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All Journal Indonesian Journal of Cancer Chemoprevention JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Kefarmasian Indonesia Jurnal Agripet
Meitasari, Annisa Diyan
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Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences

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Formulation and Activity of Sunscreen Cream from Ethanol Extract of Calendula officinalis L Flowers Rohmani, Sholichah; Mar’atushsholihah, Luthfia; Darojati, Ulfa Afrinurfadhillah; Meitasari, Annisa Diyan; Susanto, Bela Novita Amaris
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.48-57.2024

Abstract

Sunscreen made of natural ingredients is an alternative to protect the skin from excess UV radiation and a substitute for chemical products that have side effects. It was reported that Calendula officinalis L. has flavonoid and saponin metabolite compounds which function as photoprotective agents. This research aims to formulate sunscreen cream and examine the effect of variations in Calendula officinalis L flower extract (5%;7%;10% w/v) on physicochemical properties, stability, and values of the Sun Protecting Factor (SPF) in vitro using UV-Vis spectrophotometry and in vivo using wistar line rat test animals to see the time of formation of Minimum Erythema Dose (MED). It has been proven that variations in the concentration of Calendula officinalis L. extract affected the physicochemical properties, such as pH value, viscosity, spreadability, and adhesion strength. However, the overall results of the physicochemical properties still met the requirements. Variations in extract concentration affected the SPF value. In vitro SPF test showed the minimum protection category for F1, extra protection for F2, maximum protection for F3, and no protection for F0. Meanwhile, the in vivo SPF test showed the minimal protection category for F1, medium protection for F2, extra protection for F3, and no protection for F0.
Pelatihan Pembuatan Lulur Tradisional Berbahan Dasar TOGA di Kelompok Wanita Tani (KWT) Bagas Waras Boyolali: Training on Making Traditional Scrubs Based on TOGA at KWT Bagas Waras Boyolali Darojati, Ulfa Afrinurfadhilah; Rohmani, Sholichah; Sasongko, Heru; Susanto, Nindita Clourisa Amaris; Zulpadly, M. Fiqri; Utami, Diyah Tri; Meitasari, Annisa Diyan; Untari, Meta Kartika; Ermawati, Dian Eka; Artanti, Anif Nur
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 9 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i9.8562

Abstract

The Bagas Waras Women's Farmers Group (KWT) is one of the women's groups that cultivates a lot of TOGA in Banyuanyar Village, Boyolali. Their seriousness in cultivating TOGA is proven by the establishment of Omah TOGA, which has become an educational tourism destination. KWT members also have high enthusiasm for developing TOGA's potential and have produced many processed food products from TOGA. KWT Bagas Waras needs innovations in TOGA products, namely traditional cosmetic products. The service team provides scientific insight through training on developing traditional cosmetic products, namely body scrubs made from various types of TOGA. This activity involves 40 KWT members who will participate in a series of stages: preparation, training, practice, and evaluation. This training activity can increase the scientific insight of KWT members and help them develop traditional body scrubs made from TOGA and good packaging methods. This training has gone well, with all participants very enthusiastically listening to material related to traditional cosmetics and demonstrating how to make body scrubs. The results obtained are traditional body scrubs with various variants originating from TOGA.
Diversifikasi Minyak Atsiri Sereh Wangi Sebagai Bisnis KUB Aroma Alam Desa Sruni Boyolali Suhesti, Iin; Purwanto, Diyan Sakti; Meitasari, Annisa Diyan; Permadi, Dedi Setyo; Kurniawan, Marcela Lexi Putri
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 6, No 2 (2023): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v6i2.4051

