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All Journal Dentika Dental Journal PENGABDI: Jurnal Hasil Pengabdian Masyarakat Indonesian Journal of Cancer Journal of Public Health and Pharmacy Linggamas: Jurnal Pengabdian Masyarakat
Nawangtantrini, Gita
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Effect Of Ethanol Extract From Lingzhi Fungi (Ganoderma Lucidum) Cianjur Isolate On Syndecan-1 Expressions In Kb CCL17 Oral Cancer Cell: Efek Ekstrak Ethanol Dari Jamur Lingzhi (Ganoderma Lucidum) Isolat Cianjur Terhadap Ekspresi Syndecan-1 Pada Sel Kanker Rongga Mulut Kb Ccl-17 Ashar, Fadli; Widodo, Haris Budi; Wahyono, Daniel Joko; Ratnaningtyas, Nuniek Ina; Nawangtantrini, Gita; Novrial, Dody; Dwiandhono, Irfan
Dentika: Dental Journal Vol. 24 No. 2 (2021): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v24i2.4189

Abstract

Intercellular adhesion plays a role in cancer formation and protein has a key potential in maintaining cell adhesion, including syndecan-1. Meanwhile, oral cancer originates from the oral epithelium, which has an invasive and metastatic level. Its treatments involving chemotherapy and radiotherapy commonly leave unfavorable side effects, hence, suitable alternatives are needed. Natural ingredients are widely used as an alternative treatment for cancer, for example, Ganoderma lucidum (G. lucidum) which has anti-cancer and anti-angiogenic properties, induces apoptosis, stimulates an immune response, inhibits the degradation of Extracellular matrix (ECM), reduces inflammation, affects cell cycles, cytotoxic, and acts as an antioxidant.This study aims to determine the effect of ethanol extract from Ganoderma lucidum Cianjur isolate on syndecan-1 expression in KB CCL-17 oral cell cancer. This was an experimental study with a post-test only control group design, the treatment group used G. lucidum ethanol extract with a concentration of 2.12 μg/ml (P1), 4.24 μg/ml (P2), and 8.49 μg/ml (P3), while the positive control group used cisplatin with a concentration of 11.5 μg/ml (K1). In contrast, the negative control used aquadest (K0), while syndecan-1 expression was observed using the immunohistochemical examination.The highest syndecan-1 expansion rate was found in the treatment group with a concentration of 8.49 μg/ml. A significant difference was indicated by one-way ANOVA (p<0.05) between K0 - K1, K0 - P1, K0 - P2, K0 - P3, K1 - P1, K1 - P2, K1 - P3, P1 - P2, as well as P1 and P3. The administration of ethanol extract from G. lucidum Cianjur isolate increases syndecan-1 expression in KB CCL-17 oral cell cancer.
Peran Pemberdayaan Komunitas dalam Menjamin Peningkatan Mutu dan Keamanan Pangan Jajanan Anak Sekolah (PJAS) di Wilayah Cilacap Pribadi, Fajar Wahyu; Nawangtantrini, Gita; Widiartini, Catharina
PENGABDI PENGABDI: VOL. 5, NO.2 (2024)
Publisher : Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26858/pengabdi.v5i2.67651

Abstract

Pangan Jajanan Anak Sekolah (PJAS) adalah makanan siap saji yang sering dikonsumsi oleh anak-anak di sekolah, memenuhi 31,1% kebutuhan kalori dan 27,4% kebutuhan protein mereka. Namun, PJAS kerap kali tidak aman karena risiko kontaminasi biologis dan kimiawi. Hasil observasi dan wawancara menunjukkan bahwa sebagian besar penyedia PJAS belum memiliki pengetahuan khusus mengenai mutu dan keamanan PJAS, belum pernah membaca referensi terkait, serta tidak pernah mengikuti pelatihan yang berfokus pada aspek tersebut. Kegiatan ini bertujuan untuk meningkatkan pemahaman tentang pentingnya mutu dan keamanan PJAS di wilayah Cilacap melalui komunitas dalam hal ini adalah staf dan kader Yayasan Cerdas Bersinergi. Metode yang diterapkan mencakup ceramah, diskusi, dan pemutaran video. Berdasarkan kuesioner pra-kegiatan, 46,875% peserta memiliki pemahaman yang sangat kurang, 31,25% kurang, 21,875% cukup, dan 0% yang benar-benar memahami mutu dan keamanan PJAS. Setelah kegiatan, hasil kuesioner menunjukkan peningkatan, di mana 18,75% peserta memiliki pemahaman cukup dan 81,25% benar-benar memahami materi tersebut. Dengan tambahan leaflet, peserta dapat mengingat kembali materi dan berpotensi menyebarluaskannya kepada para penyedia PJAS lainnya.
Black Garlic Supplementation and Glomerular Protection in Hyperuricemic Rats: A Study on Kidney Health Prevention Wahyudin, Wahyudin; Wahyu Pribadi, Fajar; Nawangtantrini, Gita; Riski Fatah, Muhammad; Zainuddin, Zainuddin
Journal of Public Health and Pharmacy Vol. 4 No. 3: NOVEMBER 2024
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v4i3.5496

