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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Abdi Insani
Supriyanta, Jaka
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology

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Characterization and dissolution test of recrystallized mefenamic acid by fast cooling methods Rasydy, La Ode Akbar; Damayanti, Hilda; Satrio, Erza; Supriyanta, Jaka
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.26467

Abstract

Mefenamic acid, classified as a Biopharmaceutics Classification System (BCS) Class II drug, exhibits high permeability but low dissolution rates, limiting its bioavailability. This study aims to enhance the dissolution rate of mefenamic acid through crystal structure modification using fast cooling recrystallization with three distinct solvents: acetone (AMA), ether (AMEt), and ethyl acetate (AME). The recrystallized crystals were characterized using advanced techniques, including polarized microscopy, X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy, and Differential Scanning Calorimetry (DSC), alongside solubility and dissolution testing. Recrystallization yielded crystals with varied morphologies and sizes, achieving high crystal yields of 92.66% (AMA), 85.54% (AMEt), and 94.59% (AME). FTIR analysis revealed that AME crystals exhibited stronger OH bonding, indicated by the highest peak intensity. XRD diffractograms demonstrated distinct peak patterns at specific 2θ positions for AME crystals, suggesting internal structural changes (polymorphism) while maintaining identical chemical composition. DSC thermograms further confirmed variations in melting points between recrystallized crystals and pure mefenamic acid. Dissolution tests revealed that recrystallized mefenamic acid exhibited significantly improved solubility and dissolution rates compared to its pure form. These findings highlight that rapid cooling recrystallization can produce mefenamic acid polymorphs with optimized dissolution properties, potentially enhancing its pharmacological performance and also provides a promising approach to improving the bioavailability of poorly soluble drugs, offering significant implications for pharmaceutical formulation development.
KULIAH KERJA NYATA UNIMAR 2025: IMPLEMENTASI PENGABDIAN MASYARAKAT BERDAMPAK DI KECAMATAN CISOKA, KABUPATEN TANGERANG Rohimah, Anni; Rasydy, La Ode Akbar; Naim, Abu; Gumilar, Yogi; Rosidawaty, Rosidawaty; Aminudin, Dindin; Setiani, Nurul; Supriyanta, Jaka; Setiawan, Abdul Aziz; Dadang, Dadang; Utami, Fitria Budi; Atmaja, Sena
Jurnal Abdi Insani Vol 13 No 1 (2026): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v13i1.2986

Abstract

Fiels Study and Community Service Program is the realization of community service by Unimar students and lecturers in rural community development. Unimar's 2025 Fiels Study and Community Service Program was conducted in four villages in Cisoka District, namely Jeungjing, Cisoka, Caringin, and Bojong Loa. The scope of activities carried out included education, health, social, and religious fields. The objective of Unimar's Fiels Study and Community Service Program activities is to train students' soft skills so they can have a positive impact on the community. The activity was opened by the Regent of Tangerang and the release was carried out by the Cisoka Subdistrict Head. The method used was participatory, involving the community. The programs carried out included education, social, health, MSME empowerment, and simple technological innovations. The output of Fiels Study and Community Service Program was to show an increase in community participation in maintaining environmental health, awareness of stunting prevention, and strengthening collaboration between students and villagers. The Fiels Study and Community Service Program program is a tangible manifestation of campus-community synergy in achieving Sustainable Development Goals (SDGs) 3 (Good Health and Well-being) and 6 (Clean Water and Sanitation). The outcomes of the service program include the availability of supporting facilities for waste management and sanitation.
Co-Authors Abu Naim Aminudin, Dindin Anni Rohimah Atmaja, Sena DADANG DADANG Damayanti, Hilda Fitria Budi Utami Nurul Setiani Rasydy, La Ode Akbar Rosidawaty Rosidawaty Satrio, Erza Setiawan, Abdul Aziz Yogi Gumilar