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All Journal Jurnal Tumbuhan Obat Indonesia Biota Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi Pharmed: Journal of Pharmaceutical Science and Medical Research Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Sains dan Kesehatan

Weka Sidha Bhagawan

Universitas PGRI Madiun

Author-ID : 3163814

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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OPTIMIZATION AND QUERCETIN RELEASE TEST OF MORINGA LEAF EXTRACT (MORINGA OLEIFERA) IN GEL-MICROEMULSION PREPARATION Bhagawan, Weka Sidha; Atmaja, Ria Ramadhani Dwi; Atiqah, Sri Nur
Journal of Islamic Pharmacy Vol 2, No 2 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i2.4508

Quercetin is a flavonoid compound of the flavonol group that has various biological activities for health. Moringa leaf is one of the plants rich in quercetin which is about 384.61 mg / 100 g. Quercetin is practically insoluble (4.5 Î¼g / mL). To increase the solubility and release of quercetin microemulsion may be used as Drug Delivery Systems formulated with gels for transdermal use.The aim of this research is to obtain optimum combination formulation of surfactant (tween 80): cosurfactant (propylene glycol) to form optimal microemulsion system, to find out the characteristics of the preparation and to find out the rate of quercetin release of Moringa leaf extract (M. oliefera) in a gel-microemulsion preparation compared with a control gel (without microemulsion) using an HPMC (Hydroxypropyl methylcellulose) gel basis.The result shows that optimal concentration tween 80 comparison : propylene glycol to form optimal microemulsion system up to 30%: 20 % with VCO (virgin coconut oil) oil phase 5%. The characteristics observed including organoleptic, pH, viscosity, and stability are showing optimal condition. The average of quercetin content in gel-microemulsion preparation was 2,22 Â± 0,077 ppm and on control gel was 2.37 Â± 0.042 ppm. Quercetin release test using Franz diffusion cell using cellophane membrane, saline phosphate buffer pH 7,4 Â± 0,05 and temperature 37 Â± 0,5 Â°C for 6 hours. The average quercetin release flux in the gel-microemulsion preparation was 9.436 Â± 1.178 (Î¼g/cm 2/min1/2) and the control gel was 5,816 Â± 0.485 (Î¼g/cm2/min1/2).Based on these results it can concluded that the microemulsion gel preparation gives significant difference of quercetin flux rate compared with gel preparation.Â Keywords: Quercetin, Gel-Microemulsion, quercetin release, moringa leaf extract (Moringa oliefera)

OPTIMIZATION OF CARBOPOL 940 AND OLEIC ACID IN DICLOFENAC SODIUM BASE GEL USING FACTORIAL DESIGN 22 METHOD Rahmawati, Eka Diana; Bhagawan, Weka Sidha; Rizkiah, Fidia
Journal of Islamic Pharmacy Vol 3, No 1 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i1.4993

The aim of the present study was to determine the effect of carbopol 940, oleic acid and interaction of both in the value of viscosity and release rate and to find optimum formula of diclofenac sodium base gel which can produced viscoisity between 20 dPa.s - 200 dPa.s and rate release 50Î¼g/cm2.menit1/2 - 150Î¼g/cm2.menit1/2 using factorial design 22. The level of carbopol 940 were 1,3% and 0,8% while the level of oleic acid were 5% and 20%. Analysis of the research used Design Expert 10 software.The results showed that carbopol 940 and oleic acid had significant effect in determining the viscosity response and the release rate. The addition of carbopol 940 and oleic acid l increased the viscosity response and the addition of carbopol 940 and oleic acidÂ decreased the release flux response. There were 100 optimum compositions of combination of carbopol 940 between 0.8% to 1,194% and oleic acid between 5% and 19.95% which can be used to obtain sodium diclofenac base gel preparation with viscosity responses between 76,042 dPa.s -199,570 dPa.s and flux release responses from 101,000 Î¼g/cm2.minute1/2 until 124,250 Î¼g/cm2.minute1/2.

