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Department Of Pharmacy, Faculty Of Pharmacy And Science UHAMKA, Jl. Delima II Klender Jakarta 13460, Indonesia
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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Tyrosinase Inhibition from Green Tea (Camellia sinensis (L.) Kuntze) gel Hanifah Rahmi; Supandi Supandi; Naniek Setiadi Radjab; Tiara Julianti
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.27145

Abstract

Green tea (Camellia sinensis (L.) Kuntze) leaf has polyphenol substance that able to inhibit tyrosinase enzyme. Tyrosinase enzyme is one of the essential components that can be initiated melanin formation on the skin (melanogenesis). The natural inhibitory enzyme can be utilized in cosmetics and medicinal industries as depigmentation agent. Green tea leaf was formulated in the dosage form of a gel with carbomer 934 as a gelling agent. This study aimed to determine the optimum concentration of carbomer 934 on green tea leaf extract gel that has an inhibitory tyrosinase activity. This research used three carbomer 934 concentration, there was 0.5%, 0.75%, and 1% respectively. Which every formula was evaluated during six weeks involve organoleptic, homogeneity, viscosity, pH, centrifuge, and freeze-thaw test (during six cycles). The optimum formula was evaluated tyrosinase activity used a spectrophotometer-vis. The results showed that the great concentration of carbomer 934 was contained on the first formula, which has not phase separation and 49.62 ppm of IC50 value. This research showed that green tea leaf extract gel with 0,5% carbomer 934 prevented tyrosinase activity. Keywords: Carbomer 934, gel, green tea leaf extract, inhibitory of tyrosinase
Co-Authors Andini Fikarda Ani Pahriyani Ani Pahriyani Anisa Amalia Dedi Hidayat Dwitiyanti Dwitiyanti Fith Khaira Nursal Frisca Ananda Dwi Cristina Hanifah Rahmi Harmita Harmita Isnaeni Isnaeni Khoerul Umam Kriana Efendi Laksmi Dewi Kasmiarno Lusi Putri Dwita Naniek Setiadi Radjab Nining, Nining Nonni Soraya Sambudi Oetari Anggun Larasati Pramulani Mulya Lestari Reforny Kristianti Gunawan Rizka Andalusia Rizky Arcinthya Rachmania Rizky Arcinthya Rachmania Siska Siska Slamet Slamet Tahyatul Bariroh Tiara Julianti Tri Wintolo Apoko Yahdiana Harahap Yeni Yeni Yeni Yulianindra Khalishah