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All Journal Jurnal Kedokteran Diponegoro International Journal of Cell and Biomedical Science
Azzahara, Salma Yasmine
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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THE COMPARISON BETWEEN PLYOMETRICS EXERCISE WITH AEROBIC EXERCISE TOWARDS DECISION-MAKING IN YOUNG ADULTS Azzahara, Salma Yasmine; Ambarwati, Endang; Kumaidah, Endang; Widodo, Sumardi
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29333

Abstract

Background: Lack of physical activity in individual has a big impact towards brain as if in the cognitive parts of the brain, especially decision making and memory. The relation between physical activity and cognitive ability is related to angiogenesis and neurogenesis that is more optimal in individuals who do their physical activity routine. Plyometrics and Aerobic exercise are proven to have a positive effect on the body, but there has been no further research on the comparison of the two sports.  Aim: to understand the comparison between plyometrics exercise with aerobic exercise towards decision-making in young adults . Methods: This study used quasi experimental design pretest and posttest. The subjects were 39 aged, all of whom are students of Fakultas Kedokteran Universitas Diponegoro. Subjects divided into 3 groups as control, Plyometrics exercise, and Aerobic exercise. Decision-making score measured by IOWA Gambling Task (IGT). Data’s significance was analyzed with paired t-test.  Results: There was significant difference in decision-making score before (pre-test) and after (post-test) Plyometrics and Aerobic exercise (p<0,05). Nevertheless, higher score was found in experimental group 1 which is the Plyometrics exercise (p=0,000). Furthermore, there was significant difference towards decision-making score in experimental and control group (p<0,05). Conclusion: Plyometrics and Aerobic exercise increase decision-making score for young adults. A more significant increase was found in the Plyometrics group (p=0,000).
Therapeutic Potential of Secretome-Derived Wharton's Jelly Mesenchymal Stem Cells in Psoriasis Vulgaris: A Case Study Azzahara, Salma Yasmine; Agustina, Rita; Prawitasari, Salindri
International Journal of Cell and Biomedical Science Vol 2 No 5 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v2i5.37

Abstract

Background: Psoriasis is a chronic, immune-mediated skin disease that also has systemic manifestations. Case: In this report, we discuss our findings about a 47-years old psoriasis suffering male patient with a Psoriasis Area Severity Index (PASI) score of 10.8, treated with Wharton’s Jelly Mesenchymal Stem Cells-derived Secretome (S-MSCs). Remarkably, complete regression was recorded within a treatment period of a week only. Result: The patient demonstrated a decrease in PASI, from 10.8 to 3.2 after 1 infusion and followed by 4 intramuscular injections of S-MSCs. Bioactive factors secreted by MSCs, cytokines and growth factors, are very likely to be the principal molecules which play a vital role in inflammatory modulation and skin tissue regeneration. No serious adverse events were noted for the patient as a result of secretome infusion and intramuscular injection. Conclusion: This report demonstrates safety and promises to be an effective strategy using S-MSCs treatment for managing the psoriatic issue and, thus, may offer as an alternative approach to overcome the limitations of the cell-based therapy.
Time-Dependent Simulation Identifies Critical Hour Phase of Intestinal Acute Injury in Sepsis Mouse Model Istanti, Yusrina; Anggoro, Naufal Sebastian; Husain, Sofian Azalia; Azzahara, Salma Yasmine
International Journal of Cell and Biomedical Science Vol 3 No 9 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i9.64

Abstract

Background: Understanding the dynamic process of intestinal injury and repair during sepsis is essential for identifying optimal therapeutic windows. This study aimed to determine the critical time phase of intestinal acute injury by analyzing histological changes over a 24-hour period in a sepsis mouse model. Methods: Mice were divided into four groups—Control, 9 h, 12 h, and 24 h—and intestinal tissue samples were assessed using the Chiu histological scoring system. A time-dependent simulation was conducted to evaluate average changes in tissue damage and to identify key transition points between injury and recovery phases. Statistical analysis was performed using one-way ANOVA followed by post hoc comparisons to determine significant differences among time points. Results: The simulation demonstrated a marked increase in intestinal damage between 9 h and 12 h, followed by partial recovery at 24 h. Statistical analysis revealed a significant difference (p < 0.05) corresponding to this shift. These findings suggest that peak tissue injury occurs around 12 hours post-sepsis induction, preceding the onset of repair mechanisms. Conclusion: The study provides quantitative insight into the temporal progression of intestinal injury in sepsis, identifying the 12–24 hour period as a critical therapeutic window for potential interventions.
Co-Authors Agustina, Rita Anggoro, Naufal Sebastian Endang Ambarwati, Endang Endang Kumaidah Husain, Sofian Azalia Prawitasari, Salindri Sumardi Widodo Yusrina Istanti