Abstract

Introduction: Hyperuricemia is a significant risk factor for the development of chronic kidney disease. Excessive uric acid can deposit in the kidneys, triggering inflammatory reactions and oxidative stress, leading to structural damage in the glomeruli. Black garlic, with its antioxidant and bioactive compounds, has the potential to protect the kidneys from hyperuricemia-induced damage. Our objective is to evaluate the effect of black garlic supplementation on the histopathological features of glomeruli in a hyperuricemic rat model. Methods: This study was an analytical observational study using Biological Remnant Materials (BRM) from a previous study. The sample consisted of 30 male Sprague-Dawley rats divided into 5 groups: disease control, drug control (allopurinol), and 3 black garlic dose groups (240 mg/day, 480 mg/day, and 960 mg/day). Data were collected through histopathological examination of kidney tissue using the glomerular damage scoring method (0-3). Data analysis was performed using one-way ANOVA and post hoc LSD tests. Results: Black garlic demonstrated protective effects on the histopathological features of glomeruli in hyperuricemic rats. The 240 mg/day dose showed the most significant improvement in kidney health, reducing glomerular damage scores compared to the disease control group (p < 0.05). These findings suggest that black garlic can serve as a preventive agent against kidney complications caused by hyperuricemia. Conclusion: Black garlic provides protective effects on glomerular histopathology in hyperuricemic rats, with the 240 mg/day dose being the most effective. These results suggest potential use for black garlic in preventing kidney complications in hyperuricemia.
Meningkatkan Kesehatan Saraf Lansia melalui Edukasi Gangguan Tidur, Neuropati, dan Penerapan Senam Otak di Posyandu Lansia Gunarto, Untung; Nawangtantrini, Gita; Hapsari, Ariadne Tiara; Wahyudin, Wahyudin; Sutrisna, Eman
Linggamas: Jurnal Pengabdian Masyarakat Vol 3 No 1 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.3.1.17356

Abstract

Peningkatan jumlah lansia di Indonesia membawa tantangan dalam pemeliharaan kesehatan saraf, khususnya terkait gangguan tidur, neuropati, dan penurunan fungsi kognitif. Pengabdian masyarakat ini bertujuan meningkatkan kesehatan saraf lansia melalui edukasi gangguan tidur, edukasi neuropati, dan penerapan senam otak di Posyandu Lansia Istiqomah Purwokerto. Kegiatan dilaksanakan pada 27 Juli di pelataran Masjid Fastabiqul Khaerat, Berkoh, melibatkan penyuluhan interaktif, sesi tanya jawab, serta praktik senam otak yang dipandu oleh dr. Untung Gunarto, Sp.S. Metode partisipatif digunakan untuk memfasilitasi transfer pengetahuan dan keterampilan secara langsung. Hasil menunjukkan lansia mampu mengingat kembali materi penyuluhan, memahami cara pencegahan gangguan tidur dan neuropati, serta mempraktikkan senam otak secara mandiri. Kader posyandu juga menunjukkan kesiapan menjadi penggerak kesehatan di komunitas. Kegiatan ini berpotensi direplikasi sebagai model pembinaan kesehatan lansia yang efektif dan berkelanjutan.
A Metastase Clear Cell Papillary Renal Cell Carcinoma (ccpRCC): A Case Report Octavian, Aditya Eka; Rahmadianto, Hajid; Nawangtantrini, Gita
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1217

Abstract

Introduction: Clear cell papillary renal cell carcinoma (ccpRCC) was recently identified, which acts like a benign tumor entity introduced by WHO in 2016. It shares morphologic features in both clear cells and papillary cells. It is characterized by its unique immunohistochemical, morphologic, and genetic features and indolent behavior with no reported recurrence or metastasis before. This paper presents a case of ccpRCC in adulthood with spinal metastasis.Case Presentation: A 16-year-old female patient presented to the urology polyclinic of Prof. Dr. Margono Soekarjo Hospital with an abdominal lump and hematuria. Subsequently, the patient underwent radical nephrectomy. Histopathological examination confirmed ccpRCC. After six months, the patient exhibited weakness in the lower extremities, sensory disturbances, and urinary retention. She was referred to the Neurology department, where physical examinations revealed paraplegia inferior and segmental hypoesthesia at the vertebrae T12 level. MRI examination showed signs of vertebral metastases. After receiving immediate treatment from the neurology department, the neurosurgery department scheduled the patient for a surgical procedure. The case was followed for eight months. Conclusions: ccpRCC is a benign kidney tumor exhibiting a combination of clear cell and papillary cell carcinoma characteristics. While patients with ccpRCC are typically asymptomatic, cases are presenting with symptoms such as hematuria. This case demonstrates the occurrence of hematogenic metastases in ccpRCC, highlighting the need for surgical intervention to preserve existing functionality
Co-Authors Ariadne Tiara Hapsari Ashar, Fadli Daniel Joko Wahyono Dody Novrial, Dody Eman Sutrisna Fajar Wahyu Pribadi Fajar Wahyu Pribadi, Fajar Wahyu Haris Budi Widodo Irfan Dwiandhono Nuniek Ina Ratnaningtyas Octavian, Aditya Eka Rahmadianto, Hajid Riski Fatah, Muhammad Untung Gunarto, Untung Wahyudin Wahyudin Widiartini, Catharina Zainuddin Zainuddin