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Journal : Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)

UJI AKTIVITAS ANTIOKSIDAN DAN SPF (Sun Protection Factor) LENDIR BEKICOT (Achatina fulica) MENGGUNAKAN SPEKTROFOTOMETER UV-VIS Suhesti, Iin; Setiyanto, Riyan; Islami, Nabila Nurhaliza; Anggia, Cinti
Media Farmasi: Jurnal Ilmu Farmasi Vol. 18 No. 2: September 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v18i2.21849

Abstract

Hewan bekicot (Achatina fulica) banyak dimanfaatkan sebagai pengobatan tradisional dan kosmetik karena mengandung protein achasin, acharan sulfat, zat beta aglutinin, asam hialuronat, enzim glikoprotein, proteoglycan, glycosaminoglycan dan allantoin. Tujuan penelitian ini yaitu untuk mengetahui aktivitas antioksidan dan tabir surya pada lendir bekicot menggunakan spektrofotometer uv-vis. Metode penelitian ini adalah eksperimental, menggunakan sampel lendir bekicot dengan konsentrasi 5%, 10%, dan 15%. Hasil skrining fitokimia diperoleh bahwa lendir bekicot mengandung senyawa metabolit sekunder berupa alkaloid, fenol, saponin, dan tanin. Berdasarkan hasil penelitian, aktivitas antioksidan lendir bekicot pada konsentrasi 5%, 10%, dan 15% memiliki nilai IC50 berturut-turut yaitu 83,63 ± 0,57 ppm; 57,93 ± 0,82 ppm; dan 31,59 ± 0,59 ppm dengan kategori kuat (IC50 50-100 ppm) dan kategori sangat kuat (IC50 < 50 ppm). Nilai SPF diperoleh berturut-turut yaitu 14,77 ± 0,42; 21,67 ± 0,06 dan 27,67± 0,59 dengan tipe proteksi maksimal (SPF 8-15) dan tipe proteksi ultra (SPF > 15). Berdasarkan analisis SPSS menggunakan One Way Anova diketahui bahwa variasi konsentrasi lendir bekicot berpengaruh signifikan terhadap hasil aktivitas antioksidan dan tabir surya sehingga dapat disimpulkan bahwa lendir bekicot memiliki aktivitas antioksidan yang dapat mencegah terbentuknya senyawa radikal bebas pada kulit dari dalam dan aktivitas tabir surya yang dapat melindungi kulit dari luar akibat radiasi sinar UV yang dipaparkan pada kulit setiap hari.
Formulation and anti-bacterial of liquid soap combination of Citronella (Cymbopogon nardus L. Rendle), Cinnamon (Cinnamomum burmanni Ness Ex Bi.), and Orange Lemon (Citrus lemon L.) Essential Oils on Staphylococcus epidermidis Nafisah, Umi; Suhesti, Iin; Albetia, Puput
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.22387

Abstract

The condition of our community in the midst of a pandemic makes us aware of the importance of cleanliness. One way to maintain cleanliness is to clean our self with soap. Cinnamon has antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis. Lemongrass has antibacterial activity against Staphylococcus aureus, while lemons are able to inhibit the growth of Staphylococcus epidermidis and Propionibacterium acnes bacteria. The aims of this study are to determine the formulation and physical stability of liquid soap with a combination of lemongrass, cinnamon, and lemon essential oils and to determine its antibacterial activity against Staphylococcus epidermidis. Physical evaluation of soap includes organoleptic, homogeneity, viscosity, pH, and specific gravity which is compared with SNI, and hedonic test is performed. Antibacterial test was performed against Staphylococcus epidermidis.The results of the study obtained homogeneous liquid soap preparations, thick liquid form, a yellow-orange color, distinctive smell of citronella. Specific gravity (g/ml) test results meet the requirements of SNI, which is between 1.01 – 1.10 at room temperature. The results of the pH test meet the requirements of SNI, which are between 8 – 11. The results of the viscosity (cPas) test show that there is an increase in viscosity from week 1 to week 6. The increase in viscosity is related to particle size during storage. The foam height (cm) test results obtained F1: 11.76 ± 0.67, F2: 11.67 ± 1.25, F3: 11.33 ± 1.02, F4: 11.60 ± 0.79, F5: 11.18 ± 0.84. The results of the hedonic test obtained that the average respondent liked the foam produced, the shape, color, comfort when used, and the smell. The lowest value of the hedonic test is the smell of the liquid soap that is produced. From the results of antibacterial test against S. Epidermidis, it is known that liquid soap has antibacterial activity with strong inhibitory power.
The Potential of Sugarcane Bagasse (Saccharum officinarum Linn.) as a Basic Ingredient for Making Cosmetics and Its Effectiveness as an Exfoliator and Skin Moisturizer Suhesti, Iin; Sari, Yunita Dian Permata; Oktofiani, Fauziyah; Janah, Aprillia Nurul
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.27915

Abstract

Sugarcane bagasse (Saccharum officinarum Linn.) contains most of the phenolic compounds including gallic acid, ferulic acid, epicatechin, quercetin, and kaempferol. Various phenolic compounds contained in sugarcane bagasse, especially phenolic acids, have important bioactivity for the cosmetics industry. The aim of this research is to determine the potential of sugarcane bagasse as an active ingredient in cosmetics and its effectiveness as an exfoliator and skin moisturizer. This research method is experimental, using sugarcane bagasse samples with concentrations of 1%, 3% and 5%. The results of phytochemical screening showed that sugarcane bagasse contains phenolic compounds, flavonoids and phytosterols. Based on the research results, sugarcane bagasse exfoliating gel at concentrations of 1%, 3%, and 5% increased skin tone respectively, namely 1.00 ± 0.67; 0.40±0.49; and 0.30 ± 0.39. Sugarcane bagasse moisturizing gel at concentrations of 1%, 3%, and 5% had a percent increase in skin water content, respectively, namely 6.92 ± 11.094; 2.72±10.21; and 3.36 ± 6.49. Based on SPSS analysis, it is known that variations in the concentration of bagasse extract and the time of use have a significant effect on increasing skin tone. Meanwhile, variations in the concentration of bagasse extract did not have a significant effect on increasing skin water content. However, the time of use has a significant effect on the increase in skin water content. So, it can be concluded that sugarcane bagasse extract has the potential to be an active ingredient in making cosmetics and is effective as an exfoliator and skin moisturizer.