Garuda - Garba Rujukan Digital

Potential of Red Okra Extract (Abelmoschus esculentus L. Moench) to Restore Kidney Damage due to Sodium Nitrite Wahyuningsih, Sri Puji Astuti; Fachrisa, Amalia; Nisaâ€™, Nabilatun; Kusuma, Baskara Wiku Adi; Shoukat, Nadia; Ahmar, Rasyidah Fauzia; Alifiyah, Na'ilah Insani
Biosaintifika: Journal of Biology & Biology Education Vol 13, No 1 (2021): April 2021
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v13i1.28141

Sodium nitrite (NaNO2) found in vegetables, drinking water, and cured meats, can damage tissue because it is an oxidant. Plant phytochemicals such as quercetin are antioxidants. This study aimed to determine the potential of red okra pods ethanol extract (ROE) to repair kidney damage in mice (Mus musculus) induced by NaNO2. The red okra pods were extracted three times with saturated ethanol. The experiment used 36 male BALB/c mice aged 6-8 weeks and body weight of about 28 g. There are six research groups, namely, normal control, negative control (exposure to NaNO2 50 mg/kg BW), treatment of exposure to NaNO2 and administration of ROE at doses of 25, 50, 75, and 100 mg/kg BW. Sodium nitrite and ROE were given daily for 23 days by gavage. On day 24, the serum was isolated. Blood urea nitrogen (BUN) and creatinine (Cre) levels are measured to assess kidney function, as well as measuring the oxidant malondialdehyde (MDA) and the antioxidant enzyme of superoxide dismutase (SOD). The kidneys were made histological preparations and analyzed on the proximal convoluted tubule (PCT).Â All data were statistically analyzed (Î±=0.05). This study indicated that the administration of ROE at a 100 mg/kg BW dose is the most optimal in repairing damage to the PCT with increased normal cells and reduced necrosis. Besides, it degraded BUN, Cre, and MDA levels in the serum of mice exposed to NaNO2 compared to the other treatments. All doses of ROE promoted the SOD level. ROE restore kidney tissue, especially on PCT to normal. Kidney damage due to exposure to NaNO2 preservatives can be reduced by administering ROE. ROE prevents kidney damage through an increase in antioxidant enzymes. ROE can be used as a food ingredient as a source of antioxidants, thereby reducing the impact of oxidant compounds.

Enhancing the Anticancer Activity of Squamocin for Breast Cancer Treatment Using Nanodiamond Nanoparticles: An In Vivo Study Firli Rahmah Primula Dewi; Sri Puji Astuti Wahyuningsih; Rasyidah Fauzia Ahmar; Na'ilah Insani Alifiyah; Vuanghao Lim; Muhammad Darwin Prenggono
HAYATI Journal of Biosciences Vol. 30 No. 1 (2023): January 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.1.131-139

Squamocin is one of the annonaceous acetogenins produced by the Annonaceae family and displays potent anti-cancer activity against cancer cell lines. This study aimed to investigate the growth inhibition activity of squamocin coupled with nanodiamond on rats (Rattus norvegicus)-induced breast cancer. Twenty-five female R. norvegicus were divided into five groups (n = 5), including normal control (without any treatment), negative control, group treated with nanodiamond only (ND), group treated with squamocin only (SQ), and the group treated with squamocin coupled with nanodiamond (NDSQ). All of the animal models were induced for breast cancer, except for the normal control group. Breast cancer induction was performed using two doses of N-nitroso-N-methylurea (NMU) injection (50 and 30 mg/kg body weight) intraperitoneally and waited for 22 weeks until the tumor was detected to formed. Nanodiamond coupled with squamocin were administered by intraperitoneal injection (1.5 mg/kg body weight) for 5 weeks, one injection per 3 days. This study showed that the treatment with squamocin coupled with nanodiamond (NDSQ) significantly reduced the proliferation (Ki-67) and induced apoptosis (Caspase-3) of breast cancer cells, corresponding to the reduction of the thickness of the mammary ductal epithelium (p<0.001) and the lower level of CA-153 in serum. In addition, the treatment significantly reduced the malondioldehyde (MDA) and PI3KCA and increased the p53 level significantly. Altogether, in this study, we are the first to report the anti-cancer activity of squamocin in rat-induced breast cancer and the potency of nanodiamond as a carrier of squamocin to increase its anti-cancer activity.

