Articles
<![CDATA[Sifilis Pada Kehamilan ]]>
<![CDATA[Darmawan, Hari]]>;
<![CDATA[Purwoko, Izazi Hari]]>;
<![CDATA[Devi, Mutia]]>
<![CDATA[ Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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<![CDATA[Syphilis is a sexually transmitted infection caused by bacterium Treponema pallidum which can be transmitted through sexual intercourse, blood transfusion, and vertically from mother to fetus. If pregnant woman suffers from syphilis, transplacental infection can occur to the fetus, causing abortion, prematurity, low birth weight, stillbirth, or congenital syphilis. The diagnosis of syphilis in pregnancy is established based on history, clinical manifestations, laboratory and serologic examination. Screening in the first trimester with non-treponema tests such as rapid plasma reagin (RPR) or venereal disease research laboratory (VDRL) combined with a treponema test such as the treponema pallidum hemagglutination assay (TPHA) is important for every pregnant woman. Clinical manifestations of syphilis to the fetus depend by gestational age and stage of maternal syphilis also fetal immune response. Early detection and adequate management are important to prevent the transmission of syphilis infection from mother to fetus.]]>
<![CDATA[Herpes Zoster: Clinical Manifestation, Treatment, and Prevention ]]>
<![CDATA[Muhammad Izazi Hari Purwoko]]>;
<![CDATA[Hari Darmawan]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v4i3.129
<![CDATA[Herpes zoster (HZ, shingles, zoster) is a disease due to reactivation and multiplication of persistent varicella zoster virus (VVZ) after suffering from previous varicella with characteristics of dermatomal rashes, pain, and unilateral. Dermatoms most often involved in HZ lesions are thoracal, trigeminal, lumbal, and cervical. The first lesion is usually erythematous macule or papule, which then turns into vesicle, then to pustule and to become crust, and persists for 2-3 weeks. The main goal of antiviral therapy in HZ patients is to reduce the expansion, duration, and severity of rashes and pain in primary dermatomes; prevent the spread of HZ to other places; and prevent post-herpes neuralgia. One of the prevention strategies for HZ in the elderly and high-risk individuals is vaccination using the varicella zoster virus vaccine that is live zoster vaccine or recombinant zoster vaccine.]]>
<![CDATA[Efficacy of Calcipotriol 0.005% Ointment for Uremic Xerosis with Pruritus in Chronic Kidney Diseases Undergoing Hemodialysis Patients: Randomized Double Blind Clinical Trial ]]>
<![CDATA[Widyastuti]]>;
<![CDATA[Yulia Farida Yahya]]>;
<![CDATA[Suroso Adi Nugroho]]>;
<![CDATA[Soenarto Kartowigno]]>;
<![CDATA[M. Izazi Hari Purwoko]]>;
<![CDATA[Irsan Saleh]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v5i6.319
<![CDATA[Introduction: Uremic xerosis with pruritus (UXP) is a chronic cutaneous complication among patients undergoing maintenance renal dialysis. Uremic xerosis level is directly related with pruritus severity or vice versa. Uremic xerosis with pruritus may lead to discomfort and negative psychological effect. The ethiopathogenesis still unknown, Most of treatments are empirical, and there is no effective and safe therapy. Emollient has not been effective enough to improve quality of life. There is some report about efficacy of topical vitamin D in xerosis and chronic pruritus. Objective: We evaluate the efficacy of calcipotriol 0.005% ointment for uremic xerosis and uremic pruritus in chronic kidney disease patients undergoing hemodialysis. Material & methode: Sixty two patients with UXP were enrolled, randomized double blind study. Patients were divided to two group, calcipotriol 0.005% ointment group or placebo. In baseline, patients were instructed to apply twice daily for four weeks. We assesesment the efficacy and safety of calcipotriol 0.005% ointment and placebo after 2nd and 4th weeks treatment using overall dry skin score (ODSS), visual analog scale (VAS), corneometer and sebumeter. We also assessed adverse effect and tolerance this drugs using visual assessment scale. Results: Overall dry skin score (ODSS) and visual analog scale (VAS) significantly decreased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Skin hydration level based on Corneometer score and skin surface lipid based on Sebumeter score was significantly increased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Cure rate and clinical improvement for calcipotriol 0.005% ointment group was significantly higher than placebo group. There was no adverse effect between two groups after treatment. Conclusion: calcipotriol 0.005% ointment is effective than placebo and can be used as alternative or adjuctive treatment and safe and tolerance for UXP.]]>
<![CDATA[Etiology, Diagnosis, and Treatment of Leukorrhea ]]>
<![CDATA[Damai Trilisnawati]]>;
<![CDATA[Izazi Hari Purwoko]]>;
<![CDATA[Mutia Devi]]>;
<![CDATA[Suroso Adi Nugroho]]>;
<![CDATA[Fitriani]]>;
<![CDATA[Theresia L. Toruan]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v5i6.323