Abstract

KUB Aroma Alam merupakan suatu kelompok usaha bersama yang didirikan oleh bapak Sriyanto Broto Suseno yang terletak di Dk. Watesari, Desa Sruni, Kec. Musuk, Boyolali, Jawa Tengah. KUB Aroma Alam memproduksi minyak atsiri dari berbagai jenis tumbuhan dan air mawar yang telah disalurkan ke beberapa kota besar di Indonesia seperti Sulawesi, Surabaya, Bogor dan beberapa kota lainnya. Pemasaran yang dilakukan di kota-kota besar hanya dilakukan jika mendapatkan permintaan, tetapi belum mengalami penjualan yang signifikan. Hal ini masih menjadi permasalahan yang dialami oleh KUB Aroma Alam, karena kurangnya pemahaman tentang cara pembuatan sediaan farmasi ataupun kosmetik yang berasal dari minyak atsiri. Salah satu minyak atsiri yang dibuat yaitu minyak atsiri sereh wangi atau dikenal dengan Citronella Oil. Tujuan kegiatan pengabdian kepada masyarakat ini yaitu untuk memberikan peluang bisnis kepada KUB Aroma Alam dan masyarakat sekitar dengan memberikan pengetahuan tentang cara pembuatan sediaan kosmetik yang berasal dari minyak atsiri yaitu berupa spray anti nyamuk. Metode pelaksanaan pengabdian ini dilakukan dengan 3 tahap yaitu ceramah, demonstrasi dan pelatihan, serta dilanjutkan dengan diskusi. Kegiatan ini diikuti oleh 40 Orang Warga Dk. Watesari. Peserta sangat antusias memperhatikan dan bertanya mengenai cara pengolahan minyak atsiri menjadi spray anti nyamuk. Target luaran yang dicapai dari kegiatan ini yaitu berupa produk spray anti nyamuk yang dapat diproduksi oleh masyarakat guna meningkatkan taraf ekomomi keluarga.
Physicochemical Characterization, Cytotoxic Activity, and Caspase-9 Expression of Nanogold-Parijoto (Medinilla Speciosa Reinw .Ex, Bl ) in Hela Cell Lines Artanti, Anif Nur; Rohmani, Sholichah; Prihapsara, Fea; Utami, Diyah Tri; Amaris Susanto, Nindita Clourisa; Zulphadly, M.Fiqri; Meitasari, Annisa Diyan; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika; Sasongko, Heru; Ermawati, Dian Eka
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp175-185

Abstract

Parijoto (Medinilla speciosa, Reinw. ex. Bl.), a tropical plant native to Southeast Asia, contains flavonoids, tannins, and saponins, which have the potential as an anticancer. Gold nanoparticle-based drug formulations are applied to increase the anticancer effectiveness of herbal medicines. The compounds in the stalk of parijoto have the potential to be bioreductor in the biosynthesis of gold nanoparticles. This study aims to determine the physicochemical characterization, cytotoxic activity, and expression of protein caspase-9 after treatment with nanogold parijoto (AuNPs-PR) on HeLa cell. The nanogold biosynthesis process was done by reacting 1 mM HAuCl4 with parijoto aqueous extract (EP). Physicochemical characterization measure of particle size, Polydisperse Index (PdI), and zeta potential of AuNPs-PR was carried out using a particle size analyzer. The cytotoxic effect and viability cell of AuNPs- PR were carried out using the MTT assay. The expression of caspase-9 was observed by immunocytochemistry assay. Physicochemical characterization of AuNPs-PR shows that the particle size value is 160.8 nm with PdI and zeta potential values of 0.430 and -4.56 mV respectively. In the MTT assay, both AuNPs-PR and EP demonstrated a reduction in the viability of Hela cells after 24 h in a dose-dependent manner, yielding IC50 values of 3.28 μg/mL and 19.22 μg/mL, respectively. AuNPs-PR and EP showed low cytotoxic activity against Vero normal cells, with IC50 values of over 500 μM. Further, the immunocytochemistry assay indicated that there was upregulation of caspase-9 by their expression. These results indicate that AuNPs-PR could effectively induce apoptosis in HeLa cells by upregulating caspase-9.Keywords: caspase-9, HeLa cells, MTT, nanogold, parijoto.
The Impact of Turmeric, Curcuma, and Ginger Feed Additives on the Productivity of Kaur Cattle as a Genetic Resource in Bengkulu Zulpadly, M. Fiqri; Meitasari, Annisa Diyan
Jurnal Agripet Vol 24, No 2 (2024): Volume 24, No. 2, October 2024
Publisher : Faculty of Agriculture

