Article Per Year (5 Year)
p-Index From 2021 - 2026
1.456
P-Index
This Author published in this journals
All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Pharmacy MEDIC MEdical Dedication Electronic Journal Scientific of Environmental Health And Diseases Journal of Medical Studies
Ekaputri, Tia Wida
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Other

Published : 9 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 9 Documents
Search

 1 
AT Genotype of FTO rs9939609 Enhances Risk for Central Obesity Under Obesogenic Lifestyle Maharani, Citra; Puspasari, Anggelia; Enis, Rina Nofri; Ekaputri, Tia Wida; Shafira, Nyimas Natasha Ayu
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.38811

Abstract

Background: Central obesity is a major risk factor for cardiovascular diseases, influenced by both genetic and lifestyle factors. The rs9939609 variant of Fat Mass and Obesity-Associated (FTO) gene has been associated with increased risk of central obesity, potentially modulated by dietary intake and physical activity. Objective: This study aimed to investigate the association between the FTO rs9939609 variant and central obesity, and its interaction with dietary intake and physical activity among adults in Jambi, Indonesia. Method: A cross-sectional study was conducted on 175 adults. Central obesity was defined using NCEP ATP III criteria. Dietary intake and physical activity were assessed using 24-hour food recall and the IPAQ, respectively. Genotyping was performed using the Tetra ARMS-PCR. Bivariate analysis was used to assess associations. Results: Individuals with the AT genotype had a significantly increased risk of central obesity (OR= 3.29; 95% CI: 1.30–8.35; p= 0.01). Under the dominant model (AAAT), the association remained significant (OR= 2.90; 95% CI: 1.17-7.16; p= 0.02). The risk was higher among individuals with high caloric intake (OR= 4.64) and low to moderate physical activity (OR= 4.77). Conclusion: The FTO rs9939609 variant is associated with increased central obesity risk, and in the presence of obesogenic lifestyle factors.
Training Mothers on Complementary Feeding Preparation and Toddler Growth Screening at Olak Kemang Health Center Harahap, Huntari; Aurora, Wahyu Indah Dewi; Hanina, Hanina; Ekaputri, Tia Wida; Ayudia, Esa Indah
Scientific Of Environmental Health and Diseases Vol. 5 No. 1 (2025): Scientific of Environmental Health And Diseases
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/e-sehad.v5i2.37910

Abstract

Background: Proper complementary feeding is crucial for optimal child growth and development. However, many mothers lack knowledge about the correct preparation, timing, and nutritional composition of complementary feeding, increasing the risk of malnutrition and stunting in toddlers. This community service program aimed to enhance maternal knowledge on complementary feeding and conduct growth and development screenings for toddlers. Method: The program was conducted at Olak Kemang Health Center and involved 15 mothers and their children. The intervention included hands-on training led by nutrition experts on the proper preparation and nutritional composition of complementary feeding. Additionally, toddlers underwent growth and development assessments using anthropometric measurements and the Pre-Screening Questionnaire for Development (KPSP). Result: The majority of toddlers (73.33%) had normal nutritional status, while 13.33% were underweight and 13.33% were overweight. Growth and development screening showed that 93.3% of toddlers demonstrated normal development, whereas 6.67% had developmental delays. The training significantly improved mothers' knowledge of complementary feeding preparation. Conclusion: Regular educational programs are essential to improve maternal knowledge on complementary feeding and enhance early childhood growth monitoring. These efforts can help reduce the risk of malnutrition and stunting among toddlers.
OPTIMIZING MATERNAL AND CHILD HEALTH: ENHANCING PUBLIC AWARENESS OF TORCH INFECTIONS DURING PREGNANCY Ekaputri, Tia Wida; Enis, Rina Nofri; Tarawifa, Susan; Harahap, Huntari; Syauqy, Ahmad; Perkasa, Tengku Arief Buana
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 1 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

TORCH infections (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes simplex) pose significant risks during pregnancy, contributing to congenital abnormalities and adverse neonatal outcomes. In Indonesia, limited public awareness and inadequate preventive practices exacerbate these risks. This community service initiative aimed to enhance knowledge about TORCH infections among reproductive-aged women through a hybrid educational seminar. Conducted in collaboration with Peduli TORCH, the program utilized the "5P Framework" (Pathogen Awareness, Prenatal Screening, Pathogen Management, Postnatal Monitoring, Preventive Practices) to deliver evidence-based strategies. A total of 54 participants (87% female, 61.1% from Jambi Province) attended the seminar, combining in-person and virtual engagement. Pre- and post-tests assessed knowledge improvement, revealing a statistically significant median score increase from 70.0 to 100.0 (p<0.001, Wilcoxon test). Participants reported high satisfaction with the seminar’s content, interactive format, and accessibility, though logistical refinements were suggested for future iterations. The initiative successfully bridged knowledge gaps, emphasizing the importance of early screening, vaccination, and hygiene practices. By empowering women and leveraging community engagement, this program highlights the potential of targeted educational interventions to reduce TORCH-related morbidity and improve maternal-child health outcomes. Culturally adapted, hybrid approaches demonstrate promise for scalable public health strategies in low-resource settings.
The Effect of Ethanol Extract of Senggani Leaves (Melastoma malabathricum) on Reducing Paw Edema in Rats Induced By Carrageenan Ekaputri, Tia Wida; Dewi, Hasna; Wulandari, Putri Sari; Enis, Rina Nofri
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.38925

