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All Journal Journal of Food and Pharmaceutical Science LLT Journal: A Journal on Language and Language Teaching Kinerja: Jurnal Ekonomi dan Manajemen JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Madrosatuna: Journal of Islamic Elementary School Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Edukasia: Jurnal Pendidikan dan Pembelajaran JURNAL MUARA PENDIDIKAN Journal of Food and Pharmaceutical Sciences Keyboard Jurnal Pengabdian Masyarakat International Conferences On Early Childhood Education Proceedings Indonesian Journal of Pharmacology and Therapy
Ika Puspitasari
Departemen Farmakologi Dan Toksikologi, Farmasi Universitas Gadjah Mada
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Evaluation of empirical antibiotic usage and cost analysis of patients with nosocomial pneumonia in ICU of RSUP Dr. Sardjito, yogyakarta Minar Paskah Lianti Manik; Rizka Humardewayanti Asdie; Ika Puspitasari
Indonesian Journal of Pharmacology and Therapy Vol 1 No 2 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.573

Abstract

The rationality of antibiotic usage has an implication on the therapeutic quality and antimicrobial resistance control. Qualitative and quantitative evaluation of this rationality becomes one quality indicator of hospitals' antimicrobial resistance programs. Therefore, this study aims to determine the relationship between the rationality of antibiotic usage with clinical outcomes and the total cost in nosocomial pneumonia patients treated in the Intensive Care Unit (ICU). The method used was descriptive-analytic observational research with a cross-sectional design analysis, and data were collected retrospectively from the medical and financial record of patients with inclusion criteria. The data were then analyzed descriptively using the Gyssens flowchart. Fisher statistical test was conducted to analyze the relationship between rationality data and therapeutic outcomes. Furthermore, the Mann Whitney statistical test was conducted to examine the relationship between rationality data and the cost, while the paired t-test was conducted to analyze the resistance pattern. The results showed that antibiotic usage in patients with nosocomial pneumonia at the ICU of RSUP Dr. Sardjito was irrational and rational by 30.21% (29 regimens) and 69.79% (67 regimens) respectively. This rationality has a relation with clinical outcome based on Fisher test with p-value = 0.001 (p <0.05). Considering these results, the antibiotics cost both in the rational and irrational category has no significant difference with the p-value of 0.90 (p<0.05).
Effectiveness evaluation of antibiotic use in patients with Methicillin-resistant Staphylococcus aureus (MRSA) infection: a review As, Musdalifa; Ika Puspitasari; Nuryastuti, Titik
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.10771

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that become a public health problem due to its ability to be resistant to more than three classes of antibiotics. Evaluation of the effectiveness of antibiotic use in patients with MRSA is important to optimize antibiotic use and to control antibiotic resistance. This article review attempted to evaluate the effectiveness of antibiotics in patients with MRSA. This review explored the results of previous research from PubMed as a literature source and the PRISMA flow diagram as a protocol for the article selection process. Eight studies reviewed the evaluation of the effectiveness of antibiotic use in MRSA patients with various clinical conditions, such as uncomplicated wound infections, cellulitis and no wound, purulent drainage or abscess, cSSSI infections caused by MRSA, infections caused by MRSA bacteremia and nosocomial infections caused by MRSA. In conclusion, the effectiveness of antibiotics in patients with MRSA infection depends on the clinical condition of each patient. Therefore, the use of antibiotics is adjusted based on the type of infection and the efficacy of the antibiotics. Combination therapy is recommended for MRSA patients considering its life-threatening ability.
Co-Authors Abdul Gofir Adela Yuana Ramadhani Alexxander Alexxander AM Wara Kusharwanti Ambar Yunita Nugraheni As, Musdalifa Asrul Ismail Atika Hanum Falihah Cecep Sugeng Kristanto Devinta Puspita Ratri Dini Khairunnisa Djoko Wahyono Fitri Rahmantika Gendro Wiyono Gitawidya Amalia Nurbidayah Hasdiana Sudar I Dewa Putu Pramantara Kurniasih Kurniasih Mawaddah Rifka Salafia Mika Tri Kumala Swandari Minar Paskah Lianti Manik Muhammad Novrizal Abdi Sahid Nadiyah Azhar Firdausi Nurul Chusna Okky Puspitasari Sugiyarto Peptia Asrining Tyas Probosuseno Probosuseno Pujiarto Pujiarto Ratna Ahsanty Rizaldy T Pinzon Rizka Humardewayanti Asdie Savina Aulia Azzahra Sokhibul Arifin Sri Fitri Yuningsih Sri Hermuningsih Sri Purwati Sri Watini Susi Ari Kristina Titik Nuryastuti Tri Murti Andayani Wisnu Amboro Yani Suryani