan sistem imunonlogi resipien karena penggunaan obat-obat imunosupresi. Komplikasi infeksi tersebut merupakan penyebab penting kejadian infeksi terhadap morbiditas dan mortalitas pada anak anak yang menjalani transplantasi hati.  Obat-obatan profilaksis sebelum dan setelah operasi yang direkomendasikan disesuaikan dengan pola mikroba yang berkaitan di setiap rumah sakit. Uji tapis infeksi bakteri penting untuk mencegah terjadinya infeksi pasca-transplantasi hati. Komplikasi terjadinya infeksi sekunder oleh bakteri disebabkan oleh karena penggunaan alat-alat invasif dalam jangka waktu yang lama seperti kateter vena sentral, kateter akses arterial, endotracheal tube, kateter ureter, dan sebagainya. Keberhasilan efektivitas pengobatan antimikroba ditentukan oleh pengelolaan pemasangan atau pelepasan semua alat invasif dan pengontrolan infeksi di rumah sakit.
Tata laksana Infeksi Sitomegalovirus pada Pasien Transplantasi Organ Padat Lucyana Alim Santoso; Mulya Rahma Karyanti; Nina Dwi Putri
Sari Pediatri Vol 19, No 3 (2017)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.572 KB) | DOI: 10.14238/sp19.3.2017.172-82

Abstract

Pasien kandidat transplan organ padat merupakan populasi yang berisiko tinggi mengalami infeksi, terutama setelah transplantasi, karena pasien akan menerima terapi imunosupresan sehingga infeksi maupun reaktivasi patogen lebih mudah terjadi. Patogen penyebab morbiditas tersering adalah sitomegalovirus (CMV). Infeksi sitomegalovirus dapat bersifat simtomatik maupun asimtomatik. Penyakit CMV timbul apabila infeksi bersifat simtomatik dan dapat terjadi baik oleh infeksi primer, reaktivasi, maupun superinfeksi virus. Gejala penyakit CMV pada pasien imunokompromais dapat menjadi diseminata. Baku emas untuk mendiagnosis CMV adalah dengan polymerase chain reaction (PCR) CMV. Namun demikian, belum ada panduan tatalaksana profilaksis maupun batasan titer CMV yang memerlukan terapi. Makalah ini bertujuan untuk menelaah literatur sehingga dapat menghasilkan panduan profilaksis dan terapi penyakit CMV pada pasien transplantasi organ padat di Indonesia.
Prediktor Sindrom Syok Dengue pada Anak di Rumah Sakit Umum Daerah dr. H. Andi Abdurrahman Noor, Tanah Bumbu, Kalimantan Selatan Irma Annisa; Merry Angeline Halim; RR Putri Zatalini Sabila; Atut Vebriasa; Tety Nidiawati; I Dewa Gede Ariputra; Aryono Hendarto; Nina Dwi Putri
Sari Pediatri Vol 23, No 4 (2021)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp23.4.2021.228-34

Abstract

Latar belakang. Efusi pleura merupakan salah satu tanda kebocoran plasma pada pasien demam berdarah dengue (DBD) yang dapat dinilai dengan indeks efusi pleura (IEP). Nilai trombosit, hematokrit, dan IEP dapat digunakan untuk mengidentifikasi keparahan DBD. Tujuan. Mengetahui perbedaan nilai trombosit, hematokrit, dan IEP antara pasien anak yang didiagnosis dengan sindrom syok dengue (SSD) dan DBD tanpa syok. Metode. Penelitian ini merupakan studi observasional analitik dengan desain cross-sectional. Sampel penelitian ini adalah anak usia 1 bulan−14 tahun. Analisis statistik bivariat dilakukan untuk mencari hubungan antara nilai trombosit, persentase hemokonsentrasi, dan IEP dengan kejadian SSD. Selanjutnya, dilakukan analisis multivariat dengan uji regresi logistik.Hasil. Hemokonsentrasi berperan secara signifikan sebagai preditor SSD (p=0,001 dan OR 1,102). Nilai IEP tidak bermakna sebagai prediktor SSD (p=0,052), tetapi IEP tetap dimasukkan ke dalam analisis menurut pertimbangan klinis. Sementara itu, angka trombosit tidak terbukti sebagai prediktor SSD dengan p=0,549 dan OR 1,000. Pada kurva ROC didapatkan titik potong skor prediktor SSD adalah -1,6 dengan titik potong hemokonsentrasi 23% dan IEP 25%. Pada analisis diagnostik titik potong skor prediktor tersebut untuk menilai kejadian SSD didapatkan sensitivitas 92% dan spesifisitas 83%.Kesimpulan. Indeks efusi pleura (IEP) bersama dengan hemokonsentrasi dapat digunakan sebagai faktor prediktor kejadian SSD pada anak. Skor prediktor >-1,6 memiliki kemungkinan terjadinya SSD 15,6 kali lebih besar dibandingkan skor prediktor ≤ -1,6.
Protokol Evaluasi Infeksi Virus Pasien Transplantasi Hati Anak Mulya Rahma Karyanti; Nina Dwi Putri; Hanifah Oswari
Sari Pediatri Vol 20, No 4 (2018)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.421 KB) | DOI: 10.14238/sp20.4.2018.258-64

