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All Journal Dentika Dental Journal Journal of Dental and Biosciences
Ashar, Fadli
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Dentistry Health Professions Medicine & Pharmacology Public Health

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The Effect Of Ethanol Extract From Lingzhi Fungi (Ganoderma Lucidum) Cianjur Isolate On Syndecan-1 Expressions In Kb CCL17 Oral Cancer Cell: Efek Ekstrak Ethanol Dari Jamur Lingzhi (Ganoderma Lucidum) Isolat Cianjur Terhadap Ekspresi Syndecan-1 Pada Sel Kanker Rongga Mulut Kb Ccl-17 Ashar, Fadli; Widodo, Haris Budi; Wahyono, Daniel Joko; Ratnaningtyas, Nuniek Ina; Nawangtantrini, Gita; Novrial, Dody; Dwiandhono, Irfan
Dentika: Dental Journal Vol. 24 No. 2 (2021): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v24i2.4189

Abstract

Intercellular adhesion plays a role in cancer formation and protein has a key potential in maintaining cell adhesion, including syndecan-1. Meanwhile, oral cancer originates from the oral epithelium, which has an invasive and metastatic level. Its treatments involving chemotherapy and radiotherapy commonly leave unfavorable side effects, hence, suitable alternatives are needed. Natural ingredients are widely used as an alternative treatment for cancer, for example, Ganoderma lucidum (G. lucidum) which has anti-cancer and anti-angiogenic properties, induces apoptosis, stimulates an immune response, inhibits the degradation of Extracellular matrix (ECM), reduces inflammation, affects cell cycles, cytotoxic, and acts as an antioxidant.This study aims to determine the effect of ethanol extract from Ganoderma lucidum Cianjur isolate on syndecan-1 expression in KB CCL-17 oral cell cancer. This was an experimental study with a post-test only control group design, the treatment group used G. lucidum ethanol extract with a concentration of 2.12 μg/ml (P1), 4.24 μg/ml (P2), and 8.49 μg/ml (P3), while the positive control group used cisplatin with a concentration of 11.5 μg/ml (K1). In contrast, the negative control used aquadest (K0), while syndecan-1 expression was observed using the immunohistochemical examination.The highest syndecan-1 expansion rate was found in the treatment group with a concentration of 8.49 μg/ml. A significant difference was indicated by one-way ANOVA (p<0.05) between K0 - K1, K0 - P1, K0 - P2, K0 - P3, K1 - P1, K1 - P2, K1 - P3, P1 - P2, as well as P1 and P3. The administration of ethanol extract from G. lucidum Cianjur isolate increases syndecan-1 expression in KB CCL-17 oral cell cancer.
Studi In Vivo Pengaruh Gel Ekstrak Etanol Daun Carica (Carica Pubescens) Terhadap Re-Epitelisasi Dan Ukuran Luka Pada Proses Penyembuhan Luka Insisi Gingiva Azizah, Yuliya Zalma Noor; Hirawan, Helmi; Taqwim, Ali; Ashar, Fadli
Journal of Dental and Biosciences Vol 2 No 01 (2025): Journal of Dental and Biosciences
Publisher : Jurusan Kedokteran Gigi Fakultas Kedoketaran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jdentbios.2025.2.01.12508

Abstract

Latar belakang: Luka insisi merupakan luka akibat benda tajam yang ditandai dengan terputusnya pembuluh darah kapiler pada jaringan. Luka akan sembuh melalui proses penyembuhan yang terdiri dari fase inflamasi, proliferasi, dan remodeling. Fase proliferasi meliputi terjadinya re-epitelisasi sebagai respon akibat adanya kerusakan jaringan. Re-epitelisasi akan membangun kembali jaringan yang rusak menyebabkan terjadinya penurunan ukuran luka hingga luka tertutup sempurna. Ekstrak etanol daun carica (Carica pubescens) diketahui mengandung zat aktif seperti, flavonoid, saponin, tanin dan triterpenoid yang dapat mempengaruhi proses penyembuhan luka. Tujuan dari penelitian ini mengetahui pengaruh ekstrak etanol daun carica terhadap re-epitelisasi dan penurunan ukuran luka pada proses penyembuhan luka insisi gingiva. Metode: Penelitian ini terbagi menjadi 5 kelompok perlakuan, yaitu P1 (gel ekstrak etanol daun carica 3%), P2 (gel ekstrak etanol daun carica 6%), P3 (gel ekstrak etanol daun carica 12%), KP (Aloclair® Plus Gel), dan KN (gel tanpa ekstrak). Data dianalisis menggunakan uji ANOVA dengan Post-Hoc LSD. Hasil: Analisis statistik menunjukkan hasil terdapat perbedaan signifikan (p≤0,05) antara seluruh kelompok dengan kontrol negatif gel tanpa ekstrak. Gel ekstrak konsentrasi 6% tidak menunjukkan perbedaan yang signifikan dengan kontrol positif Aloclair® Plus Gel. Simpulan: Simpulan penelitian ini adalah terdapat pengaruh ekstrak etanol daun carica terhadap re-epitelisasi dan penurunan ukuran luka.
Co-Authors Ali Taqwim Azizah, Yuliya Zalma Noor Daniel Joko Wahyono Dody Novrial, Dody Haris Budi Widodo Hirawan, Helmi Irfan Dwiandhono Nawangtantrini, Gita Nuniek Ina Ratnaningtyas