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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia International Journal of Cell and Biomedical Science
Kusumaningrum, Novi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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A Novel Regenerative Approach for Acne Vulgaris Using Combined Umbilical Cord Mesenchymal Stem Cell-Derived Secretome and Platelet-Rich Plasma: A Case Report Zamzam, Salsabillah; Kusumaningrum, Novi; Prawitasari, Salindri; Cahyani, Dini; Adityani, Resanti
International Journal of Cell and Biomedical Science Vol 4 No 11 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i11.71

Abstract

Background: Acne vulgaris is a chronic inflammatory skin disorder that often leads to scarring and pigmentation. Conventional therapies may provide limited improvement and are frequently associated with adverse effects. Recent advances in regenerative medicine suggest that stem cell–derived secretome and platelet-rich plasma (PRP) may promote skin repair and rejuvenation through anti-inflammatory and regenerative pathways. Case Presentation: A 21-year-old male presented with persistent inflammatory acne and post-acne hyperpigmentation. The patient underwent two sessions of combined SH-MSCs-derived secretome and PRP therapy at two-week intervals. Facial assessments were performed using the Janus Skin Analyzer at baseline, day 14, and day 28. Quantitative analysis revealed significant improvement in multiple parameters, including reduction of pore size, pigmentation index, and sebum levels, accompanied by enhanced skin elasticity. Clinically, the patient exhibited visible improvement in overall skin texture, evenness, and clarity without any adverse reactions. Results: Marked clinical improvement was observed after the second session, with visible reduction in acne lesions, fading of post-acne marks, and overall improvement in skin radiance. Quantitative analysis demonstrated a 30% reduction in pore condition, 58% increase in elasticity, 35% decrease in pigmentation index, and 227% reduction in sebum levels compared to baseline. These findings indicate significant enhancement in skin texture, tone, and elasticity. Conclusion: Combination therapy using SH-MSCs-derived secretome and PRP demonstrated promising regenerative and aesthetic outcomes in this patient with acne vulgaris. Larger-scale clinical studies are warranted to validate efficacy and optimize treatment protocols.
Pengaruh waktu pemanasan dan pengasaman terhadap kadar albumin ekstrak ikan gabus : The effect of long heating and aciditing time on albumin levels in snakehead fish extract Yuniati, Renni; Nurtari, Rahma Yulia; Annaafi, Alviona Denti; Priguna, Tangkas Mukti; Anggita, Vinka Dwi; Kusumaningrum, Novi; Saraswati, Indah; Muslimin, Muslimin; Putra, Farmaditya Eka; Hardian, Hardian
Jurnal Pengolahan Hasil Perikanan Indonesia Vol. 27 No. 2 (2024): Jurnal Pengolahan Hasil Perikanan Indonesia 27(2)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v27i2.46448

Abstract

Snakehead fish, specifically the Channa striata species, are known to have an abundance of albumin. However, there is limited information available regarding alterations in the properties of snakehead fish extracts that have undergone high heat and acid treatment. This presents a compelling research area for further exploration and study. The aim of this study was to determine the optimal portion of the fish and to examine the effect of heating and acidification time on albumin concentration in snakehead fish. The method employed in this study involved heating samples at 70 °C for 0, 15, and 30 min and subjecting them to acidification at pH 1, 4, and 7. The extraction process was conducted using centrifugation at a speed of 6,000 rpm for 60 minutes, followed by absorbance measurement at a wavelength of 280 nm using a UV-Vis spectrophotometer to evaluate the properties of protein extracts.The relationship between albumin levels and protein levels is one of direct proportionality.According to recent studies, snakehead fish extract is a safe and effective topical treatment for skin conditions, with a pH level ranging from 4.5 to 6.5. Furthermore, snakehead meat is a rich source of albumin, containing approximately 22.4 mg of protein per 100 g. The absorbance exhibited a more substantial rise at a temperature of 70oC over a 15-minute period and in a highly acidic environment (pH 1.0). Snakehead fish protein extract is less stable and more susceptible to denaturation than standard bovine serum albumin (BSA).
Co-Authors Adityani, Resanti Anggita, Vinka Dwi Annaafi, Alviona Denti Cahyani, Dini Farmaditya Eka Putra Hardian Hardian Indah Saraswati Muslimin Muslimin Nurtari, Rahma Yulia Prawitasari, Salindri Priguna, Tangkas Mukti Renni Yuniati Zamzam, Salsabillah