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All Journal SRIWIJAYA JOURNAL OF MEDICINE PREPOTIF : Jurnal Kesehatan Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of General Procedural Dermatology and Venereology Indonesia Ebers Papyrus Bali Dermatology Venereology and Aesthetic Journal
Purwoko, Izazi Hari
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Sifilis Pada Kehamilan Darmawan, Hari; Purwoko, Izazi Hari; Devi, Mutia
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Syphilis is a sexually transmitted infection caused by bacterium Treponema pallidum which can be transmitted through sexual intercourse, blood transfusion, and vertically from mother to fetus. If pregnant woman suffers from syphilis, transplacental infection can occur to the fetus, causing abortion, prematurity, low birth weight, stillbirth, or congenital syphilis. The diagnosis of syphilis in pregnancy is established based on history, clinical manifestations, laboratory and serologic examination. Screening in the first trimester with non-treponema tests such as rapid plasma reagin (RPR) or venereal disease research laboratory (VDRL) combined with a treponema test such as the treponema pallidum hemagglutination assay (TPHA) is important for every pregnant woman. Clinical manifestations of syphilis to the fetus depend by gestational age and stage of maternal syphilis also fetal immune response. Early detection and adequate management are important to prevent the transmission of syphilis infection from mother to fetus.
Herpes Zoster: Clinical Manifestation, Treatment, and Prevention Muhammad Izazi Hari Purwoko; Hari Darmawan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i3.129

Abstract

Herpes zoster (HZ, shingles, zoster) is a disease due to reactivation and multiplication of persistent varicella zoster virus (VVZ) after suffering from previous varicella with characteristics of dermatomal rashes, pain, and unilateral. Dermatoms most often involved in HZ lesions are thoracal, trigeminal, lumbal, and cervical. The first lesion is usually erythematous macule or papule, which then turns into vesicle, then to pustule and to become crust, and persists for 2-3 weeks. The main goal of antiviral therapy in HZ patients is to reduce the expansion, duration, and severity of rashes and pain in primary dermatomes; prevent the spread of HZ to other places; and prevent post-herpes neuralgia. One of the prevention strategies for HZ in the elderly and high-risk individuals is vaccination using the varicella zoster virus vaccine that is live zoster vaccine or recombinant zoster vaccine.
Efficacy of Calcipotriol 0.005% Ointment for Uremic Xerosis with Pruritus in Chronic Kidney Diseases Undergoing Hemodialysis Patients: Randomized Double Blind Clinical Trial Widyastuti; Yulia Farida Yahya; Suroso Adi Nugroho; Soenarto Kartowigno; M. Izazi Hari Purwoko; Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.319

Abstract

Introduction: Uremic xerosis with pruritus (UXP) is a chronic cutaneous complication among patients undergoing maintenance renal dialysis. Uremic xerosis level is directly related with pruritus severity or vice versa. Uremic xerosis with pruritus may lead to discomfort and negative psychological effect. The ethiopathogenesis still unknown, Most of treatments are empirical, and there is no effective and safe therapy. Emollient has not been effective enough to improve quality of life. There is some report about efficacy of topical vitamin D in xerosis and chronic pruritus. Objective: We evaluate the efficacy of calcipotriol 0.005% ointment for uremic xerosis and uremic pruritus in chronic kidney disease patients undergoing hemodialysis. Material & methode: Sixty two patients with UXP were enrolled, randomized double blind study. Patients were divided to two group, calcipotriol 0.005% ointment group or placebo. In baseline, patients were instructed to apply twice daily for four weeks. We assesesment the efficacy and safety of calcipotriol 0.005% ointment and placebo after 2nd and 4th weeks treatment using overall dry skin score (ODSS), visual analog scale (VAS), corneometer and sebumeter. We also assessed adverse effect and tolerance this drugs using visual assessment scale. Results: Overall dry skin score (ODSS) and visual analog scale (VAS) significantly decreased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Skin hydration level based on Corneometer score and skin surface lipid based on Sebumeter score was significantly increased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Cure rate and clinical improvement for calcipotriol 0.005% ointment group was significantly higher than placebo group. There was no adverse effect between two groups after treatment. Conclusion: calcipotriol 0.005% ointment is effective than placebo and can be used as alternative or adjuctive treatment and safe and tolerance for UXP.
Etiology, Diagnosis, and Treatment of Leukorrhea Damai Trilisnawati; Izazi Hari Purwoko; Mutia Devi; Suroso Adi Nugroho; Fitriani; Theresia L. Toruan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.323