Abstract

Background: The extract of senggani leaves (Melastoma malabathricum) has attracted attention as a potential anti-inflammatory agent due to its diverse phytochemical content, including flavonoids, tannins, and other polyphenols, which have been shown to possess antioxidant and anti-inflammatory activities in several previous studies. This study aims to determine the difference in the percentage of inflammation inhibition of paw edema in rats induced by carrageenan through the administration of senggani leaves extract. Methods: In this study, 24 rats were divided into 4 groups. Negative control group was given Na-CMC 0.5%, Positive control group was given Na-diclofenac 50 mg/kg BW. Two dosage groups were given senggani extract solution at 250 and 500 mg/kg BW. Carrageenan is used to induce local inflammation by injecting a 2% carrageenan solution in physiological NaCl subcutaneously into the subplantar region of all test animal groups to elicit an edema response. Paw thickness is measured using calipers at hour 0 before inflammation induction, followed by measurements at hours 1, 2, 3, 4, and 5. Results: The peak inhibitory effect (62.10% and 60.41%) for both doses of senggani extract was observed at the 3rd hour, suggesting a rapid onset of action. At the higher dose (500 mg/kg BW), senggani extract exhibited comparable or even slightly superior inhibitory effects to Na-diclofenac. Conclusion: Senggani extract has potential as a natural anti-edema agent. Further research is needed to explore its mechanism of action and optimize its therapeutic use.
Uji Beda Leukosit dan NLR (Neutrophil Lymphocyte-Ratio) terhadap Luaran Pasien Sepsis Rawat ICU (Intensive Care Unit) RSUD Raden Mattaher Jambi 2019 - Oktober 2022 Aidil Rahmat Ilham; Lipinwati, Lipinwati; Ahmad Syauqy; Samsirun Halim; Sotianingsih, Sotianingsih; Ekaputri, Tia Wida
Journal of Medical Studies Vol. 4 No. 1 (2024): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v4i1.31935

Abstract

ABSTRACT Background: Sepsis is a clinical syndrome caused by an overreaction of the body's immune response stimulated by microbes or bacteria inside and outside the body. There is visible organ dysfunction. Of an increase of 2 or more scoresSequential Organ Failure Assessment (SOFA). Early diagnosis and treatment by assessing inflammatory factors such as leukocytes and NLR (Neutrophil-to-lymphocyte ratio). This study aims to determine the difference between leukocyte levels and NLR values based on the outcome of septic patients. Method: This study used an analytic observational cohort method with a retrospective and prospective approach involving 54 research subjects, using consecutive sampling. Sampling was done by calculating leukocyte levels and NLR values at 0, 24, 72, and 144 hours in septic patients. Results: The patients who died for more than 24 hours were 36 patients. The highest average results were measured at 24 hours, with leukocytes 17.48 ± 8.49 and NLR 24.96 ± 22.17. The mean leukocyte and NLR levels were higher in the death group. The analysis found no significant difference between the leukocyte and NLR with the outcomes in septic patients (p >0.05). Conclusion: There was no significant difference between leukocytes and NLR with the outcome of septic patients. Keywords: Biomarkers, Leukocytes, Mortality, NLR, Sepsis   ABSTRAK Latar Belakang: Sepsis adalah suatu sindrom klinik oleh karena reaksi yang berlebihan dari respon imun tubuh yang distimulasi mikroba atau bakteri dari dalam dan luar tubuh. Terdapat disfungsi organ yang terlihat. dari peningkatan 2 atau lebih skor Sequential Organ Failure Assessment (SOFA). Diagnosis dan penanganan lebih awal dengan menilai faktor inflamasi seperti leukosit dan NLR (Neutrophil-to-lymphocyte rasio). Penelitian ini bertujuan untuk mengetahui perbedaan antara kadar leukosit dan nilai NLR berdasarkan luaran pasien sepsis. Metode: Penelitian ini menggunakan metode analitik observasional kohort, dengan pendekatan retrospektif dan prospektif yang melibatkan 54 subjek penelitian, menggunakan teknik consecutive sampling. Pengambilan sampel dilakukan dengan cara menghitung kadar leukosit dan nilai NLR pada jam ke-0, 24, 72, dan 144 pada pasien sepsis. Hasil: Dari 54 sampel, hasil luaran pasien meninggal lebih banyak pada jam 24 sebanyak 36 pasien. Rerata hasil tertinggi pada pada pengukuran jam 24 dengan Leukosit 17,48±8,49 dan NLR 24,96±22,17. Rerata kadar leukosit dan nilai NLR lebih tinggi pada kelompok luaran meninggal. Hasil analisis tidak terdapat perbedaan yang signifikan antara Leukosit dan NLR dengan luaran pasien sepsis (p >0,05). Kesimpulan: Tidak terdapat perbedaan yang signifikan antara Leukosit dan NLR terhadap luaran pasien sepsis. Kata Kunci: Biomarker, Leukosit, Mortalitas, NLR, Sepsis
Correlation of IL-10 Levels with the Bacterial Index in Multibacillary Leprosy Fitriyanti, Fitriyanti; Lipinwati, Lipinwati; Istarini, Attiya; Ekaputri, Tia Wida; Nastiti, Niken Irfa; Adnyana, I Made Dwi Mertha
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 2 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i2.48898