ANTICANCER ACTIVITIES AND METABOLITE FINGERPRINTING OF UPLC-QToF-MS/MS METHOD FROM Chrysanthemum cinerariifolium (Trev) Listiyana, Anik; Lestari, Nia Ayu; Irawati, Santia; Indrawijaya, Yen Yen Ari; Annisa, Rahmi; Bhagawan, Weka Sidha; Mutiah, Roihatul; Ma'arif, Burhan
Journal of Islamic Pharmacy Vol 4, No 1 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i1.7728

Chrysanthemum cinerariifolium (C. cinerariifolium) is an empirically proven medicinal plant that has anticancer activities. This study aimed to profile metabolites, and cytotoxic activity of root, leaf, stem, and root extracts C. cinerariifolium on T47D cells and to determine the correlation of metabolite content with cytotoxic activity. The metabolite profile was carried out using UPLC-QToF-MS / MS, and cytotoxic activity was carried out using the MTT method. The results obtained in the form of a chromatogram were processed with the application Masslynk so that a metabolite profile data obtained. The data is then analyzed statistically using Principal Component Analysis (PCA). The results obtained on metabolite profiling showed that there were differences in metabolite profiles in the roots, stems, leaves, and chrysanthemums. The characteristic compounds in the flower section are D - (-) - Morphine and in the leaf part of genistein Â and N - [(5-Chloro-1,2,3-thiadiazol-4-yl) methyl] -1- (2-isopropyl-4 -methyl-1,3-thiazol-5-yl) -N-methyl ethanolamine. The major compounds in the roots, stems, and leaves are Orphenadrine with successive percentages of 9.11%, 10.16%, and 3.24%, and the major compounds in the flower section are D - (-) - Morphine with a percentage of 10, 86%. Furthermore, the results of the cytotoxic activity test showed differences in anticancer cytotoxic activity in the parts of the flower, leaf, stem, and root of C. cinerariifolium. Besides, there is a relationship between the metabolite content and anticancer cytotoxic activity of each part of C. cinerariifolium. The higher the level of orphenadrine compounds in the plant, the higher the potential for anticancer.Â Keywords: C. cinerariifolium, UPLC-QToF-MS/MS, T47D cells.

CYTOTOXIC ACTIVITY AND PHYSICOCHEMICAL PROPERTIES OF GENDARUSIN A-E COMPOUNDS ON ESTROGEN ALFA RECEPTORS (2JF9) Indrawijaya, Yen Yen Ari; Octavia, Nur Ika; Mutiah, Roihatul; Bhagawan, Weka Sidha; Ma'arif, Burhan
Journal of Islamic Pharmacy Vol 4, No 1 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i1.9037

Estrogen Alfa (ERÎ±) is a receptor used as the main marker to identify the presence of tumors in the breast.compounds Gendarusin A-E have anticancer activity by inhibiting the poliferation of cancer cells and inducing apoptosis. The purpose of this research are to predict the cytotoxic activity, physicochemical properties, and toxicity of the gendarusin A-E compound. The predictions of physicochemical properties were tested in compliance with the Five Lipinski Rules and the results of the ADME process (absorption, distribution, metabolism, and excretion) using the application pkCSM Online tool. Prediction of cytotoxic activity using Molegro Virtual Docker (MVD) by validating receptors and molecular docking. Cancer receptor protein used in Estrogen Alfa with PDB code 2JF9. Toxicity prediction using the Protox II Online tool. The results of this study indicate that the Gendarusin A-E compound didnâ€™t completed the Five Lipinski Rules. Gendarusin A-E compounds had activity against receptors Estrogen Alpha which is shown by the results of RMSD 2 and Gendarusin A compounds had the smallest Rerank Score of -70.9817 compared to other compounds. Gendarusin B compound had the highest LD50Â 1212 mg / kg and classified in grade 4.

Pendekatan Etnofarmasi Tumbuhan Obat Imunomodulator Suku Tengger Desa Ngadas, Kabupaten Malang, Indonesia Bhagawan, Weka Sidha; Aziz, Yaya Sulthon; Teguh Pamungkas, Rizki Putra
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10290

Background: Ethnopharmaceutical is an approach that is emphasized to explore and inventory the local knowledge of an ethnic community or group about the use of a substance for treatment. The Tengger tribe is one of the tribes in Indonesia that still maintains knowledge of medicine from their ancestors.This study documents medicinal plant species and traditional knowledge related to the immunomodulators of the Tengger tribe who inhabit Ngadas village in TNBTS, Indonesia.Methods: This study uses the Snowball Sampling method which begins with the determination of the key sample with purposive sampling. Furthermore, the data were analyzed by UV, ICF, and FL.Results: This study documented 21 types of traditional medicinal plants belonging to 18 families used to treat 8 types of diseases of the human immune system. The data collection on the 10 selected immunomodulatory medicinal plants showed that the leaves, decoction, and oral use were the highest yields.Conclusion: Use Value, Informant Consensus Factor, and Fidelity Level value of recorded immunomodulatory medicinal plant species will provide a phytochemical basis reference in the discovery of new active compounds in the future and conservation practices In this regard, it is necessary to pay attention to the conservation of traditional medicinal plants and indigenous knowledge related to medicine in the Tengger tribe of Ngadas Village to preserve them in the future.