Abstract

The most frequently reported complaints in the urogenital organ system is leukorrhea, also known as fluor albus. Leukorrhea is a discharge secreted from the genital organs, mostly occur in female. Leukorrhea has a significant incidence rate and varies according to many factors such as hormone and infection. Leukorrhea can be physiological in female, but when excess discharge is accompanied by other characteristics, the leukorrhea is considered pathological. This genital discharge also occurs in male for pathological reasons, mainly caused by infection. Several pathogenic infections, whether transmitted through secual contact or not, are the etiology of complaints of leukorrhea. Some specific pathogens will cause different symptoms in the two sex groups. To make a diagnosis, it is important for the examiner to carry out a detailed and coherent history, especially regarding sexual contact and a history of risky sexual behavior. Although some infections are asymptomatic, complications may occur if infections are not treated properly as early as possible. The management of leukorrhea is based on an examination and treatment algorithm with syndromic approach.
Granuloma Inguinale Adi Agung Anantawijaya D; Muhammad Izazi Hari Purwoko; Mutia Devi; Suroso Adi Nugroho
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 7 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i7.330

Abstract

Granuloma ingunale (GI) or donovanosis is a genital ulcer disease caused by theCalymmatobacterium granulomatis. It is a Gram-negative, facultative, obligateintracellular and pleomorphic bacterium. This bacterium has phylogeneticallyclosed to and placed within the Klebsiella genus. Clinically, the disease is com-monly characterized as painless, slowly progressive ulcerative lesions on thegenitals or perineum without regional lymphadenopathy. The lesions are highlyvascular and bleed easily on contact Extragenital lesions may occur but are rareand more common in newborns from mothers with GI genital lesions. Thisdisease is often neglected, therefore it is often misdiagnosed and inaccuratetherapy. Treatment time is 3 weeks or until clinical cure has been achieved forall proposed regimens. It often occurs both in men and women of reproductiveage (20-40 years). This article consists of several theoretical references that havebeen viewed to have a better understanding of GI.
Laboratory Examination of Syphilis M. Izazi Hari Purwoko; Mutia Devi; Suroso Adi Nugroho; Fitriani Fitriani; Raden Pamudji; Nofilia Citra Candra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i8.339

Abstract

Syphilis, is sexually transmitted disease caused by spirochete Treponema pallidum subsp.pallidum. It have many diverse clinical manifestations that occur in distinct stages. Early diagnosis and management are the main things to prevent transmission and complication. Direct test or morphological observation is the definitive diagnosis of syphilis. This can be done through animal inoculation test, dark field microscopy, direct fluorescence antibody (DFA), and nucleid acid amplification test (NAAT). While the indirect test is a nontreponemal serologic test consist of Wasserman test, venereal disease research laboratory (VDRL), toluidine red unheated serum test (TRUST), unheated serum reagin (USR), rapid plasma reagin (RPR) and treponemal serologic test, such as T. pallidum passive particle agglutination (TPPA), T. pallidum haemagglutination assay (TPHA), fluorescent treponemal antibody absorption (FTA-Abs), enzyme immunoassay (EIA) and rapid test. The algorithm of serologic test can be divided into traditional or reverse.
Risk Factors for HIV-positive Status In Condyloma Acuminata Purwoko, Izazi Hari; Karim, Putri Laksmi; Nugroho, Suroso Adi; Toruan, Theresia; ., Fitriani
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Condyloma acuminata (CA) is a sexually transmitted infection (STI) caused by human papillomavirus (HPV), especially types 6 and 11. The number of HPV infections increases in immunosuppressed conditions, such as human immunodeficiency virus (HIV) infection. Risk factors in CA patients such as gender, sexual partner, sexual orientation, and sexual intercourse can increase HIV status. Methods: This is a descriptive-analytic study with a cohort retrospective design. The subjects are all CA patients who visited the polyclinic STI Dr. Mohammad Hoesin, General Hospital, Palembang, Indonesia, between 2016-2020. The number of CA patients included in the study were 115 patients aged 14 to 71 years old. Chi-square and multivariate logistic regression were used to analyze the independent variables. Results: The total number of HIV-positive CA patients was 31 (26.8%) out of 115. There were more males than females, and the mean age was 29±9.90, with a range of 14-71 years old. The most common location was the genital (58.3%). Gender, marital status, number of partners, sexual orientation, sexual intercourse, location, and type of lesions had p Conclusion: Risk factors for HIV in CA patients are age, marital status, sexual partner, sexual orientation, and location of lesions. CA patients who were MSM had a 22-fold higher risk for HIV-positive status.
THE CORRELATION BETWEEN ADHERENCE TO ANTIRETROVIRAL (ARV) MEDICATION AND CD4 COUNT IN THE OCCURRENCE OF VIROLOGICAL FAILURE AMONG INDIVIDUALS WITH HIV/AIDS Purwoko, Muhammad Izazi Hari; Santoso, Ritchie; Fitriani, Fitriani; Bahar, Erial; Chandra, Riza; Diba, Sarah; Budiamal, Susanti
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.36873

