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All Journal Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research IJOEP : International Journal of Ecophysiology
Keliat, Jane Melita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Journal : Indonesian Journal of Pharmaceutical and Clinical Research

 1 
ANTIFUNGAL OF SOKA FLOWER (Ixora Chinensis Lam.) ETHANOL EXTRACT AGAINST Candida albicans AND Pityrosporum ovale Keliat, Jane Melita; Sumayyah, Tengku
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.19926

Abstract

Pathogenic fungi are microorganisms that cause infectious diseases in humans and are capable of growing and developing in various environments. The types of fungi that most often cause skin infections are Candida albicans and Pityrosporum ovale. The soka flower plant (Ixora chinensis Lam.), commonly found in Indonesia, is known to have antibacterial properties. The antifungal strength of the soka flower comes from the natural chemicals in its ethanol extract, which stops the growth of Candida albicans and Pityrosporum ovale. The research method was conducted experimentally, which included stages such as the preparation of dry powder, characterization of dry powder, phytochemical screening both on dry powder and the ethanol extract of soka flowers, preparation of the ethanol extract, standardization of the extract, and evaluation of the antifungal activity of the ethanol extract against both types of fungi. The research results indicate that the minimum inhibitory concentration of the ethanol extract of the soka flower against Candida albicans is 5.5 mg/ml with an inhibition zone diameter of 8.8 mm ±0.05, while for Pityrosporum ovale, the minimum inhibitory concentration is 50 mg/ml with an inhibition zone diameter of 10.7 mm ±0.50. The statistical analysis from Kruskal-Wallis tests show a significant difference in the amounts of ethanol extract from soka flowers based on the size of the inhibition zones for Candida albicans and Pityrosporum ovale, with probabilities of 0.000 and 0.001, both of which are below 0.05.
EFFECT OF CASSAVA TUBER PROCESSING ON Candida albicans GROWTH ON MANIHOT DEXTROSE AGAR Patilaya, Popi; Sumantri, Imam Bagus; Keliat, Jane Melita
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.20763

Abstract

This study evaluated the effect of cassava tuber processing on Candida albicans growth on Manihot Dextrose Agar (MDA). The sliced cassava tubers were divided into three groups. G1 was milled and dried in an oven at 60°C. G2 was directly dried in the oven. G3 was milled without drying. Each group was soaked in distilled water (1,000 mL) for 15 min and filtered with a flannel cloth. The filtrate was oven-dried, then pulverized to obtain the cassava powder. The powder (8 g) was combined with dextrose (20 g) and agar (15 g). The mixture was suspended in distilled water (1,000 mL), boiled, and sterilized at 121°C for 15 min. The solution was placed into a petri dish and allowed to form agar media. The media derived from G1, G2, and G3 were considered as F1, F2, and F3. A suspension of C. albicans was cultured on the media and incubated for 48 h. The fungal growth was observed by calculating the viable colonies. The data were analyzed with one-way ANOVA and followed by Duncan’s test at the confidence level of 95%. The results showed that C. albicans grown on media F1, F2, and F3 had colony numbers of 128±2.08 x 105 cfu/mL, 64±5.57 x 105 cfu/mL, and 44±3.51 x 105 cfu/mL, respectively. Statistical analysis indicated a significant difference in the fungal growth on the three media (p < 0.05). This study proved that the processing methods of cassava tubers for MDA significantly affected the growth of C. albicans.
Co-Authors . Marianne Eka Nugraha, Sony Emil Salim Febiola P, Dian Kumar, Manan Maha, Hetty Lendora Marline Nainggolan Patilaya, Popi Siregar, Syifa Sabila Yassarah Sumantri, Imam Bagus Sumayyah, Tengku Togatorop, Grace Mutiara