Abstract

Background: Multibacillary (MB) leprosy is characterised by a high bacillary burden and a tolerogenic immune profile. Interleukin-10 (IL-10) is a key immunoregulatory cytokine that may reflect bacillary load. Objective: To compare bacillary burden and IL-10 between MB patients and controls and to examine the correlation between the Bacterial Index (BI) and IL-10 among MB patients. Methods: A comparative cross-sectional study included 68 participants (MB n=34; controls n=34). Categorical variables were analysed using Chi-square tests, and medians were used with Mann–Whitney U tests. Spearman’s rank correlation was used to assess the BI–IL-10 relationship in MB. Results: Age distribution was similar between groups (p=0.451), whereas occupation (p=0.040) and education (p=0.027) differed. BI was markedly higher in MB than in controls (median 2.5 [IQR 4] vs 0 [0]; p<0.001). IL-10 concentrations were also higher in MB (1.96 [4.03] pg/mL) than in controls (1.12 [1.94] pg/mL; p=0.029). Among MB patients, BI correlated positively with IL-10 (ρ = 0.358; p = 0.038). Conclusion: MB leprosy shows substantially greater bacillary burden and elevated IL-10 relative to controls. The positive association between BI and IL-10 supports the role of an immunoregulatory milieu linked to bacillary load. These findings highlight IL-10 as a potential biomarker for disease burden in MB leprosy and warrant validation in larger, adjusted cohorts.
Assessing The Impact of Color Vision Deficiency on Quality of Life in High School Students Tarawifa, Susan; Jeane, Jessica; Enis, Rina Nofri; Ekaputri, Tia Wida; Putriyudi, Mandy
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 2 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i2.48979

Abstract

Background: Color vision deficiency (CVD) is a hereditary visual disorder that limits color discrimination and may affect daily functioning, learning performance, and psychosocial well-being. Despite its prevalence, awareness and screening among students in Indonesia remain low. Methods: A cross-sectional analytical study was conducted among 672 high school students selected through a cluster random sampling method. Color vision was evaluated using the Ishihara 38 Plates test, and quality of life was assessed using the Color Blindness Quality of Life (CBQoL) questionnaire, covering health, emotional, and daily activity domains. Data were analyzed using independent t-tests. Results: Of 672 participants, 24 (3.6%) had CVD, predominantly males (91.7%). The deutan type was the most frequent (75%). Students with CVD showed significantly lower CBQoL scores than those with normal color vision in health (3.50 ± 1.11 vs. 5.49 ± 0.54), emotional (3.64 ± 1.13 vs. 5.78 ± 0.35), and daily activity domains (3.71 ± 1.27 vs. 5.72 ± 0.45; p < 0.001). Conclusion: CVD significantly reduces students' quality of life. Early detection, educational adaptation, and awareness programs are essential in supporting students affected by these issues and promoting inclusive learning environments.
Uji Aktivitas Sediaan Gel Berbasis Ekstrak Daun Kayu Manis (Cinnamomum burmannii) sebagai Agen Antiinflamasi pada Model Tikus Putih Jantan dengan Induksi Karagenan Kasmadi, Fathnur Sani; Putri, Azelia; Pratiwi, Puspa Dwi; Humaryanto, Humaryanto; Ekaputri, Tia Wida
Jurnal Ilmiah Pharmacy Vol 13, No 1 (2026)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v13i1.917