Metabolite Profiling of Eleutherine palmifolia (L.) Merr. By HPTLC-Densitometry and its Correlation with Anticancer Activities and In Vitro Toxicity Mutiah, Roihatul; Hadya, Chorida Muhjatul; Ma'arif Z.A, Burhan; Bhagawan, Weka Sidha; Annisa, Rahmi; Indrawijaya, Yen Yen Ari; Huwaida, Fadhila Isma; Ramadhani D.A., Ria; Susilowati, Retno; Taufik, Imam
Indonesian Journal of Pharmacy Vol 30 No 3, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Eleutherine palmifolia (L.) Merr. (E. palmifolia) is a plant that used as raw material for herbal medicines. The difference of growing location the medicinal plants affects the difference of metabolite content, It also affects the pharmacological activity and toxicity of the plant. This study aims to determine the profile of metabolites (metabolite fingerprinting), anticancer profiles, toxicity/safety profiles from several different regions in Indonesia for the purpose of authentication, efficacy, safety and quality control of these plants. Samples were sampled from 6 different locations in Indonesia, they were West Java, Central Java, East Java, East Borneo, Central Borneo, and South Borneo. Metabolite fingerprinting was determined by HPTLC-densitometry method, the profile of anticancer activity and toxicity was known by the MTT-ELISA method. The difference between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Principal Component Analysis (PCA) and Hierarchical Component Analysis (HCA). Whereas the relation between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Partial Least Square (PLS). The results of the metabolite profile analysis with PCA showed that E. palmifolia from 6 different locations gave different metabolite profiles and there were 3 metabolites that had a significant effect on cluster formation. samples are Rf 055, 059, and 044. The results of the HCA analysis showed that the 6 regions are in one cluster the same one. The analysis of PLS-DA showed that the metabolites for anticancer activity are found in Rf 059, 076, 093 and Rf 034. While the metabolites for toxicity are Rf 002, Rf 044 and Rf 059.

FORMULATION AND CARACTERIZATION OF QUERCETIN NIOSOME WITH CONCENTRATION VARIATIONS OF SPAN 20 SURFACTANT Weka Sidha Bhagawan; Rahmi Annisa; Atiza Fajrin Maulidya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Quercetin has low solubility, absorption and bioavailability which limits its practical use as a drug or supplement. Therefore, it is important to formulate a quercetin niosome system with various concentrations of span 20 as a surfactant. This investigation aimed to formulate and analyse a quercetin niosome preparation with span 20 variations to provide optimal quercetin solubility. Niosomes were prepared using various concentrations of span 20. In the present study, the quercetin niosome used the reverse phase evaporation (RPE) method. Quercetin niosome is characterised by its organoleptic properties, pH value, particle morphology comprising the particle shape and size, and encapsulation efficiency. Organoleptic observations of the quercetin niosome included a yellow colour, distinctive quercetin odour and thick consistency for all formulas. The pH remained within the physiological pH range of skin. Quercetin niosome morphology was close to spherical while the niosome particle size results were 2.13 µm (F1), 2.99 µm (F2) and 3.31 µm (F3). The quercetin niosome encapsulation efficiency results were 81.86 ± 0.47% (F1), 84.02 ± 0.26% (F2) and 88.24 ± 0.10% (F3). Quercetin niosome were successfully prepared using multiple span 20 concentrations below the cholesterol concentration characterised by the measurement results of organoleptic, pH, particle morphology and encapsulation efficiency.

Metabolite Fingerprinting Eleutherine palmifolia (L.) Merr. Using UPLC-QTOF-MS/MS Roihatul Mutiah; Weka Sidha Bhagawan; Burhan Ma'arif; Jauhar Maknun Septaza Rahmandika
Majalah Obat Tradisional Vol 24, No 3 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.44883

Eleutherine palmifolia (L.) Merr. (E. palmifolia) is an Indonesian native plant that has the potential to be developed into phytopharmaca. The differences in growth locations are thought to cause variation in the content of metabolite compounds which affect differences in pharmacological activity. This study aims to determine the profile of metabolites E. palmifolia bulb from several regions in Indonesia. The samples were collected from six different locations, namely East Java, Central Java, West Java, East Borneo, Central Borneo, and South Borneo. Sample extraction was carried out using Ultrasonic Assisted Extraction (UAE) method with 96% ethanol. The analysis of the content of metabolites was carried out using UPLC-QTOF-MS/MS with a stationary phase column C18 (Okta Decyl Silica), mobile phase mixture of formic acid /water 0.1/99.9 (v/v), and formic acid/acetonitrile 0,1/99,9 (v/v). The results of the analysis were interpreted using software Masslynx and continued with chemometric analysis using the method Principle Component Analysis (PCA). The results showed that there were differences in the content of the metabolite compounds in E. palmifolia bulb originating from six different regions.