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17969/agripet.v24i2.33489

Abstract

Kaur cattle, a local breed in Bengkulu, represent a valuable genetic resource that requires preservation and effective utilization to enhance livestock production. Turmeric, curcuma, and ginger are plants known for their essential oils and curcumin content, which offer numerous proven benefits. This study aimed to evaluate the impact of these feed additives on the productivity of Kaur cattle. A quantitative research method employing a completely randomized design was used, consisting of four treatments and four replications. The diet comprised wild grass (10% of body weight) and palm kernel meal in an 80:20 ratio. The treatments were as follows: P0 (control: wild grass and palm kernel meal), P1 (wild grass, palm kernel meal, and turmeric powder Curcuma xanthorrhiza Roxb.), P2 (wild grass, palm kernel meal, and curcuma powder Curcuma longa L.), and P3 (wild grass, palm kernel meal, and ginger powder Zingiber officinale Rosc.). The study involved 16 male Kaur cattle aged 1.5-2 years, with an average body weight of 160-180 kg, observed over 60 days. The variables measured included average daily weight gain, forage consumption, total feed consumption, feed efficiency, and cost efficiency. Data were analyzed using a one-way ANOVA. The results showed that the mean daily weight gain (kg/head/day) was P0=0.352.57, P1=0.472.39, P2=0.502.46, and P3=0.492.88, with no significant differences between treatments. The mean feed efficiency (%) was P0=0.124.44, P1=0.254.71, P2=0.275.22, and P3=0.264.38, also showing no significant differences. The mean cost efficiency for feed use was P0=35,8697.47, P1=34,2817.08, P2=33,2207.39, and P3=35,4107.21, with no significant differences observed. Overall, the addition of turmeric, curcuma, and ginger powders to the feed did not significantly impact the productivity of Kaur cattle.
Evaluation of Virgin Coconut Oil Concentration Variations in Emulgel Formulations of Garlic (Allium sativum L.) Extract as an Antibacterial Hand Sanitizer Rohmani, Sholichah; Fitria, Krismona Rizky Nur; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Ermawati, Dian Eka; Sasongko, Heru; Zulpadly, M. Fiqri; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Aratanti, Anif Nur; Untari, Meta Kartika
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One of the effective ways to stay healthy is maintaining cleanliness, including hand hygiene. Various diseases can be easily transmitted through the hands. However, modern developments have changed the habit of handwashing with water to using hand antiseptics. Hand sanitizer is an alternative to overcome this problem. Unfortunately, some hand sanitizer gels on the market still contain alcohol as an antibacterial ingredient. It is necessary to innovate in making hand sanitizers using non-alcoholic ingredients as antibacterials, for example, natural ingredients like garlic. Garlic contains allicin that functions as an antibacterial. Meanwhile, VCO contains high lauric acid with antibiotic properties that function as antiviral, antibacterial, and antiprotozoal. It also contains capric acid, with antiviral and antibacterial functions. This study aims to examine the effect of concentration variation of VCO on the physical stability of garlic extract emulgel preparation and antibacterial effectiveness against the growth of Staphylococcus aureus. The concentration variation of VCO in this study was 3%, 5%, and 7% for 3 types of formulas. The results showed that the concentration variation of VCO in emulgel preparations gave differences in the physical properties of the gel, including pH, viscosity, adhesive strength, and spreadability. It can be concluded that the higher the VCO concentration, the higher the pH, viscosity, and adhesive power, and the lower the spreadability and antibacterial inhibition power against Staphylococcus aureus. The best result from the evaluation of physicochemical properties and antibacterial tests was Formula 1, although it was still in the weak inhibitory power category.
Co-Authors Amaris Susanto, Nindita Clourisa Anif Nur Artanti, Anif Nur Aratanti, Anif Nur Darojati, Ulfa Afrinurfadhilah Darojati, Ulfa Afrinurfadhillah ERMAWATI, DIAN EKA Fitria, Krismona Rizky Nur Heru Sasongko Mar’atushsholihah, Luthfia Prihapsara, Fea Purwanto, Diyan Sakti Sholichah Rohmani, Sholichah suhesti, iin Susanto, Bela Novita Amaris Susanto, Nindita Clourisa Amaris untari, meta kartika Utami, Diyah Tri Zulpadly, M. Fiqri Zulphadly, M.Fiqri