Abstract

Uji tapis terhadap infeksi virus sebelum transplantasi hati dapat memperkecil risiko reaktivasi atau transmisi infeksi virus dalam proses transplantasi hati. Biasanya, pasien transplantasi hati mendapatkan terapi imunosupresan untuk mencegah rejeksi sehingga memperbesar risiko terkena infeksi. Cytomegalovirus (CMV), Ebstein-barr virus (EBV), dan Herpes Simplex Virus (HSV) merupakan virus penyebab tersering komplikasi infeksi pada pasien transplan hati. Komplikasi disebabkan oleh CMV, antara lain, viral syndrome, hepatitis, pneumonitis, dan kolitis. Ebstein-Barr Virus dapat menyebabkan Post-transplant Lymphoproliferative Disorder (PTLD). Infeksi HSV pasien transplan hati akan memberikan manifestasi klinis yang lebih berat dan respon terapi yang lambat. Makalah ini bertujuan untuk membuat protokol evaluasi infeksi virus pada saat uji tapis, pencegahan dan tata laksana antivirus untuk pasien transplantasi hati.
Prognostic factors and survivals of children with steroid-resistant nephrotic syndrome Partini Pudjiastuti Trihono; Nina Dwi Putri; Aman B Pulungan
Paediatrica Indonesiana Vol 53 No 1 (2013): January 2013
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.126 KB) | DOI: 10.14238/pi53.1.2013.42-9

Abstract

Background Children with steroid resistant nephrotic syndrome(SRNS) generally survive, although during the course of diseasetheir kidney function may decrease, leading to end-stage renaldisease (ESRD). There have been few studies reporting on thesurvivals of children with SRNS.Objectives To determine patient and kidney survival rates in childrenwith SRNS at the first, second, third, fourth, and fifth years; and toevaluate the effects of age at onset, initial kidney function, hypertension,and type of resistance, on the survivals of children with SRNS.Methods This retrospective cohort study was performed usingsecondary data obtained from medical records of patients with SRNS inDepartment of Child Health, Cipto Mangunkusumo Hospira~ between2004-2011. The outcomes of kidney survivals were defined in two ways:lack of doubling of base creatinine levels and lack of ESRD.Results There were 45 children with SRNS in our study. Their medianduration ofillness was 24 (range 12-95) months. Twenty percent of thesubjects died, 31.1 % had a doublingofbase creatinine levels, and 13.4%developed ESRD. Life survival rates of subjects at the first, second,third, fourth, and fifth years after diagnosis were 93 %, 84%, 80"/ri, 7 2%,and 61 %, respectively. Kidney survival rates determined by the lackof doubling of base creatinine levels at the first, second, third, fourthand fifth years were 92%, 72%, 56%, 42%, and 34%, respectively, whilekidney survival rates determined by the lack ofESRD were 97%, 88%,81 %, 70"/o, and 58%, respectively. Age at onset, initial kidney function,hypertension at onset, and type of resistance, did not significantly affectthe survivals of children with SRNS.Conclusion Children with SRNS are prone to develop a doublingof base creatinine levels and ESRD. Factors such as age, initialkidney function, hypertension at onset, and type ofresistance, donot significantly affect both, life and kidney survivals of childrenwith SRNS.
Natural Evolution of Regurgitation in Children Aged 12-24 Months: A 1-year Cohort Study Badriul Hegar; Fatima Safra Alatas; Muzal Kadim; Nina Dwi Putri; Wahyu Ika Wardhani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 1, April 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.871 KB) | DOI: 10.24871/141201313-18