PENDEKATAN ETNOBOTANI TUMBUHAN OBAT UNTUK PERMASALAHAN SEKSUAL SUKU TENGGER DI DESA ARGOSARI, LUMAJANG, INDONESIA Weka Sidha Bhagawan; Ubaidillah Abdel Barsyaif; Mochammad Amrun Hidayat
Jurnal Tumbuhan Obat Indonesia Vol 14 No 2 (2021): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v14i2.4169

ABSTRACT The people of Tengger in Argosari village receive their knowledge of traditional medicine from their ancestors. This traditional knowledge is inherited and subsequently preserved across generations. This ethnobotanical medicinal plant study began with the participation observatory method and interviewed 28 local Tenggerese people who were selected by purposive and snowball sampling. Ethnobotanical data were analyzed to understand the proportion of cited plants. The analysis was calculated to obtain species use-value (SUV), family use-value (FUV), and fidelity level (FL). We have inventoried 16 species of plants belonging to 9 families to treat five types of sexual problems. The result showed that Piper betle L. had the highest SUV (1.21). Zingiberaceae was recorded as the largest family (6 plant species) with high FUV (0.69). Rhizome (47,06%) and leaves (41.18%) are the most dominant parts used as ingredients in traditional medicine. The majority of Argosari villagers prepare medicinal plants by decoction techniques (94.12%), then use them orally (94.12%). Pimpinella pruatjan Molkenb. (purwoceng) that is used for aphrodisiac has the highest FL value (78.57%). So it has the potential to be developed related to its pharmacological effects and the content of its active secondary metabolites. Since P. pruatjan is categorized as rare and protected species, so it requires a policy on its use as raw material for traditional medicines. Keywords: Ethnobotany, Medicinal plants, Sexual problems, Tengger tribe, Argosari Village. ABSTRAK Masyarakat suku Tengger di desa Argosari mendapatkan ilmu pengobatan tradisional dari nenek moyang mereka. Pengetahuan tumbuhan obat ini diwariskan dan selanjutnya dilestarikan dari generasi ke generasi. Pendekatan etnobotani tumbuhan obat ini dimulai dengan metode participation observatory dan mewawancarai 28 masyarakat lokal suku Tengger yang diseleksi secara purposive dan snowball sampling. Analisis data etnobotani digunakan untuk memahami proposi tumbuhan yang tersitasi, yaitu: species use-value (SUV), family use-value (FUV), dan fidelity level (FL). Studi ini telah berhasil menginventarisasi 16 spesies tumbuhan yang termasuk dalam 9 famili untuk pengobatan 5 jenis penyakit permasalahan seksual. Sirih (Piper betle L.) memiliki SUV tertinggi yaitu 1,21, sedangkan Zingiberaceae terdata sebagai famili terbanyak (6 spesies tumbuhan) dengan FUV tertinggi (0,69). Rimpang (47,06%) dan daun (41,18%) merupakan bagian yang dominan digunakan sebagai bahan obat tradisional. Mayoritas masyarakat desa Argosari mempreparasi tumbuhan obat tersebut dengan tehnik dekokta (94,12%), selanjutnya menggunakannya secara oral (94,12%). Pimpinella pruatjan Molkenb. (purwoceng) yang berfungsi sebagai tumbuhan afrodisiak memiliki nilai FL tertinggi (78,57%), sehingga sangat berpotensi dikembangkan terkait efek farmakologis dan kandungan metabolit sekunder aktifnya. P. pruatjan termasuk dalam spesies langka dan dilindungi sehingga memerlukan kebijakan dalam pemanfaatannya sebagai bahan baku ramuan obat tradisional. Kata kunci: Etnobotani, Tumbuhan obat, Permasalahan seksual, Suku Tengger, Desa Argosari.

