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All Journal Jurnal SOLMA Jurnal Farmamedika (Pharmamedica Journal) Mobile and Forensics Jurnal Aisyah : Jurnal Ilmu Kesehatan Molekul: Jurnal Ilmiah Kimia Borneo Journal of Pharmacy
Setiawan, Abdul Aziz
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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ANALISIS KADAR ASAM KLOROGENAT PADA EKSTRAK ETANOL 96% KULIT BUAH KOPI ROBUSTA (Coffea canephora) MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Setiawan, Abdul Aziz; Imaniar, Nina; Rustandi , Adam
Jurnal Farmamedika (Pharmamedika Journal) Vol 10 No 1 (2025): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v10i1.419

Abstract

Kulit biji kopi merupakan limbah dari hasil produksi bubuk biji kopi yang dijadikan minuman yang kini banyak digemari oleh banyak orang, kulit biji kopi memiliki manfaat untuk tubuh manusia antara lain sebagai antidiabetes dan antioksidan karena senyawa asam klorogenat yang terkandung dalam kulit biji kopi. Penelitian ini dilakukan untuk mengetahui karakteristik kulit biji kopi dan kadar asam klorogenat yang terkandung dalam kulit biji kopi robusta (Coffea canephora). Karakterisitik yang di lakukan pada kulit biji kopi robusta antara lain uji kadar air pada simplisia, rendemen ekstrak, uji tingkat keasamaan pada ekstrak, uji oranoleptik pada ekstrak, dan skrining fitokimia pada ekstrak. Kemudian dilakukan pengukuran kadar asam klorogenat menggunakan spektrofotometri UV-Vis. Hasil dari uji karakteristik, kadar air yang terkandung dalam simplisia sebesar 8,5%, rendemen ekstrak sebesar 10,73% dengan ekstrak yang diperoleh sebanyak 64,43 gram, tingkat keasaman sebesar 4,10. Organoleptisk ekstrak memiliki bentuk cairan kental, berwarna hitam kecoklatan, dan memiliki bau khas kopi, senyawa metabolit skunder yang terkandung antara lain alkaloid, flavonoid, tanin, terpenoid, dan saponin. Kadar asam klorogenat yang terkandung dalam ekstrak kulit biji kopi robusta dengan rata – rata sebesar 15,32%. Kata kunci: Asam Klorogenat, Ekstrak, Kulit biji kopi robusta (Coffea canephora), Spektrofotometri UV-Vis.
Antibacterial activity test of 70% ethanol extract on leaves katuk (Sauropus androgynous (L.) Merr.) against Klebsiella pneumoniae bacteria Setiawan, Abdul Aziz; Fhatonah, Nuriyatul; Wahyuni, Arinda
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.2850

Abstract

Bacteria Klebsiella pneumoniae known as reason infection channel breathing lower I with symptoms of cough and difficulty breathing. Klebsiella pneumoniae is a gram-negative bacterium from the Enterobactericeae family, non-motile, short rod-shaped and facultative anaerobic which can result in infection channel urine, infection breathing And bacteremia especially in individual whose immune system is weak. One of the herbal plants with active ingredients that have antibacterial properties is katuk leaves. Katuk leaves have the ability to inhibit growth bacteria Because contain compound saponins, flavonoid And tannin. The study aims to determine the antibacterial activity and the best concentration of 70% ethanol extract of katuk leaves against Klebsiella pneumoniae bacteria. The cup-plate or well method was used with concentrations of 100%, 70%, 40%, 10%, ciprofloxacin as K+ and aquadest as K-.It was found that 70% ethanol extract of katuk leaves has antibacterial activity against Klebsiella pneumoniae bacteria. The conclusion of this study was that the most optimum antibacterial activity at a concentration of 100% with an inhibition zone diameter of 7.69 mm was classified as a moderate growth inhibition response category.
Formulation and Evaluation of Antioxidant Activity of Instant Granules from 70% Ethanol Extract of Single Black Garlic (Allium sativum L.) Setiawan, Abdul Aziz; Yuniarto, Ari; Taptajani, Emir Rizky
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.9059

Abstract

Free radicals contribute to various diseases by inducing oxidative stress. Single black garlic (Allium sativum L.) is recognized for its phenolic compounds, which possess radical-scavenging properties. This study aimed to develop and evaluate instant granules containing black A. sativum extract for their antioxidant activity and physicochemical characteristics. An instant granule formulation was developed using a 70% ethanol extract of a single black A. sativum, with three distinct formulas containing 5%, 7.5%, and 10% extract (Formulas 1, 2, and 3, respectively). The granules were subjected to comprehensive physical quality assessments, including organoleptic properties, moisture content, angle of repose, flow rate, dissolution time, and tapped density. Antioxidant activity was quantified using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, reporting IC50 values. All instant granule formulations successfully met the established physical quality requirements across all evaluated parameters. Furthermore, the antioxidant activity demonstrated a concentration-dependent effect, with IC50 values of 119.576 ppm for Formula 1, 82.000 ppm for Formula 2, and 59.962 ppm for Formula 3. This study confirms that instant granules formulated with a single black A. sativum extract exhibit significant antioxidant potential and possess desirable physical characteristics, indicating their promise as a natural antioxidant supplement.
Edukasi Pengenalan Dan Pengendalian Bahaya Potensial Pekerjaan Pada Guru SD Muhammadiyah 16 Dan 15 Bukit Duri Mawanti, Wening Tri; Harahap, Roito Elmina Gogo; Yati, Kori; Setiawan, Abdul Aziz; Khoirunisa, Irbah; Intan, Annisa; Abdulloh, Abdulloh
Jurnal SOLMA Vol. 14 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i2.15248