Abstract

Background: There are very limited cohort studies regarding long term outcome of gastroesophageal reflux diseases (GERD), especially until 24 months old. The aim of this study is to see the natural history of GERD in12-24 months old children based on their clinical signs and symptoms.Method: Prospective one year population base cohort study involving 262 children. Their regurgitation history and GERD symptoms were recorded every two months.Results: Two hundred and  fivety three children completed the study. Seventy three children (27.8%) were still having regurgitation when they were 6 months old, 44 (16.7%) until 9 months old, and 24 (9.2%) until 12months old. During 12 months follow-up the prevalence and frequency of regurgitation decreased to 2.4% and 1.2% in the age of 18 and 24 months respectively. Infant with regurgitation at 6 months old were 13.2 times more likely to have regurgitation at 12 months old (RR = 13.2; 95% CI = 4.8-36.6). Prevalence of regurgitation after 18 months old were 37 times higher risk compared to those not regurgitating at the age of 12 months (RR = 37; 95% CI = 2.2–613.9). GERD symptoms were higher in children that were still regurgitating until 9 months old 64.5% (RR = 2.3; 95% CI = 1.7-3.0) compared to those only experiencing until 6 months old 54.7% (RR = 1.3; 95% CI = 1.7-3.0).Conclusion: Regurgitation decrease during 12-24 months old period. The history of regurgitation in 6 and 9 months old is related to the probability to become GERD in 12-24 months old period. Keywords: gastroesophageal reflux, children 12-24 months, GERD symptoms
Antimicrobial activity of homemade WHO ethanol-based hand rub solution in pediatric department, Dr. Cipto Mangunkusumo National Referral Hospital Nina Dwi Putri; Hindra Irawan Satari; Mulya Rahma Karyanti; Ari Prayitno; Pratama Wicaksana; Anis Karuniawati; Delly Chipta Lestari; Nabila Maudy Salma; Shindy Claudya Aprianti; Amalia Almira; Andi Annisa Rusyda Khafiyani
Paediatrica Indonesiana Vol 62 No 4 (2022): July 2022
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi62.4.2022.232-6

Abstract

Background Hand hygiene is essential in reducing healthcare-associated infections. Alcohol-based hand rub solutions have been reported to have superior antimicrobial efficacy on both bacteria and lipophilic viruses compared to washing with hand soap. In low- and middle-income countries, the cost of infection control poses a challenge. Our hospital produced an ethanol-based hand rub based on a WHO formulation to reduce the infection prevention costs. Objectives To identify the antimicrobial activity of a WHO ethanol-based hand rub solution against bacterial contamination on the hands of healthcare workers at the Department of Child Health, Dr. Cipto Mangunkusumo National Referral Hospital. Methods This cross-sectional study was performed on the hands of healthcare workers (physicians and nurses) working in the Department of Child Health, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta. A total of 225 specimens from 75 subjects were obtained by collecting swabs on both hands before and after participants worked in the Department of Child Health, Dr. Cipto Mangunkusumo General Hospital. Bacterial culture tests were performed to identify gram-positive and gram-negative bacteria. Bacteria were grouped into no-growth/Bacillus sp, Enterobacteriaceae, cocci, and non-fermenter groups. Results The use of our WHO ethanol-based hand rub solution, generally resulted in a statistically significant decrease in bacterial growth from 84 to 54.6%, before compared to after the hand rub was performed. In more detail, there was a 72.7% decrease in Enterobacteriaceae, a 71.4% decrease in non-fermenters, an 8.6% decrease in cocci and a 44.1% increase in the number of specimens showing no growth bacteria/Bacillus sp. Conclusion Our WHO ethanol-based hand rub has significant antimicrobial activity for common nosocomial pathogens (e.g., Staphylococcus aureus, P. aeruginosa, and K. pneumoniae).
Inflammatory and coagulation marker profiles in severe pediatric COVID-19 patients: a systematic review Tartila Fathan; Antonius Hocky Pudjiadi; Nina Dwi Putri; Nindya Permata; Yosilia Nursakina
Paediatrica Indonesiana Vol 62 No 6 (2022): November 2022
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi62.6.2022.411-21

Abstract

Background Children are susceptible to SARS-CoV-2 infection and often present mild manifestations. However, severe and critical cases have also been reported. The inflammation and coagulation marker profile pattern in these patients along with the white blood cell differential count in critical PICU cases with non-COVID-19 etiology is not entirely clear. Objective To evaluate the inflammation and coagulation profiles in children presenting with severe/critical SARS-CoV-2 infection. Methods A systematic search and review of scientific literature was conducted following the PRISMA guidelines using ProQuest, SCOPUS, EBSCOHost, ScienceDirect, Cochrane, EMBASE, and Pubmed databases. All relevant original studies until March 11, 2021, were included. The risk of bias was appraised using the Modified Newcastle Ottawa Scale and JBI Critical Appraisal Checklist tools. Results We identified 14 studies across 6 countries, including a total sample of 159 severe and critically ill pediatric COVID-19 patients. Most of the subjects showed normal leukocytes, but increased CRP, procalcitonin, ferritin, and IL-6. Studies on coagulation profiles showed normal thrombocytes, PT, aPTT, and inconsistent D-dimer results. Conclusion Inflammation and coagulation parameters in severe/critically ill children with COVID-19 are atypical. Several inflammatory markers were elevated, including CRP, ferritin, procalcitonin, and IL-6. However, the elevated marker values are still lower compared to non-COVID infection patients. Further investigation of the parameters need to be done in serial examination multicenter studies, which include control subjects.
Non-comorbid Respiratory Factor and Work of Breathing in Pediatric COVID-19 Patient: How is Their Synergistic Correlation with the Level of Care? Defi Efendi; Maria Dyah Kurniasari; Mega Hasanul Huda; Raudha Ilmi Farid; Yohanes Andy Rias; Yogi Prawira; Nina Dwi Putri; Ayuni Rizka Utami; Titik Ambar Asmarini; Pande Lilik Lestari; Pricilia Mais; Abram Babakal
Nurse Media Journal of Nursing Vol 12, No 3 (2022): (December 2022)
Publisher : Department of Nursing, Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/nmjn.v12i3.45340

