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Glaukoma yang Diinduksi Steroid Oculi Dextra Et Sinistra Rahmanindya Defiyandini Puteri; M. Yusran
Medula Vol 10 No 1 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i1.45

Steroids are a group of anti-inflammatory drugs, commonly used to treat ocular and systemic conditions. Unmonitored use of steroids especially in eye drop formulations is common in situations when it is easily available over-the-counter, resulting in undesirable side effects. Ms. L, 17 years old, both eyes could not see without red eyes since 8 months ago. Initially the patient feels increasingly blurry until finally unable to see. Before experiencing this the patient had a history of using eye drops cointaing steroid for almost 1 year because her eyes were often red. Ophthalmological examination obtained vision oculus dextra: ½/60, vision oculus sinistra 1/300, no injection of right and left conjunctiva, deep right and left front chambers, pupillary light reflexes decreased in both eyes, right and left clear lens, oculi tension N+1 per palpation, narrow vision field, and in fundoscopic examination found cupping of the optic disc with cup disc ratio of 0.9, nasalisation of blood vessels and lamina cribosa were clearly seen in both eyes. Therapy given to this patient was Timolol maleate 0,5% eye drop 1 drop /12 hours and Latanoprost 0.005% eye drop 1 drop /24 hours. Patients were also planned for trabeculectomy surgery.

Efek Curcumin Sebagai Pengobatan Penyakit Jantung Koroner Anggun Elidiya; Rizki Hanriko; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.264

Atherosclerosis is a chronic and progressive problem due to the inflammatory response, oxidative stress (OS), lipid deregulation, and epigenetic disorders. Curcumin is the main compound in turmeric and is responsible for turmeric yellow and contains 50% of turmeric. Curcumin has a hypolipidemic effect along with antioxidant and anti-inflammatory, it can contribute to reduce the incidence of atherosclerosis. The extraordinary antioxidant content of curcumin reduces lipid peroxidation and oxLDL formation, and consequently, reduces the inflammatory response and the development of atherosclerosis. Another study shows that curcumin can alter gene expression associated with leukocyte adhesion and transendothelial migration in aortic tissue by increasing expression of NF-κB protein inhibitors (IκB) and decreasing NF-κB bonds and transcription activity after stimulation with tumor necrosis factor-α (TNF-α). In addition, it is proven that curcumin can regulate the activation of toll-like receptor 4 (TLR4), a receptor that recognizes exogenous or endogenous molecular patterns and modulates immune and inflammatory responses. The role of other curcumin for atherosclerosis is smooth muscle cell proliferation. Curcumin is an antioxidant that can be one of the management of coronary heart disease due to be able to suppress the formation of atherosclerosis and reduce cholesterol levels in the blood. It is expected that curcumin can be the first treatment for coronary heart disease.

Potensi Metformin sebagai Agen Anti-Kanker Ni Made Dewi Puspita Sari; Muhartono; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.271

Metformin is one of the often prescribed anti-diabetic drugs. As an anti-diabetes effect, metformin also becomes anti-cancer. The mechanism of metformin as an anti-cancer through direct and indirect effects. Indirect sugar with loss of glucose levels, effects of hyperinsulinemia, levels of Insulin Growth Factor-1 (IGF-1), and immune responses to cancer cells. A direct effect on AMPK activation stimulation which works molecularly on cancer cells. This makes the metformation is potential as an anti-cancer agent alone or in combination with other chemotherapy agents or radiation.

Terapi Madu Pada Penderita Ulkus Diabetikum Ayu Ningsih; Susianti; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.275

Diabetes Mellitus (DM) is a metabolic disorder characterized by high levels of sugar (hyperglycemia) due to decreased insulin secretion by the pancreas, reduced insulin sensitivity, or both. One complication of DM is diabetic ulcer. Diabetic ulcers occur due to reduced vascular supply of blood vessels at the peripheral end resulting in the absence of oxygen so the tissue becomes necrotic. The importance of wound care is important to prevent the occurrence of fatal complications in the form of amputation in response to Wagner 5 criteria. Treatment of wounds in the form of herbal ingredients such as olive oil, honey and aloe vera has been done. Honey has several ingredients that are useful as antibacterial, anti-inflammatory, autolysis and wound healing. while the important enzymes contained in honey are diastase, invertase, glucose oxidase, peroxidase, and lipase. Antibacterial honey has a mixture of 48% sugar and 15-20% moisture content so that the content makes the bacteria unable to live. Honey can activate plasminogen into plasmin, this plasmin will become a fibrin thread which facilitates blood flow. The high glucose level of honey increases glucolysis which produces an energy source for macrophages.