<![CDATA[The most frequently reported complaints in the urogenital organ system is leukorrhea, also known as fluor albus. Leukorrhea is a discharge secreted from the genital organs, mostly occur in female. Leukorrhea has a significant incidence rate and varies according to many factors such as hormone and infection. Leukorrhea can be physiological in female, but when excess discharge is accompanied by other characteristics, the leukorrhea is considered pathological. This genital discharge also occurs in male for pathological reasons, mainly caused by infection. Several pathogenic infections, whether transmitted through secual contact or not, are the etiology of complaints of leukorrhea. Some specific pathogens will cause different symptoms in the two sex groups. To make a diagnosis, it is important for the examiner to carry out a detailed and coherent history, especially regarding sexual contact and a history of risky sexual behavior. Although some infections are asymptomatic, complications may occur if infections are not treated properly as early as possible. The management of leukorrhea is based on an examination and treatment algorithm with syndromic approach.]]>
<![CDATA[Granuloma Inguinale ]]>
<![CDATA[Adi Agung Anantawijaya D]]>;
<![CDATA[Muhammad Izazi Hari Purwoko]]>;
<![CDATA[Mutia Devi]]>;
<![CDATA[Suroso Adi Nugroho]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 7 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v5i7.330
<![CDATA[Granuloma ingunale (GI) or donovanosis is a genital ulcer disease caused by theCalymmatobacterium granulomatis. It is a Gram-negative, facultative, obligateintracellular and pleomorphic bacterium. This bacterium has phylogeneticallyclosed to and placed within the Klebsiella genus. Clinically, the disease is com-monly characterized as painless, slowly progressive ulcerative lesions on thegenitals or perineum without regional lymphadenopathy. The lesions are highlyvascular and bleed easily on contact Extragenital lesions may occur but are rareand more common in newborns from mothers with GI genital lesions. Thisdisease is often neglected, therefore it is often misdiagnosed and inaccuratetherapy. Treatment time is 3 weeks or until clinical cure has been achieved forall proposed regimens. It often occurs both in men and women of reproductiveage (20-40 years). This article consists of several theoretical references that havebeen viewed to have a better understanding of GI.]]>
<![CDATA[Laboratory Examination of Syphilis ]]>
<![CDATA[M. Izazi Hari Purwoko]]>;
<![CDATA[Mutia Devi]]>;
<![CDATA[Suroso Adi Nugroho]]>;
<![CDATA[Fitriani Fitriani]]>;
<![CDATA[Raden Pamudji]]>;
<![CDATA[Nofilia Citra Candra]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v5i8.339
<![CDATA[Syphilis, is sexually transmitted disease caused by spirochete Treponema pallidum subsp.pallidum. It have many diverse clinical manifestations that occur in distinct stages. Early diagnosis and management are the main things to prevent transmission and complication. Direct test or morphological observation is the definitive diagnosis of syphilis. This can be done through animal inoculation test, dark field microscopy, direct fluorescence antibody (DFA), and nucleid acid amplification test (NAAT). While the indirect test is a nontreponemal serologic test consist of Wasserman test, venereal disease research laboratory (VDRL), toluidine red unheated serum test (TRUST), unheated serum reagin (USR), rapid plasma reagin (RPR) and treponemal serologic test, such as T. pallidum passive particle agglutination (TPPA), T. pallidum haemagglutination assay (TPHA), fluorescent treponemal antibody absorption (FTA-Abs), enzyme immunoassay (EIA) and rapid test. The algorithm of serologic test can be divided into traditional or reverse.]]>
<![CDATA[Herpes Zoster: Clinical Manifestation, Treatment, and Prevention ]]>
<![CDATA[Muhammad Izazi Hari Purwoko]]>;
<![CDATA[Hari Darmawan]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v4i3.129
<![CDATA[Herpes zoster (HZ, shingles, zoster) is a disease due to reactivation and multiplication of persistent varicella zoster virus (VVZ) after suffering from previous varicella with characteristics of dermatomal rashes, pain, and unilateral. Dermatoms most often involved in HZ lesions are thoracal, trigeminal, lumbal, and cervical. The first lesion is usually erythematous macule or papule, which then turns into vesicle, then to pustule and to become crust, and persists for 2-3 weeks. The main goal of antiviral therapy in HZ patients is to reduce the expansion, duration, and severity of rashes and pain in primary dermatomes; prevent the spread of HZ to other places; and prevent post-herpes neuralgia. One of the prevention strategies for HZ in the elderly and high-risk individuals is vaccination using the varicella zoster virus vaccine that is live zoster vaccine or recombinant zoster vaccine.]]>
<![CDATA[Efficacy of Calcipotriol 0.005% Ointment for Uremic Xerosis with Pruritus in Chronic Kidney Diseases Undergoing Hemodialysis Patients: Randomized Double Blind Clinical Trial ]]>
<![CDATA[Widyastuti]]>;
<![CDATA[Yulia Farida Yahya]]>;
<![CDATA[Suroso Adi Nugroho]]>;
<![CDATA[Soenarto Kartowigno]]>;
<![CDATA[M. Izazi Hari Purwoko]]>;
<![CDATA[Irsan Saleh]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
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DOI: 10.32539/bsm.v5i6.319
