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All Journal CHEMPUBLISH JOURNAL Helium: Journal of Science and Applied Chemistry
Fahmi, Rifaldi Lutfi
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology

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Exploring the Viability of Waste Durian (Durio zibethinus) Seeds and Cempedak (Artocarpus integer) Seeds as Nutritive Resources: An Analytical Study of Their Suitability via Alcohol and Glucose Assays Syarpin, Syarpin; Saputra, Rizki Rachmad; Haliza , Nur; Anista, Anista; Yanti, Helda; Sisilya, Tahsya Amanda; Fahmi, Rifaldi Lutfi
Chempublish Journal Vol. 7 No. 2 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i2.27983

Abstract

Durian (Durio zibethinus) and Cempedak (Artocarpus integer), prominent staples in Indonesia, harbor seeds that can be harnessed for the production of 'Tapai', a traditional fermented product. This fermentation process within cempedak and durian seeds manifests in the generation of alcohol and glucose at discernible thresholds. Motivated by the prevalent underutilization of durian and cempedak seeds leading to wastage, this study aims to assess the viabilities of Tapai derived from these seeds by scrutinizing their alcohol and glucose profiles. Employing a quantitative descriptive approach, the research centers on cempedak and durian seed Tapais as the primary samples. Focusing on variables like alcohol and glucose content, the investigative technique incorporates distillation and titration using the Luff Schoorl method. Results are subsequently organized in frequency distribution tables following coding and tabulation. Observations reveal that alcohol and glucose levels in cempedak seed Tapai on the 10th day stand at 0.00% and 30.05%, respectively, while on the 15th day, they escalate to 4.88% and 41.92%. In the case of durian seed Tapai, levels on the 10th day are recorded at 4.88% for alcohol and 36.90% for glucose. On the 15th day, these figures rise to 16.57% for alcohol and 46.53% for glucose. Ultimately, this study underscores that the alcohol and glucose concentrations in cempedak and durian seed Tapais experience progressive augmentation over a 5-day period, rendering them safely consumable in moderate quantities.
Targeting Dopamine Transporter (DAT) with Peronema canescens Bioactives: A Molecular Docking Study for Stroke-Related Pain and Sedation Management Saputra, Rizki Rachmad; Fahmi, Rifaldi Lutfi; Novitasari, Eka; Maknun, Luluil; Yanti, Jeddah; Fairozi, Raiyan
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 1 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i1.19

Abstract

Pain and drowsiness are common symptoms of stroke recovery, which can be difficult to manage owing to neurochemical abnormalities in the dopamine system. The Dopamine Transporter (DAT) controls dopamine levels, which influences pain perception and neurological recovery. This study examines bioactive chemicals found in Peronema canescens leaves and their possible interactions with DAT. AutoDock Vina was used to perform molecular docking simulations to determine the binding affinities of Peronemin derivatives (A2, A3, and B2) to the Dopamine Transporter (DAT). The receptor structure (PDB ID: 4M48) was created by eliminating water molecules, introducing polar hydrogens, and optimizing the structure using AutoDockTools. Ligand structures were translated to the proper format, and docking was conducted using a grid box centered on DAT's active site, with an exhaustiveness value of 10. The Peronemin derivatives A2, A3, and B2 demonstrated binding affinities stronger than nortriptyline, native ligand (−10.6, −10.5, and −10.3 kcal/mol, respectively) and binding similarities ranging from 72.2% to 94.4%. These findings suggest that Peronema canescens bioactives may be promising candidates for stroke-related pain and sedative control, warranting further experimental validation.
Co-Authors Anista, Anista eka novitasari Fairozi, Raiyan Haliza , Nur Jeddah Yanti Maknun, Luluil Rizki Rachmad Saputra Sisilya, Tahsya Amanda syarpin, syarpin Yanti, Helda