Uji Aktivitas Antibakteri Tumbuhan Caesalpinia sappan L Berdasarkan Studi Etnobotani Di Hutan Lereng Gunung Wilis Pada Bakteri Shigella dysenteriae Lisniawati Lisniawati; Weka Sidha Bhagawan; Arum Suproborini
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 4, No 2 (2021)
Publisher : Universitas PGRI Madiun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/pharmed.v4i2.10292

Masyarakat di Indonesia telah memanfaatkan teknik pengobatan tradisional sejak dahulu. Hasil dari studi etnobotani salah satu tanaman yang digunakan sebagai obat tradisional adalah tanaman kayu Secang (Caesalpinia sappan L). Tanaman kayu Secang (Caesalpinia sappan L) merupakan salah satu obat tradisional yang tidak hanya di manfaatkan sebagai seduhan minuman melainkan mengobati berbagai penyakit karena tanaman kayu secang memiliki kandungan kimia flavonoid, brazilin, alkaloid, saponin,tanin, fenil propane, dan terpenoid. Tujuan dari penelitian ini adalah untuk menguji aktivitas antibakteri kayu secang (Caesalpinia sappan L) dan sebagai langkah awal penemuan obat baru. Penelitian ini adalah penelitian kuantitatif dengan metode eksperimental laboratorium yang menggunakan rancangan True Experimental post test control design dengam pengujian antibakteri dengan menggunakan metode difusi sumuran. Hasil penelitian ini menunjukan bahwa semua konsentrasi 2,5 mg/ml, 5 mg/ml, 10 mg/ml, 20 mg/ml, 40 mg/ml ekstrak etanol kayu secang Caesalpinia sappan L memiliki aktivitas antibakteri pada bakteri Shigella dysenteriae. pada konsnetrasi 40 mg/ml memiliki nilai rata-rata tertinggi yaitu 14,36 mm. Berdasarkan uji one way anova, menunjukan adanya pengaruh aktivitas antibakteri pada bakteri Shigella dysenteriae dengan nilai sig 0,00 (a <0,05). Hal ini menunjukan adanya perbedaan aktivitas antibakteri tumbuhan kayu secang (Caesalpinia sappan L) pada berbagai konsentrasi.

Co-Authors . Waris Agnis Pondineka Ria Aditama Aissyah Nurfatma Amaranto, Jennifer Anik Listiyana Annisa, Rahmi Arum Suproborini Arum Suproborini Asri Wido Mukti Asti Rahayu Atiqah, Sri Nur Atiza Fajrin Maulidya Bhagawan, Weka Burhan Ma'arif Burhan Ma’arif Cicilia Novi Primiani Cicilia Novi Primiani Devi Safrina Dewi Ratih Tirto Sari Dian Susanti Donato, Percival Faisal Akhmal Muslikh Fidia Rizkiah Inayatilah Firsta Roisatul Islamiyah Hadya, Chorida Muhjatul Heni Pujiastuti Hison, Jade Huwaida, Fadhila Isma Irawati, Santia Izza Nailia Shirvi Jauhar Maknun Septaza Rahmandika Krisnamurti, Gabriella Chandrakirana Kurniawan Hidayat Perdana Putra Lestari, Nia Ayu Lisniawati Lisniawati M Bakti Samsu Adi Ma'arif Z.A, Burhan Ma'arif, Burhan Ma'arif, Burhan Mandalawati, Titin Maritha, Vevi Mochammad Amrun Hidayat Muhammad Evy Prastiyanto Norachuriya, Zedny Nur Rahmawati Wijaya Nurfatma, Aissyah Octavia, Nur Ika Peria, Jo Prasetyo, Yona Primiani, Cicilia Novi Primiani, Cicilia Novi Primiani Pujiati Pujiati Pujiati Putra, Aditya Dwi Permana Rahmawati, Eka Diana Rahmi Annisa Ramadhani D.A., Ria Ramdhani, Alfina Widya Retno Susilowati Ria Ramadhani Dwi Atmaja Rina Nurmaulawati Rivera, Alice Rizal Maarif Rukmana, Rizal Maarif Rizkiah, Fidia Roihatul Mutiah Roihatul Mutiah Safitri, Rusiana Yulia Santos, Gema Silfarohana, Rantika Suproborini, Arum Tanghal, Analiza Taufik, Imam Teguh Pamungkas, Rizki Putra Ubaidillah Abdel Barsyaif Yanuar Ashari Cahyaningrum Yaya Sulthon Aziz Yen Yen Ari Indrawijaya Zatalini, Dioni Zatalini, Dioni Fadia

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