<![CDATA[Introduction: Uremic xerosis with pruritus (UXP) is a chronic cutaneous complication among patients undergoing maintenance renal dialysis. Uremic xerosis level is directly related with pruritus severity or vice versa. Uremic xerosis with pruritus may lead to discomfort and negative psychological effect. The ethiopathogenesis still unknown, Most of treatments are empirical, and there is no effective and safe therapy. Emollient has not been effective enough to improve quality of life. There is some report about efficacy of topical vitamin D in xerosis and chronic pruritus. Objective: We evaluate the efficacy of calcipotriol 0.005% ointment for uremic xerosis and uremic pruritus in chronic kidney disease patients undergoing hemodialysis. Material & methode: Sixty two patients with UXP were enrolled, randomized double blind study. Patients were divided to two group, calcipotriol 0.005% ointment group or placebo. In baseline, patients were instructed to apply twice daily for four weeks. We assesesment the efficacy and safety of calcipotriol 0.005% ointment and placebo after 2nd and 4th weeks treatment using overall dry skin score (ODSS), visual analog scale (VAS), corneometer and sebumeter. We also assessed adverse effect and tolerance this drugs using visual assessment scale. Results: Overall dry skin score (ODSS) and visual analog scale (VAS) significantly decreased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Skin hydration level based on Corneometer score and skin surface lipid based on Sebumeter score was significantly increased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Cure rate and clinical improvement for calcipotriol 0.005% ointment group was significantly higher than placebo group. There was no adverse effect between two groups after treatment. Conclusion: calcipotriol 0.005% ointment is effective than placebo and can be used as alternative or adjuctive treatment and safe and tolerance for UXP.]]>
<![CDATA[Etiology, Diagnosis, and Treatment of Leukorrhea ]]>
<![CDATA[Damai Trilisnawati]]>;
<![CDATA[Izazi Hari Purwoko]]>;
<![CDATA[Mutia Devi]]>;
<![CDATA[Suroso Adi Nugroho]]>;
<![CDATA[Fitriani]]>;
<![CDATA[Theresia L. Toruan]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
Show Abstract
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Download Original
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Original Source
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Check in Google Scholar
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DOI: 10.32539/bsm.v5i6.323
<![CDATA[The most frequently reported complaints in the urogenital organ system is leukorrhea, also known as fluor albus. Leukorrhea is a discharge secreted from the genital organs, mostly occur in female. Leukorrhea has a significant incidence rate and varies according to many factors such as hormone and infection. Leukorrhea can be physiological in female, but when excess discharge is accompanied by other characteristics, the leukorrhea is considered pathological. This genital discharge also occurs in male for pathological reasons, mainly caused by infection. Several pathogenic infections, whether transmitted through secual contact or not, are the etiology of complaints of leukorrhea. Some specific pathogens will cause different symptoms in the two sex groups. To make a diagnosis, it is important for the examiner to carry out a detailed and coherent history, especially regarding sexual contact and a history of risky sexual behavior. Although some infections are asymptomatic, complications may occur if infections are not treated properly as early as possible. The management of leukorrhea is based on an examination and treatment algorithm with syndromic approach.]]>
<![CDATA[Granuloma Inguinale ]]>
<![CDATA[Adi Agung Anantawijaya D]]>;
<![CDATA[Muhammad Izazi Hari Purwoko]]>;
<![CDATA[Mutia Devi]]>;
<![CDATA[Suroso Adi Nugroho]]>
<![CDATA[ Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 7 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research ]]>
Publisher : <![CDATA[HM Publisher ]]>
Show Abstract
|
Download Original
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Original Source
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Check in Google Scholar
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DOI: 10.32539/bsm.v5i7.330
<![CDATA[Granuloma ingunale (GI) or donovanosis is a genital ulcer disease caused by theCalymmatobacterium granulomatis. It is a Gram-negative, facultative, obligateintracellular and pleomorphic bacterium. This bacterium has phylogeneticallyclosed to and placed within the Klebsiella genus. Clinically, the disease is com-monly characterized as painless, slowly progressive ulcerative lesions on thegenitals or perineum without regional lymphadenopathy. The lesions are highlyvascular and bleed easily on contact Extragenital lesions may occur but are rareand more common in newborns from mothers with GI genital lesions. Thisdisease is often neglected, therefore it is often misdiagnosed and inaccuratetherapy. Treatment time is 3 weeks or until clinical cure has been achieved forall proposed regimens. It often occurs both in men and women of reproductiveage (20-40 years). This article consists of several theoretical references that havebeen viewed to have a better understanding of GI.]]>