Abstract

Background: Work of breathing (WOB) and non-comorbidities factors in the respiratory system are the two probable findings in pediatric COVID-19 patients. However, the association of those factors with level of care was not well reported.Purpose: This study aimed to identify the relation between potential predictors including comorbidity, low nutritional fulfillment, infectious disease, shock, cough, O2 saturation reduction, abnormal blood gas analysis and sore throat with the level of care among pediatric COVID-19 patients. We also analyzed the synergistic correlation of non-comorbidities factors in the respiratory system and work of breathing to predict level of care in pediatric COVID-19 patients.Methods: A cross-sectional study was conducted in the six referral hospitals from July to September 2020 in four provinces in Indonesia. An observation checklist was used to collect data from the medical records of pediatric patients with COVID-19, including medical diagnosis, demographic, and clinical manifestation. This study included 423 participants aged from 0 to 18. The multivariate logistic regression was performed to test the adjusted odds ratios (AORs) with the 95% confidence intervals (CIs) of the association between WOB, non-comorbid respiratory, and level of care. Moreover, dummy variables (2x2) were made to analyze synergistic correlation of non-comorbid respiratory disease and WOB. The AOR with the 95% CIs was applied in the association between the complication of non-comorbid respiratory diseases and high work of breathing with level of care among pediatric patients with COVID-19.Results: Results showed that age, presence of comorbidity, nutritional fulfillment, infectious disease, shock, work of breathing, O2 saturation reduction, abnormal blood gas analysis, sore throat, and convulsive meningeal consciousness were significantly associated with the level of care (p<0.05). Pediatric patients with non-comorbid respiratory and increased work of breathing had a 15.59 times higher risk of requiring PICU care level (p<0.01). Meanwhile, pediatric patients who experienced both non-comorbid respiratory and increased work of breathing had a 5.76 times risk of requiring an intermediate level of care (p<0.05), and 9.32 times higher risk of requiring a PICU level of care (p<.05).Conclusion: It was found that both non-comorbid respiratory and increased WOB had a significant relationship with the level of care for pediatric patients with COVID-19. Nurse should take into account those clinical findings to increase the awareness in monitoring clinical deterioration in pediatric COVID-19 patients.
Co-Authors Abram Babakal Amalia Almira Aman B Pulungan Andi Annisa Rusyda Khafiyani Anis Karuniawati Antonius H. Pudjiadi Ari Prayitno Aria Kekalih Aryana, Nurfathonah Aryono Hendarto Atmalia, Khafifah Puja Atut Vebriasa Ayuni Rizka Utami Bachti Alisjahbana Badriul Hegar Badriul Hegar Balfas, Rania Reiza Faris Defi Efendi Delly Chipta Lestari Dwihardiani, Bintari Fatima Safra Alatas Felisia . Finny Fitry Yani Gultom, Septiani Madonna Hafifah, Cut Nurul Hanifah Oswari Hindra Irawan Satari I Dewa Gede Ariputra Irma Annisa Koesoemadinata, Raspati C. Kumalawati, July Kusumaningrum, Tina Linny Luciana Lucyana Alim Santoso Mega Hasanul Huda Merry Angeline Halim Mulya Rahma Karyanti, Mulya Rahma Muzal Kadim Nabila Maudy Salma Nindya Permata Pande Lilik Lestari Partini Pudjiastuti Trihono Pratama Wicaksana Pricilia Mais R. Rr Maria Dyah Kurniasari Raudha Ilmi Farid Rina Triasih Rivaldi Febrian RR Putri Zatalini Sabila Safari, Dodi Shindy Claudya Aprianti Stephen M. Graham, Stephen M. Tafroji, Wisnu Tartila Fathan Tety Nidiawati Titik Ambar Asmarini Trisasi Lestari, Trisasi Wahyu Ika Wardhani Wulandari Hidaya Yogi Prawira Yohanes Andy Rias Yosilia Nursakina