Abstract

Kegagalan virologi merupakan tantangan yang dihadapi oleh pasien human immunodeficiency virus (HIV) setelah memulai pengobatan, dan dipengaruhi oleh berbagai faktor. Modalitas terapi pada pasien HIV dilakukan dengan antiretroviral (ARV), dengan jumlah sel CD4 memainkan peran penting dalam menentukan waktu untuk memulai ARV. Oleh karena itu, tujuan dari penelitian ini adalah untuk menyelidiki hubungan antara kepatuhan terhadap ARV dan jumlah sel CD4 yang terkait dengan kegagalan virologi pada pasien HIV/AIDS yang telah diobati selama minimal 12 bulan dengan rejimen ARV. Penelitian analitik observasional dengan desain potong lintang dilakukan menggunakan teknik consecutive sampling pada 74 pasien berusia 17 tahun dan menjalani pengobatan ARV selama minimal 12 bulan di Departemen Rawat Jalan Konseling dan Pengujian Sukarela (VCT) dan Penyakit Menular Seksual (STD) Dermatologi, Venereologi, dan Estetika RSMH/FK UNSRI Palembang, serta Pusat Kesehatan Masyarakat Sukarami dan Dempo dari Juni hingga Agustus 2023. Dari total sampel penelitian sebanyak 74 pasien, 26 di antaranya (35,1%) mengalami kegagalan virologi. Kepatuhan terhadap antiretroviral (ARV) (p<0,001) dan jumlah sel CD4 (p<0,001) secara signifikan terkait dengan kegagalan virologi. Analisis multivariat menunjukkan bahwa kepatuhan terhadap ARV (p<0,001) dan jumlah sel CD4 (p<0,001) sangat terkait dengan kegagalan virologi. Penelitian ini menunjukkan bahwa kepatuhan terhadap ARV yang buruk dan jumlah sel CD4 yang rendah terkait dengan kegagalan virologi. Penguatan konseling kepatuhan ARV diperlukan untuk memperbaiki kondisi imunologis dan meningkatkan penekanan virus pada pasien HIV/AIDS.
FAKTOR RISIKO KEJADIAN GAGAL VIROLOGIK PADA PENATALAKSANAAN PASIEN HIV Santoso, Ritchie; Purwoko, Muhammad Izazi Hari; Fitriani, Fitriani; Bahar, Erial; Chandra, Riza; Diba, Sarah; Budiamal, Susanti
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.30539

Abstract

KONDILOMATA AKUMINATA PADA PASIEN HUMAN IMMUNODEFICIENCY VIRUS DITERAPI LARUTAN ASAM TRIKLOROASETAT 80% DAN TABLET SIMETIDIN Darmawan, Hari; Devi, Mutia; Purwoko, Izazi Hari
Ebers Papyrus Vol. 27 No. 2 (2021): EBERS PAPYRUS
Publisher : Fakultas Kedokteran Universitas Tarumanagara

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Abstract

Kondilomata akuminata (KA) adalah salah satu penyakit proliferatif epitel disebabkan human papilloma virus (HPV). Infeksi human immunodeficiency virus (HIV) dapat mempengaruhi patogenesis penyakit terkait HPV. Lesi KA pada pasien HIV biasa lebih besar, multipel, refrakter terhadap pengobatan konvensional, dan sering rekuren. Terapi kombinasi digunakan untuk mempercepat klirens lesi secara total. Laki-laki, 32 tahun, datang dengan keluhan papul verukosa multipel sewarna kulit di perianal sejak 2 bulan lalu. Lesi di perianal menunjukkan fenomena acetowhitening. Pemeriksaan serologik menunjukkan seropositif-HIV dengan kadar CD4 absolut 547 sel/mm3. Pasien didiagnosis sebagai KA dengan infeksi HIV. Pasien mendapat terapi tutul larutan trichloroacetic acid (TCA) 80%, tablet simetidin, dan antiretroviral therapy (ART). Lesi membaik setelah sesi pengobatan pertama. KA berhubungan dengan HIV dan juga sebaliknya. Lesi KA diterapi TCA 80% yang merupakan agen kaustik sehingga menyebabkan nekrosis dan koagulasi jaringan. Pemberian ART pada pasien KA dengan HIV akan mempercepat penyembuhan lesi. Simetidin merupakan obat golongan antagonis reseptor histamin 2 (AH-2) yang memiliki efek imunomodulator. Efektivitas simetidin sebagai terapi kombinasi KA terjadi melalui peningkatan sistem imun selular host. 
Co-Authors Adi Agung Anantawijaya D Chandra, Riza Damai Trilisnawati Diba, Sarah Erial Bahar, Erial Fitriani Fitriani . Fitriani Fitriani Fitriani Fitriani Hari Darmawan Hari Darmawan Indah Astri Aryani Karim, Putri Laksmi Kartowigno, Soenarto Kiki Septiafni Muhammad Irsan Saleh Mutia Devi Mutia Devi Mutia Devi Mutia Devi Mutia Devi, Mutia Nofilia Citra Candra Nugroho, Suroso Adi Octyvani, Tiar Marina Raden Pamudji Santoso, Ritchie Soenarto Kartowigno Susanti Budiamal Toruan, Theresia Toruan, Theresia Lumban Widyastuti Yuli Kurniawati, Yuli Yulia Farida Yahya