Abstract

Background: Upaya penerapan Keselamatan dan Kesehatan Kerja di sekolah melalui edukasi pengenalan dan pengendalian bahaya potensial terutama bagi para guru penting dilakukan agar proses belajar-mengajar tidak terhambat yang diakibatkan oleh guru yang cidera atau sakit. Meningkatkan pengetahuan setiap guru tentang berbagai bahaya potensial pekerjaannya dan mampu melakukan langkah pengendalian terhadap bahaya potensial yang ditemukan. Metode: Metode yang digunakan adalah penyuluhan atau edukasi ceramah dengan penyajian materi selama 30 menit, diikuti diskusi tanya jawab. Peserta yang terlibat adalah guru SD Muhammadiyah 16 dan 52 Bukit Duri. Peningkatan pengetahuan diukur dengan melakukan pre-tes sebelum ceramah dan dilakukan post-test setelah ceramah. Hasil pre-test dan post-test dilakukan analisis menggunakan program IBM SPSS Statistic 24 metode uji paired T-test. Hasil: Nilai Korelasi antara 2 variabel pretest dan posttest responden penyuluhan “Edukasi Potensi Bahaya Keselamatan dan Kesehatan Kerja Guru di SDN Muhammadiyah 16 dan 52 Bukit Duri” sebesar 0,632, artinya terdapat hubungan yang hubungan kuat dan positif. Nilai probabilitas/p value uji T Paired sebesar 0,027, artinya terdapat perbedaan antara sebelum dan sesudah perlakuan, sebab nilai p value < 0,05 (95 % kepercayaan). Kesimpulan: Edukasi pengenalan dan pengendalian bahaya potensial pekerjaan efektif dalam meningkatkan pengetahuan Guru SD Muhammadiyah 16 dan 52 Bukit Duri.
Identification of Antibacterial Compounds in Black Garlic against Salmonella typhimurium using HPLC-Fingerprinting and Chemometrics Abiyyuddin, M. Farras; Rahayu, Winiati P; Yuliana, Nancy Dewi; Setiawan, Abdul Aziz; Anggraeni, Ririn; Marwanta, Edy; Marasabessy, Ahmad
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.11378

Abstract

ABSTRACT. Black garlic is an aged product derived from fresh garlic and exhibits potential antibacterial properties. This study aims to identify the antibacterial compounds in black garlic against Salmonella typhimurium using HPLC fingerprinting and chemometrics. The antibacterial activity of the n-hexane fraction, methanol fraction, and water fraction were analyzed using the well diffusion method. Only the water fraction exhibited an inhibitory zone against S. typhimurium of 11.96 ± 1.86 mm. The chemical profile of each fraction, analyzed by HPLC-MWD, was correlated with antibacterial activity data using Orthogonal Projection to Latent Structure. A retention interval of 2.50 – 2.99 and 2.00 – 2.49 minutes of the water fraction at a wavelength of 214 nm demonstrated a correlation with antibacterial activity. The peaks identified in HPLC-MWD at a retention interval of 2.50 – 2.99 and 2.00 – 2.49 minutes exhibited a similar pattern to the peaks appearing at a retention time of 1.12 and 1.06 minutes on the UHPLC-Q-Orbitrap-HRMS chromatogram. The resultant peak in the UHPLC-Q-Orbitrap-HRMS analysis of the water fraction indicated that it was attributed to S-allyl cysteine and S-allyl mercaptocysteine. Keywords: black garlic, metabolomics, S-allyl cysteine, S-allyl mercapto cysteine
Forensic Analysis of Mobile Application Security Using the IDFIF v2 Framework Setiawan, Abdul Aziz; Sutanto, Imam
Mobile and Forensics Vol. 7 No. 1 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v7i1.12660

Abstract

Mobile application security has become an important issue in the midst of increasing cyber attacks, especially on the Android platform. This research aims to analyse the vulnerability of mobile applications using the Integrated Digital Forensics Investigation Framework (IDFIF) version 2 framework with a focus on the Laboratory Process stage. The tool used is Mobile Security Framework (MobSF) for static and dynamic analysis, supported by Genymotion emulator.The results show that the tested application has several vulnerabilities, such as malicious permissions (READ_EXTERNAL_STORAGE and WRITE_EXTERNAL_STORAGE), the use of v1 signature schemes that are vulnerable to Janus attacks, as well as the ability to manipulate the application through bypass debugging. However, no vulnerabilities were found in the SSL Pinning process. These findings provide important insights into security mitigation measures, such as removing malicious permissions, updating certificate mechanisms, and encrypting sensitive data.The application of IDFIF v2 in this investigation demonstrates its effectiveness in systematically detecting and analysing mobile application vulnerabilities, contributing to the development of better security protocols in the future.
Co-Authors Abdulloh Abdulloh Abiyyuddin, M. Farras Ahmad Marasabessy, Ahmad Edy Marwanta, Edy Fhatonah, Nuriyatul Harahap, Roito Elmina Gogo Imaniar, Nina Intan, Annisa khoirunisa, irbah Kori Yati Mawanti, Wening Tri Nancy Dewi Yuliana Ririn Anggraeni Rustandi , Adam Sutanto, Imam Taptajani, Emir Rizky Wahyuni, Arinda Winiati P Rahayu Yuniarto, Ari