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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Aplikasi dan Inovasi Iptek (JASINTEK) Jurnal Ilmiah Medicamento Poltekita: Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy
Herleeyana Meriyani
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Economics, Econometrics & Finance Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Other

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Association Between Antibiotic Consumption and Pseudomonas aeruginosa Non-Susceptibility: A Five-Year Ecological Study at Bali Regional General Hospital Dwi Arymbhi Sanjaya; Herleeyana Meriyani; Rr. Asih Juanita; Nyoman Budiartha Siada; I Putu Yudistira Mahaputra
Jurnal Ilmiah Medicamento Vol 12 No 2 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i2.14763

Abstract

Background: Pseudomonas aeruginosa is a major cause of healthcare-associated infections (HAIs), which are difficult to eradicate because of the bacterium’s intrinsic and acquired resistance mechanisms. However, evidence regarding the association between hospital antibiotic consumption and antimicrobial resistance remains inconsistent.Objective: This study determines the association between systemic antibiotic consumption and P. aeruginosa non-susceptibility using five years of hospital surveillance data.Methods: A retrospective ecological study was conducted using surveillance data from Bali Regional General Hospital between January 2019 and December 2023. The relationship between antibiotic consumption [defined as daily doses (DDD) per 100 patient-days] and resistance was analyzed by a generalized linear model in which the number of non-susceptible isolates was used as the dependent variable. Moreover, antibiotic consumption, the bed occupancy rate (BOR), the calendar year, and the antibiotic agent (with meropenem taken as the reference category) were used as independent variables.Results: The study included 77 P. aeruginosa isolates and 35 antibiotic-year observations. No statistically significant association was found between antibiotic consumption and non-susceptibility (OR 1.049, 95% CI 0.980–1.122; p = 0.168) or between BOR and non-susceptibility (OR 1.024, 95% CI 0.992–1.057; p = 0.152). Calendar year was inversely associated with the modeled non-susceptibility outcome (OR 0.716, 95% CI 0.592–0.866; p < 0.001). Ceftazidime and cefepime had higher odds of non-susceptibility than meropenem.Conclusion: Antibiotic consumption does not fully explain P. aeruginosa non-susceptibility. Factors such as antibiotic-specific resistance mechanisms and infection prevention and control practices might also have a role in the differences in non-susceptibility.
Co-Authors Ciptawati, Ni Wayan Dwi A. Sanjaya Dwi Arymbhi Sanjaya Fitria Megawati Fredinan Yulianda I Made Agus Sunadi Putra I Putu Yudistira Mahaputra I Wayan Maysa Yudiartha Kadek Suryawan Kamalia, Made Gek Adisti Ketupapa, Florentina Gabriela Ketut Agus Adrianta Komang Triani Lestari Lusy Noviani Made Elvenia Ambara Damayanti Made Gek Adisti Kamalia Mahaputra, I Putu Yudistira Mahaputra, Yudistira Megawati, Fitria Ni Kadek Ayu Sartikawati Ni Kadek Sukertiasih Ni Made Dharma Shantini Suena Ni Nyoman Wahyu Udayani Ni Putu Nadya Kirana Wulandari Ni Putu Udayana Antari Ni Wayan Ciptawati Ni Wayan Sutariani Nurul Chusna Nyoman Ayu Prascitasari Nyoman B. Siada Nyoman Budiartha Siada Putra, I Made Agus Sunadi Putu Sukma Purnamasari Rr Asih Juanita Rr Asih Juanita Rr Asih Juanita Rr. Asih Juanita RR. Asih Juanita SARTIKAWATI, NI KADEK AYU Siluh Putu Astini Triska Ananda Rahayu Wardani, I Gusti Agung Ayu Kusuma Wintariani, Ni Putu Woro Enjang Santi Prihatin