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All Journal Jurnal Kedokteran Brawijaya Medica Hospitalia International Journal of Cell and Biomedical Science
Yusrina Istanti
Laboratorium Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Diponegoro/Rumah Sakit Umum Pusat Dr. Kariadi Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Korelasi Antara Transforming Growth Factor -Î’1 Monosit dengan Kebocoran Vaskuler pada Demam Berdarah Dengue Supriatna, Mohamad; Tondy, Haryson; Ermin, Tatty; Istanti, Yusrina; RMD, Kisdjamiatun
Jurnal Kedokteran Brawijaya Vol 26, No 1 (2010)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1126.587 KB) | DOI: 10.21776/ub.jkb.2010.026.01.1

Abstract

ABSTRAKSel monosit merupakan target utama infeksi virus Demam Berdarah Dengue (DBD) yang dapat memproduksi faktor vasoaktif yang mempengaruhi fungsi sel endotel dan berperan dalam kebocoran vaskuler. Transforming growth factor beta 1 (TGF-1) merupakan salah satu sitokin yang mempunyai banyak peran dalam patogenesis DBD. Penelitian ini dilakukan untuk mengidentifikasi hubungan antara TGF-1 terhadap indeks efusi pleura (IEP), total protein, albumin dan hematokrit sebagai indikator kebocoran vaskular. Studi dilakukan dengan desain cross sectional pada pasien DBD usia 13-14 tahun di RS dr. Kariadi selama Juli 2005 hingga Juli 2006. Sampel pemeriksaan adalah kultur whole blood supernatant culture yang diinduksi LPS pada subyek penelitian. Kadar monosit TGF-1, PEI, total protein, albumin dan hematokrit diukur pada hari 0 dan 2. Data di analisis dengan uji Wilcoxon dan korelasi Spearman. Pada hari 0 dan 2 dianalisis korelasi antara kadar monosit TGF-1, PEI juga protein total, albumin dan hematokrit. Rerata kadar TGF-1 monosit pada hari ke 2 (43.29±28.012 pg/ml) lebih tinggi dari hari 0 (35.27 ± 34.642 pg/ml, p=0.09, Wilcoxon test). Pada hari 0 terdapat korelasi signifikan level TGF-1 monosit dengan PEI (r=-0.31, p=0.04), tetapi tidak dengan total protein (r=0.19, p=0.2), albumin (r=0.11, p=0.5 ; r=--.08, p=0.6). Pada hari kedua tidak ada korelasi signifikan antara level TGF-1 monosit level dan PEI (r=-0.2,p=0.3), total protein (r=0.2, p=0.2), albumin (r-0.2, p=0.2) dan hematokrit (r=-0.04, p=0.8). Dapat di simpulkan bahwa TGF-1 mungkin berperan dalam proses inflamasi DBD melalui PEI sebagai salah satu indikator kebocoran plasma.Kata Kunci : Albumin, DBD, hematokrit, IEP, TGF-1, protein totalβ
Time-Dependent Simulation Identifies Critical Hour Phase of Intestinal Acute Injury in Sepsis Mouse Model Istanti, Yusrina; Anggoro, Naufal Sebastian; Husain, Sofian Azalia; Azzahara, Salma Yasmine
International Journal of Cell and Biomedical Science Vol 3 No 9 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i9.64

Abstract

Background: Understanding the dynamic process of intestinal injury and repair during sepsis is essential for identifying optimal therapeutic windows. This study aimed to determine the critical time phase of intestinal acute injury by analyzing histological changes over a 24-hour period in a sepsis mouse model. Methods: Mice were divided into four groups—Control, 9 h, 12 h, and 24 h—and intestinal tissue samples were assessed using the Chiu histological scoring system. A time-dependent simulation was conducted to evaluate average changes in tissue damage and to identify key transition points between injury and recovery phases. Statistical analysis was performed using one-way ANOVA followed by post hoc comparisons to determine significant differences among time points. Results: The simulation demonstrated a marked increase in intestinal damage between 9 h and 12 h, followed by partial recovery at 24 h. Statistical analysis revealed a significant difference (p < 0.05) corresponding to this shift. These findings suggest that peak tissue injury occurs around 12 hours post-sepsis induction, preceding the onset of repair mechanisms. Conclusion: The study provides quantitative insight into the temporal progression of intestinal injury in sepsis, identifying the 12–24 hour period as a critical therapeutic window for potential interventions.
Faktor Risiko Terjadinya Pneumonia Oleh Carbapenem-Resistant Organism (Cro) Pada Bayi Dan Anak di Ruang Perawatan Intensif : Sebuah studi di RSUP Dr. Kariadi Arkhaesi, Nahwa; Istanti, Yusrina; Saputra, Mohammad Supriatna Toto; Priyatiningsih, Dewi Ratih; Soleha, Indah; Salsabila, Salma Tyas
Medica Hospitalia : Journal of Clinical Medicine Vol. 13 No. 1 (2026): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v13i1.1353

Abstract

BACKGROUND: Inappropriate antibiotic use has led to bacterial resistance, including carbapenem-resistant organisms (CROs), which cause severe infections in neonatal intensive care unit (NICU) and pediatric intensive care unit (PICU) patients. CRO infections are associated with high morbidity and mortality rates, with limited treatment options. Risk factors such as prolonged hospitalization, broad-spectrum antibiotic use, invasive procedures, and prior infections contribute to these cases. This study is the first in Indonesia to specifically examine CRO pneumonia risk factors in NICU and PICU children. OBJECTIVES: This study aimed to analyze the risk factors for pneumonia caused by carbapenem-resistant organisms (CROs) in children in the pediatric and neonatal intensive care unit. METHODS: This case-control study was conducted in neonatal intensive care unit (NICU) and Pediatric Intensive Care Unit (PICU) of Dr. Kariadi Hospital, Semarang, using medical records of patients admitted between November 2022 and October 2024. This study analyzed the relationship between various risk factors, including hospitalization duration, antibiotic use, mechanical ventilation, catheterization, prior surgery, and bacterial infection history, with CRO pneumonia in NICU and PICU patients. RESULTS: This case-control study in NICU and PICU on 87 pediatric pneumonia patients found that 55.2% had CRO pneumonia. Multivariate analysis revealed that carbapenem use for >7 days (p = 0.049), mechanical ventilation (p = 0.044), and urinary catheterization (p = 0.020) were independent risk factors for CRO pneumonia. CONCLUSION: CRO infections in NICU and PICU patients are highly prevalent, with prolonged carbapenem use, mechanical ventilation, and urinary catheterization as independent risk factors for CRO pneumonia.
Co-Authors Anggoro, Naufal Sebastian Azzahara, Salma Yasmine Haryson Tondy Husain, Sofian Azalia Kisdjamiatun RMD Mohamad Supriatna Nahwa Arkhaesi Priyatiningsih, Dewi Ratih Salsabila, Salma Tyas Saputra, Mohammad Supriatna Toto Soleha, Indah Tatty Ermin