Potential of Red Okra Extract (Abelmoschus esculentus L. Moench) to Restore Kidney Damage due to Sodium Nitrite Sri Puji Astuti Wahyuningsih; Amalia Fachrisa; Nabilatun Nisaâ€™; Baskara Wiku Adi Kusuma; Nadia Shoukat; Rasyidah Fauzia Ahmar; Na'ilah Insani Alifiyah
Biosaintifika: Journal of Biology & Biology Education Vol 13, No 1 (2021): April 2021
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v13i1.28141

Sodium nitrite (NaNO2) found in vegetables, drinking water, and cured meats, can damage tissue because it is an oxidant. Plant phytochemicals such as quercetin are antioxidants. This study aimed to determine the potential of red okra pods ethanol extract (ROE) to repair kidney damage in mice (Mus musculus) induced by NaNO2. The red okra pods were extracted three times with saturated ethanol. The experiment used 36 male BALB/c mice aged 6-8 weeks and body weight of about 28 g. There are six research groups, namely, normal control, negative control (exposure to NaNO2 50 mg/kg BW), treatment of exposure to NaNO2 and administration of ROE at doses of 25, 50, 75, and 100 mg/kg BW. Sodium nitrite and ROE were given daily for 23 days by gavage. On day 24, the serum was isolated. Blood urea nitrogen (BUN) and creatinine (Cre) levels are measured to assess kidney function, as well as measuring the oxidant malondialdehyde (MDA) and the antioxidant enzyme of superoxide dismutase (SOD). The kidneys were made histological preparations and analyzed on the proximal convoluted tubule (PCT).Â All data were statistically analyzed (Î±=0.05). This study indicated that the administration of ROE at a 100 mg/kg BW dose is the most optimal in repairing damage to the PCT with increased normal cells and reduced necrosis. Besides, it degraded BUN, Cre, and MDA levels in the serum of mice exposed to NaNO2 compared to the other treatments. All doses of ROE promoted the SOD level. ROE restore kidney tissue, especially on PCT to normal. Kidney damage due to exposure to NaNO2 preservatives can be reduced by administering ROE. ROE prevents kidney damage through an increase in antioxidant enzymes. ROE can be used as a food ingredient as a source of antioxidants, thereby reducing the impact of oxidant compounds.

Phytochemical Constituents, Nutritional Composition, and Pharmacological Potentials of Mangifera foetida: A Comprehensive Review Alifiyah, Na'ilah Insani; Aryanto, Arie; Zikriyani, Hikmah
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9167

Mangifera foetida, commonly referred to as bacang, is a tropical fruit tree of the Anacardiaceae family widely used in traditional medicine throughout Southeast Asia for a variety of therapeutic purposes. Recent scientific studies have validated many of these ethnomedicinal uses by uncovering a diverse phytochemical composition alongside notable pharmacological activities. This review synthesizes current knowledge on the nutritional content, bioactive compounds, and pharmacological effects of M. foetida, with particular focus on its antioxidant, antimicrobial, cytotoxic, antidiabetic, and anti-inflammatory properties. Key secondary metabolites, including mangiferin, phenolic compounds, flavonoids, and essential oils, are believed to underpin its therapeutic efficacy. Moreover, the fruit and other plant parts provide considerable nutritional benefits, supplying essential vitamins, minerals, and dietary fiber. Despite these promising findings, further investigations are needed to clarify underlying mechanisms, improve extraction techniques, and evaluate clinical effectiveness. This review seeks to establish a comprehensive reference to support future research and facilitate the development of M. foetida-derived nutraceuticals and pharmaceuticals.

Earthworm Cultivation (Lumbricus rubellus) Using Cattle Manure Waste in Pangalengan District, Bandung Regency Aryanto, Arie; Alifiyah, Na'ilah Insani; Zikriyani, Hikmah
ORGANISMS: JOURNAL OF BIOSCIENCES Vol. 5 No. 1 (2025): Organisms: Journal of Biosciences
Publisher : Pusat HKI, Paten, dan Publikasi Ilmiah Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/es4z7c38

This high level of organic waste poses significant environmental risks if left unmanaged. Therefore, there is a need for waste management strategies that are simple, cost-effective, and environmentally sustainable. One such approach is vermiculture the cultivation of earthworms to convert organic waste into nutrient-rich vermicompost. Integrating Effective Microorganisms (EM4) and tomato waste into cattle manure feed has the potential to enhance nutrient bioavailability through microbial fermentation, which in turn supports earthworm metabolism and growth. This study aims to evaluate the productivity of Lumbricus rubellus and the efficiency of vermicompost production under different feed formulations. The experiment was conducted using a completely randomized design (CRD) with four feed treatments: cow manure (P1), cow manure + EM4 (P2), cow manure + tomato waste (P3), and cow manure + tomato waste + EM4 (P4), with three replications per treatment. The observed parameters included earthworm weight, earthworm length, vermicompost production, and proximate analysis of earthworm biomass. This study also assesses the impact of these feed combinations on the growth performance of L. rubellus and the resulting vermicompost yield, within the agroclimatic conditions of Pangalengan. Additionally, the nutritional composition of the harvested earthworm biomass is evaluated to explore its potential as a supplementary protein source for livestock feed contributing to sustainable and circular agricultural practices in dairy farming systems.