Efek Aloe vera dalam Menurunkan Risiko Penyakit Stroke Angwen Rial Huga; Anggraeni Janar Wulan; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.278

Stroke is a non communicable disease whose prevalence is increasing in Indonesia. The results of the Riset Kesehatan Dasar (Riskesdas) in 2018 showed that an increase in the prevalence of stroke from 7% (in 2013) to 10.9% with the highest proportion was in East Kalimantan (14.7%) and the lowest proportion was in the Papua region (4.1%). The increased prevalence is related to unhealthy lifestyles. Besides that hypercholesterolemia (high cholesterol levels in the blood) is also a risk factor for stroke which if not handled properly will lead to atherosclerotic plaque formation in blood vessels. This plaque can block the flow of blood that carries oxygen to the brain so that it can cause a stroke. One type of plant in Indonesia that has benefits in lowering cholesterol levels is Aloe vera. There are many ingridients of Aloe vera such as amino acids, salicylic acids, anthraquinons, enzymes, magnesiums, zincs, minerals, vitamins (A, C, E), lignins, saponins, phytosterols, monosaccharides, and polysaccharides (glucomannans and acemannans). Based on several studies, Aloe vera can reduce blood cholesterol levels with saponins, phytosterols, and glucomannans compound that have a direct role in lowering cholesterol levels. Saponin will inhibit the absorption of cholesterol in the gastrointestinal tract and increase its excretion, phytosterols will bind cholesterol and prevent cholesterol from being absorbed by the gastrointestinal tract, whereas glucomannan which is fiber will absorb water and inhibit the process of recycling bile salts so that only a few will return to the liver and more excreted through feces. Reduced blood cholesterol levels due to Aloe vera will have a good effect on atherosclerotic plaque so as to reduce the risk of stroke.

Efektivitas Dari Tanaman Zodia (Evodia Suaveolens) Sebagai Insektisida Nabati Nyamuk Aedes aegypti Penyebab Demam Berdarah Anniza Agustina; Betta Kurniawan; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.282

Dengue Hemorrhagic Fever (DHF) is a problem of one infectious disease in the community. Dengue virus infection through Aedes aegypti mosquito bites to humans as a vector. Eradication of vectors using insecticides must be environmentally friendly and safe for the ecosystem. Vegetable insecticide was chosen because it is easy to obtain and friendly to the environment. Zodia plants have been widely used by the people, especially the people of Papua as an anti-mosquito. Because of the content of evodiamine, rutaecarpine, and linalool, a-pinene is very effective as a mosquito repellent. Three ways of working plant-based insecticides work, namely: contact poison, gas poison and stomach poison. Research by calculating the average number of mosquitoes - the number of mosquitoes perched on the probandus arm with a concentration of 5%, 10%, 15%, 20%, 25%, 30% proves that the concentration of 25% has a longer protective power of 4 hours with an average of an average of 91%. Other studies say that the concentration of Zodia leaves can last five hours with a concentration of 60% even though it has only 48% protective power. The addition of a fragrant aroma that is fixative can increase protective power. This zodia plant contains linalool (46%) and a-pinene (13.26%). Linalool in zodia leaf essential oils have active ingredients such as evodiamine and rutaceacarpine which have a bitter taste and distinctive aroma.

THE SETTLEMENT OF THE DISPUTE OF “COLLECTIVE” VIOLENCE BY THE POLICE M. Yusran
Jurnal IUS Kajian Hukum dan Keadilan Vol 1, No 3 (2013): APAKAH HUKUM SUDAH MATI?
Publisher : Fakultas Hukum Universitas Mataram

Indonesia Republic State Police is a tool that plays a role in maintaining state security and public order, enforce the law and provide protection, guidance, and service to the community within the framework of maintaining internal security “. According to Police Act Number 2 of Year 2002 in Article 18 explained that the police were given the authority under certain circumstances to do according to his own judgment or be known as a functional discretionary powers which puts persons of police as a central factor in law enforcement. Discretion is the authority of the police to make a decision or choose different actions in resolving issues of law or violation of criminal cases are handled. Police discretion is an authority given to the police, to make decisions in certain situations that require separate consideration and involves moral issues and lies within the boundary line between the legal and the moral. One of the scope of police discretion is collective violence. Collective violence is violence committed by a group of people who performed together , this collective violence associated with irrationality, emotionality and impersonation individuals who escape the social restrictions of a social organization. Individuals who are in a group / crowd considered mimic each other, so that mutually reinforce and enlarge emotionality and irrationality of others Keywords : Policing , Discretion , Collective Violence

Merokok Sebagai Faktor Risiko Thyroid Eye Disease Febri Nadyanti; M. Yusran
MAJORITY Vol 10 No 1 (2021): MAJORITY
Publisher : Majority

Show Abstract | Download Original | Original Source | Check in Google Scholar

Thyroid-Associated Ophthalmopathy (TAO), known as Graves Ophthalmopathy (GO) or Thyroid Eye Disease (TED), is the most common cause of orbital disease in adults and a significant cause of morbidity in patients with Graves' disease. The main cause of this disease is the occurence of inflammation, which results in the overproduction of glycosaminglycans (GAG) and adipogenesis. This process is caused by the release of local inflammatory cytokines. Smoking is suspected to be one of risk factor that associated with the severity of TED. Tobacco smoke has cyanide, this substance will be converted into chemical thyocyanates when inhaled. Exposure to that smoke can increase the production and adipogenesis which is the cause of Thyroid Eye Disease.

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