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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Indonesia Sosial Sains Gunung Djati Conference Series Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Yulistiani
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Journal : jurnal farmasi dan ilmu kefarmasian indonesia

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Effect of Atorvastatin on Lipoprotein Lipase and Lipid Profile in Children with Refractory Nephrotic Syndrome and Hyperlipidemia Damayanti, Nurul; Yulistiani; Ninik Asmaningsih Soemyarso; Mariyatul Qibtiyah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.84-91

Abstract

Background: Statin are Food and Drug Administration (FDA)-approved for hyperlipidemia but remain controversial in children. This study provides novel evidence of the molecular effects of atorvastatin on lipoprotein lipase (LPL) in children with refractory nephrotic syndrome, a population in which such data are limited. Objectives: This study aims to evaluate the effects of atorvastatin on serum lipoprotein lipase (LPL) levels and lipid profile parameters in children with refractory nephrotic syndrome. Methods: Randomized controlled trial (RCT) double-blind study of 31 children with hyperlipidemia and refractory nephrotic syndrome, included pre- and post-test groups. A placebo was given to the first group (n = 18 patients), while atorvastatin was administered to the treatment group (n = 13 patients). Results: Total cholesterol and Low-Density Lipoprotein (LDL) levels decreased significantly after treatment in both groups (p<0.05). In the atorvastatin group, LDL reduction was more pronounced compared to baseline. High-Density Lipoprotein (HDL) and Triglyceride (TG) levels showed no significant changes in either group (p>0.05). Lipoprotein Lipase (LPL) levels increased in the atorvastatin group and decreased in the control group; however, these changes were not statistically significant. No significant differences were observed between the atorvastatin and control groups in terms of changes in lipid profile parameters and LPL levels (p>0.05). Conclusions: Atorvastatin reduced cholesterol and LDL levels within the treatment group, although no significant differences were observed compared to the control group.
Co-Authors Asmaningsih, Ninik Cotama, Cahana Rastra Damayanti, Nurul Dharliana Hardjowikarto Kuswandi, Nabila Aulia Yasmin Mariyatul Qibtiyah Ninik Asmaningsih Soemyarso Nur Permatasari, Andinny Pondawinata, Marizki Siti Khumayah