Improving The Quality of Solid Organic Fertilizer using Decomposer Aryanto, Arie; Zikriyani, Hikmah; Gerungan, Raflen Ari; Hamdani, Fauzan; Mustaking; Insani Alifiyah, Na’ilah
Jurnal Biogenerasi Vol. 10 No. 1 (2024): Volume 10 Nomor 1, Agustus 2024 - Februari 2025
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v10i1.5201

The utilization of cow manure can reduce environmental pollution around livestock farms. One way to utilize cow manure is by turning it into solid organic fertilizer. The quality of solid organic fertilizer is determined by various factors, including the raw materials, fermentation methods, and composting time. The aim of this study is to improve the quality of solid organic fertilizer using a decomposer. The production of solid organic fertilizer in this study was carried out in two ways: first, by turning the cow manure every 10 days for 40 days (A), and second, using a decomposer with ratio of 1 Liter/3 tons to the cow manure and then turning it every 10 days for 40 days (B). The results showed an increase in C-organic content by 9.56%, nitrogen by 42.02% , phosphate by 19.00% and potassium by 6.56%. This indicates that the addition of a decomposer in the composting process can improve the quality of solid organic fertilizer.

Peningkatan Kapasitas Kelompok Ibu PKK Desa Situ Udik melalui Pembuatan Kompos Limbah Rumah Tangga Hikmah Zikriyani; Dewi Juliah Ratnaningsih; Elizabeth Novi Kusumaningrum; Venty Fitriany Nurunisa; Arie Aryanto; Na’ilah Insani Alifiyah; Faujatul Hasanah; Nurul Nisa'a Amin; Mukhammad Rozaq Sutoni; Restu Para Ratu
I-Com: Indonesian Community Journal Vol 5 No 2 (2025): I-Com: Indonesian Community Journal (Juni 2025)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70609/icom.v5i2.6881

Situ Udik Village faces household waste issues due to population growth and changing consumption patterns, leading to environmental pollution. The 2024 National Community Service Program by Indonesia Open University aims to address this problem by utilizing organic waste as compost to enhance agricultural productivity. The methods include expert-led socialization, compost-making training, and the application of simple technology using buckets as composters. The composting process involves burned rice husks, rice bran, and household organic waste, which are fermented for 21 days (about 3 weeks). The results indicate that the produced compost has a neutral pH and optimal fertility for use as a planting medium. This program not only reduces waste but also improves soil fertility and enhances community welfare through new economic opportunities. Moving forward, research will focus on analyzing the chemical composition of the planting medium and its impact on agricultural productivity. Keywords: Situ Udik Village, Compost, Household Waste

Tinjauan Kuantitatif terhadap Distribusi dan Faktor Lingkungan Jamur Phallus sp. di Indonesia Berdasarkan Literatur Zikriyani, Hikmah; Aryanto, Arie; Alifiyah, Na’ilah Insani
Jurnal Penelitian Sains Vol 28, No 1 (2026)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v28i1.1201

Jamur Phallus sp. termasuk dalam ordo Phallales dan tersebar di berbagai wilayah Indonesia. Kajian literatur ini bertujuan untuk memetakan pola persebaran geografis serta menganalisis faktor lingkungan yang mendukung keberadaannya. Metode penelitian dilakukan melalui pencarian artikel ilmiah di Google Scholar dan aplikasi Publish or Perish, kemudian data dari penelitian terdahulu diolah dengan pendekatan meta-analisis. Faktor lingkungan seperti suhu, kelembapan, intensitas cahaya, dan pH substrat dianalisis untuk memperoleh nilai rata-rata beserta standar error. Hasil kajian menunjukkan bahwa Phallus sp. ditemukan di Sumatera, Jawa, Kalimantan, Sulawesi, Bali, dan Papua. Persebaran ini dipengaruhi oleh iklim tropis, kelembapan tinggi, ketersediaan substrat organik, serta keberadaan hutan alami. Temuan ini menegaskan bahwa keragaman habitat di Indonesia memberikan peluang besar bagi kelestarian dan eksplorasi spesies jamur tersebut sebagai bagian dari kekayaan biodiversitas nasional.

Lichen diversity as an air quality bioindicator in the Mount Tilu Nature Reserve (MTNR) Bandung Aryanto, Arie; Nurmawati, Subekti; Alifiyah, Na’ilah I.; Zikriyani, Hikmah; Hamdani, Fauzan; Sinyo, Filemon M.
Jurnal Biologi Papua Vol 18 No 1 (2026)
Publisher : Jurusan Biologi FMIPA Universitas Cenderawasih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31957/jbp.5295

MTNR in Pangalengan, West Java, is a conservation area with high biodiversity that is increasingly pressured by tourism and agricultural activities, which may affect air quality. This study aimed to examine the relationship between air quality and lichen diversity as bioindicators of air pollution. A descriptive exploratory method was applied at four site types representing different levels of human activity: forest, roadside, plantation, and tourist areas. The results showed that microclimatic conditions and air quality at all sites were classified as good according to Government Regulation No. 22/2021. However, lichen diversity and thallus composition varied among sites in response to environmental conditions. Crustose lichens dominated roadside and plantation areas with higher environmental stress, while foliose and fruticose lichens were more abundant in forest areas characterized by lower temperatures, higher humidity, and minimal pollution. The presence of sensitive species such as Usnea sp. and Ramalina sp. indicated superior air quality in forest sites. In conclusion, lichen distribution reflects an air quality gradient across the study area, confirming the effectiveness of lichens as reliable bioindicators for ecological monitoring in conservation areas.

Title

Found 9 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 9 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 9 Documents
Search