Abstract

Inflamasi merupakan mekanisme pertahanan fisiologis tubuh yang berperan dalam membatasi perluasan kerusakan jaringan, menekan pertumbuhan mikroorganisme patogen, serta memfasilitasi proses perbaikan jaringan yang mengalami cedera akibat suatu kondisi patologis. Proses ini tergolong respon biologis normal sebagai bagian dari sistem proteksi tubuh. Salah satu tanaman yang diketahui memiliki aktivitas dalam penyembuhan luka adalah daun kayu manis, yang dilaporkan mengandung berbagai metabolit sekunder yaitu fenolik, flavonoid, saponin, steroid, dan tanin yang berkontribusi dalam modulasi proses inflamasi. Formulasi ekstrak daun kayu manis dalam bentuk gel bertujuan untuk meningkatkan penetrasi zat aktif kejaringan target serta memberikan efek pendingin (cooling effect) yang mendukung proses penyembuhan inflamasi. Penelitian ini dilakukan untuk mengevaluasi aktivitas antiinflamasi sediaan gel ekstrak daun kayu manis serta menentukan konsentrasi yang paling optimal dalam menghasilkan efek terapeutik. Metode yang digunakan adalah penelitian eksperimental dengan desain post test only control group. Kelompok perlakuan dibagi menjadi 5 yaitu kontrol positif, kontrol negatif, formula I (ekstrak 2,5%), formula II (ekstrak 5%, dan formula III (ekstrak 10%) yang diaplikasikan secara topikal pada area punggung tikus yang telah diinduksi dengan karagenan 1%. Perlakuan dilakukan selama 4 hari parameter yang diamati berupa volume eksudat dan profil diferensiasi leukosit dalam darah. Hasil penelitian menunjukkan bahwa formulasi gel ekstrak daun kayu manis dengan konsentrasi 10% memberikan aktivitas antiinflamasi paling optimal yang dibuktikan dengan mampu menurunkan volume eksudat. Efektivitas terbaik di tunjukkan dengan nilai persen inhibisi inflamasi pada kosentrasi 10% adalah sebesar 89,47%.
Dose-Dependent Mild Kidney Injury Induced by Ethanol Extract of Rhodomyrtus tomentosa in Female Rats Ekaputri, Tia Wida; Andani, Firstasya; Enis, Rina Nofri; Tarawifa, Susan; Puspasari, Anggelia; Maharani, Citra; Utami, Erisca Ayu
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 14 No. 1 (2026): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v14i1.54229

Abstract

Background: Rhodomyrtus tomentosa is widely used in traditional medicine, but its subchronic renal safety profile remains insufficiently explored. This study aimed to assess mild kidney injury induced by R. tomentosa leaf ethanol extract through qualitative and quantitative histopathological evaluation in female Rattus norvegicus. Methods: Twenty-four female rats were divided into six groups: a control and five treatment groups receiving the extract at doses of 200, 400, 800, 1600, and 3200 mg/kgBW for 14 days. Kidney tissues were evaluated via hematoxylin-eosin staining and image-based digital quantification across five fields of view per specimen to determine glomerular and tubular damage. Results: Qualitative evaluation revealed dose-dependent alterations, transitioning from mild glomerular hypercellularity at lower doses to focal necrosis and hemorrhage at higher doses. Quantitative analysis clarified a distinct compartmental vulnerability. Glomerular damage showed a descriptive upward trend across doses (9.75% to 13.53%) but lacked statistical significance (Kruskal-Wallis, p = 0.05). Conversely, tubular damage increased sharply from 1.99% to 17.49%, demonstrating a highly significant dose-dependent escalation (p = 0.001). Post-hoc pairwise comparisons confirmed that significant tubular degeneration manifested critically at elevated exposures of 1600 mg/kgBW (p = 0.014) and 3200 mg/kgBW (p = 0.002) compared to the control group. Conclusion: The ethanol extract of R. tomentosa leaves induces dose-dependent renal alterations, with tubular structures exhibiting significantly higher susceptibility than glomeruli due to active metabolic clearance. However, the absolute tissue damage remains strictly within the mild, non-destructive category, establishing a reassuring safety margin for its pharmaceutical development.
Co-Authors Adnyana , I Made Dwi Mertha Ahmad Syauqy Ahmad Syauqy Aidil Rahmat Ilham Andani, Firstasya Anggelia Puspasari ATTIYA ISTARINI Citra Maharani dewi, hasna Esa Indah Ayu, Esa Indah Fitriyanti Fitriyanti Hanina, Hanina Humaryanto, Humaryanto Huntari Harahap Jeane, Jessica Lipinwati ., Lipinwati Niken Irfa Nastiti Nyimas Natasha Ayu Shafira Puspa Dwi Pratiwi Putri Sari Wulandari Putri, Azelia Putriyudi, Mandy Rina Nofri Enis Samsirun Halim Sani K, Fathnur Sotianingsih, Sotianingsih Tarawifa, Susan Tengku Arief Buana Perkasa Utami, Erisca Ayu Wahyu Indah Dewi Aurora